Cell cycle (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none S-phase proteins,Cyclin EOrigin recognitioncomplexORC1ORC2ORC3ORC4ORC5ORC6G1DNA damage checkpointSR-point(start)CohesinGrowth factorSecurin+pGrowth factor withdrawalMG2SeparinCDC7DBF4ACDK7CCNHPLK1CDKN2ACDKN2BCDKN2CCDKN2DMAD2L2MAD1L1BUB3PCNAPCDK2CCNA1CCNA2GSK3BESPL1MCM2MCM3MCM4MCM5MCM6MCM7PPPTP53PCDC25BCDC25CCC14BCC14ACCNA2PPPCDK1CCNA1RB1HDAC1HDAC2PPRBL2PPPRBL1CDC45ATMATRTGFB1TGFB2TGFB3PTTG1PTTG2PPPCHK2PPCHK1PKMYT1MAPK signaling pathwayCDC20ANAPC10ANAPC13ANAPC2ANAPC4ANAPC5ANAPC7ANAPC11ANAPC1CDC23CDC16CDC27SMAD4PSMAD3PSMAD2CCNE1CCNE2PCDK2ApoptosisABL1RB1SFNPFZR1CDC20ANAPC10ANAPC13ANAPC2ANAPC4ANAPC5ANAPC7ANAPC11ANAPC1CDC23CDC16CDC27SKP1SKP2CUL1RBX1YWHABYWHAEYWHAHYWHAQYWHAZYWHAGGADD45ACDK6PCCND2CDK4PCCND3PCCND1PPPCDC6EP300PCDKN1CCDKN1APCDKN1BPRB1CCNB3CCNB2CCNB1CDK1WEE1WEE2DNA biosynthesisPRKDCORC1ORC2ORC3ORC4ORC5ORC6SMC3SMC1BSMC1ASTAG1STAG2RAD21MDM2Ubiquitin-mediated proteolysisBUB1RBL1E2F4E2F5TFDP1TFDP2CDKN2AMYCZBTB17E2F1E2F2TFDP1E2F3TFDP2E2F4E2F5TFDP1TFDP2GADD45BGADD45GPCDC25ATTKPMD1L1SKP1SKP2CUL1RBX1MCM2MCM3MCM4MCM5MCM6MCM7Minichromosome maintenance complexName: Cell cycleOrganism: Homo sapiens


Description

The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Sources: [Cell cycle](http://en.wikipedia.org/wiki/Cell_cycle), [KEGG](http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html). Protein phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP179).

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Quality Tags

Image:Featured.pngReview changes for Featured
Image:Curated.pngApproved version
Image:Wplogo_31.pngCommunity: PancCanNet
Image:Wplogo_31.pngCommunity: CPTAC
Image:MissingXref.pngAnnotate nodes

Ontology Terms

 

Bibliography

  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia
  2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137104
Approved
view22:55, 27 February 2025KhanspersModified description
127277
Featured
PancCanNet
CPTAC
view15:52, 1 September 2023Khanspersfixed phospho site
127262view04:52, 30 August 2023Khanspersadded phospho sites
127255view18:16, 28 August 2023Khanspersadded lliterature reference and updated description
127172view06:20, 9 August 2023Fehrhartbox for pathway
127158view23:32, 7 August 2023Khanspersupdated ptms
122978view19:12, 8 June 2022Mkutmonfix unconnected pathway node
122977view19:09, 8 June 2022Mkutmonremoved empty groups
120742view23:40, 27 December 2021EweitzRefine graphics, text; use gene symbols
120027view22:50, 15 October 2021Khanspersupdate phosphosites
120026view20:26, 15 October 2021Khanspersupdate phosphosites
120025view20:12, 15 October 2021Khanspersupdate phosphosites
120024view19:57, 15 October 2021Khanspersupdated phosphosites
116693view15:31, 9 May 2021EweitzModified title
114261view13:57, 2 January 2021EgonwThree more pathways clickable
112039view17:58, 16 September 2020Khanspersupdated phospho site
106351view21:36, 21 August 2019KhanspersModified description
105448view04:58, 8 August 2019KhanspersModified description
105235view13:42, 23 July 2019EgonwNo gene-gene conversion.
103430view16:00, 28 February 2019DeSlRemoved last modified item
97174view17:12, 3 May 2018AlexanderPicochanged complex to paralog group
96994view21:13, 25 April 2018Khanspersadded phosphosites
96993view20:19, 25 April 2018Khanspersinteractions and phosphosites
96985view05:19, 25 April 2018Khanspersoverhaul: updated to Ensembl, added phoshposites, complexes etc
96984view01:20, 25 April 2018Khanspersoverhaul in progress
96983view23:29, 24 April 2018Khanspersoverhaul in progress
93002view18:31, 21 July 2017KhanspersReverted to version '10:59, 16 September 2016' by Khanspers
92878view08:44, 13 July 2017JosipMadunicCell Cycle
89516view10:59, 16 September 2016Mkutmonontology tag fix
89470view13:39, 15 September 2016Mkutmonremove space from ontology term id
70629view00:22, 20 August 2013MaintBotUpdated xrefs by Anatoly Urisman
69900view19:28, 11 July 2013AlexanderPicoModified title
67101view10:06, 26 June 2013Christine ChichesterOntology Term : 'cell cycle pathway, mitotic' added !
63158view20:18, 8 May 2013MaintBotUpdating gpml version
59175view18:43, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45137view00:58, 7 October 2011AlexanderPico
45136view00:57, 7 October 2011AlexanderPicoModified description
45135view00:56, 7 October 2011AlexanderPicoModified description
45134view00:56, 7 October 2011AlexanderPicoModified description
45133view00:55, 7 October 2011AlexanderPicoModified description
45089view21:00, 6 October 2011AlexanderPico
45087view20:58, 6 October 2011AlexanderPicodb refs
45084view20:51, 6 October 2011AlexanderPicofixed pathway refs
45079view20:41, 6 October 2011AlexanderPicoadded groups
45075view20:31, 6 October 2011AlexanderPicoadded groups and db refs
45071view20:14, 6 October 2011AlexanderPicoadded db ref and group
41134view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
35361view09:11, 12 February 2010MartijnVanIerselModified description
34663view12:07, 8 January 2010ThomasReverted color change of gene boxes by BadrulYahaya (no meaning for the color provided)
32357view13:40, 15 August 2009MaintBotFixed text labels

External references

DataNodes

View all...
Name  â†“Type  â†“Database reference  â†“Comment  â†“
ABL1GeneProductENSG00000097007 (Ensembl) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
ANAPC10GeneProductENSG00000164162 (Ensembl)
ANAPC11GeneProductENSG00000141552 (Ensembl)
ANAPC13GeneProductENSG00000129055 (Ensembl)
ANAPC1GeneProductENSG00000153107 (Ensembl)
ANAPC2GeneProductENSG00000176248 (Ensembl)
ANAPC4GeneProductENSG00000053900 (Ensembl)
ANAPC5GeneProductENSG00000089053 (Ensembl)
ANAPC7GeneProductENSG00000196510 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
ATRGeneProductENSG00000175054 (Ensembl) ATR; ataxia telangiectasia and Rad3 related
ApoptosisPathwayWP254 (WikiPathways)
BUB1GeneProductENSG00000169679 (Ensembl) BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
BUB3GeneProductENSG00000154473 (Ensembl) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
CC14AGeneProductENSG00000079335 (Ensembl) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
CC14BGeneProductENSG00000081377 (Ensembl) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
CCNA1GeneProductENSG00000133101 (Ensembl) CCNA1; cyclin A1
CCNA2GeneProductENSG00000145386 (Ensembl) CCNA2; cyclin A2
CCNB1GeneProductENSG00000134057 (Ensembl) CCNB1; cyclin B1
CCNB2GeneProductENSG00000157456 (Ensembl) CCNB2; cyclin B2
CCNB3GeneProductENSG00000147082 (Ensembl) CCNB3; cyclin B
CCND1GeneProductENSG00000110092 (Ensembl) CCND3; cyclin D3
CCND2GeneProductENSG00000118971 (Ensembl) CCND2; cyclin D2
CCND3GeneProductENSG00000112576 (Ensembl) CCND3; cyclin D3
CCNE1GeneProductENSG00000105173 (Ensembl) CCNE1; cyclin E
CCNE2GeneProductENSG00000175305 (Ensembl) CCNE2; cyclin E
CCNHGeneProductENSG00000134480 (Ensembl) CCNH; cyclin H
CDC16GeneProductENSG00000130177 (Ensembl)
CDC20GeneProduct991 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
CDC23GeneProductENSG00000094880 (Ensembl)
CDC25AGeneProductENSG00000164045 (Ensembl) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
CDC25BGeneProductENSG00000101224 (Ensembl) CDC25C; cell division cycle 25C [EC:3.1.3.48]
CDC25CGeneProductENSG00000158402 (Ensembl) CDC25B; cell division cycle 25B [EC:3.1.3.48]
CDC27GeneProductENSG00000004897 (Ensembl)
CDC45GeneProductENSG00000093009 (Ensembl) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CDC6GeneProductENSG00000094804 (Ensembl) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
CDC7GeneProductENSG00000097046 (Ensembl) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDK1GeneProductENSG00000170312 (Ensembl) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
CDK2GeneProductENSG00000123374 (Ensembl) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDK4GeneProductENSG00000135446 (Ensembl) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDK6GeneProductENSG00000105810 (Ensembl) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CDK7GeneProductENSG00000134058 (Ensembl) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDKN1AGeneProductENSG00000124762 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN1CGeneProductENSG00000129757 (Ensembl) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN2AGeneProductENSG00000147889 (Ensembl)
CDKN2BGeneProductENSG00000147883 (Ensembl)
CDKN2CGeneProductENSG00000123080 (Ensembl)
CDKN2DGeneProductENSG00000129355 (Ensembl)
CHK1GeneProduct1111 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
CHK2GeneProduct11200 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
CUL1GeneProductENSG00000055130 (Ensembl)
DBF4AGeneProductENSG00000006634 (Ensembl) ASK; activator of S phase kinas
DNA biosynthesisPathway
E2F1GeneProductENSG00000101412 (Ensembl) E2F1; E2F transcription factor 1
E2F2GeneProductENSG00000007968 (Ensembl) E2F2; E2F transcription factor 2
E2F3GeneProductENSG00000112242 (Ensembl) E2F3; E2F transcription factor 3
E2F4GeneProductENSG00000205250 (Ensembl) E2F4; E2F transcription factor 4 p107/p130-binding
E2F5GeneProductENSG00000133740 (Ensembl) E2F5; E2F transcription factor 5 p130-binding
EP300GeneProductENSG00000100393 (Ensembl) EP300; E1A binding protein p300
ESPL1GeneProductENSG00000135476 (Ensembl) ESPL1; extra spindle poles like 1 (S. cerevisiae
FZR1GeneProductENSG00000105325 (Ensembl)
GADD45AGeneProductENSG00000116717 (Ensembl)
GADD45BGeneProductENSG00000099860 (Ensembl)
GADD45GGeneProductENSG00000130222 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl) GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
HDAC1GeneProductENSG00000116478 (Ensembl) HDAC1; histone deacetylase 1
HDAC2GeneProductENSG00000196591 (Ensembl) HDAC2; histone deacetylase 2
MAD1L1GeneProductENSG00000002822 (Ensembl) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
MAD2L2GeneProductENSG00000116670 (Ensembl) MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
MAPK signaling pathwayPathwayWP382 (WikiPathways)
MCM2GeneProductENSG00000073111 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
MCM3GeneProductENSG00000112118 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
MCM4GeneProductENSG00000104738 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
MCM5GeneProductENSG00000100297 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
MCM6GeneProductENSG00000076003 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
MCM7GeneProductENSG00000166508 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
MD1L1GeneProductENSG00000002822 (Ensembl) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
MDM2GeneProductENSG00000135679 (Ensembl) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
MYCGeneProductENSG00000136997 (Ensembl)
ORC1GeneProductENSG00000085840 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
ORC2GeneProductENSG00000115942 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
ORC3GeneProductENSG00000135336 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
ORC4GeneProductENSG00000115947 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
ORC5GeneProductENSG00000164815 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
ORC6GeneProductENSG00000091651 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
PCNAGeneProductENSG00000132646 (Ensembl) PCNA; proliferating cell nuclear antigen
PKMYT1GeneProductENSG00000127564 (Ensembl) PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
PLK1GeneProductENSG00000166851 (Ensembl) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
PRKDCGeneProductENSG00000253729 (Ensembl) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
PTTG1GeneProductENSG00000164611 (Ensembl) PTTG1; pituitary tumor-transforming
PTTG2GeneProductENSG00000250254 (Ensembl) PTTG2; pituitary tumor-transforming
RAD21GeneProductENSG00000164754 (Ensembl) ESPL1; extra spindle poles like 1 (S. cerevisiae
RB1GeneProductENSG00000139687 (Ensembl)
RBL1GeneProductENSG00000080839 (Ensembl)
RBL2GeneProductENSG00000103479 (Ensembl) RB1; retinoblastoma 1 (including osteosarcoma)
RBX1GeneProductENSG00000100387 (Ensembl)
SFNGeneProductENSG00000175793 (Ensembl) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
SKP1GeneProductENSG00000113558 (Ensembl)
SKP2GeneProductENSG00000105810 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
SKP2GeneProductENSG00000145604 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
SMAD2GeneProductENSG00000175387 (Ensembl) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
SMAD3GeneProductENSG00000166949 (Ensembl) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
SMAD4GeneProductENSG00000141646 (Ensembl) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
SMC1AGeneProductENSG00000072501 (Ensembl) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
SMC1BGeneProductENSG00000077935 (Ensembl) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
SMC3GeneProductENSG00000108055 (Ensembl) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
STAG1GeneProductENSG00000118007 (Ensembl) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
STAG2GeneProductENSG00000101972 (Ensembl) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
TFDP1GeneProductENSG00000198176 (Ensembl) TFDP1; transcription factor Dp-1
TFDP2GeneProductENSG00000114126 (Ensembl) TFDP1; transcription factor Dp-1
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
TTKGeneProductENSG00000112742 (Ensembl) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
Ubiquitin-mediated proteolysisPathwayWP183 (WikiPathways)
WEE1GeneProductENSG00000166483 (Ensembl) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
WEE2GeneProductENSG00000214102 (Ensembl) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
YWHABGeneProduct7529 (Entrez Gene)
YWHAEGeneProduct7531 (Entrez Gene)
YWHAGGeneProduct7532 (Entrez Gene)
YWHAHGeneProduct7533 (Entrez Gene)
YWHAQGeneProduct10971 (Entrez Gene)
YWHAZGeneProduct7534 (Entrez Gene)
ZBTB17GeneProductENSG00000116809 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP179"
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