Serotonin receptor 4/6/7 and NR3C signaling (Homo sapiens)

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10, 931338, 573, 10137, 39, 54, 82, 88...7, 2736, 10049, 7544, 61, 64, 65, 68...5, 16, 31, 41, 55...741, 15, 24, 81, 8433, 912, 4, 23, 40, 7732, 981314, 53, 59, 956, 4518, 9980, 9442, 9652, 6271, 859, 2012, 25, 30, 51, 60...977929884322, 47, 56, 67, 76...48317, 19, 35, 46, 58...8, 1121, 26, 28, 50, 63...10534, 73, 86GNASMAP2K2NR3C1SRFMAPK3HTR4CREB1RAP1ACyclic AMPRPS6KHTR7HTR6EGR1serotoninMAP2K1PKARPS6KA5MAPKAPK2BRAFMAPK1ADCYATF1ELK1ELK4Synthesis Functional Protein ClassSmall MoleculeLEGENDProtein ModificationReceptorIndirect RegulationPromoter BindingBindingProteinDirect Regulation


Description

This pathway depicts the downstream signaling of serotonin via receptors 4, 6, and 7, resulting in the activation of EGR1 and NR3C1. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Bibliography

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125662view16:06, 6 March 2023DeSlChanged color for Metabolite DataNodes
125660view16:05, 6 March 2023DeSlAdded legend from WP722
125626view01:53, 6 March 2023AlexanderPicoModified description
117826view15:06, 22 May 2021EweitzModified title
106485view21:40, 4 September 2019KhanspersModified description
105811view22:54, 15 August 2019KhanspersModified description
101930view12:33, 18 November 2018EgonwRemoved whitespace in one more PubMed identifier.
101925view17:08, 17 November 2018EgonwRemoved whitespace in PubMed identifiers.
74438view06:47, 20 April 2014EgonwRemoved brackets and text from PubMed IDs, e.g. "10542136 The " changed to "10542136".
70102view18:49, 12 July 2013MaintBotupdated to 2013 schema
49544view10:12, 20 July 2012AndraWp tidy
46089view02:26, 15 December 2011AllanKuchinskyupdated HGNC IDs
45037view18:51, 6 October 2011ThomasOntology Term : 'neuron' added !
45028view18:45, 6 October 2011ThomasOntology Term : 'serotonin signaling pathway' added !
41156view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
39769view07:55, 17 January 2011AlexanderPico
34438view18:16, 10 December 2009MaintBotAutomatic update of empty xrefs
33188view18:03, 5 November 2009KhanspersModified categories
31152view04:06, 5 August 2009ArukeModified description
30237view22:53, 16 July 2009ArukeUpdated all interactions and references
30236view22:47, 16 July 2009ArukePeriodical save, work in progress
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30233view21:43, 16 July 2009ArukePeriodical save, work in progress
30232view21:32, 16 July 2009ArukePeriodical save, work in progress
30231view21:22, 16 July 2009ArukePeriodical save, work in progress
30230view21:12, 16 July 2009ArukePeriodical save, work in progress
30229view21:01, 16 July 2009ArukePeriodical save, work in progress
30228view20:51, 16 July 2009ArukePeriodical save, work in progress
30227view20:41, 16 July 2009ArukePeriodical save, work in progress
30226view20:31, 16 July 2009ArukePeriodical save, work in progress
30225view17:24, 16 July 2009ArukeUpdated all nodes
30224view17:16, 16 July 2009ArukePeriodical save, work in progress
30223view17:06, 16 July 2009ArukePeriodical save, work in progress
30222view16:55, 16 July 2009ArukeNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCYGeneProductAdenylate cyclase
ATF1GeneProduct466 (Entrez Gene) activating transcription factor 1
BRAFGeneProduct673 (Entrez Gene) v-raf murine sarcoma viral oncogene homolog B1
CREB1GeneProduct1385 (Entrez Gene) cAMP response element-binding protein 1
Cyclic AMPMetabolite60-92-4 (CAS)
EGR1GeneProduct1958 (Entrez Gene) early growth response protein
ELK1GeneProduct2002 (Entrez Gene) ELK1, member of ETS oncogene family
ELK4GeneProduct2005 (Entrez Gene) ETS domain-containing protein Elk-4 (SRF accessory protein 1)
GNASGeneProduct2778 (Entrez Gene) GNAS (guanine nucleotide binding protein, alpha stimulating)
HTR4GeneProduct3360 (Entrez Gene) 5 hydroxytryptamine (serotonin) receptor 4
HTR6GeneProduct3362 (Entrez Gene) 5-hydroxytryptamine (serotonin) receptor 6
HTR7GeneProduct3363 (Entrez Gene) 5-hydroxytryptamine (serotonin) receptor 7
MAP2K1GeneProduct5604 (Entrez Gene) mitogen activated protein kinase kinase 1
MAP2K2GeneProduct5605 (Entrez Gene) mitogen activated protein kinase kinase 2
MAPK1GeneProductMAPK1 (HGNC) mitogen activated protein kinase 1
MAPK3GeneProduct5595 (Entrez Gene) mitogen activated protein kinase 3
MAPKAPK2GeneProduct9261 (Entrez Gene) MAP kinase-activated protein kinase 2
NR3C1GeneProduct2908 (Entrez Gene) nuclear receptor, subfamily 3, group C, member 1
PKAGeneProductcAMP-dependent protein kinase, protein kinase A
RAP1AGeneProduct5906 (Entrez Gene) RAS-related protein-1a
RPS6KGeneProductribosomal protein S6 kinase
RPS6KA5GeneProduct9252 (Entrez Gene) ribosomal protein S6 kinase, polypeptide 5
SRFGeneProduct6722 (Entrez Gene) serum response factor
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions

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