Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none JNK consists of 10 isoforms:JNK1 (4 isoforms)-> MAPK8JNK2 (four isoforms)-> MAPK9JNK3 (two isoforms)-> MAPK10ENPP2Intraocular pressureSIS3FN1CCN2COL1A1ACTA2TGFB3STAT3LPARHOMAPK8MAPK9MAPK10TGFB1TGFB2SMAD3Name: Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humorOrganism: Homo sapiens


Description

This pathway visualises the potential mechanisms of TGF-β3-mediated ENPP2 (or ATX) expression and fibrotic changes in HTM cells. This pathway was created using the PFOCR project, based on [these results](https://pfocr.wikipathways.org/figures/PMC9496180__biomolecules-12-01231-g008.html).

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Quality Tags

Image:Curated.pngApproved version
Image:PLoS_OpenAccess.pngOpen Access

Ontology Terms

Bibliography

  1. Liu M, Honjo M, Yamagishi R, Igarashi N, Nakamura N, Kurano M, Yatomi Y, Igarashi K, Aihara M; ''Fibrotic Response of Human Trabecular Meshwork Cells to Transforming Growth Factor-Beta 3 and Autotaxin in Aqueous Humor.''; Biomolecules, 2022 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139134
Approved
view23:30, 22 May 2025EweitzRefine graphics for phenotype node
139133view23:28, 22 May 2025EweitzUse gene symbols
139132view23:27, 22 May 2025EweitzEconomize layout
139108view01:34, 22 May 2025EweitzOntology Term : 'trabecular meshwork cell' added !
139107view01:33, 22 May 2025EweitzModified title
139069view07:09, 18 May 2025EgonwModified title
139068view07:09, 18 May 2025EgonwModified description
138962view15:23, 9 May 2025DeSlOntology Term : 'signaling pathway' added !
138961view15:23, 9 May 2025DeSlOntology Term : 'transforming growth factor-beta signaling pathway' added !
138960view15:22, 9 May 2025DeSlOntology Term : 'glaucoma' added !
138959view15:20, 9 May 2025DeSlAdded PFOCR info in description
138958view15:19, 9 May 2025DeSlUpdated description
138957view15:18, 9 May 2025DeSlChanged title to keep Eric happy
138956view15:17, 9 May 2025DeSlNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ACTA2GeneProduct59 (Entrez Gene) "α-SMA" originally
CCN2GeneProduct1490 (Entrez Gene) alternative name: CTGF
COL1A1GeneProduct1277 (Entrez Gene) OCR lexicon match: COL1A1
ENPP2GeneProduct5168 (Entrez Gene) alternative name: ATX
FN1GeneProduct2335 (Entrez Gene)
  • "Fibronectin" originally
  • "Fibronectin exists as a protein dimer, consisting of two nearly identical monomers linked by a pair of disulfide bonds." Source: Wikipedia, https://en.wikipedia.org/wiki/Fibronectin
Intraocular pressureQ650050 (Wikidata)
LPAGeneProduct4018 (Entrez Gene) OCR lexicon match: LPA
MAPK10GeneProduct5602 (Entrez Gene) OCR lexicon match: JNK
MAPK8GeneProduct5599 (Entrez Gene) OCR lexicon match: JNK
MAPK9GeneProduct5601 (Entrez Gene) OCR lexicon match: JNK
RHOGeneProduct6010 (Entrez Gene) OCR lexicon match: RHO
SIS3ProteinQ8GYT9 (Uniprot-TrEMBL)
SMAD3GeneProduct4088 (Entrez Gene) OCR lexicon match: SMAD3
STAT3GeneProduct6774 (Entrez Gene) OCR lexicon match: STAT3
TGFB1GeneProduct7040 (Entrez Gene) OCR lexicon match: TGF-B1
TGFB2GeneProduct7042 (Entrez Gene) OCR lexicon match: TGF-B2
TGFB3GeneProduct7043 (Entrez Gene) OCR lexicon match: TGF-B3

Annotated Interactions

No annotated interactions

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