Omega-6-fatty acids in senescence (Homo sapiens)

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72, 120, 135, 1534, 819, 233, 1791464, 78110411062, 151351128, 13815151, 1561746, 147, 18639, 116106, 16824, 421389710695, 14396, 16014, 73, 1226217, 85, 1013, 1796, 83, 9662110128, 13886, 105, 126, 14695, 1435273, 86, 109, 12214611017, 85, 10117339, 10617395129039, 11617, 85, 129904, 7855, 11717072, 120, 153, 1824, 78, 96113, 143, 187109, 1223524, 7012916796, 16015686, 1226, 83, 96, 9881, 11111017, 109, 173106116032, 74, 112, 139169106, 1686296, 97, 14396, 160109, 14397, 1431281061, 27, 87, 92, 110...19, 101, 105, 131, 146351094, 832, 7423, 56, 154, 166109, 117155146621101, 27, 3710614, 12217, 109, 12911106, 16871, 95, 11762906211022, 64116110155101, 131, 17011011, 242210696, 16017017, 129117, 291096246, 76, 88, 97, 103...38, 74, 118, 120, 153...1064, 78, 96128, 138101, 14390109, 1701382244113, 143, 18718748, 10775, 1731552911983, 96, 9816862116105, 141, 146, 16624, 421281061664, 78, 96126, 83, 96, 9814317395, 143101, 14396, 160354, 6, 78, 83, 966, 8395955910615, 15257621172, 74, 138, 15313011048, 1434, 78, 96107, 137, 1462914381, 11132, 741494678, 96, 13490, 137PHypothetical reaction LegendExcretion via urineNo ID foundDietary LipidsPhosphorylationPAcProteinMetaboliteAcetylationGi13,14-dihydro-PGF2αDehydrationIsomerization20-COOH-LTB4Ca2+LGE2ABCC4Beta-oxidationTxB1DH-PGJ2Prostaglandin [e]GSHDPEPLinoleic acid (18:2,w6)Omega-oxidationMitochondrial dysfunction-associated senescenceOncogene-induced senescence IsomeraseALOX15CYP4F8ALOX1213,14-dihydro-PGE2*GPX1EXD415-deoxy-Δ12,14-PGJ210,11-dihydro-LTB4SLCO2A16-trans-LTB4Ca2+18-COOH-dinor-LTB4Bicyclo-PGE2Tetracosapentaenoic acid (24:5,w-6)Adrenic acid (22:4,w6)12-oxo-LTB49,15-dideoxy-Δ9,12,14-PGD2*10-HOTrEPGJ2NAT2PGB1Excretion via urine15-hydroxy PG dehydrogenase*prostaglandin Δreductase*β-oxidase*15-keto-PGF2αMAPKTXASBeta-oxidationΔ12-PGJ2Tetracosatetraenoic acid (24:4, w-6)Cell Cycle ArrestSenescenceDH-PGF1α*UnknownOsbond acid (22:5,w6)2,3 dinor-6-keto-PGF1αPGFSβ-oxidationBeta-oxidationExcretion via urineAKR1C3Δ9-Elongase*5(S),6(R)-DiHETEcAMPHydrolaseALOXE3w-hydroxylase*Non-enzymatic conversion15-keto-PGE1Dinor-4-keto-7,9,13-trihydroxy-prosta-11,12-enoic acid*15-keto-13,14-dihydro-PGE1GqGSTP1ALOX15B12(S)-HETEArachidonic Acid (20:4,w6)LTF4Non-enzymatic degradationPTGESUnknownLTC4Sγ-GTEXE415-ketoprostaglandin reductaseNon-enzymatic9α, 11α-dihydroxy-11-keto-2,3,4,5-tetranorprostane-1,16-dioic acid*DehydrationAKR1B1PGA116-COOH-tetranor-LTE3LXB4TRXB313,14-dihydro-15-keto-PGE2IP36-keto-PGE1PTGDR9-hydroxyprostaglandin dehydrogenase*18-COOH-dinor-LTE4PGDSPGDS5(S),6(S)-epoxy-15(R)-HpETE*9-deoxy-Δ12-PGD2*TBXAS115-epi-LXA45(S),15(S)-DiHpETE*y-linolenic acid (18:3,w6)PGE synthase20-COOH-LTE4Irradiation-induced senescencePTGER1DH-PGF2α9α, 11β-dihydroxy-15-oxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid*PGI1*Radiation-induced senescenceTRXA3PGG1DH-TxA2*4,13-diketo-7,9-dihydroxy-2,3-dinor prostanoic acid*15-keto-13,14-dihydro-PGF2αPGI2Eicosadienoic acid (20:2,w6)16-COOH-tetranor-LTB3*H-PGDS5α,7α-dihydroxy-11-keto tetranor-prostane-1,16-dioic acid*Beta-oxidationDehydrase9α,11α-PGF2αBeta-oxidationGsIP3Gq5(S),6(S)-DiHETEHXB3p53PRAK19-OH-PGE1Carboxypeptidase ATxA1*12(S)-HpETEΔ12-PGD2Δ13-reductaseDihomo-y-linolenic acid (20:3,w6)DH-15d-PGJ2TxAPGD1Senescence phenotype15(S)-HETECarbonyl reductase*Spontaneous hydrolysisAKR1C3PGG2PGA2Δ6-trans-12-epi-LTB4DH-PGH2*GPX1PGC111-dehydro-TxB26-keto-PGF1αDH-15d-Δ12,14-PGD215(R)-HpETE15-epi-LXB411α-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoic acidNAT1 delta10-reductasePGF1αPPARγ5(S)-HETEEXA4PGE215-ketoprostaglandin reductasePGESPGH212-oxo-10,11-dihydro-LTB4Reductase9α,11β-PGF2α13,14-dihydro-15-keto-PGA22,4-dienoyl-CoA reductase15-keto-PGI214-COOH-hexanor-LTE4*EPHX2ALOX12CYP8A1PG-9KRCYP4F8 5(S),6(S)-epoxy-15(S)-HETEDH-TxB2*IsomeraseTetranor-PGDMOmega-oxidationLXA4p2115(S)-HpETELGD2Non-enzymatic rearrangementPGD2Albumin-mediated degradationRASPGH1DH-PGD2PGES13,14-dihydro-15-keto-PGD2 GGT1CYP4F8L-PGDSPGE1EXC415-keto-PGD2N-acetyl- LTE4HPGD Excretion via urine19-OH-PGH2*DH-PGE2HXA322, 64127, 14816514316120161359112016112710548, 95, 132, 136, 184143143137, 14350, 51, 107, 137, 143...44, 48, 107, 137, 143...48, 51, 107, 146105, 1239, 12, 41, 105, 141...69, 97, 126, 18436, 69, 105, 132, 145...PTGES2PTGES3AKR1B158, 67, 97, 17058, 97, 1701, 27, 37PTGDR2 12719-OH-PGE215-keto-PGE2PTGER2PTGER322, 6422, 64PTGER422, 64PGC2PGB2PTGFR TxBTBXA2RGsPTGIRcAMPMembrane phospholipids1817Cytosolic phospholipase A2Cytosolic phospholipase A2p38 MAPKNon-enzymatic dehydration11-hydroxy-9,15-dioxo-prost-5-en-1,20-dioic acid*7α-hydroxy-5,11-diketo-tetranorprosta-1,16-dioc acid*143177Dinor-4,13-diketo-7,9-dihydroxy-prostanoic acid*Dinor-4,13-diketo-7,9-dihydroxy-prostan-1,18-dioic acid*Unknown2,3-dinor 6-keto pentanor*19-OH-6-keto-PGF1α6,15-Diketo-13,14-dihydro-PGF1α6,15-Diketo-13,14-dihydro-2,3-dinor PGF1α*Unknown2,3-dinor-11β-PGF2αUnknown12723, 56, 15419, 23, 9623, 9623, 9619, 23, 96, 15423, 9623, 74, 118, 12023, 74, 82, 118, 120...23, 38, 43, 932,3-Dinor-TxB211-hydroxythromboxane B2 dehydrogenaseUnknownUnknownUnknownUnknownPPTGS1PTGS215-deoxy-Δ12,14-PGD2ELOVL2575740, 5740404040, 954040404040, 57404040ELOVL5FADS2FADS1ELOVL5Excretion via urineExcretion via urineExcretion via urineExcretion via urineΔ13-reductaseUnknownΔ13-reductaseExcretion via urine6,15-diketo PGF1αUnknown28, 39, 9430, 947, 627DPEP1GGT1DPEP2LTC4SGGT5LTA4H30, 77, 94, 17528, 30, 941328, 30, 943928, 30, 62, 9413131313ALOX5LTB45(S)-HpETELTD4LTA4LTE4LTC4SASPFLAPHPGD HPGD HPGD Prostaglandin [c]Prostaglandin [e]Prostaglandin [c]Prostaglandin [e]Prostaglandin [c]DH-PGI2Non-enzymatic3939, 6639, 66, 8439, 6684667, 39, 62CysLT1RSIRT184p5384ROSp53Pp21RbRbP39, 66PAI-184, 183Senescence84, 183p53Ac20-OH-LTB466Oncogene-induced senescenceDNA damage-induced senescenceOxidative stress-induced senescenceReplicative senescenceIrradiation-induced senescenceReplicative senescenceRadiation-induced senescenceMtochondrial dysfunction-associated senescenceOncogene-induced senescence161161SASPDH-PGG2*Irradiation-induced senescence161Irradiation-induced senescenceIrradiation-induced SenescenceOncogene-induced senescence (RAS)1611616262, 15962, 78Radiation-induced senescenceOncogene-induced senescence(RAS)62161Irradiation-induced senescence161Oncogene-induced senescence(RAS)6216162Mitochondrial dysfunction-associated senescenceOncogene-induced senescence(RAS)1616262626262Oncogene-induced senescence(RAS)1616262DNA damage-induced senescenceOncogene-induced senescence161Mitochondrial dysfunction-associated senescenceOncogene-induced senescence(RAS)Irradiation-induced senescence161Replicative senescenceOncogene-induced senescence(RAS)161161Paracrine senescence16161, 100, 14061, 80, 100, 14061, 80, 100, 14054, 61, 80, 100, 14080, 11579, 80, 17954, 80, 14080, 1405252, 55, 97, 10854, 61, 80, 100, 14054, 61, 80, 100, 14025, 80, 12480, 11580, 12454, 80, 14054, 80, 14052, 558-iso-15-keto-PGF2α79, 80, 1792,3-dinor-5,6-dihydro-8-iso-PGF2α*2,3-dinor-8-IsoPGF2α15-E2-IsoK*8-iso-13,14-dihydro-15-keto-PGF2α15-TxB2-IsoP*15-D2-IsoK*α-tetranor-15-keto-13,14-dihydro-8-iso-PGF2α*15-TxA2-IsoP*15-H2-IsoP*15-G2-IsoP*15-F2-IsoP15-D2-IsoP15-J2-IsoP15-15d-J2-IsoP*15-E2-IsoP8015-A2-IsoP80, 14080, 11512480, 14280, 14061, 80, 100, 14080, 14080, 14080, 11512461, 80, 100, 14012-E2-IsoK*12-D2-IsoK*12-H2-IsoP12-G2-IsoP12-F2-IsoP12-D2-IsoP12-J2-IsoP12-15d-J2-IsoP8012-E2-IsoP12-A2-IsoP12-Dioxolane-IsoP*12-TxA2-IsoP*12-TxB2-IsoP*80, 11580, 14261, 80, 100, 14080, 14080, 14061, 80, 100, 14080, 11512412480, 14080, 1408-Dioxolane-IsoP*8-D2-IsoK*8-E2-IsoK*8-H2-IsoP*8-G2-IsoP*8-F2-IsoP8-D2-IsoP8-J2-IsoP8-15d-J2-IsoP8-E2-IsoP808-A2-IsoP8-TxA2-IsoP*8-TxA2-IsoP*80, 14080, 11512480, 11561, 80, 100, 14080, 14014012480, 14061, 80, 100, 1405-D2-IsoK*5-E2-IsoK*5-TxA2-IsoP*5-H2-IsoP*5-G2-IsoP*5-F2-IsoP5-D2-IsoP5-J2-IsoP5-15d-J2-IsoP5-E2-IsoP805-A2-IsoP5-TxB2-IsoP*Free radical-catalyzed peroxidationExcretion via urineHPGD 5353537-DH-F2-IsoP5314-DH-F2-IsoP10-DH-F2-IsoP17-DH-F2-IsoPLeukotriene 3-series8-iso-13,14-dihydro-15-keto-PGE2*4511-deoxy-13,14-dihydro-15-keto-11β,16-cyclo-PGE1Upregulation/OverexpressionDownregulation/UnderexpressionConversionStimulationCatalysisSenescence phenotypeCytosolic phospholipase A2Metabolite*ELOVL2FADS2ALOX15Omega-oxidationBeta-oxidationPTGS2AcALOX5ALOX15BALOX15BALOX15ALOX15Beta-oxidation6262