Serotonin receptor 2 and ELK-SRF/GATA4 signaling (Homo sapiens)

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8594, 9619, 23, 81, 92, 1053, 1121, 26, 43, 71, 101...75, 762, 14, 20, 30, 697333, 34, 37, 42, 44...6, 10, 27, 31, 67...1184912, 4757, 7929, 66, 83, 8640, 5313, 39, 72, 789, 32, 41, 60, 70...874, 5917, 975, 8, 24, 64, 80...51, 10025, 38, 55, 63, 77...35, 10428, 5215, 48RASRAF1ELK1MAP2K2HTR2CHTR2BMAPKAPK2SerotoninPLCHRASNRASELK4MAPK1SRFGNAQHTR2ARASGRF1GATA4MAP2K11,4,5-Insp3MAPK3KRASCalciumRASGRP1ITPR146, 50, 54, 68, 9116, 22, 36, 45, 56...7, 82Synthesis Functional Protein ClassSmall MoleculeLEGENDProtein ModificationReceptorIndirect RegulationPromoter BindingBindingProteinDirect Regulation


Description

This pathway depicts the downstream signaling of serotonin via receptors 2A, 2B, and 2C, resulting in the activation of ELK-SRF and GATA4. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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  105. Zhou B, Zhang ZY; ''The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  106. Cox DA, Watts SW, Cohen ML; ''Neomycin selectively inhibits 5-hydroxytryptamine-induced contraction in the guinea pig trachea.''; J Pharmacol Exp Ther, 1996 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125659view16:04, 6 March 2023DeSlAdded missing ID for PLC
125658view16:03, 6 March 2023DeSlAdding legend from WP722
125628view01:55, 6 March 2023AlexanderPicoModified description
120591view20:22, 17 December 2021EweitzTighten graphics, standardize datanode colors
117824view15:06, 22 May 2021EweitzModified title
106487view21:40, 4 September 2019KhanspersModified description
105809view22:54, 15 August 2019KhanspersModified description
101994view19:25, 22 November 2018EgonwRemoved whitespace in PubMed identifiers.
101953view21:03, 20 November 2018EgonwRemoved whitespace in PubMed identifiers.
80010view13:49, 30 April 2015ZariAnnotated RAS gene
74437view06:40, 20 April 2014EgonwRemoved brackets and text from PubMed IDs, e.g. "9016798 (Tis" changed to "9016798".
70101view18:49, 12 July 2013MaintBotupdating to 2013 schema
49572view05:46, 21 July 2012AndraRDF Tidy
49546view10:22, 20 July 2012AndraRDF Tidy
46088view02:25, 15 December 2011AllanKuchinskyupdated HCNC IDs
45038view18:51, 6 October 2011ThomasOntology Term : 'neuron' added !
45026view18:44, 6 October 2011ThomasOntology Term : 'serotonin signaling pathway' added !
41122view23:37, 1 March 2011MaintBotRemoved redundant pathway information and comments
39766view07:53, 17 January 2011AlexanderPico
34476view18:35, 10 December 2009MaintBotAutomatic update of empty xrefs
33186view18:02, 5 November 2009KhanspersModified categories
31149view03:55, 5 August 2009ArukeModified description
30213view22:12, 14 July 2009ArukeUpdated all interactions
30212view20:41, 14 July 2009ArukeSpecify description
30211view20:32, 14 July 2009ArukeUpdated node properties
30210view19:57, 14 July 2009ArukeSpecify description
30207view19:07, 14 July 2009ArukeSpecify description
30206view18:38, 14 July 2009ArukeNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,4,5-Insp3Metabolite85166-31-0 (CAS) 1,4,5-Insp3
Calcium Metabolite7440-70-2 (CAS)
ELK1GeneProduct2002 (Entrez Gene) ELK1, member of ETS oncogene family
ELK4GeneProduct2005 (Entrez Gene) ETS domain-containing protein Elk-4 (SRF accessory protein 1)
GATA4GeneProduct2626 (Entrez Gene) GATA-binding protein 4/5/6
GNAQGeneProduct2776 (Entrez Gene) guanine nucleotide binding protein, alpha q polypeptide
HRASGeneProduct3265 (Entrez Gene)
HTR2AGeneProduct3356 (Entrez Gene) 5-hydroxytryptamine (serotonin) receptor 2A
HTR2BGeneProduct3357 (Entrez Gene) 5-hydroxytryptamine (serotonin) receptor 2B
HTR2CGeneProduct3358 (Entrez Gene) 5-hydroxytryptamine (serotonin) receptor 2C
ITPR1GeneProduct3708 (Entrez Gene) inositol 1,4,5-triphosphate receptor 1
KRASGeneProduct3845 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene) mitogen activated protein kinase kinase 1
MAP2K2GeneProduct5605 (Entrez Gene) mitogen activated protein kinase kinase 2
MAPK1GeneProductMAPK1 (HGNC) mitogen activated protein kinase 1
MAPK3GeneProduct5595 (Entrez Gene) mitogen activated protein kinase 3
MAPKAPK2GeneProduct9261 (Entrez Gene) MAP kinase-activated protein kinase 2
NRASGeneProduct4893 (Entrez Gene)
PLCProtein3.1.4.11 (Enzyme Nomenclature) phospholipase C group
RAF1GeneProduct5894 (Entrez Gene) v-raf-leukemia viral oncogene 1
RASGRF1GeneProduct5923 (Entrez Gene) RAS protein-specific guanine nucleotide-releasing factor 1
RASGRP1GeneProduct10125 (Entrez Gene) RAS guanyl releasing protein 1
SRFGeneProduct6722 (Entrez Gene) serum response factor
SerotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP732"
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