Glucuronidation (Homo sapiens)
From WikiPathways
Description
Glucuronidation is a phase II biotransformation reaction in which glucuronide acts as a conjugation molecule and binds to a substrate via the catalysis of glucuronosyltransferases. First, in a series of reactions the cosubstrate uridine diphosphate glucuronic acid (UDPGA) is formed. The glucuronosyltransferases (UGTs) then catalyze the transfer of glucuronic acid from UDPGA to a substrate resulting in a glucuronidated substrate and leaving uridine 5'-diphosphate. UGTs are a very broad and divers group of enzymes and count as the most significant group of conjugation enzymes in xenobiotic metabolism, qualitatively because glucuronic acid can be coupled to a large diversity of functional groups and quantitatively because of the large and divers number of substrates that are formed.
Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP698)Quality Tags
Ontology Terms
Bibliography
- Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008 PubMed Europe PMC Scholia
- Wei Q, Galbenus R, Raza A, Cerny RL, Simpson MA; ''Androgen-stimulated UDP-glucose dehydrogenase expression limits prostate androgen availability without impacting hyaluronan levels.''; Cancer Res, 2009 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
---|---|---|---|
2H+ | Metabolite | CHEBI:15378 (ChEBI) ![]() | |
Adenosine 3',5'-diphosphate | Metabolite | HMDB0000061 (HMDB) ![]() | |
Adenosine triphosphate | Metabolite | HMDB0000538 (HMDB) ![]() | |
D-Glucose | Metabolite | HMDB0000122 (HMDB) ![]() | |
Glucose 1-phosphate | Metabolite | HMDB0001586 (HMDB) ![]() | |
Glucose 6-phosphate | Metabolite | HMDB0001401 (HMDB) ![]() | |
HK1 | GeneProduct | ENSG00000156515 (Ensembl) ![]() | |
NADH | Metabolite | HMDB0001487 (HMDB) ![]() | |
NAD | Metabolite | HMDB0000902 (HMDB) ![]() | |
PGM1 | GeneProduct | ENSG00000079739 (Ensembl) ![]() | |
PGM2 | GeneProduct | ENSG00000169299 (Ensembl) ![]() | |
PGM3 | GeneProduct | ENSG00000013375 (Ensembl) ![]() | |
PGM5 | GeneProduct | ENSG00000154330 (Ensembl) ![]() | |
Phosphate | Metabolite | HMDB0001429 (HMDB) ![]() | |
UGDH | GeneProduct | ENSG00000109814 (Ensembl) ![]() | |
UGP2 | GeneProduct | ENSG00000169764 (Ensembl) ![]() | |
UGT1A10 | GeneProduct | 54575 (Entrez Gene) ![]() | |
UGT1A1 | GeneProduct | 54658 (Entrez Gene) ![]() | |
UGT1A3 | GeneProduct | 54659 (Entrez Gene) ![]() | |
UGT1A4 | GeneProduct | 54657 (Entrez Gene) ![]() | |
UGT1A5 | GeneProduct | 54579 (Entrez Gene) ![]() | |
UGT1A6 | GeneProduct | 54578 (Entrez Gene) ![]() | |
UGT1A7 | GeneProduct | 54577 (Entrez Gene) ![]() | |
UGT1A8 | GeneProduct | 54576 (Entrez Gene) ![]() | |
UGT1A9 | GeneProduct | 54600 (Entrez Gene) ![]() | |
UGT2A1 | GeneProduct | 10941 (Entrez Gene) ![]() | |
UGT2A2 | GeneProduct | 574537 (Entrez Gene) ![]() | |
UGT2A3 | GeneProduct | 79799 (Entrez Gene) ![]() | |
UGT2B10 | GeneProduct | 7365 (Entrez Gene) ![]() | |
UGT2B11 | GeneProduct | ENSG00000213759 (Ensembl) ![]() | |
UGT2B15 | GeneProduct | 7366 (Entrez Gene) ![]() | |
UGT2B17 | GeneProduct | 7367 (Entrez Gene) ![]() | |
UGT2B28 | GeneProduct | 54490 (Entrez Gene) ![]() | |
UGT2B4 | GeneProduct | 7363 (Entrez Gene) ![]() | |
UGT2B7 | GeneProduct | 7364 (Entrez Gene) ![]() | |
Uridine 5'-diphosphate | Metabolite | HMDB0000295 (HMDB) ![]() | |
Uridine diphosphate glucose | Metabolite | HMDB0000286 (HMDB) ![]() | |
Uridine diphosphate glucuronic acid | Metabolite | HMDB0000935 (HMDB) ![]() | |
Uridine triphosphate | Metabolite | HMDB0000285 (HMDB) ![]() | |
Water | Metabolite | HMDB0002111 (HMDB) ![]() |
Annotated Interactions
No annotated interactions