Aflatoxin B1 metabolism (Pan troglodytes)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none nonenzymaticnonenzymatic(pH-dependent)DNA adductsAflatoxin B1 C8-monoalcoholAflatoxin-endo-B1-8,9-epoxideAflatoxin B1 exo-8,9-epoxide-GSHXR_022976.1Q9N256_PANTRAflatoxin B1-6,8-dialcoholAflatoxin B1 8,9-dihydrodiolAflatoxin B1 dialdehydeQ9N256_PANTRaflatoxin B1Aflatoxin B1 exo-8,9-epoxideAflatoxin M1Aflatoxin B1 C8-monoaldehydeAflatoxin M1 epoxideCYP2A13Aflatoxin B1 C6-monoalcoholAflatoxin Q1B1NL93_PANTRAflatoxin B1 C6-monoaldehydeAKR7A2AKR7A3Q9N256_PANTRCYP2A13B1NL93_PANTRGSTT1GSTM1Name: Aflatoxin B1 metabolismLast Modified: 2/20/2013Organism: Pan troglodytes


Description

Aflatoxins are naturally occurring [mycotoxins](https://en.wikipedia.org/wiki/Mycotoxin) that are produced by many species of [Aspergillus](https://en.wikipedia.org/wiki/Aspergillus), a [fungus](https://en.wikipedia.org/wiki/Fungus), most notably [Aspergillus flavus](https://en.wikipedia.org/wiki/Aspergillus_flavus) and [Aspergillus parasiticus](https://en.wikipedia.org/wiki/Aspergillus_parasiticus). After entering the body, aflatoxins are metabolized by the liver to a reactive intermediate, aflatoxin M1, an [epoxide](https://en.wikipedia.org/wiki/Epoxide). Aflatoxin B1 is considered the most toxic and is produced by both Aspergillus flavus and Aspergillus parasiticus. Source: [Wikipedia](https://en.wikipedia.org/wiki/Aflatoxin)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP699(r30253) with a 83% conversion rate.

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Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes
Image:Unconnected.pngFix interactions
Homology Converted

Ontology Terms

 

Bibliography

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  1. Stewart RK, Smith GB, Donnelly PJ, Reid KR, Petsikas D, Conlan AA, Massey TE; ''Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B(1) in human lung: differential cellular distribution and lack of significance of the GSTM1 genetic polymorphism.''; Carcinogenesis, 1999 PubMed Europe PMC Scholia
  2. Jin Y, Penning TM; ''Aldo-keto reductases and bioactivation/detoxication.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC Scholia
  3. Guengerich FP; ''Cytochrome P450s and other enzymes in drug metabolism and toxicity.''; AAPS J, 2006 PubMed Europe PMC Scholia
  4. Guengerich FP, Cai H, McMahon M, Hayes JD, Sutter TR, Groopman JD, Deng Z, Harris TM; ''Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.''; Chem Res Toxicol, 2001 PubMed Europe PMC Scholia
  5. Tiemersma EW, Omer RE, Bunschoten A, van't Veer P, Kok FJ, Idris MO, Kadaru AM, Fedail SS, Kampman E; ''Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma.''; Cancer Epidemiol Biomarkers Prev, 2001 PubMed Europe PMC Scholia
  6. He XY, Tang L, Wang SL, Cai QS, Wang JS, Hong JY; ''Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract.''; Int J Cancer, 2006 PubMed Europe PMC Scholia
  7. Kensler TW, Qian GS, Chen JG, Groopman JD; ''Translational strategies for cancer prevention in liver.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia
  8. Guengerich FP, Arneson KO, Williams KM, Deng Z, Harris TM; ''Reaction of aflatoxin B(1) oxidation products with lysine.''; Chem Res Toxicol, 2002 PubMed Europe PMC Scholia
  9. Zhu LR, Thomas PE, Lu G, Reuhl KR, Yang GY, Wang LD, Wang SL, Yang CS, He XY, Hong JY; ''CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody.''; Drug Metab Dispos, 2006 PubMed Europe PMC Scholia
  10. Barski OA, Tipparaju SM, Bhatnagar A; ''The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.''; Drug Metab Rev, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
136899
Approved
view19:22, 26 February 2025KhanspersModified description
136893view19:18, 26 February 2025KhanspersModified description
106938view13:40, 17 September 2019MaintBotHMDB identifier normalization
69252view18:36, 8 July 2013MaintBotUpdated to 2013 gpml schema
67033view09:56, 26 June 2013Christine ChichesterOntology Term : 'aflatoxin metabolic pathway' added !
58907view04:48, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
57008view14:19, 19 January 2013EgonwCorrected to the correct PubChem-compound data source.
57007view14:19, 19 January 2013EgonwHorizontally aligned to top boxes.
41559view01:59, 2 March 2011MaintBotRemoved redundant pathway information and comments
35015view08:25, 11 February 2010ThomasModified description
33579view09:49, 1 December 2009MaintBotRemoved group label
31602view22:09, 13 August 2009MaintBotFixed text labels
30494view21:40, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKR7A2GeneProductENSPTRG00000000265 (Ensembl)
AKR7A3GeneProductENSPTRG00000000264 (Ensembl)
Aflatoxin B1 8,9-dihydrodiolMetabolite3035008 (PubChem-compound)
Aflatoxin B1 C6-monoalcoholMetabolite
Aflatoxin B1 C6-monoaldehydeMetabolite
Aflatoxin B1 C8-monoalcoholMetabolite
Aflatoxin B1 C8-monoaldehydeMetabolite
Aflatoxin B1 dialdehydeMetabolite
Aflatoxin B1 exo-8,9-epoxide-GSHMetabolite5460816 (PubChem-compound)
Aflatoxin B1 exo-8,9-epoxideMetabolite104756 (PubChem-compound)
Aflatoxin B1-6,8-dialcoholMetabolite
Aflatoxin M1 epoxideMetabolite
Aflatoxin M1Metabolite15558498 (PubChem-compound)
Aflatoxin Q1Metabolite104757 (PubChem-compound)
Aflatoxin-endo-B1-8,9-epoxideMetabolite
B1NL93_PANTRGeneProductENSPTRG00000019460 (Ensembl)
CYP2A13GeneProduct
GSTM1GeneProductENSPTRG00000001061 (Ensembl)
GSTT1GeneProductENSPTRG00000014166 (Ensembl)
Q9N256_PANTRGeneProductENSPTRG00000007281 (Ensembl)
XR_022976.1GeneProductENSPTRG00000002039 (Ensembl)
aflatoxin B1MetaboliteHMDB0006552 (HMDB)

Annotated Interactions

No annotated interactions
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