Lacto series sphingolipid metabolism (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Lewis ALewis BLc3CerType I H antigenType IA antigenFUT3Sialyl-lactotetraosylceramideSialyl Lewis AType IB antigenA Lewis BLc4Cer/LM1FUT2FUT1B3GALT1B3GALT2LacCerB3GNT5FUT3Name: Lacto series sphingolipid metabolismOrganism: Homo sapiens


Description

Ganglio- series of glycosphingolipids, biosynthesis

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

  1. Merril AH Jr; ''SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids.''; Glycobiology, 2005 PubMed Europe PMC Scholia
  2. ''Handbook of Glycosyltransferases and Related Genes''; https://doi.org/10.1007/978-4-431-67877-9, 2002 DOI Scholia
  3. Yamashiro S, Haraguchi M, Furukawa K, Takamiya K, Yamamoto A, Nagata Y, Lloyd KO, Shiku H; ''Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells.''; J Biol Chem, 1995 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134476
Approved
view00:56, 22 July 2024EweitzFix truncated label in node, improve node alignment, economize layout
125334view22:31, 31 January 2023LarsgwAdd DOI to reference
125140view00:36, 25 January 2023AlexanderPicoadded missing BiopaxRef
125117view05:36, 24 January 2023AlexanderPicoadding prefix to doi in PublicationXref
125111view15:03, 23 January 2023Conroy lipidsadd EC
125110view13:51, 23 January 2023Conroy lipidsadd EC numbers
124671view14:12, 21 November 2022Conroy lipidsOntology Term : 'lacto-series glycosphingolipid metabolic pathway' added !
124670view14:11, 21 November 2022Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
124669view13:04, 21 November 2022Conroy lipidsNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
A Lewis BMetaboliteLMSP0504AH00 (LIPID MAPS)
B3GALT1GeneProductQ9Y5Z6 (Uniprot-TrEMBL)
B3GALT2GeneProductO43825 (Uniprot-TrEMBL)
B3GNT5GeneProductQ9BYG0 (Uniprot-TrEMBL)
FUT1GeneProductP19526 (Uniprot-TrEMBL)
FUT2GeneProductQ10981 (Uniprot-TrEMBL)
FUT3GeneProductP21217 (Uniprot-TrEMBL)
LacCerMetaboliteLMSP0501AB00 (LIPID MAPS)
Lc3CerMetaboliteLMSP0504AA00 (LIPID MAPS)
Lc4Cer/LM1MetaboliteLMSP0504AB00 (LIPID MAPS) ChEBI 17292, Smap 8
Lewis AMetaboliteLMSP0504AC00 (LIPID MAPS)
Lewis BMetaboliteLMSP0504AI00 (LIPID MAPS)
Sialyl Lewis AMetaboliteLMSP0601DL00 (LIPID MAPS)
Sialyl-lactotetraosylceramideMetaboliteLMSP0601DK00 (LIPID MAPS)
Type I H antigenMetaboliteLMSP0504AD00 (LIPID MAPS)
Type IA antigenMetaboliteLMSP0504AF00 (LIPID MAPS)
Type IB antigenMetaboliteLMSP0504AE00 (LIPID MAPS)

Annotated Interactions

Source  ↓Target  ↓Type  ↓Database reference  ↓Comment  ↓
LacCerLc3Cermim-conversion13906 (Rhea) EC:2.4.1.206
Lc3CerLc4Cer/LM1mim-conversion16046 (Rhea) EC:2.4.1.86
Lc4Cer/LM1Lewis Amim-conversion48329 (Rhea) EC:2.4.1.65
Lc4Cer/LM1Type I H antigenmim-conversion32176 (Rhea) EC:2.4.1.69
Sialyl-lactotetraosylceramideSialyl Lewis Amim-conversion47889 (Rhea) EC:2.4.1.65
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