Hepatocyte growth factor receptor signaling (Drosophila melanogaster)

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1RHOpathwayCDC42pathwayTrancriptionCytoplasmAKT PathwayTranscriptionExtracellularRAC1pathwayAnoikisActinChanges in Cytoskeletonand Cell mobilityTranscriptionof Cox2AP-1PtenITGA1CRKLMetSTAT3ELK1CrkPakMAPK8Dsor1PIK3CAvapMAPK3rlRAP1BFak56DPaxRRAF1HRASHGFmbcMAP4K1PaxdrkPTK2BSrc64BMAP2K2SosPTK2BFOSFak56DGAB1cswmysC3GSrc64BJraPPP


Description

Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion..

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP313(r21339) with a 52% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118759view11:31, 1 June 2021DeSlOntology Term : 'Rho/Rac/Cdc42 mediated signaling pathway' added !
118758view11:31, 1 June 2021DeSlOntology Term : 'hepatocyte' added !
118757view11:30, 1 June 2021DeSlAdded description from WP313
118756view11:29, 1 June 2021DeSlConverted "P" to states
118755view11:28, 1 June 2021DeSlConverted ReceptorSquare to MIMBinding with lit ref
118754view11:28, 1 June 2021DeSlConverted lines to Graphical Lines
118753view11:27, 1 June 2021DeSlRemoved textlabel
118035view11:47, 23 May 2021EweitzModified title
87667view08:55, 25 July 2016LindarieswijkOntology Term : 'scatter factor/hepatocyte growth factor signaling pathway' added !
79358view19:11, 21 March 2015Khanspersupdate
79357view19:10, 21 March 2015KhanspersReverted to version '22:35, 1 March 2011' by Khanspers
68730view22:05, 6 July 2013MaintBotUpdated to 2013 gpml schema
40906view22:35, 1 March 2011MaintBotRemoved redundant pathway information and comments
34161view21:10, 9 December 2009MaintBotAutomatic update of empty xrefs
32277view13:07, 15 August 2009MaintBotFixed text labels
31815view12:22, 14 August 2009MaintBotFixed group labels
31305view20:12, 13 August 2009MaintBotFixed text labels
30775view23:23, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
C3GGeneProduct31618 (Entrez Gene)
CRKLGeneProduct
CrkGeneProduct43775 (Entrez Gene)
Dsor1GeneProduct31872 (Entrez Gene)
ELK1GeneProduct
FOSGeneProduct
Fak56DGeneProduct37233 (Entrez Gene)
GAB1GeneProduct
HGFGeneProduct
HRASGeneProduct
ITGA1GeneProduct
JraGeneProduct36057 (Entrez Gene)
MAP2K2GeneProduct
MAP4K1GeneProduct
MAPK3GeneProduct
MAPK8GeneProduct
MetGeneProduct32114 (Entrez Gene)
PIK3CAGeneProduct
PTK2BGeneProduct
PakGeneProduct44039 (Entrez Gene)
PaxGeneProduct35215 (Entrez Gene)
PtenGeneProduct43991 (Entrez Gene)
RGeneProduct38244 (Entrez Gene)
RAF1GeneProduct
RAP1BGeneProduct
STAT3GeneProduct
SosGeneProduct34790 (Entrez Gene) Son of sevenless homolog 1 (Drosophila) (predicted)
Src64BGeneProduct48973 (Entrez Gene)
cswGeneProduct45278 (Entrez Gene)
drkGeneProduct36497 (Entrez Gene)
mbcGeneProduct42817 (Entrez Gene) Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
mysGeneProduct44885 (Entrez Gene)
rlGeneProduct3354888 (Entrez Gene)
vapGeneProduct32569 (Entrez Gene)

Annotated Interactions

No annotated interactions
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