Omega-6-fatty acids in senescence (Homo sapiens)
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72, 120, 135, 153
4, 8
19, 23
3, 179
146
4, 78
110
4
110
62, 151
35
1
128, 138
15
151, 156
17
46, 147, 186
39, 116
106, 168
24, 42
138
97
106
95, 143
96, 160
14, 73, 122
62
17, 85, 101
3, 179
6, 83, 96
62
110
128, 138
86, 105, 126, 146
95, 143
52
73, 86, 109, 122
146
110
17, 85, 101
173
39, 106
173
95
12
90
39, 116
17, 85, 129
90
4, 78
55, 117
170
72, 120, 153, 182
4, 78, 96
113, 143, 187
109, 122
35
24, 70
1
29
167
96, 160
156
86, 122
6, 83, 96, 98
81, 111
110
17, 109, 173
106
1
160
32, 74, 112, 139
169
106, 168
62
96, 97, 143
96, 160
109, 143
97, 143
128
106
1, 27, 87, 92, 110...
19, 101, 105, 131, 146
35
109
4, 8
32, 74
23, 56, 154, 166
109, 117
155
146
62
110
1, 27, 37
106
14, 122
17, 109, 129
11
106, 168
71, 95, 117
62
90
62
110
22, 64
116
110
155
101, 131, 170
110
11, 24
22
106
96, 160
170
17, 129
1
17, 29
109
62
46, 76, 88, 97, 103...
38, 74, 118, 120, 153...
106
4, 78, 96
128, 138
101, 143
90
109, 170
138
22
44
113, 143, 187
187
48, 107
75, 173
155
29
119
83, 96, 98
168
62
116
105, 141, 146, 166
24, 42
128
106
166
4, 78, 96
12
6, 83, 96, 98
143
173
95, 143
101, 143
96, 160
35
4, 6, 78, 83, 96
6, 83
95
95
59
106
15, 152
57
62
11
72, 74, 138, 153
130
110
48, 143
4, 78, 96
107, 137, 146
29
143
81, 111
32, 74
149
46
78, 96, 134
90, 137
P
Hypothetical reaction
Legend
Excretion via urine
No ID found
Dietary Lipids
Phosphorylation
P
Ac
Protein
Metabolite
Acetylation
Gi
13,14-dihydro-PGF2α
Dehydration
Isomerization
20-COOH-LTB4
Ca2+
LGE2
ABCC4
Beta-oxidation
TxB1
DH-PGJ2
Prostaglandin [e]
GSH
DPEP
Linoleic acid (18:2,w6)
Omega-oxidation
Mitochondrial dysfunction-associated senescence
Oncogene-induced senescence
Isomerase
ALOX15
CYP4F8
ALOX12
13,14-dihydro-PGE2*
GPX1
EXD4
15-deoxy-Δ12,14-PGJ2
10,11-dihydro-LTB4
SLCO2A1
6-trans-LTB4
Ca2+
18-COOH-dinor-LTB4
Bicyclo-PGE2
Tetracosapentaenoic acid (24:5,w-6)
Adrenic acid (22:4,w6)
12-oxo-LTB4
9,15-dideoxy-Δ9,12,14-PGD2*
10-HOTrE
PGJ2
NAT2
PGB1
Excretion via urine
15-hydroxy PG dehydrogenase*
prostaglandin Δreductase*
β-oxidase*
15-keto-PGF2α
MAPK
TXAS
Beta-oxidation
Δ12-PGJ2
Tetracosatetraenoic acid (24:4, w-6)
Cell Cycle Arrest
Senescence
DH-PGF1α*
Unknown
Osbond acid (22:5,w6)
2,3 dinor-6-keto-PGF1α
PGFS
β-oxidation
Beta-oxidation
Excretion via urine
AKR1C3
Δ9-Elongase*
5(S),6(R)-DiHETE
cAMP
Hydrolase
ALOXE3
w-hydroxylase*
Non-enzymatic conversion
15-keto-PGE1
Dinor-4-keto-7,9,13-trihydroxy-prosta-11,12-enoic acid*
15-keto-13,14-dihydro-PGE1
Gq
GSTP1
ALOX15B
12(S)-HETE
Arachidonic Acid (20:4,w6)
LTF4
Non-enzymatic
degradation
PTGES
Unknown
LTC4S
γ-GT
EXE4
15-ketoprostaglandin reductase
Non-enzymatic
9α, 11α-dihydroxy-11-keto-2,3,4,5-tetranorprostane-1,16-dioic acid*
Dehydration
AKR1B1
PGA1
16-COOH-tetranor-LTE3
LXB4
TRXB3
13,14-dihydro-15-keto-PGE2
IP3
6-keto-PGE1
PTGDR
9-hydroxyprostaglandin dehydrogenase*
18-COOH-dinor-LTE4
PGDS
PGDS
5(S),6(S)-epoxy-15(R)-HpETE*
9-deoxy-Δ12-PGD2*
TBXAS1
15-epi-LXA4
5(S),15(S)-DiHpETE*
y-linolenic acid (18:3,w6)
PGE synthase
20-COOH-LTE4
Irradiation-induced senescence
PTGER1
DH-PGF2α
9α, 11β-dihydroxy-15-oxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid*
PGI1*
Radiation-induced senescence
TRXA3
PGG1
DH-TxA2*
4,13-diketo-7,9-dihydroxy-2,3-dinor prostanoic acid*
15-keto-13,14-dihydro-PGF2α
PGI2
Eicosadienoic acid (20:2,w6)
16-COOH-tetranor-LTB3*
H-PGDS
5α,7α-dihydroxy-11-keto tetranor-prostane-1,16-dioic acid*
Beta-oxidation
Dehydrase
9α,11α-PGF2α
Beta-oxidation
Gs
IP3
Gq
5(S),6(S)-DiHETE
HXB3
p53
PRAK
19-OH-PGE1
Carboxypeptidase A
TxA1*
12(S)-HpETE
Δ12-PGD2
Δ13-reductase
Dihomo-y-linolenic acid (20:3,w6)
DH-15d-PGJ2
TxA
PGD1
Senescence phenotype
15(S)-HETE
Carbonyl reductase*
Spontaneous hydrolysis
AKR1C3
PGG2
PGA2
Δ6-trans-12-epi-LTB4
DH-PGH2*
GPX1
PGC1
11-dehydro-TxB2
6-keto-PGF1α
DH-15d-Δ12,14-PGD2
15(R)-HpETE
15-epi-LXB4
11α-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoic acid
NAT1
delta10-reductase
PGF1α
PPARγ
5(S)-HETE
EXA4
PGE2
15-ketoprostaglandin reductase
PGES
PGH2
12-oxo-10,11-dihydro-LTB4
Reductase
9α,11β-PGF2α
13,14-dihydro-15-keto-PGA2
2,4-dienoyl-CoA reductase
15-keto-PGI2
14-COOH-hexanor-LTE4*
EPHX2
ALOX12
CYP8A1
PG-9KR
CYP4F8
5(S),6(S)-epoxy-15(S)-HETE
DH-TxB2*
Isomerase
Tetranor-PGDM
Omega-oxidation
LXA4
p21
15(S)-HpETE
LGD2
Non-enzymatic rearrangement
PGD2
Albumin-mediated degradation
RAS
PGH1
DH-PGD2
PGES
13,14-dihydro-15-keto-PGD2
GGT1
CYP4F8
L-PGDS
PGE1
EXC4
15-keto-PGD2
N-acetyl- LTE4
HPGD
Excretion via urine
19-OH-PGH2*
DH-PGE2
HXA3
22, 64
127, 148
165
143
161
20
161
35
91
1
20
161
127
105
48, 95, 132, 136, 184
143
143
137, 143
50, 51, 107, 137, 143...
44, 48, 107, 137, 143...
48, 51, 107, 146
105, 123
9, 12, 41, 105, 141...
69, 97, 126, 184
36, 69, 105, 132, 145...
PTGES2
PTGES3
AKR1B1
58, 67, 97, 170
58, 97, 170
1, 27, 37
PTGDR2
127
19-OH-PGE2
15-keto-PGE2
PTGER2
PTGER3
22, 64
22, 64
PTGER4
22, 64
PGC2
PGB2
PTGFR
TxB
TBXA2R
Gs
PTGIR
cAMP
Membrane phospholipids
181
7
Cytosolic phospholipase A2
Cytosolic phospholipase A2
p38 MAPK
Non-enzymatic dehydration
11-hydroxy-9,15-dioxo-prost-5-en-1,20-dioic acid*
7α-hydroxy-5,11-diketo-tetranorprosta-1,16-dioc acid*
143
177
Dinor-4,13-diketo-7,9-dihydroxy-prostanoic acid*
Dinor-4,13-diketo-7,9-dihydroxy-prostan-1,18-dioic acid*
Unknown
2,3-dinor 6-keto pentanor*
19-OH-6-keto-PGF1α
6,15-Diketo-13,14-dihydro-PGF1α
6,15-Diketo-13,14-dihydro-2,3-dinor PGF1α*
Unknown
2,3-dinor-11β-PGF2α
Unknown
127
23, 56, 154
19, 23, 96
23, 96
23, 96
19, 23, 96, 154
23, 96
23, 74, 118, 120
23, 74, 82, 118, 120...
23, 38, 43, 93
2,3-Dinor-TxB2
11-hydroxythromboxane B2 dehydrogenase
Unknown
Unknown
Unknown
Unknown
P
PTGS1
PTGS2
15-deoxy-Δ12,14-PGD2
ELOVL2
57
57
40, 57
40
40
40
40, 95
40
40
40
40
40, 57
40
40
40
ELOVL5
FADS2
FADS1
ELOVL5
Excretion via urine
Excretion via urine
Excretion via urine
Excretion via urine
Δ13-reductase
Unknown
Δ13-reductase
Excretion via urine
6,15-diketo PGF1α
Unknown
28, 39, 94
30, 94
7, 62
7
DPEP1
GGT1
DPEP2
LTC4S
GGT5
LTA4H
30, 77, 94, 175
28, 30, 94
13
28, 30, 94
39
28, 30, 62, 94
13
13
13
13
ALOX5
LTB4
5(S)-HpETE
LTD4
LTA4
LTE4
LTC4
SASP
FLAP
HPGD
HPGD
HPGD
Prostaglandin [c]
Prostaglandin [e]
Prostaglandin [c]
Prostaglandin [e]
Prostaglandin [c]
DH-PGI2
Non-enzymatic
39
39, 66
39, 66, 84
39, 66
84
66
7, 39, 62
CysLT1R
SIRT1
84
p53
84
ROS
p53
P
p21
Rb
Rb
P
39, 66
PAI-1
84, 183
Senescence
84, 183
p53
Ac
20-OH-LTB4
66
Oncogene-induced senescence
DNA damage-induced senescence
Oxidative stress-induced senescence
Replicative senescence
Irradiation-induced senescence
Replicative senescence
Radiation-induced senescence
Mtochondrial dysfunction-associated senescence
Oncogene-induced senescence
161
161
SASP
DH-PGG2*
Irradiation-induced senescence
161
Irradiation-induced senescence
Irradiation-induced Senescence
Oncogene-induced senescence (RAS)
161
161
62
62, 159
62, 78
Radiation-induced senescence
Oncogene-induced senescence(RAS)
62
161
Irradiation-induced senescence
161
Oncogene-induced senescence(RAS)
62
161
62
Mitochondrial dysfunction-associated senescence
Oncogene-induced senescence(RAS)
161
62
62
62
62
62
Oncogene-induced senescence(RAS)
161
62
62
DNA damage-induced senescence
Oncogene-induced senescence
161
Mitochondrial dysfunction-associated senescence
Oncogene-induced senescence(RAS)
Irradiation-induced senescence
161
Replicative senescence
Oncogene-induced senescence(RAS)
161
161
Paracrine senescence
161
61, 100, 140
61, 80, 100, 140
61, 80, 100, 140
54, 61, 80, 100, 140
80, 115
79, 80, 179
54, 80, 140
80, 140
52
52, 55, 97, 108
54, 61, 80, 100, 140
54, 61, 80, 100, 140
25, 80, 124
80, 115
80, 124
54, 80, 140
54, 80, 140
52, 55
8-iso-15-keto-PGF2α
79, 80, 179
2,3-dinor-5,6-dihydro-8-iso-PGF2α*
2,3-dinor-8-IsoPGF2α
15-E2-IsoK*
8-iso-13,14-dihydro-15-keto-PGF2α
15-TxB2-IsoP*
15-D2-IsoK*
α-tetranor-15-keto-13,14-dihydro-8-iso-PGF2α*
15-TxA2-IsoP*
15-H2-IsoP*
15-G2-IsoP*
15-F2-IsoP
15-D2-IsoP
15-J2-IsoP
15-15d-J2-IsoP*
15-E2-IsoP
80
15-A2-IsoP
80, 140
80, 115
124
80, 142
80, 140
61, 80, 100, 140
80, 140
80, 140
80, 115
124
61, 80, 100, 140
12-E2-IsoK*
12-D2-IsoK*
12-H2-IsoP
12-G2-IsoP
12-F2-IsoP
12-D2-IsoP
12-J2-IsoP
12-15d-J2-IsoP
80
12-E2-IsoP
12-A2-IsoP
12-Dioxolane-IsoP*
12-TxA2-IsoP*
12-TxB2-IsoP*
80, 115
80, 142
61, 80, 100, 140
80, 140
80, 140
61, 80, 100, 140
80, 115
124
124
80, 140
80, 140
8-Dioxolane-IsoP*
8-D2-IsoK*
8-E2-IsoK*
8-H2-IsoP*
8-G2-IsoP*
8-F2-IsoP
8-D2-IsoP
8-J2-IsoP
8-15d-J2-IsoP
8-E2-IsoP
80
8-A2-IsoP
8-TxA2-IsoP*
8-TxA2-IsoP*
80, 140
80, 115
124
80, 115
61, 80, 100, 140
80, 140
140
124
80, 140
61, 80, 100, 140
5-D2-IsoK*
5-E2-IsoK*
5-TxA2-IsoP*
5-H2-IsoP*
5-G2-IsoP*
5-F2-IsoP
5-D2-IsoP
5-J2-IsoP
5-15d-J2-IsoP
5-E2-IsoP
80
5-A2-IsoP
5-TxB2-IsoP*
Free radical-catalyzed peroxidation
Excretion via urine
HPGD
53
53
53
7-DH-F2-IsoP
53
14-DH-F2-IsoP
10-DH-F2-IsoP
17-DH-F2-IsoP
Leukotriene 3-series
8-iso-13,14-dihydro-15-keto-PGE2*
45
11-deoxy-13,14-dihydro-15-keto-11β,16-cyclo-PGE1
Upregulation/Overexpression
Downregulation/Underexpression
Conversion
Stimulation
Catalysis
Senescence phenotype
Cytosolic phospholipase A2
Metabolite*
ELOVL2
FADS2
ALOX15
Omega-oxidation
Beta-oxidation
PTGS2
Ac
ALOX5
ALOX15B
ALOX15B
ALOX15
ALOX15
Beta-oxidation
62
62