De novo NAD biosynthesis (Saccharomyces cerevisiae)
From WikiPathways
Description
Most organisms synthesize NAD+ from simple components. The specific set of reactions differs among organisms, but a common feature is the generation of quinolinic acid (QA) from an amino acid – either tryptophan (Trp) in animals and some bacteria, or aspartic acid (Asp) in some bacteria and plants. The quinolinic acid is converted to nicotinic acid mononucleotide (NaMN) by transfer of a phosphoribose moiety. An adenylate moiety is then transferred to form nicotinic acid adenine dinucleotide (NaAD). Finally, the nicotinic acid moiety in NaAD is amidated to a nicotinamide (Nam) moiety, forming nicotinamide adenine dinucleotide.
Description adapted from Wikipedia.
Quality Tags
Ontology Terms
Bibliography
- ''NAD de novo biosynthesis II (from tryptophan)''; YeastPathways,
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
2-Amino-3-carboxymuconate semialdehyde | Metabolite | CHEBI:995 (ChEBI) ![]() | |
3-hydroxy-L-kynurenine | Metabolite | 606-14-4 (CAS) ![]() | |
3-hydroxyanthranilate | Metabolite | CHEBI:36559 (ChEBI) ![]() | |
AMP | Metabolite | CHEBI:16027 (ChEBI) ![]() | |
ATP | Metabolite | 1927-31-7 (CAS) ![]() | |
BNA1 | GeneProduct | S000003786 (SGD) ![]() | |
BNA2 | GeneProduct | S000003839 (SGD) ![]() | |
BNA3 | GeneProduct | S000003596 (SGD) ![]() | |
BNA4 | GeneProduct | S000000194 (SGD) ![]() | |
BNA5 | GeneProduct | S000004221 (SGD) ![]() | |
BNA6 | GeneProduct | S000001943 (SGD) ![]() | |
CO2 | Metabolite | CHEBI:16526 (ChEBI) ![]() | |
H2O | Metabolite | HMDB02111 (HMDB) ![]() | |
L-Formylkynurenine | Metabolite | 1022-31-7 (CAS) ![]() | |
L-alanine | Metabolite | CHEBI:16977 (ChEBI) ![]() | |
L-glutamate | Metabolite | 56-86-0 (CAS) ![]() | |
L-glutamine | Metabolite | 56-85-9 (CAS) ![]() | |
L-tryptophan | Metabolite | 73-22-3 (CAS) ![]() | |
NAD | Metabolite | CHEBI:16908 (ChEBI) ![]() | |
NADP | Metabolite | CHEBI:44409 (ChEBI) ![]() | |
NADPH | Metabolite | 53-57-6 (CAS) ![]() | |
NMA1 | GeneProduct | S000004320 (SGD) ![]() | |
NMA2 | GeneProduct | S000003242 (SGD) ![]() | |
O2 | Metabolite | CHEBI:25805 (ChEBI) ![]() | |
PRPP | Metabolite | 97-55-2 (CAS) ![]() | |
QNS1 | GeneProduct | S000001116 (SGD) ![]() | |
deamido-NAD | Metabolite | Q28529688 (Wikidata) ![]() | |
formate | Metabolite | CHEBI:15740 (ChEBI) ![]() | |
kynurenine | Metabolite | 343-65-7 (CAS) ![]() | |
pyrophosphate | Metabolite | 2466-09-3 (CAS) ![]() | |
quinolinate | Metabolite | CHEBI:29959 (ChEBI) ![]() |
Annotated Interactions
No annotated interactions