Induction of autophagy and toll-like receptor signaling by graphene oxide (Homo sapiens)

From WikiPathways

Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none GOIFN-betaautophagyGOIFN-gammaTNF-alphaNF-kappaBTRAF6MYD88TLR4TRIFIRF3autophagyNF-kappaBTRAF6MYD88IRF3IFN-betaIFN-gammaTNF-alphaTLR9Beclin1LC3Beclin1LC3Name: Induction of autophagy and toll-like receptor signaling by graphene oxideOrganism: Homo sapiens


Description

Graphene oxide has been found in the RAW264.7 to trigger a cytokine response and resulting autophagy. It was found to be mediated by activation of TLR4 and TLR9, signalling MyD88, TRAF6, and NF-κB, resulting in cytokine expression. However, TLR signaling did not cause IFN-β expression nor IRF3 activation. The process also shows activation of Beclin 1 and LC3.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Image:Wplogo_31.pngCommunity: Adverse Outcome Pathways
Image:Curated.pngApproved version

Ontology Terms

Bibliography

  1. Chen GY, Yang HJ, Lu CH, Chao YC, Hwang SM, Chen CL, Lo KW, Sung LY, Luo WY, Tuan HY, Hu YC; ''Simultaneous induction of autophagy and toll-like receptor signaling pathways by graphene oxide.''; Biomaterials, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129743
Approved
view01:54, 22 May 2024EweitzModified title
126593
AOP
view08:29, 6 June 2023EgonwMore identifiers
126592view08:04, 6 June 2023EgonwAdded more identifiers
125993view15:22, 24 March 2023EgonwOntology Term : 'classic metabolic pathway' added !
125992view15:22, 24 March 2023EgonwOntology Term : 'cytokine mediated signaling pathway' added !
125679view21:29, 6 March 2023EgonwAdded a number of identifiers
125667view16:18, 6 March 2023EgonwAdded the reference
125663view16:11, 6 March 2023EgonwAdded interactions
125657view16:01, 6 March 2023EgonwModified description
125653view15:53, 6 March 2023EgonwNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
Beclin1GeneProductQ14457 (Uniprot-TrEMBL)
GOMetaboliteQ95981922 (Wikidata) graphene oxide
IFN-betaGeneProductP01574 (Uniprot-TrEMBL)
IFN-gammaGeneProductP01579 (Uniprot-TrEMBL)
IRF3GeneProductENSG00000126456 (Ensembl)
LC3GeneProductQ9H492 (Uniprot-TrEMBL) Guess based on Wikipedia, which mentions this LC3 in the context of autophagy.
MYD88GeneProductENSG00000172936 (Ensembl)
NF-kappaBGeneProductP19838 (Uniprot-TrEMBL) ID annotation derived from the label.
TLR4GeneProductENSG00000136869 (Ensembl)
TLR9GeneProductENSG00000239732 (Ensembl)
TNF-alphaGeneProductP01375 (Uniprot-TrEMBL)
TRAF6GeneProductENSG00000175104 (Ensembl)
TRIFGeneProduct
autophagyPathwayWP4923 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5336"
Personal tools