Nephrotoxcicity adverse outcome pathway (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Inflammatory response pathwayKE1968: Increase, mitochondrial dysfunctionKE1194: Increase, DNA damageDNA damage responsep53 transcriptional gene networkKE1923: Altered gene expression, P53 dependent apoptosis pathwayKE1815: Activation of ER stressCytokines and inflammatory responseFerroptosisAutophagyRIPK1-mediated regulated necrosisKE814: Occurence, kidney toxicityKE1633: Increase in inflammationApoptosis modulation and signalingTLR4 signaling and toleranceOxidative stress responseOverview of proinflammatory and profibrotic mediatorsKE1115: Increased, Reactive oygen speciesKE55: Cell injury/deathKE1262: ApoptosisApoptosis modulation and signalingDNA repair pathways, full networkElectron transport chain: OXPHOS system in mitochondriaKE1848: Toll Like Receptor (TLR) dysregulationToll-like receptor signaling pathwayKE1496: Increased, secretion of proinflammatory mediatorsUnfolded protein responseOxidative damage responseSLC22A2SLC31A1Name: Nephrotoxcicity adverse outcome pathwayOrganism: Homo sapiens


Description

Adverse outcome pathway showing the events of nephrotoxicity leading to tubular cell injury and death.

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Quality Tags

Image:Wplogo_31.pngCommunity: Adverse Outcome Pathways
Image:Curated.pngApproved version

Ontology Terms

Disease : hepatitis B
Cell Type : hepatocyte
 

Bibliography

  1. Perazella MA, Rosner MH; ''Drug-Induced Acute Kidney Injury.''; Clin J Am Soc Nephrol, 2022 PubMed Europe PMC Scholia
  2. Manohar S, Leung N; ''Cisplatin nephrotoxicity: a review of the literature.''; J Nephrol, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134519
Approved
view12:43, 22 July 2024EweitzStandardize case
129363
AOP
view09:38, 27 March 2024MkutmonOntology Term : 'disease pathway' added !
123080view17:34, 26 June 2022JuliajohnssonChanged arrow
123079view14:10, 24 June 2022Juliajohnssonannotated key event
123078view14:03, 24 June 2022JuliajohnssonAdded key event
122984view10:54, 9 June 2022Juliajohnssonfixed pathway interaction
122918view21:29, 2 June 2022JuliajohnssonAdded gene name
122752view10:33, 9 May 2022JuliajohnssonAdded gene name.
122712view13:38, 4 May 2022JuliajohnssonFixed interactions
122707view13:21, 4 May 2022JuliajohnssonChnaged pathway node to event node
122706view13:16, 4 May 2022JuliajohnssonChanged empty type columns to events
122700view14:50, 3 May 2022Marvin M2created event node
122696view14:02, 3 May 2022JuliajohnssonModified description
122695view13:54, 3 May 2022JuliajohnssonAdded literature and fixed interactions.
122689view14:46, 2 May 2022JuliajohnssonOntology Term : 'CL:1000497' removed !
122688view14:46, 2 May 2022JuliajohnssonOntology Term : 'DOID:0050855' removed !
122687view14:46, 2 May 2022JuliajohnssonOntology Term : 'DOID:557' removed !
122686view14:44, 2 May 2022JuliajohnssonOntology Term : 'renal fibrosis' added !
122685view14:40, 2 May 2022JuliajohnssonOntology Term : 'kidney disease' added !
122684view14:36, 2 May 2022JuliajohnssonOntology Term : 'chronic kidney disease' added !
122683view14:35, 2 May 2022JuliajohnssonOntology Term : 'kidney tubule cell' added !
122682view14:34, 2 May 2022JuliajohnssonOntology Term : 'acute kidney tubular necrosis' added !
122681view14:31, 2 May 2022JuliajohnssonModified description
122680view11:04, 2 May 2022Juliajohnssonupdated one key event
122679view10:52, 2 May 2022Juliajohnssonupdated key events
122678view10:30, 2 May 2022JuliajohnssonOntology Term : 'kidney cell' added !
122677view10:29, 2 May 2022JuliajohnssonNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
Apoptosis modulation and signalingPathwayWP1772 (WikiPathways)
AutophagyPathwayWP4923 (WikiPathways)
Cytokines and inflammatory responsePathwayWP530 (WikiPathways)
DNA damage responsePathwayWP707 (WikiPathways)
DNA repair pathways, full networkPathwayWP4946 (WikiPathways)
Electron transport chain: OXPHOS system in mitochondriaPathwayWP111 (WikiPathways)
FerroptosisPathwayWP4313 (WikiPathways)
Inflammatory response pathwayPathwayWP453 (WikiPathways)
KE1115: Increased, Reactive oygen speciesEvent1115 (AOP-Wiki KE)
KE1194: Increase, DNA damageEvent1194 (AOP-Wiki KE)
KE1262: ApoptosisEvent1262 (AOP-Wiki KE)
KE1496: Increased, secretion of proinflammatory mediatorsEvent1496 (AOP-Wiki KE)
KE1633: Increase in inflammationEvent1633 (AOP-Wiki KE)
KE1815: Activation of ER stressEvent1815 (AOP-Wiki KE)
KE1848: Toll Like Receptor (TLR) dysregulationEvent1848 (AOP-Wiki KE)
KE1923: Altered gene expression, P53 dependent apoptosis pathwayEvent1923 (AOP-Wiki KE)
KE1968: Increase, mitochondrial dysfunctionEvent1968 (AOP-Wiki KE)
KE55: Cell injury/deathEvent55 (AOP-Wiki KE)
KE814: Occurence, kidney toxicityEvent814 (AOP-Wiki KE)
Overview of proinflammatory and profibrotic mediatorsPathwayWP5095 (WikiPathways)
Oxidative damage responsePathwayWP3941 (WikiPathways)
Oxidative stress responsePathwayWP408 (WikiPathways)
RIPK1-mediated regulated necrosisPathwayWP5022 (WikiPathways)
SLC22A2GeneProductENSG00000112499 (Ensembl)
SLC31A1GeneProductENSG00000136868 (Ensembl)
TLR4 signaling and tolerancePathwayWP3851 (WikiPathways)
Toll-like receptor signaling pathwayPathwayWP75 (WikiPathways)
Unfolded protein responsePathwayWP4925 (WikiPathways)
p53 transcriptional gene networkPathwayWP4963 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5229"
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