Hallmark of cancer: sustaining proliferative signaling (Homo sapiens)

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Proliferative signalling in cancer cells

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Bibliography

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  7. Huleihel M, Goldsborough M, Cleveland J, Gunnell M, Bonner T, Rapp UR; ''Characterization of murine A-raf, a new oncogene related to the v-raf oncogene.''; Mol Cell Biol, 1986 PubMed Europe PMC Scholia
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  11. Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M; ''MEK drives BRAF activation through allosteric control of KSR proteins.''; Nature, 2018 PubMed Europe PMC Scholia
  12. Shaul YD, Seger R; ''The MEK/ERK cascade: from signaling specificity to diverse functions.''; Biochim Biophys Acta, 2007 PubMed Europe PMC Scholia
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  26. Landa I, Ibrahimpasic T, Boucai L, Sinha R, Knauf JA, Shah RH, Dogan S, Ricarte-Filho JC, Krishnamoorthy GP, Xu B, Schultz N, Berger MF, Sander C, Taylor BS, Ghossein R, Ganly I, Fagin JA; ''Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.''; J Clin Invest, 2016 PubMed Europe PMC Scholia
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  32. Vitagliano D, Portella G, Troncone G, Francione A, Rossi C, Bruno A, Giorgini A, Coluzzi S, Nappi TC, Rothstein JL, Pasquinelli R, Chiappetta G, Terracciano D, Macchia V, Melillo RM, Fusco A, Santoro M; ''Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas.''; Oncogene, 2006 PubMed Europe PMC Scholia
  33. Ikawa S, Fukui M, Ueyama Y, Tamaoki N, Yamamoto T, Toyoshima K; ''B-raf, a new member of the raf family, is activated by DNA rearrangement.''; Mol Cell Biol, 1988 PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
135759view12:06, 9 November 2024EgonwRemoved template comments
135540view19:30, 23 September 2024KhanspersOntology Term : 'signaling pathway' added !
135539view19:29, 23 September 2024KhanspersOntology Term : 'cancer pathway' added !
134341view13:50, 20 July 2024EweitzModified title
134340view13:49, 20 July 2024EweitzModified title
134337view13:40, 20 July 2024EweitzModified title
133258view09:54, 10 June 2024PhilipErnst
130816view14:05, 30 May 2024PhilipErnstNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment

RAS

ProteinENSG00000133703 (Ensembl) RAS protein has three isoforms ( K,N and H RAS). the isoforms differ in ability of activating RAF protein, the isoform which is responsable the most of activating of Raf protein is Kras> also, HRAS has the ability of activating the RAF proteins but less efficiently than KRAS. (PMID: 9727023)
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
AML1GeneProductLRG_482 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
AXINGeneProductENSG00000168646 (Ensembl)
BCL9GeneProductENSG00000116128 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl) IKKa
CK1GeneProductENSG00000113712 (Ensembl)
CRAF GeneProductENSG00000132155 (Ensembl)
CSF1RGeneProductENSG00000182578 (Ensembl)
Catenin beta-1ProteinB4DGU4 (Uniprot-TrEMBL)
DEPTORGeneProductENSG00000155792 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
EPHA2GeneProductENSG00000142627 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FGFR3GeneProductENSG00000068078 (Ensembl)
FGFR4GeneProductENSG00000160867 (Ensembl)
FLT1GeneProductENSG00000102755 (Ensembl)
FLT3GeneProductENSG00000122025 (Ensembl)
FLT4GeneProductENSG00000037280 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FrizzledProteinE5RGK8 (Uniprot-TrEMBL) Frizzled Not Specified
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2GeneProductENSG00000177885 (Ensembl)
GRB2ProteinQ75VX8 (Uniprot-TrEMBL)
GSK3BGeneProductENSG00000082701 (Ensembl)
GTPMetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:37565 (ChEBI)
IGF1RGeneProductENSG00000140443 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl) IKKy
IL-11ProteinENSG00000095752 (EMBL)
IL6GeneProduct3569 (Entrez Gene)
IL6RGeneProduct3570 (Entrez Gene)
INSRGeneProductENSG00000171105 (Ensembl)
JAK2GeneProduct3717 (Entrez Gene)
Junction plakoglobinProteinP14923 (Uniprot-TrEMBL)
KDRGeneProductENSG00000128052 (Ensembl)
KITGeneProductENSG00000157404 (Ensembl)
KSR1GeneProductENSG00000141068 (Ensembl)
LEFGeneProductENSG00000138795 (Ensembl) LEF Not Specified
LRP5GeneProductENSG00000162337 (Ensembl)
LRP6GeneProductENSG00000070018 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK3 GeneProductENSG00000102882 (Ensembl) Also known as ERK
MAPK3GeneProductENSG00000102882 (Ensembl) Also known as ERK
MDM2GeneProductENSG00000135679 (Ensembl)
METGeneProductENSG00000105976 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NFKBIEGeneProductENSG00000146232 (Ensembl)
NGFRGeneProductENSG00000064300 (Ensembl)
NTRK1GeneProductENSG00000198400 (Ensembl)
NTRK2GeneProductENSG00000148053 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
P21GeneProductENSG00000124762 (Ensembl)
PDGFRAGeneProductENSG00000134853 (Ensembl)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3CGGeneProductENSG00000105851 (Ensembl)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLZFGeneProductENSG00000109906 (Ensembl)
PMLGeneProductENSG00000140464 (Ensembl)
PPARDGeneProductENSG00000112033 (Ensembl)
PRAS40GeneProductENSG00000204673 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
PYGOGeneProductENSG00000171016 (Ensembl) PYGO Not Specified
PhosphateMetaboliteHMDB0001429 (HMDB)
RAFGeneProductENSG00000132155 (Ensembl)
RARAGeneProductENSG00000131759 (Ensembl)
RASGeneProductENSG00000174775 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl) RelA
RELGeneProductENSG00000162924 (Ensembl) c-Rel
RETNProteinENSG00000104918 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
RUNX1T1GeneProductENSG00000079102 (Ensembl)
SALL4GeneProductENSG00000101115 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SHCGeneProductENSG00000160691 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STAT3GeneProduct6774 (Entrez Gene)
TCFGeneProductENSG00000071564 (Ensembl) TCF Not Specified
TEKGeneProductENSG00000120156 (Ensembl)
TEL2GeneProductENSG00000100726 (Ensembl)
TP53ProteinENSG00000141510 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
TTI1GeneProductENSG00000101407 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
WNTGeneProductENSG00000125084 (Ensembl) Wnt Not Specified
c-FOSGeneProductENSG00000170345 (Ensembl)
c-JUNGeneProductENSG00000177606 (Ensembl)
c-MYCGeneProductENSG00000136997 (Ensembl)
cyclin-D1ProteinP24385 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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