Oxidative phosphorylation (Homo sapiens)

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Oxidative phosphorylation is the process in which ATP is formed as a result of the transfer of electrons from NADH or FADH2 to O2 by a series of electron carriers. This process, which takes place in mitochondria, is the major source of ATP in aerobic organisms. [1] Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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  1. Mitchell P, Moyle J; ''Chemiosmotic hypothesis of oxidative phosphorylation.''; Nature, 1967 PubMed Europe PMC Scholia
  2. Quinton TM, Kim S, Jin J, Kunapuli SP; ''Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation.''; J Thromb Haemost, 2005 PubMed Europe PMC Scholia
  3. Crane FL; ''Biochemical functions of coenzyme Q10.''; J Am Coll Nutr, 2001 PubMed Europe PMC Scholia
  4. Porter RK, Brand MD; ''Mitochondrial proton conductance and H+/O ratio are independent of electron transport rate in isolated hepatocytes.''; Biochem J, 1995 PubMed Europe PMC Scholia
  5. Schultz BE, Chan SI; ''Structures and proton-pumping strategies of mitochondrial respiratory enzymes.''; Annu Rev Biophys Biomol Struct, 2001 PubMed Europe PMC Scholia
  6. Mitchell P; ''Keilin's respiratory chain concept and its chemiosmotic consequences.''; Science, 1979 PubMed Europe PMC Scholia
  7. Rutkowski B, Swierczynski J, Slominska E, Szolkiewicz M, Smolenski RT, Marlewski M, Butto B, Rutkowski P; ''Disturbances of purine nucleotide metabolism in uremia.''; Semin Nephrol, 2004 PubMed Europe PMC Scholia
  8. Rich PR; ''The molecular machinery of Keilin's respiratory chain.''; Biochem Soc Trans, 2003 PubMed Europe PMC Scholia
  9. Dimroth P, Kaim G, Matthey U; ''Crucial role of the membrane potential for ATP synthesis by F(1)F(o) ATP synthases.''; J Exp Biol, 2000 PubMed Europe PMC Scholia
  10. Tager JM, Veldsema-Currie RD, Slater EC; ''Chemi-osmotic theory of oxidative phosphorylation.''; Nature, 1966 PubMed Europe PMC Scholia
  11. Mathews FS; ''The structure, function and evolution of cytochromes.''; Prog Biophys Mol Biol, 1985 PubMed Europe PMC Scholia


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107189view14:27, 17 September 2019MaintBotChEBI identifier normalization
106566view21:14, 6 September 2019KhanspersModified description
106209view12:10, 16 August 2019MaintBotHMDB identifier normalization
105773view19:40, 15 August 2019KhanspersModified description
96245view13:43, 2 March 2018Fehrhartcorrected stacking of nodes
96197view15:43, 25 February 2018EgonwPretty sure this should be H+
96023view15:30, 15 February 2018DeSlRemoved licence number and last modified part.
96022view15:29, 15 February 2018DeSlModified description
86899view07:58, 14 July 2016MkutmonOntology Term : 'oxidative phosphorylation pathway' added !
86898view07:58, 14 July 2016MkutmonOntology Term : 'PW:0000034' removed !
79961view13:33, 28 April 2015ZariChanged LOC727762 to new Id
79520view09:43, 24 March 2015Zariadded Entrez ID for GZMB
68894view17:28, 8 July 2013MaintBotUpdated to 2013 gpml schema
59095view22:10, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
46087view02:24, 15 December 2011AllanKuchinskyupdated HGNC IDs
45305view20:01, 7 October 2011KhanspersOntology Term : 'oxidative phosphorylation pathway' added !
41046view23:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
38777view00:02, 24 September 2010AlexanderPicobeautification
32171view14:08, 14 August 2009MaintBotFixed group labels
29958view13:40, 17 June 2009AndraAdded references from Wikipedia
29743view22:40, 1 June 2009KhanspersModified categories
29613view12:11, 23 May 2009MartijnVanIerselUpdated ensembl references
28181view13:49, 30 January 2009AndraPeriodical save, work in progress
28180view13:39, 30 January 2009AndraPeriodical save, work in progress
28179view12:02, 30 January 2009Andratemp save
28176view16:46, 29 January 2009AndraGenes involved in ATP synthase production added
28175view16:36, 29 January 2009AndraPeriodical save, work in progress
28174view16:26, 29 January 2009AndraPeriodical save, work in progress
28173view16:16, 29 January 2009AndraPeriodical save, work in progress
28172view16:06, 29 January 2009AndraPeriodical save, work in progress
28171view15:55, 29 January 2009AndraPeriodical save, work in progress
28170view15:44, 29 January 2009AndraPeriodical save, work in progress
28169view15:25, 29 January 2009AndraCreation of a stub
28168view15:19, 29 January 2009AndraPeriodical save, work in progress
28167view15:09, 29 January 2009AndraNew pathway

External references


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NameTypeDatabase referenceComment
ADPMetaboliteHMDB0001341 (HMDB)
AQDQGeneProduct4724 (Entrez Gene)
ASHIGeneProduct4714 (Entrez Gene)
ATP5A1GeneProduct498 (Entrez Gene)
ATP5BGeneProduct506 (Entrez Gene)
ATP5DGeneProduct513 (Entrez Gene)
ATP5EGeneProduct514 (Entrez Gene)
ATP5F1GeneProduct515 (Entrez Gene)
ATP5G1GeneProduct516 (Entrez Gene)
ATP5G2GeneProduct517 (Entrez Gene)
ATP5G3GeneProduct518 (Entrez Gene)
ATP5HGeneProduct10476 (Entrez Gene)
ATP5IGeneProduct521 (Entrez Gene)
ATP5J2GeneProduct9551 (Entrez Gene)
ATP5JGeneProduct522 (Entrez Gene)
ATP5LGeneProduct10632 (Entrez Gene)
ATP5OGeneProduct539 (Entrez Gene)
ATP5SGeneProduct27109 (Entrez Gene)
ATP6GeneProduct4508 (Entrez Gene)
ATP6AP1GeneProduct537 (Entrez Gene)
ATP6AP2GeneProduct10159 (Entrez Gene)
ATPMetaboliteHMDB0000538 (HMDB)
B13GeneProduct4698 (Entrez Gene)
B14.5aGeneProduct4701 (Entrez Gene)
B14.5bGeneProduct4718 (Entrez Gene)
B14GeneProduct4700 (Entrez Gene)
B15GeneProduct4710 (Entrez Gene)
B17GeneProduct4712 (Entrez Gene)
B18GeneProduct4713 (Entrez Gene)
B22GeneProduct4715 (Entrez Gene)
B9GeneProduct4696 (Entrez Gene)
CI-42KDGeneProduct4705 (Entrez Gene)
CI-51kDGeneProduct4723 (Entrez Gene)
CI-75KdGeneProduct4719 (Entrez Gene)
CI-SGDHGeneProduct4707 (Entrez Gene)
CI-SGDHGeneProduct4711 (Entrez Gene)
FASN2AGeneProduct4706 (Entrez Gene)
GZMBGeneProduct3002 (Entrez Gene)
HydrogenMetaboliteCHEBI:15378 (ChEBI)
KFYIGeneProduct4717 (Entrez Gene)
MT-ATP6GeneProductENSG00000198899 (Ensembl)
MT-ATP8GeneProductENSG00000198744 (Ensembl)
NADHMetaboliteHMDB0001487 (HMDB)
NADMetaboliteHMDB0000902 (HMDB)
ND1GeneProduct4535 (Entrez Gene)
ND2GeneProduct4536 (Entrez Gene)
ND3GeneProduct4537 (Entrez Gene)
ND4GeneProduct4538 (Entrez Gene)
ND4LGeneProduct4539 (Entrez Gene)
ND5GeneProduct4540 (Entrez Gene)
ND6GeneProduct4541 (Entrez Gene)
NDUFA11GeneProduct126328 (Entrez Gene)
NDUFA2GeneProduct4695 (Entrez Gene)
NDUFA4GeneProduct4697 (Entrez Gene)
NDUFA8GeneProduct4702 (Entrez Gene)
NDUFA9GeneProduct4704 (Entrez Gene)
NDUFB10GeneProduct4716 (Entrez Gene)
NDUFB2GeneProduct4708 (Entrez Gene)
NDUFB4GeneProduct4710 (Entrez Gene)
NDUFS2GeneProduct4720 (Entrez Gene)
NDUFS3GeneProduct4722 (Entrez Gene)
NDUFS5GeneProduct4725 (Entrez Gene)
NDUFS6GeneProduct4726 (Entrez Gene)
NDUFS7GeneProduct374291 (Entrez Gene)
NDUFS8GeneProduct4728 (Entrez Gene)
NDUFV2GeneProduct4729 (Entrez Gene)
NDUFV3GeneProduct4731 (Entrez Gene)
NUOMSGeneProduct56901 (Entrez Gene)

Annotated Interactions

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