Glucuronidation (Homo sapiens)
From WikiPathways
Description
Glucuronidation is a phase II biotransformation reaction in which glucuronide acts as a conjugation molecule and binds to a substrate via the catalysis of glucuronosyltransferases. First, in a series of reactions the cosubstrate uridine diphosphate glucuronic acid (UDPGA) is formed. The glucuronosyltransferases (UGTs) then catalyze the transfer of glucuronic acid from UDPGA to a substrate resulting in a glucuronidated substrate and leaving uridine 5'-diphosphate. UGTs are a very broad and divers group of enzymes and count as the most significant group of conjugation enzymes in xenobiotic metabolism, qualitatively because glucuronic acid can be coupled to a large diversity of functional groups and quantitatively because of the large and divers number of substrates that are formed.
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Bibliography
- Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008 PubMed Europe PMC Scholia
- Wei Q, Galbenus R, Raza A, Cerny RL, Simpson MA; ''Androgen-stimulated UDP-glucose dehydrogenase expression limits prostate androgen availability without impacting hyaluronan levels.''; Cancer Res, 2009 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
2H+ | Metabolite | CHEBI:15378 (ChEBI) ![]() | |
Adenosine 3',5'-diphosphate | Metabolite | HMDB0000061 (HMDB) ![]() | |
Adenosine triphosphate | Metabolite | HMDB0000538 (HMDB) ![]() | |
D-Glucose | Metabolite | HMDB0000122 (HMDB) ![]() | |
Glucose 1-phosphate | Metabolite | HMDB0001586 (HMDB) ![]() | |
Glucose 6-phosphate | Metabolite | HMDB0001401 (HMDB) ![]() | |
HK1 | GeneProduct | ENSG00000156515 (Ensembl) ![]() | |
NADH | Metabolite | HMDB0001487 (HMDB) ![]() | |
NAD | Metabolite | HMDB0000902 (HMDB) ![]() | |
PGM1 | GeneProduct | ENSG00000079739 (Ensembl) ![]() | |
PGM2 | GeneProduct | ENSG00000169299 (Ensembl) ![]() | |
PGM3 | GeneProduct | ENSG00000013375 (Ensembl) ![]() | |
PGM5 | GeneProduct | ENSG00000154330 (Ensembl) ![]() | |
Phosphate | Metabolite | HMDB0001429 (HMDB) ![]() | |
UGDH | GeneProduct | ENSG00000109814 (Ensembl) ![]() | |
UGP2 | GeneProduct | ENSG00000169764 (Ensembl) ![]() | |
UGT1A10 | GeneProduct | 54575 (Entrez Gene) ![]() | |
UGT1A1 | GeneProduct | 54658 (Entrez Gene) ![]() | |
UGT1A3 | GeneProduct | 54659 (Entrez Gene) ![]() | |
UGT1A4 | GeneProduct | 54657 (Entrez Gene) ![]() | |
UGT1A5 | GeneProduct | 54579 (Entrez Gene) ![]() | |
UGT1A6 | GeneProduct | 54578 (Entrez Gene) ![]() | |
UGT1A7 | GeneProduct | 54577 (Entrez Gene) ![]() | |
UGT1A8 | GeneProduct | 54576 (Entrez Gene) ![]() | |
UGT1A9 | GeneProduct | 54600 (Entrez Gene) ![]() | |
UGT2A1 | GeneProduct | 10941 (Entrez Gene) ![]() | |
UGT2A2 | GeneProduct | 574537 (Entrez Gene) ![]() | |
UGT2A3 | GeneProduct | 79799 (Entrez Gene) ![]() | |
UGT2B10 | GeneProduct | 7365 (Entrez Gene) ![]() | |
UGT2B11 | GeneProduct | ENSG00000213759 (Ensembl) ![]() | |
UGT2B15 | GeneProduct | 7366 (Entrez Gene) ![]() | |
UGT2B17 | GeneProduct | 7367 (Entrez Gene) ![]() | |
UGT2B28 | GeneProduct | 54490 (Entrez Gene) ![]() | |
UGT2B4 | GeneProduct | 7363 (Entrez Gene) ![]() | |
UGT2B7 | GeneProduct | 7364 (Entrez Gene) ![]() | |
Uridine 5'-diphosphate | Metabolite | HMDB0000295 (HMDB) ![]() | |
Uridine diphosphate glucose | Metabolite | HMDB0000286 (HMDB) ![]() | |
Uridine diphosphate glucuronic acid | Metabolite | HMDB0000935 (HMDB) ![]() | |
Uridine triphosphate | Metabolite | HMDB0000285 (HMDB) ![]() | |
Water | Metabolite | HMDB0002111 (HMDB) ![]() |
Annotated Interactions
No annotated interactions