Estrogen metabolism (Homo sapiens)
From WikiPathways
Description
Estrogens are metabolized via hydroxylation by cytochrome P450 enzymes such as CYP1A1 and CYP3A4 and via conjugation by estrogen sulfotransferases (sulfation) and UDP-glucuronyltransferases (glucuronidation). In addition, estradiol is dehydrogenated by 17β-Hydroxysteroid dehydrogenase into the much less potent estrogen estrone. These reactions occur primarily in the liver, but also in other tissues.
Description source: Wikipedia.
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Pathway Ontology : C18-steroid hormone biosynthetic pathway steroid hormone biosynthetic pathway
Bibliography
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- Abel EL, Lyon RP, Bammler TK, Verlinde CL, Lau SS, Monks TJ, Eaton DL; ''Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases.''; Chem Biol Interact, 2004 PubMed Europe PMC Scholia
- Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG; ''Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.''; Proc Natl Acad Sci U S A, 1997 PubMed Europe PMC Scholia
- Lakhani NJ, Sarkar MA, Venitz J, Figg WD; ''2-Methoxyestradiol, a promising anticancer agent.''; Pharmacotherapy, 2003 PubMed Europe PMC Scholia
- Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, Higginbotham SM, Cavalieri EL; ''Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer.''; Carcinogenesis, 2003 PubMed Europe PMC Scholia
- Raftogianis R, Creveling C, Weinshilboum R, Weisz J; ''Estrogen metabolism by conjugation.''; J Natl Cancer Inst Monogr, 2000 PubMed Europe PMC Scholia
- Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL; ''Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study.''; Breast Cancer Res, 2005 PubMed Europe PMC Scholia
- Guillemette C, Belanger A, Lepine J; ''Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview.''; Breast Cancer Res, 2004 PubMed Europe PMC Scholia
- Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM; ''Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.''; Mol Endocrinol, 2003 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
16a-Hydroxyestrone | Metabolite | HMDB0000335 (HMDB) | |
2-Hydroxyestradiol | Metabolite | HMDB0000338 (HMDB) | |
2-Hydroxyestrone-3-glucuronide | Metabolite | ||
2-Hydroxyestrone | Metabolite | HMDB0000343 (HMDB) | |
2-Methoxyestradiol-3-glucuronide | Metabolite | HMDB0006765 (HMDB) | |
2-Methoxyestradiol | Metabolite | HMDB0000405 (HMDB) | |
2-Methoxyestrone 3-glucuronide | Metabolite | HMDB0004482 (HMDB) | |
2-Methoxyestrone | Metabolite | HMDB0000010 (HMDB) | |
2-hydroxy-estradiol-2-glucuronide | Metabolite | ||
2-hydroxy-estradiol-sulfate | Metabolite | ||
2-hydroxyestradiol-3-glucuronide | Metabolite | ||
4-Methoxyestradiol-3-glucuronide | Metabolite | ||
4-Methoxyestradiol | Metabolite | HMDB0000405 (HMDB) | |
4-Methoxyestrone-3-glucuronide | Metabolite | CHEBI:137965 (ChEBI) | |
4-Methoxyestrone | Metabolite | 194066 (PubChem-compound) | |
4-hydroxy-estradiol-4-glucuronide | Metabolite | 90746-94-4 (CAS) | |
4-hydroxy-estradiol-sulfate | Metabolite | ||
4-hydroxyestradiol | Metabolite | 5282360 (PubChem-compound) | |
4-hydroxyestrone-3-glucuronide | Metabolite | CHEBI:136969 (ChEBI) | |
4-hydroxyestrone | Metabolite | 9971251 (PubChem-compound) | |
ARSC | GeneProduct | 412 (Entrez Gene) | |
ARSD | GeneProduct | ENSG00000006756 (Ensembl) | |
ARSE | GeneProduct | ENSG00000157399 (Ensembl) | |
COMT | GeneProduct | ENSG00000093010 (Ensembl) | |
CYP1A1 | GeneProduct | ENSG00000140465 (Ensembl) | |
CYP1A2 | GeneProduct | ENSG00000140505 (Ensembl) | |
CYP1B1 | GeneProduct | ENSG00000138061 (Ensembl) | |
CYP3A4 | GeneProduct | ENSG00000160868 (Ensembl) | |
ESTRADIOL | Metabolite | CHEBI:23965 (ChEBI) | |
Estradiol sulfate | Metabolite | 66416 (PubChem-compound) | |
Estradiol-17-glucuronide | Metabolite | 5281887 (PubChem-compound) | |
Estradiol-2,3-quinone | Metabolite | HMDB0060084 (HMDB) | |
Estradiol-2,3-semiquinone | Metabolite | ||
Estradiol-3,4-quinone | Metabolite | HMDB0060085 (HMDB) | |
Estradiol-3,4-semiquinone | Metabolite | ||
Estradiol-3-glucuronide | Metabolite | HMDB0006224 (HMDB) | |
Estrone sulfate | Metabolite | HMDB0001425 (HMDB) | |
Estrone-17-glucuronide | Metabolite | HMDB0004483 (HMDB) | |
Estrone-2,3-quinone | Metabolite | 148381 (PubChem-compound) | |
Estrone-2,3-semiquinone | Metabolite | ||
Estrone-3,4-quinone | Metabolite | 114862 (PubChem-compound) | |
Estrone-3,4-semiquinone | Metabolite | ||
Estrone-3-glucuronide | Metabolite | HMDB0004483 (HMDB) | |
Estrone | Metabolite | HMDB0000145 (HMDB) | |
GSTA1 | GeneProduct | ENSG00000243955 (Ensembl) | |
GSTM1 | GeneProduct | ENSG00000134184 (Ensembl) | |
NQO1 | GeneProduct | ENSG00000181019 (Ensembl) | |
Oxygen | Metabolite | HMDB0001377 (HMDB) | |
SULT1A1 | GeneProduct | ENSG00000196502 (Ensembl) | |
SULT1E1 | GeneProduct | ENSG00000109193 (Ensembl) | |
Superoxide | Metabolite | HMDB0002168 (HMDB) | |
UGT1A1 | GeneProduct | 54658 (Entrez Gene) | |
UGT1A3 | GeneProduct | 54659 (Entrez Gene) | |
UGT1A8 | GeneProduct | ENSG00000167165 (Ensembl) | |
UGT1A9 | GeneProduct | 54600 (Entrez Gene) | |
UGT2B7 | GeneProduct | ENSG00000171234 (Ensembl) |
Annotated Interactions
No annotated interactions