Selenium micronutrient network (Homo sapiens)

From WikiPathways

Jump to: navigation, search
156105, 2395, 19, 40, 55, 73...2021096, 134, 147, 2022635115610, 89, 156, 184182149146, 1799063, 228140, 150, 2605, 5444, 48, 82, 18410817993Lipoprotein melabolismNecessary stimulationConversionSelenoproteinsis composed ofNegative EffectLEGENDMetabolic stressBindingCleavageStatusMicronutrientsOverarching processLeukotriene metabolismStimulationInflammation and immune responseTranscription factorProtein tyrosine nitrationProstaglandins metabolismGlycogenesisBiomarker forCofactorsSelenium statusOther proteinsCa++ metabolismInhibitionEnzymesProcess or metabolism involved in Se PathwayCatalysisCofactor conversionTryptophan metabolismMetabolitesReactionLipid peroxidationFrom intracellular part to the plasmaOxidative stressIntracellularGlutathione metabolismNAD+ metabolismER protein foldingDNA oxidationFolate metabolismPlasmaEPALipoxin B4NFKB2Arachidonic acidDPAPGE2Lipoxin A4COX1PGD28-Isoprostaglandin F2aPGF2aThromboxane A2PGI2DHACOX2DPAPGG2F2-IsoprostaneLipoxin B4PGH2PGH3a-TocopherolF2-IsoprostaneFGAPGE1MDA8-Isoprostaglandin F2aLinoleic acidDGLALipoxin A4a-TocopherolPGI2PGE3ALAPGD2PGE1PGF2aThromboxane B2PGE2Arachidonic acidLinoleic acidRELAThromboxane B2DHANFKB1MDAALAEPA21, 15821911319, 47, 92, 113, 158...7, 96, 112, 213, 221...47, 215, 220, 231172, 2537, 112, 213, 221, 24821581, 172541722201724754172266471722191594729, 42, 113, 167, 215159, 172, 22529, 4224047, 26414, 172219, 24016717215921, 158219, 24011326611311321, 15824029, 42266266Kynurenine146MTR79, 109TRXR1CBS79, 237IodineIodine259259KMO14615-HETETriiodothyronine (T3)5,6-EpoxytetraeneR-Triiodothyronine (rT3)5-HETE5-HETEThyroxine (T4)5-HPETETriiodothyronine (T3)Thyroxine (T4)15-HETER-Triiodothyronine (rT3)80, 23816780, 23855, 131, 16755, 131, 16780, 25980, 238167, 26655, 131, 16726680, 25980, 259NADP+MPOCatalaseMPO72, 89, 143, 163156, 23589Uric acid41, 239CysteineFactor VIIThrombinGGT1PAI-1PLGPAI-1tPAFactor VIItPAThrombinPLG12974, 9774, 18774, 9712920074, 187129129129129GPX 4TRXR2Xantine oxidase41, 166PRDX5H2O2ALOX5ALOX15B11, 84, 92, 213, 26676, 167CopperUric acid41, 239Vitamin B1217, 385,10-Methylene-THFSelR10, 254Tryptophan146, 1795-methyl-THFSOD3PRDX1RFK174H2OGPX 3NiacinamideCTH79PNPO227Heme149, 156, 225, 235, 237NADPHLipoic acid147ManganeseFAD261Methionine sulfoxide10Dehydroascorbic acid106, 134Leukotriene A468, 133NADPHFAD261THFHydroxykynurenine146Folic acid109NADP+NADPHSeleniumSelenium137137SelKSep1520882, 184, 196GPX 6GSH189Nicotinamidase179Calcium68Methionine10ManganeseNADPHFolic acid109FMN261SelenophosphateSelenideSelenocysteine6, 806, 806, 80CysteineLeukotriene C4Leukotriene C468, 200GPX 373Dehydroascorbic acid134GPX 2SelP102Trx-S2134, 147, 202Ascorbic acid106Lipoic acid147PRDX4GPX 1NADP+HomocysteineROSRNS7, 10, 12, 41, 44...156, 182NADPHVitamin B1217, 38MTHFR109Homocysteine97SelVDIO2SelPSPS2SelHSelTSelNSelODIO3DIO1SelISelSSelM19044, 103, 148190140, 150, 190190108, 21723, 48, 17180, 176190, 26080, 104, 25980, 25912, 25, 78, 10280, 259SOD1Pyridoxal 5'-phosphate146SerineIron68HypoxanthinePRDX3GSR132LDLHDL-CSAA4APOBSAA3LDLAPOBACTSAA1APOA1-NO2TyrABCA1HDL/SAAVLDLSAA2FMNTAGoxLDLTAGACTCholesterolSRB1HDLCholesterolHDLVLDL-TAGoxLDLVLDL-TAGHDL-CLDLRVLDL/APOBAPOA1APOA1HDL/APOA1VLDL224, 2282281945, 40, 63, 143261160, 185, 230117, 194111, 228228160, 185, 2302285, 40, 63, 1432245, 40, 63, 96, 143111, 2285, 40, 63, 96, 14346228194185194228228111, 228194111, 224, 228111, 228228228194117, 194228194194O254Pyridoxal 5'-phosphate1468-OHdG8-OHdGFAD9393261PRDX2ADPLeukotriene D4Leukotriene D4200CopperChlorineChlorineCystathionineFAD261SOD2Dihydrolipoate147, 181SerineNADP+ATPZincNADP+GSSGNADPHZincNiacinLeukotriene B4Leukotriene B468, 133133Quinolinic Acid146, 179PMPO3HNO2NO2NOHOClNO72, 16372, 163NADP+GSH108, 133, 189FLAPINSHBBCCL2INSRFibrinIL10IL6D-dimerIL1BCRPFibrinIFNgIFNgD-dimersICAM-1FibrinogenTNFasICAM-1CCL2IL6INSHbA1cFibrinogenALBIL1BTNFaHbA1cIL10ALBHBA125, 2222525, 222512, 71, 90, 255255, 27, 56, 9618, 27, 2422310451, 56, 10499231118, 27, 24292, 71, 90, 117, 255116, 1296692, 71129, 187116, 12923, 78, 17018, 78, 10466129, 18718, 23, 170, 222104SelW61, 75, 189Riboflavin26SOD3105TRXR1202Ascorbate106, 134O2-radical (aka Hyperoxid or superoxide)XanthineCalcium68Kynureninase146Methionine10ADPTrx-(SH)2147, 202ONOO-/ONOOHNitrotyrosineNitrotyrosine182182ATPLeukotriene E4Leukotriene E4200GlucoseFructosamineFructosamineLeukotriene F49, 9066668, 200Iron68HypoxanthineTRXR3FLAD1100, 174Ascorbic acid7, 106, 112FGBFGG


Description

The selenium-centred micronutrient biological network. The most relevant biochemical processes related to selenium in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the selenium centred plasma metabolome. A selenoprotein database exists at: http://www.selenodb.org. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Stoffel W, LeKim D, Sticht G; ''''; , PubMed Europe PMC Scholia
  2. Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y; ''A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  3. Gautier G, Humbert M, Deauvieau F, Scuiller M, Hiscott J, Bates EE, Trinchieri G, Caux C, Garrone P; ''A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.''; J Exp Med, 2005 PubMed Europe PMC Scholia
  4. Ghosh J, Myers CE; ''Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells.''; Proc Natl Acad Sci U S A, 1998 PubMed Europe PMC Scholia
  5. Molnar J, Garamvolgyi Z, Herold M, Adanyi N, Somogyi A, Rigo J Jr; ''Serum selenium concentrations correlate significantly with inflammatory biomarker high-sensitive CRP levels in Hungarian gestational diabetic and healthy pregnant women at mid-pregnancy.''; Biol Trace Elem Res, 2008 PubMed Europe PMC Scholia
  6. Lu J, Holmgren A; ''Selenoproteins.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  7. Traber MG; ''Vitamin E regulatory mechanisms.''; Annu Rev Nutr, 2007 PubMed Europe PMC Scholia
  8. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone.''; Prostaglandins., 1982 PubMed Europe PMC Scholia
  9. Schnedl WJ, Liebminger A, Roller RE, Lipp RW, Krejs GJ; ''''; , PubMed Europe PMC Scholia
  10. Schöneich C; ''Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease.''; Biochim Biophys Acta, 2005 PubMed Europe PMC Scholia
  11. Mancini JA, Abramovitz M, Cox ME, Wong E, Charleson S, Perrier H, Wang Z, Prasit P, Vickers PJ; ''5-lipoxygenase-activating protein is an arachidonate binding protein.''; FEBS Lett, 1993 PubMed Europe PMC Scholia
  12. Steinbrenner H, Sies H; ''Protection against reactive oxygen species by selenoproteins.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  13. Baker CH, Matsuda SP, Liu DR, Corey EJ; ''Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library.''; Biochem Biophys Res Commun, 1995 PubMed Europe PMC Scholia
  14. Murakami M, Nakatani Y, Tanioka T, Kudo I; ''Prostaglandin E synthase.''; Prostaglandins Other Lipid Mediat, 2002 PubMed Europe PMC Scholia
  15. Nakamura MT, Nara TY; ''Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases.''; Annu Rev Nutr, 2004 PubMed Europe PMC Scholia
  16. Faust JR, Goldstein JL, Brown MS; ''Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC Scholia
  17. Herbert V; ''Vitamin B-12: plant sources, requirements, and assay.''; Am J Clin Nutr, 1988 PubMed Europe PMC Scholia
  18. Kovacs E; ''The serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble gp130 (sgp130) in different tumour stages. Correlation between the two parameters in progression of malignancy.''; Biomed Pharmacother, 2005 PubMed Europe PMC Scholia
  19. Banning A, Florian S, Deubel S, Thalmann S, Müller-Schmehl K, Jacobasch G, Brigelius-Flohé R; ''GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells.''; Antioxid Redox Signal, 2008 PubMed Europe PMC Scholia
  20. Nilsson A, Duan RD; ''Absorption and lipoprotein transport of sphingomyelin.''; J Lipid Res, 2006 PubMed Europe PMC Scholia
  21. Mamalakis G, Kafatos A, Tornaritis M, Alevizos B; ''Anxiety and adipose essential fatty acid precursors for prostaglandin E1 and E2.''; J Am Coll Nutr, 1998 PubMed Europe PMC Scholia
  22. Peters KL, Smith HL, Stark GR, Sen GC; ''IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC Scholia
  23. Gao Y, Hannan NR, Wanyonyi S, Konstantopolous N, Pagnon J, Feng HC, Jowett JB, Kim KH, Walder K, Collier GR; ''Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells.''; Cytokine, 2006 PubMed Europe PMC Scholia
  24. Bowser PA, Gray GM; ''Sphingomyelinase in pig and human epidermis.''; J Invest Dermatol, 1978 PubMed Europe PMC Scholia
  25. Bosschaerts T, Guilliams M, Noel W, Hérin M, Burk RF, Hill KE, Brys L, Raes G, Ghassabeh GH, De Baetselier P, Beschin A; ''Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P.''; J Immunol, 2008 PubMed Europe PMC Scholia
  26. Hoey L, McNulty H, Strain JJ; ''Studies of biomarker responses to intervention with riboflavin: a systematic review.''; Am J Clin Nutr, 2009 PubMed Europe PMC Scholia
  27. Doo YC, Han SJ, Park WJ, Kim SM, Choi SH, Cho GY, Hong KS, Han KR, Lee NH, Oh DJ, Ryu KH, Rhim CY, Lee KH, Lee Y; ''Associations between C-reactive protein and circulating cell adhesion molecules in patients with unstable angina undergoing coronary intervention and their clinical implication.''; Clin Cardiol, 2005 PubMed Europe PMC Scholia
  28. Kimura M, Okuno E, Inada J, Ohyama H, Kido R; ''Purification and characterization of amino-acid N-choloyltransferase from human liver.''; Hoppe Seylers Z Physiol Chem, 1983 PubMed Europe PMC Scholia
  29. Salem N Jr, Pawlosky R, Wegher B, Hibbeln J; ''In vivo conversion of linoleic acid to arachidonic acid in human adults.''; Prostaglandins Leukot Essent Fatty Acids, 1999 PubMed Europe PMC Scholia
  30. Bailey JM, Bryant RW, Whiting J, Salata K; ''Characterization of 11-HETE and 15-HETE, together with prostacyclin, as major products of the cyclooxygenase pathway in cultured rat aorta smooth muscle cells.''; J Lipid Res, 1983 PubMed Europe PMC Scholia
  31. MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV; ''Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms.''; Appl Environ Microbiol, 1982 PubMed Europe PMC Scholia
  32. Bohnenkamp HR, Papazisis KT, Burchell JM, Taylor-Papadimitriou J; ''Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses.''; Cell Immunol, 2007 PubMed Europe PMC Scholia
  33. Laden BP, Tang Y, Porter TD; ''Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase.''; Arch Biochem Biophys, 2000 PubMed Europe PMC Scholia
  34. Jackowski S, Fagone P; ''CTP: Phosphocholine cytidylyltransferase: paving the way from gene to membrane.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  35. Lykidis A, Wang J, Karim MA, Jackowski S; ''Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  36. Lu B, Xu FY, Jiang YJ, Choy PC, Hatch GM, Grunfeld C, Feingold KR; ''Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1).''; J Lipid Res, 2006 PubMed Europe PMC Scholia
  37. Helgerud P, Saarem K, Norum KR; ''Acyl-CoA:cholesterol acyltransferase in human small intestine: its activity and some properties of the enzymic reaction.''; J Lipid Res, 1981 PubMed Europe PMC Scholia
  38. Hoey L, Strain JJ, McNulty H; ''Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.''; Am J Clin Nutr, 2009 PubMed Europe PMC Scholia
  39. Goldstein JL, Brown MS; ''Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol.''; Proc Natl Acad Sci U S A, 1973 PubMed Europe PMC Scholia
  40. Hussein O, Rosenblat M, Refael G, Aviram M; ''Dietary selenium increases cellular glutathione peroxidase activity and reduces the enhanced susceptibility to lipid peroxidation of plasma and low-density lipoprotein in kidney transplant recipients.''; Transplantation, 1997 PubMed Europe PMC Scholia
  41. Becker BF; ''Towards the physiological function of uric acid.''; Free Radic Biol Med, 1993 PubMed Europe PMC Scholia
  42. Isseroff RR, Ziboh VA, Chapkin RS, Martinez DT; ''''; , PubMed Europe PMC Scholia
  43. Schaap D, de Widt J, van der Wal J, Vandekerckhove J, van Damme J, Gussow D, Ploegh HL, van Blitterswijk WJ, van der Bend RL; ''Purification, cDNA-cloning and expression of human diacylglycerol kinase.''; FEBS Lett, 1990 PubMed Europe PMC Scholia
  44. Ferguson AD, Labunskyy VM, Fomenko DE, Araç D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J; ''NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  45. Guzik TJ, Korbut R, Adamek-Guzik T; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol, 2003 PubMed Europe PMC Scholia
  46. Zheng L, Nukuna B, Brennan ML, Sun M, Goormastic M, Settle M, Schmitt D, Fu X, Thomson L, Fox PL, Ischiropoulos H, Smith JD, Kinter M, Hazen SL; ''Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease.''; J Clin Invest, 2004 PubMed Europe PMC Scholia
  47. Smith WL; ''Cyclooxygenases, peroxide tone and the allure of fish oil.''; Curr Opin Cell Biol, 2005 PubMed Europe PMC Scholia
  48. Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA; ''A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.''; Nature, 2004 PubMed Europe PMC Scholia
  49. Nitahara Y, Aoyama Y, Horiuchi T, Noshiro M, Yoshida Y; ''Purification and characterization of rat sterol 14-demethylase P450 (CYP51) expressed in Escherichia coli.''; J Biochem, 1999 PubMed Europe PMC Scholia
  50. Cali JJ, Russell DW; ''Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.''; J Biol Chem, 1991 PubMed Europe PMC Scholia
  51. Esmon CT; ''Does inflammation contribute to thrombotic events?''; Haemostasis, 2000 PubMed Europe PMC Scholia
  52. Semnani RT, Venugopal PG, Leifer CA, Mostbˆck S, Sabzevari H, Nutman TB; ''Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites.''; Blood, 2008 PubMed Europe PMC Scholia
  53. Itabe H; ''Oxidative modification of LDL: its pathological role in atherosclerosis.''; Clin Rev Allergy Immunol, 2009 PubMed Europe PMC Scholia
  54. Marnett LJ; ''Lipid peroxidation-DNA damage by malondialdehyde.''; Mutat Res, 1999 PubMed Europe PMC Scholia
  55. Huwyler J, Bürgin M, Zeugin T, Gut J; ''Transformation of 5-hydroperoxyeicosatetraenoic acid into dihydroxy- and cysteinyl-leukotrienes by rat hepatocytes: effects of glutathione.''; Mol Pharmacol, 1991 PubMed Europe PMC Scholia
  56. Eklund CM; ''Proinflammatory cytokines in CRP baseline regulation.''; Adv Clin Chem, 2009 PubMed Europe PMC Scholia
  57. Correa-Cerro LS, Porter FD; ''3beta-hydroxysterol Delta7-reductase and the Smith-Lemli-Opitz syndrome.''; Mol Genet Metab, 2005 PubMed Europe PMC Scholia
  58. Tomohiro S, Kawaguti A, Kawabe Y, Kitada S, Kuge O; ''Purification and characterization of human phosphatidylserine synthase 1 and 2.''; Biochem J, 2008 PubMed Europe PMC Scholia
  59. Johnson J, Albarani V, Nguyen M, Goldman M, Willems F, Aksoy E; ''Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  60. Shen W, Stone K, Jales A, Leitenberg D, Ladisch S; ''Inhibition of TLR activation and up-regulation of IL-1R-associated kinase-M expression by exogenous gangliosides.''; J Immunol, 2008 PubMed Europe PMC Scholia
  61. Whanger PD; ''Selenoprotein W: a review.''; Cell Mol Life Sci, 2000 PubMed Europe PMC Scholia
  62. Jakobsson A, Westerberg R, Jacobsson A; ''Fatty acid elongases in mammals: their regulation and roles in metabolism.''; Prog Lipid Res, 2006 PubMed Europe PMC Scholia
  63. Itabe H; ''Oxidative modification of LDL: its pathological role in atherosclerosis.''; Clin Rev Allergy Immunol, 2009 PubMed Europe PMC Scholia
  64. Glickman JF, Schmid A; ''Farnesyl pyrophosphate synthase: real-time kinetics and inhibition by nitrogen-containing bisphosphonates in a scintillation assay.''; Assay Drug Dev Technol, 2007 PubMed Europe PMC Scholia
  65. Morrow JD, Roberts LJ 2nd.; ''The isoprostanes. Current knowledge and directions for future research.''; Biochem Pharmacol., 1996 PubMed Europe PMC Scholia
  66. Youssef D, El Abbassi A, Jordan RM, Peiris AN; ''Fructosamine--an underutilized tool in diabetes management: case report and literature review.''; Tenn Med, 2008 PubMed Europe PMC Scholia
  67. Nava VE, Lacana E, Poulton S, Liu H, Sugiura M, Kono K, Milstien S, Kohama T, Spiegel S; ''Functional characterization of human sphingosine kinase-1.''; FEBS Lett, 2000 PubMed Europe PMC Scholia
  68. Peters-Golden M, Brock TG; ''5-lipoxygenase and FLAP.''; Prostaglandins Leukot Essent Fatty Acids, 2003 PubMed Europe PMC Scholia
  69. Hahn FM, Xuan JW, Chambers AF, Poulter CD; ''Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization.''; Arch Biochem Biophys, 1996 PubMed Europe PMC Scholia
  70. Paul P, Kamisaka Y, Marks DL, Pagano RE; ''Purification and characterization of UDP-glucose:ceramide glucosyltransferase from rat liver Golgi membranes.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  71. Videla LA, Rodrigo R, Araya J, Poniachik J; ''Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease.''; Trends Mol Med, 2006 PubMed Europe PMC Scholia
  72. Abu-Soud HM, Hazen SL; ''Nitric oxide is a physiological substrate for mammalian peroxidases.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  73. Brigelius-Flohé R; ''Tissue-specific functions of individual glutathione peroxidases.''; Free Radic Biol Med, 1999 PubMed Europe PMC Scholia
  74. Adams RL, Bird RJ; ''Review article: Coagulation cascade and therapeutics update: relevance to nephrology. Part 1: Overview of coagulation, thrombophilias and history of anticoagulants.''; Nephrology (Carlton), 2009 PubMed Europe PMC Scholia
  75. Jeong D, Kim TS, Chung YW, Lee BJ, Kim IY; ''Selenoprotein W is a glutathione-dependent antioxidant in vivo.''; FEBS Lett, 2002 PubMed Europe PMC Scholia
  76. Schnurr K, Belkner J, Ursini F, Schewe T, Kühn H; ''The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  77. Waterham HR, Wijburg FA, Hennekam RC, Vreken P, Poll-The BT, Dorland L, Duran M, Jira PE, Smeitink JA, Wevers RA, Wanders RJ; ''Smith-Lemli-Opitz syndrome is caused by mutations in the 7-dehydrocholesterol reductase gene.''; Am J Hum Genet, 1998 PubMed Europe PMC Scholia
  78. Hesse-Bähr K, Dreher I, Köhrle J; ''The influence of the cytokines Il-1beta and INFgamma on the expression of selenoproteins in the human hepatocarcinoma cell line HepG2.''; Biofactors, 2000 PubMed Europe PMC Scholia
  79. Finkelstein JD; ''The metabolism of homocysteine: pathways and regulation.''; Eur J Pediatr, 1998 PubMed Europe PMC Scholia
  80. Papp LV, Lu J, Holmgren A, Khanna KK; ''From selenium to selenoproteins: synthesis, identity, and their role in human health.''; Antioxid Redox Signal, 2007 PubMed Europe PMC Scholia
  81. Watanabe K; ''Prostaglandin F synthase.''; Prostaglandins Other Lipid Mediat, 2002 PubMed Europe PMC Scholia
  82. Labunskyy VM, Hatfield DL, Gladyshev VN; ''The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum.''; IUBMB Life, 2007 PubMed Europe PMC Scholia
  83. Taki T, Kanfer JN; ''Phospholipase D from rat brain.''; Methods Enzymol, 1981 PubMed Europe PMC Scholia
  84. Imai H, Narashima K, Arai M, Sakamoto H, Chiba N, Nakagawa Y; ''Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  85. Voelker DR; ''Phosphatidylserine decarboxylase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  86. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol., 2003 PubMed Europe PMC Scholia
  87. Franken PA, Van den Berg L, Huang J, Gunyuzlu P, Lugtigheid RB, Verheij HM, De Haas GH; ''Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Cleavage of a fusion protein with cyanogen bromide.''; Eur J Biochem, 1992 PubMed Europe PMC Scholia
  88. Momoi T, Ben-Yoseph Y, Nadler HL; ''Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls.''; Biochem J, 1982 PubMed Europe PMC Scholia
  89. Klebanoff SJ; ''Myeloperoxidase: friend and foe.''; J Leukoc Biol, 2005 PubMed Europe PMC Scholia
  90. Barth E, Albuszies G, Baumgart K, Matejovic M, Wachter U, Vogt J, Radermacher P, Calzia E; ''Glucose metabolism and catecholamines.''; Crit Care Med, 2007 PubMed Europe PMC Scholia
  91. Baumruker T, Bornancin F, Billich A; ''The role of sphingosine and ceramide kinases in inflammatory responses.''; Immunol Lett, 2005 PubMed Europe PMC Scholia
  92. Heirman I, Ginneberge D, Brigelius-Flohé R, Hendrickx N, Agostinis P, Brouckaert P, Rottiers P, Grooten J; ''Blocking tumor cell eicosanoid synthesis by GP x 4 impedes tumor growth and malignancy.''; Free Radic Biol Med, 2006 PubMed Europe PMC Scholia
  93. Shigenaga MK, Gimeno CJ, Ames BN; ''Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.''; Proc Natl Acad Sci U S A, 1989 PubMed Europe PMC Scholia
  94. Guan ZZ, Wang YN, Xiao KQ, Hu PS, Liu JL; ''Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease.''; Neurochem Int, 1999 PubMed Europe PMC Scholia
  95. Bose R, Kolesnick R; ''Measurement of ceramide synthase activity.''; Methods Enzymol, 2000 PubMed Europe PMC Scholia
  96. Scheurig AC, Thorand B, Fischer B, Heier M, Koenig W; ''Association between the intake of vitamins and trace elements from supplements and C-reactive protein: results of the MONICA/KORA Augsburg study.''; Eur J Clin Nutr, 2008 PubMed Europe PMC Scholia
  97. Al-Obaidi MK, Philippou H, Stubbs PJ, Adami A, Amersey R, Noble MM, Lane DA; ''Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes.''; Circulation, 2000 PubMed Europe PMC Scholia
  98. Niwa Y, Sakane T, Ichikawa M, Kondo T, Taniguchi S; ''Phospholipid transmethylation and choline phosphotransferase in microsomal fraction of human diseased liver.''; J Hepatol, 1986 PubMed Europe PMC Scholia
  99. ''''; , PubMed Europe PMC Scholia
  100. Huerta C, Borek D, Machius M, Grishin NV, Zhang H; ''Structure and mechanism of a eukaryotic FMN adenylyltransferase.''; J Mol Biol, 2009 PubMed Europe PMC Scholia
  101. Horrobin DF; ''Fatty acid metabolism in health and disease: the role of delta-6-desaturase.''; Am J Clin Nutr, 1993 PubMed Europe PMC Scholia
  102. Burk RF, Hill KE, Motley AK; ''Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P.''; J Nutr, 2003 PubMed Europe PMC Scholia
  103. Shchedrina VA, Zhang Y, Labunskyy VM, Hatfield DL, Gladyshev V; ''Structure-function relationships, physiological roles and evolution of mammalian ER-resident selenoproteins.''; Antioxid Redox Signal, 2009 PubMed Europe PMC Scholia
  104. Molnár I, Balázs C, Szegedi G, Sipka S; ''Inhibition of type 2,5'-deiodinase by tumor necrosis factor alpha, interleukin-6 and interferon gamma in human thyroid tissue.''; Immunol Lett, 2002 PubMed Europe PMC Scholia
  105. Schäfer M, Werner S; ''Oxidative stress in normal and impaired wound repair.''; Pharmacol Res, 2008 PubMed Europe PMC Scholia
  106. Verrax J, Calderon PB; ''The controversial place of vitamin C in cancer treatment.''; Biochem Pharmacol, 2008 PubMed Europe PMC Scholia
  107. Shields DJ, Lehner R, Agellon LB, Vance DE; ''Membrane topography of human phosphatidylethanolamine N-methyltransferase.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  108. Panee J, Stoytcheva ZR, Liu W, Berry MJ; ''''; , PubMed Europe PMC Scholia
  109. Kim YI; ''Role of the MTHFR polymorphisms in cancer risk modification and treatment.''; Future Oncol, 2009 PubMed Europe PMC Scholia
  110. Ho TC, Chen SL, Yang YC, Chen CY, Feng FP, Hsieh JW, Cheng HC, Tsao YP; ''15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  111. Clifton PM, Mackinnon AM, Barter PJ; ''Effects of serum amyloid A protein (SAA) on composition, size, and density of high density lipoproteins in subjects with myocardial infarction.''; J Lipid Res, 1985 PubMed Europe PMC Scholia
  112. McCay PB; ''Vitamin E: interactions with free radicals and ascorbate.''; Annu Rev Nutr, 1985 PubMed Europe PMC Scholia
  113. Basu S; ''F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications.''; Antioxid Redox Signal, 2008 PubMed Europe PMC Scholia
  114. Yamaoka S, Miyaji M, Kitano T, Umehara H, Okazaki T; ''Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  115. Okuma M, Yamashita S, Numa S; ''Enzymic studies on phosphatidic acid synthesis in human platelets.''; Blood, 1973 PubMed Europe PMC Scholia
  116. Wu C, Bates SM; ''Should D-dimer testing be used to predict the risk of recurrence after discontinuation of anticoagulant therapy for a first unprovoked episode of venous thromboembolism?''; Pol Arch Med Wewn, 2009 PubMed Europe PMC Scholia
  117. Kamagate A, Dong HH; ''FoxO1 integrates insulin signaling to VLDL production.''; Cell Cycle, 2008 PubMed Europe PMC Scholia
  118. Pyne S, Pyne NJ; ''Sphingosine 1-phosphate signalling in mammalian cells.''; Biochem J, 2000 PubMed Europe PMC Scholia
  119. Penning TM, Jin Y, Steckelbroeck S, Lanisnik Rizner T, Lewis M; ''Structure-function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteins.''; Mol Cell Endocrinol, 2004 PubMed Europe PMC Scholia
  120. Gustafsson J; ''Bile acid synthesis during development. Mitochondrial 12 alpha-hydroxylation in human fetal liver.''; J Clin Invest, 1985 PubMed Europe PMC Scholia
  121. Johnson KR, Johnson KY, Becker KP, Bielawski J, Mao C, Obeid LM; ''Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  122. Giera M, Renard D, Plössl F, Bracher F; ''Lathosterol side chain amides: a new class of human lathosterol oxidase inhibitors.''; Steroids, 2008 PubMed Europe PMC Scholia
  123. Olivier LM, Chambliss KL, Gibson KM, Krisans SK; ''Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting.''; J Lipid Res, 1999 PubMed Europe PMC Scholia
  124. Setty BN, Stuart MJ, Walenga RW; ''Formation of 11-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid in human umbilical arteries is catalyzed by cyclooxygenase.''; Biochim Biophys Acta, 1985 PubMed Europe PMC Scholia
  125. Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ; ''Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  126. Johnsen IB, Nguyen TT, Ringdal M, Tryggestad AM, Bakke O, Lien E, Espevik T, Anthonsen MW; ''Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.''; EMBO J, 2006 PubMed Europe PMC Scholia
  127. Yang P, Chan D, Felix E, Cartwright C, Menter DG, Madden T, Klein RD, Fischer SM, Newman RA; ''Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells.''; J Lipid Res, 2004 PubMed Europe PMC Scholia
  128. Lööf L, Wengle B; ''Enzymatic sulphation of bile salts in human liver.''; Biochim Biophys Acta, 1978 PubMed Europe PMC Scholia
  129. Lijnen HR; ''Elements of the fibrinolytic system.''; Ann N Y Acad Sci, 2001 PubMed Europe PMC Scholia
  130. Leung DW, Tompkins CK, White T; ''Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.''; DNA Cell Biol, 1998 PubMed Europe PMC Scholia
  131. Engels F, Nijkamp FP; ''Pharmacological inhibition of leukotriene actions.''; Pharm World Sci, 1998 PubMed Europe PMC Scholia
  132. Kalpakcioglu B, Senel K; ''The interrelation of glutathione reductase, catalase, glutathione peroxidase, superoxide dismutase, and glucose-6-phosphate in the pathogenesis of rheumatoid arthritis.''; Clin Rheumatol, 2008 PubMed Europe PMC Scholia
  133. Hammarström S; ''Leukotrienes.''; Annu Rev Biochem, 1983 PubMed Europe PMC Scholia
  134. May JM, Mendiratta S, Hill KE, Burk RF; ''Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductase.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  135. Bakovic M, Fullerton MD, Michel V; ''Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2).''; Biochem Cell Biol, 2007 PubMed Europe PMC Scholia
  136. Bütikofer P, Yee MC, Schott MA, Lubin BH, Kuypers FA; ''Generation of phosphatidic acid during calcium-loading of human erythrocytes. Evidence for a phosphatidylcholine-hydrolyzing phospholipase D.''; Eur J Biochem, 1993 PubMed Europe PMC Scholia
  137. Agaugué S, Perrin-Cocon L, Coutant F, André P, Lotteau V; ''1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity.''; J Immunol, 2006 PubMed Europe PMC Scholia
  138. Yasutomi M, Ohshima Y, Omata N, Yamada A, Iwasaki H, Urasaki Y, Mayumi M; ''Erythromycin differentially inhibits lipopolysaccharide- or poly(I:C)-induced but not peptidoglycan-induced activation of human monocyte-derived dendritic cells.''; J Immunol, 2005 PubMed Europe PMC Scholia
  139. Draus E, Niefind J, Vietor K, Havsteen B; ''Isolation and characterization of the human liver ethanolamine kinase.''; Biochim Biophys Acta, 1990 PubMed Europe PMC Scholia
  140. Arbogast S, Beuvin M, Fraysse B, Zhou H, Muntoni F, Ferreiro A; ''Oxidative stress in SEPN1-related myopathy: from pathophysiology to treatment.''; Ann Neurol, 2009 PubMed Europe PMC Scholia
  141. Aksoy E, Vanden Berghe W, Detienne S, Amraoui Z, Fitzgerald KA, Haegeman G, Goldman M, Willems F; ''Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.''; Eur J Immunol, 2005 PubMed Europe PMC Scholia
  142. Chen Y, Dennis EA; ''Expression and characterization of human group V phospholipase A2.''; Biochim Biophys Acta, 1998 PubMed Europe PMC Scholia
  143. Malle E, Marsche G, Arnhold J, Davies MJ; ''Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid.''; Biochim Biophys Acta, 2006 PubMed Europe PMC Scholia
  144. Remoli ME, Ragimbeau J, Giacomini E, Gafa V, Severa M, Lande R, Pellegrini S, Coccia EM; ''NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation.''; J Leukoc Biol, 2007 PubMed Europe PMC Scholia
  145. Betsholtz IH, Wikvall K; ''Cytochrome P450 CYP27-catalyzed oxidation of C27-steroid into C27-acid.''; J Steroid Biochem Mol Biol, 1995 PubMed Europe PMC Scholia
  146. Bender DA; ''Biochemistry of tryptophan in health and disease.''; Mol Aspects Med, 1983 PubMed Europe PMC Scholia
  147. Arnér ES, Nordberg J, Holmgren A; ''Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase.''; Biochem Biophys Res Commun, 1996 PubMed Europe PMC Scholia
  148. Korotkov KV, Novoselov SV, Hatfield DL, Gladyshev VN; ''Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element.''; Mol Cell Biol, 2002 PubMed Europe PMC Scholia
  149. Li YC, Chiang CW, Yeh HC, Hsu PY, Whitby FG, Wang LH, Chan NL; ''Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  150. Sandrine A, Ferreiro A; ''Selenoproteins and protection against oxidative stress: selenoprotein N as a novel player at the crossroads of redox signalling and calcium homeostasis.''; Antioxid Redox Signal, 2009 PubMed Europe PMC Scholia
  151. Izzo AA, Piscitelli F, Capasso R, Marini P, Cristino L, Petrosino S, Di Marzo V; ''Basal and Fasting/Refeeding-regulated Tissue Levels of Endogenous PPAR-alpha Ligands in Zucker Rats.''; Obesity (Silver Spring), 2009 PubMed Europe PMC Scholia
  152. Shimojo T, Akino T, Miura Y, Schroepfer GJ Jr; ''Sphingolipid base metabolism. Stereospecific uptake of proton in the enzymatic conversion of sphinganine 1-phosphate to ethanolamine 1-phosphate.''; J Biol Chem, 1976 PubMed Europe PMC Scholia
  153. Pedretti A, Bocci E, Maggi R, Vistoli G; ''Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations.''; Steroids, 2008 PubMed Europe PMC Scholia
  154. Matsukura S, Kokubu F, Kurokawa M, Kawaguchi M, Ieki K, Kuga H, Odaka M, Suzuki S, Watanabe S, Takeuchi H, Kasama T, Adachi M; ''Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappaB and/or IRF-3 in airway epithelial cells.''; Clin Exp Allergy, 2006 PubMed Europe PMC Scholia
  155. Pikuleva IA, Puchkaev A, Björkhem I; ''Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1.''; Biochemistry, 2001 PubMed Europe PMC Scholia
  156. Evans P, Halliwell B; ''Free radicals and hearing. Cause, consequence, and criteria.''; Ann N Y Acad Sci, 1999 PubMed Europe PMC Scholia
  157. Hasan UA, Caux C, Perrot I, Doffin AC, Menetrier-Caux C, Trinchieri G, Tommasino M, Vlach J; ''Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  158. Levin G, Duffin KL, Obukowicz MG, Hummert SL, Fujiwara H, Needleman P, Raz A; ''Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.''; Biochem J, 2002 PubMed Europe PMC Scholia
  159. Reilly IA, FitzGerald GA; ''Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs.''; Blood, 1987 PubMed Europe PMC Scholia
  160. Kilpatrick L, Johnson JL, Nickbarg EB, Wang ZM, Clifford TF, Banach M, Cooperman BS, Douglas SD, Rubin H; ''Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin.''; J Immunol, 1991 PubMed Europe PMC Scholia
  161. Needleman P, Raz A, Minkes MS, Ferrendelli JA, Sprecher H; ''Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC Scholia
  162. Jiang LL, Kurosawa T, Sato M, Suzuki Y, Hashimoto T; ''Physiological role of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein.''; J Biochem, 1997 PubMed Europe PMC Scholia
  163. Galijasevic S, Saed GM, Hazen SL, Abu-Soud HM; ''Myeloperoxidase metabolizes thiocyanate in a reaction driven by nitric oxide.''; Biochemistry, 2006 PubMed Europe PMC Scholia
  164. Chatterjee S, Castiglione E; ''UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes.''; Biochim Biophys Acta, 1987 PubMed Europe PMC Scholia
  165. Moore SA, Hurt E, Yoder E, Sprecher H, Spector AA; ''Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid.''; J Lipid Res, 1995 PubMed Europe PMC Scholia
  166. Saavedra WF, Paolocci N, St John ME, Skaf MW, Stewart GC, Xie JS, Harrison RW, Zeichner J, Mudrick D, Marbán E, Kass DA, Hare JM; ''Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart.''; Circ Res, 2002 PubMed Europe PMC Scholia
  167. Moreno JJ; ''New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
  168. Antonenkov VD, Van Veldhoven PP, Waelkens E, Mannaerts GP; ''Substrate specificities of 3-oxoacyl-CoA thiolase A and sterol carrier protein 2/3-oxoacyl-CoA thiolase purified from normal rat liver peroxisomes. Sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in the metabolism of 2-methyl-branched fatty acids and bile acid intermediates.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  169. Goetzl EJ, Sun FF; ''Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils.''; J Exp Med, 1979 PubMed Europe PMC Scholia
  170. Sneddon AA, Wu HC, Farquharson A, Grant I, Arthur JR, Rotondo D, Choe SN, Wahle KW; ''Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants.''; Atherosclerosis, 2003 PubMed Europe PMC Scholia
  171. Gao Y, Feng HC, Walder K, Bolton K, Sunderland T, Bishara N, Quick M, Kantham L, Collier GR; ''Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein.''; FEBS Lett, 2004 PubMed Europe PMC Scholia
  172. Cipollone F, Cicolini G, Bucci M; ''Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives.''; Pharmacol Ther, 2008 PubMed Europe PMC Scholia
  173. Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M; ''Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.''; Blood, 2006 PubMed Europe PMC Scholia
  174. Karthikeyan S, Zhou Q, Osterman AL, Zhang H; ''Ligand binding-induced conformational changes in riboflavin kinase: structural basis for the ordered mechanism.''; Biochemistry, 2003 PubMed Europe PMC Scholia
  175. Bierbach H; ''Studies on long chain fatty acid:CoA ligase from human small intestine.''; Gut, 1980 PubMed Europe PMC Scholia
  176. Guimarães MJ, Peterson D, Vicari A, Cocks BG, Copeland NG, Gilbert DJ, Jenkins NA, Ferrick DA, Kastelein RA, Bazan JF, Zlotnik A; ''Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism?''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC Scholia
  177. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone''; Prostaglandins., 1982 PubMed Europe PMC Scholia
  178. Kainou T, Kawamura K, Tanaka K, Matsuda H, Kawamukai M; ''Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human.''; Biochim Biophys Acta, 1999 PubMed Europe PMC Scholia
  179. Magni G, Amici A, Emanuelli M, Orsomando G, Raffaelli N, Ruggieri S; ''Enzymology of NAD+ homeostasis in man.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  180. Eberhardt C, Gray PW, Tjoelker LW; ''Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  181. Packer L, Witt EH, Tritschler HJ; ''alpha-Lipoic acid as a biological antioxidant.''; Free Radic Biol Med, 1995 PubMed Europe PMC Scholia
  182. Abello N, Kerstjens HA, Postma DS, Bischoff R; ''Protein tyrosine nitration: selectivity, physicochemical and biological consequences, denitration, and proteomics methods for the identification of tyrosine-nitrated proteins.''; J Proteome Res, 2009 PubMed Europe PMC Scholia
  183. Spassieva S, Seo JG, Jiang JC, Bielawski J, Alvarez-Vasquez F, Jazwinski SM, Hannun YA, Obeid LM; ''''; , PubMed Europe PMC Scholia
  184. Köhrle J, Jakob F, Contempré B, Dumont JE; ''Selenium, the thyroid, and the endocrine system.''; Endocr Rev, 2005 PubMed Europe PMC Scholia
  185. Janciauskiene S, Wright HT; ''Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease.''; Bioessays, 1998 PubMed Europe PMC Scholia
  186. White BA, Cacciapuoti AF, Fricke RJ, Whitehead TR, Mosbach EH, Hylemon PB; ''Cofactor requiremets for 7 alpha-dehydroxylation of cholic and chenodeoxycholic acid in cell extracts of the intestinal anaerobic bacterium, Eubacterium species V.P.I. 13708.''; J Lipid Res, 1981 PubMed Europe PMC Scholia
  187. Weisel JW; ''Fibrinogen and fibrin.''; Adv Protein Chem, 2005 PubMed Europe PMC Scholia
  188. Liu YY, Han TY, Giuliano AE, Cabot MC; ''Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  189. Whanger PD; ''Selenoprotein expression and function-Selenoprotein W.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  190. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN; ''Characterization of mammalian selenoproteomes.''; Science, 2003 PubMed Europe PMC Scholia
  191. Cheng JB, Jacquemin E, Gerhardt M, Nazer H, Cresteil D, Heubi JE, Setchell KD, Russell DW; ''Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease.''; J Clin Endocrinol Metab, 2003 PubMed Europe PMC Scholia
  192. Johnson MR, Barnes S, Diasio RB; ''Radioassay of bile acid coenzyme A:glycine/taurine: N-acyltransferase using an n-butanol solvent extraction procedure.''; Anal Biochem, 1989 PubMed Europe PMC Scholia
  193. Ellis E, Goodwin B, Abrahamsson A, Liddle C, Mode A, Rudling M, Bjorkhem I, Einarsson C; ''Bile acid synthesis in primary cultures of rat and human hepatocytes.''; Hepatology, 1998 PubMed Europe PMC Scholia
  194. Karpe F, Bickerton AS, Hodson L, Fielding BA, Tan GD, Frayn KN; ''Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation.''; Biochem Soc Trans, 2007 PubMed Europe PMC Scholia
  195. Sala A, Voelkel N, Maclouf J, Murphy RC; ''Leukotriene E4 elimination and metabolism in normal human subjects.''; J Biol Chem, 1990 PubMed Europe PMC Scholia
  196. Gladyshev VN, Jeang KT, Wootton JC, Hatfield DL; ''A new human selenium-containing protein. Purification, characterization, and cDNA sequence.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  197. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol., 2003 PubMed Europe PMC Scholia
  198. Huijghebaert SM, Hofmann AF; ''Influence of the amino acid moiety on deconjugation of bile acid amidates by cholylglycine hydrolase or human fecal cultures.''; J Lipid Res, 1986 PubMed Europe PMC Scholia
  199. Miyazaki M, Kanto T, Inoue M, Itose I, Miyatake H, Sakakibara M, Yakushijin T, Kakita N, Hiramatsu N, Takehara T, Kasahara A, Hayashi N; ''Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I.''; J Med Virol, 2008 PubMed Europe PMC Scholia
  200. Anderson ME, Allison RD, Meister A; ''Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids.''; Proc Natl Acad Sci U S A, 1982 PubMed Europe PMC Scholia
  201. Ahlberg J, Angelin B, Björkhem I, Einarsson K, Leijd B; ''Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones.''; J Lipid Res, 1979 PubMed Europe PMC Scholia
  202. Powis G, Montfort WR; ''Properties and biological activities of thioredoxins.''; Annu Rev Pharmacol Toxicol, 2001 PubMed Europe PMC Scholia
  203. Lund EG, Kerr TA, Sakai J, Li WP, Russell DW; ''cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  204. Galton DJ; ''Lipogenesis in human adipose tissue.''; J Lipid Res, 1968 PubMed Europe PMC Scholia
  205. Selhub J.; ''Homocysteine metabolism.''; Annu Rev Nutr, 1999 PubMed Europe PMC Scholia
  206. Cuebas DA, Phillips C, Schmitz W, Conzelmann E, Novikov DK; ''The role of alpha-methylacyl-CoA racemase in bile acid synthesis.''; Biochem J, 2002 PubMed Europe PMC Scholia
  207. Stoffel W, LeKim D, Sticht G; ''Metabolism of sphingosine bases. 8. Distribution, isolation and properties of D-3-oxosphinganine reductase. Stereospecificity of the NADPH-dependent reaction of 3-oxodihydrospingosine (2-amino-1-hydroxyoctadecane-3-one).''; Hoppe Seylers Z Physiol Chem, 1968 PubMed Europe PMC Scholia
  208. Lu C, Qiu F, Zhou H, Peng Y, Hao W, Xu J, Yuan J, Wang S, Qiang B, Xu C, Peng X; ''Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.''; FEBS Lett, 2006 PubMed Europe PMC Scholia
  209. Holleran WM, Williams ML, Gao WN, Elias PM; ''''; , PubMed Europe PMC Scholia
  210. Bates CJ, Thane CW, Prentice A, Delves HT; ''Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over.''; J Trace Elem Med Biol, 2002 PubMed Europe PMC Scholia
  211. Whitaker MO, Wyche A, Fitzpatrick F, Sprecher H, Needleman P; ''Triene prostaglandins: prostaglandin D3 and icosapentaenoic acid as potential antithrombotic substances.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC Scholia
  212. Traupe H, Has C; ''The Conradi-Hünermann-Happle syndrome is caused by mutations in the gene that encodes a 8- 7 sterol isomerase and is biochemically related to the CHILD syndrome.''; Eur J Dermatol, 2000 PubMed Europe PMC Scholia
  213. Maccarrone M, Meloni C, Manca-di-Villahermosa S, Cococcetta N, Casciani CU, Finazzi-Agrò A, Taccone-Gallucci M; ''Vitamin E suppresses 5-lipoxygenase-mediated oxidative stress in peripheral blood mononuclear cells of hemodialysis patients regardless of administration route.''; Am J Kidney Dis, 2001 PubMed Europe PMC Scholia
  214. Malle E, Marsche G, Arnhold J, Davies MJ; ''Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid.''; Biochim Biophys Acta, 2006 PubMed Europe PMC Scholia
  215. Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LB, Lipsky PE; ''Cyclooxygenase in biology and disease.''; FASEB J, 1998 PubMed Europe PMC Scholia
  216. Hosaka K, Tanaka S, Nikawa J, Yamashita S; ''Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation.''; FEBS Lett, 1992 PubMed Europe PMC Scholia
  217. Ben Jilani KE, Panee J, He Q, Berry MJ, Li PA; ''Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation.''; Int J Biol Sci, 2007 PubMed Europe PMC Scholia
  218. Chen D, Zhang XY, Shi Y; ''Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria.''; Biochem J, 2006 PubMed Europe PMC Scholia
  219. Joensen AM, Schmidt EB, Dethlefsen C, Johnsen SP, Tjønneland A, Rasmussen LH, Overvad K; ''Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study.''; Br J Nutr, 2009 PubMed Europe PMC Scholia
  220. Simmons DL, Botting RM, Hla T; ''Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition.''; Pharmacol Rev, 2004 PubMed Europe PMC Scholia
  221. Abate A, Yang G, Dennery PA, Oberle S, Schröder H; ''Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin.''; Free Radic Biol Med, 2000 PubMed Europe PMC Scholia
  222. Ho AW, Wong CK, Lam CW; ''Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways.''; Immunobiology, 2008 PubMed Europe PMC Scholia
  223. Lykidis A, Jackson PD, Rock CO, Jackowski S; ''The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  224. van der Westhuyzen DR, Cai L, de Beer MC, de Beer FC; ''Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  225. Wang LH, Kulmacz RJ; ''Thromboxane synthase: structure and function of protein and gene.''; Prostaglandins Other Lipid Mediat, 2002 PubMed Europe PMC Scholia
  226. Ferré P; ''The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity.''; Diabetes, 2004 PubMed Europe PMC Scholia
  227. Kwak SE, Kim JE, Kim DW, Kwon OS, Choi SY, Kang TC; ''Pyridoxine 5'-phosphate oxidase, not pyridoxal kinase, involves in long-term potentiation induction in the rat dentate gyrus.''; Hippocampus, 2009 PubMed Europe PMC Scholia
  228. Lewis GF, Rader DJ; ''New insights into the regulation of HDL metabolism and reverse cholesterol transport.''; Circ Res, 2005 PubMed Europe PMC Scholia
  229. Schwarz M, Wright AC, Davis DL, Nazer H, Björkhem I, Russell DW; ''The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis.''; J Clin Invest, 2000 PubMed Europe PMC Scholia
  230. Bates CJ, Thane CW, Prentice A, Delves HT; ''Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over.''; J Trace Elem Med Biol, 2002 PubMed Europe PMC Scholia
  231. Smith WL, Langenbach R; ''Why there are two cyclooxygenase isozymes.''; J Clin Invest, 2001 PubMed Europe PMC Scholia
  232. Yamashita S, Hosaka K, Numa S; ''Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes.''; Eur J Biochem, 1973 PubMed Europe PMC Scholia
  233. Araya Z, Wikvall K; ''6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes.''; Biochim Biophys Acta, 1999 PubMed Europe PMC Scholia
  234. Sakurai T, Yamamoto Y, Baba N, Nakano M; ''Phospholipase A(2) activity in non-glycated and glycated low density lipoproteins.''; Biochim Biophys Acta, 1996 PubMed Europe PMC Scholia
  235. Zamocky M, Furtmüller PG, Obinger C; ''Evolution of catalases from bacteria to humans.''; Antioxid Redox Signal, 2008 PubMed Europe PMC Scholia
  236. Lee WH, Lukacik P, Guo K, Ugochukwu E, Kavanagh KL, Marsden B, Oppermann U; ''Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.''; Mol Cell Endocrinol, 2008 PubMed Europe PMC Scholia
  237. Singh S, Madzelan P, Banerjee R; ''Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase.''; Nat Prod Rep, 2007 PubMed Europe PMC Scholia
  238. Kimura T, Nakanishi K, Nakagawa T, Shibukawa A, Matsuzaki K; ''Simultaneous determination of unbound thyroid hormones in human plasma using high performance frontal analysis with electrochemical detection.''; J Pharm Biomed Anal, 2005 PubMed Europe PMC Scholia
  239. Hink HU, Santanam N, Dikalov S, McCann L, Nguyen AD, Parthasarathy S, Harrison DG, Fukai T; ''Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity.''; Arterioscler Thromb Vasc Biol, 2002 PubMed Europe PMC Scholia
  240. Lavie CJ, Milani RV, Mehra MR, Ventura HO; ''Omega-3 polyunsaturated fatty acids and cardiovascular diseases.''; J Am Coll Cardiol, 2009 PubMed Europe PMC Scholia
  241. Leonard S, Arbogast D, Geyer D, Jones C, Sinensky M; ''Localization of the gene encoding 3-hydroxy-3-methylglutaryl-coenzyme A synthase to human chromosome 5.''; Proc Natl Acad Sci U S A, 1986 PubMed Europe PMC Scholia
  242. Witkowska AM, Kuryliszyn-Moskal A, Borawska MH, Hukałowicz K, Markiewicz R; ''A study on soluble intercellular adhesion molecule-1 and selenium in patients with rheumatoid arthritis complicated by vasculitis.''; Clin Rheumatol, 2003 PubMed Europe PMC Scholia
  243. Erickson SK, Bösterling B; ''Cholesterol 7 alpha-hydroxylase from human liver: partial purification and reconstruction into defined phospholipid-cholesterol vesicles.''; J Lipid Res, 1981 PubMed Europe PMC Scholia
  244. Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A; ''Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  245. Proctor PH.; ''Free radicals, uric acid, and human disease.''; Free Radic Biol Med., 1996 PubMed Europe PMC Scholia
  246. Kilpatrick L, Johnson JL, Nickbarg EB, Wang ZM, Clifford TF, Banach M, Cooperman BS, Douglas SD, Rubin H; ''Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin.''; J Immunol, 1991 PubMed Europe PMC Scholia
  247. Schafer BL, Bishop RW, Kratunis VJ, Kalinowski SS, Mosley ST, Gibson KM, Tanaka RD; ''Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.''; J Biol Chem, 1992 PubMed Europe PMC Scholia
  248. Wu D, Mura C, Beharka AA, Han SN, Paulson KE, Hwang D, Meydani SN; ''Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E.''; Am J Physiol, 1998 PubMed Europe PMC Scholia
  249. Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML.; ''Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.''; Nat Struct Biol., 2002 PubMed Europe PMC Scholia
  250. Deo AK, Bandiera SM; ''Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid.''; Drug Metab Dispos, 2008 PubMed Europe PMC Scholia
  251. Waterham HR, Koster J, Romeijn GJ, Hennekam RC, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, Wanders RJ; ''Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis.''; Am J Hum Genet, 2001 PubMed Europe PMC Scholia
  252. Yamauchi Y, Reid PC, Sperry JB, Furukawa K, Takeya M, Chang CC, Chang TY; ''Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  253. Inoue T, Irikura D, Okazaki N, Kinugasa S, Matsumura H, Uodome N, Yamamoto M, Kumasaka T, Miyano M, Kai Y, Urade Y; ''Mechanism of metal activation of human hematopoietic prostaglandin D synthase.''; Nat Struct Biol, 2003 PubMed Europe PMC Scholia
  254. Hansel A, Heinemann SH, Hoshi T; ''Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation.''; Biochim Biophys Acta, 2005 PubMed Europe PMC Scholia
  255. Bleys J, Navas-Acien A, Guallar E; ''Serum selenium and diabetes in U.S. adults.''; Diabetes Care, 2007 PubMed Europe PMC Scholia
  256. Neumann D, Kollewe C, Resch K, Martin MU.; ''The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC Scholia
  257. Minkes M, Stanford N, Chi MM, Roth GJ, Raz A, Needleman P, Majerus PW; ''Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.''; J Clin Invest, 1977 PubMed Europe PMC Scholia
  258. Janciauskiene S, Wright HT; ''Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease.''; Bioessays, 1998 PubMed Europe PMC Scholia
  259. Bianco AC, Kim BW; ''Deiodinases: implications of the local control of thyroid hormone action.''; J Clin Invest, 2006 PubMed Europe PMC Scholia
  260. Grumolato L, Ghzili H, Montero-Hadjadje M, Gasman S, Lesage J, Tanguy Y, Galas L, Ait-Ali D, Leprince J, Guérineau NC, Elkahloun AG, Fournier A, Vieau D, Vaudry H, Anouar Y; ''Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion.''; FASEB J, 2008 PubMed Europe PMC Scholia
  261. Edmondson DE, Newton-Vinson P; ''The covalent FAD of monoamine oxidase: structural and functional role and mechanism of the flavinylation reaction.''; Antioxid Redox Signal, 2001 PubMed Europe PMC Scholia
  262. Bills TK, Smith JB, Silver MJ; ''Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.''; J Clin Invest, 1977 PubMed Europe PMC Scholia
  263. Brigelius-Flohé R; ''Glutathione peroxidases and redox-regulated transcription factors.''; Biol Chem, 2006 PubMed Europe PMC Scholia
  264. Needleman P, Raz A, Minkes MS, Ferrendelli JA, Sprecher H; ''Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC Scholia
  265. Fernandes-Costa F: Metz J.; ''Vitamin B12 binders (transcobalamins) in serum.''; Crit Rev Clin Lab Sci., 1982 PubMed Europe PMC Scholia
  266. Serhan CN; ''Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity?''; Prostaglandins, 1997 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125000view06:55, 12 January 2023SusanRemoved fill colors for the pathways listed
123380view11:44, 21 July 2022DeSlRemoved not UTF-8 encoded symbols for Hyperoxid
121694view03:28, 26 February 2022EweitzFix gene symbol
120903view14:04, 29 January 2022EgonwReplaced an old HMDB identifier with the current one
118387view13:57, 27 May 2021Marvin M2removed empty refs
117822view14:56, 22 May 2021EweitzModified title
107118view14:19, 17 September 2019MaintBotChEBI identifier normalization
106694view13:04, 17 September 2019MaintBotHMDB identifier normalization
106489view21:41, 4 September 2019KhanspersModified description
105808view22:53, 15 August 2019KhanspersModified description
105140view15:25, 10 July 2019DeSlConverted unconnected lines into graphical lines (if applicable).
105136view14:54, 10 July 2019DeSlUpdated Fibrinogen as complex with 3 subunits, changed fibrin datanode type from protein to metabolite.
98241view14:04, 14 August 2018EgonwReplace a PubChem SID with a Wikidata ID (which has more links out).
96720view21:55, 30 March 2018AlexanderPicoModified description
96318view09:09, 8 March 2018Mkutmonremove outdated pathway attributes
96278view08:13, 5 March 2018EgonwConverted interactions to regular arrows, which were not mim:conversions.
96250view14:07, 2 March 2018EgonwFixed a character encoding issue.
96249view14:06, 2 March 2018EgonwIt had the PubChem CID from the start, but that entry is not the protein fibrin, but a small compound. I now took the Wikidata entry matching the proper Wikipedia page.
94185view13:59, 25 August 2017Mkutmonadded missing metabolite identifiers
94106view09:54, 21 August 2017DeSlConnected 3 more unconnected lines.
94105view09:52, 21 August 2017DeSlConnected unconnected lines.
93691view15:50, 9 August 2017DeSlModified description
88908view08:53, 17 August 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
85060view11:16, 10 April 2016Egonw
82705view08:55, 23 October 2015EgonwMissed one oxLDL :(
82703view08:43, 23 October 2015EgonwoxLDL has a separate identifier.
82689view15:29, 22 October 2015EgonwRemoved HMDB00464 from iodine and iron data nodes.
79870view14:46, 21 April 2015Mkutmonremoved invalid annotation for "Fibrinogen" (Database: Other)
78776view23:23, 26 January 2015AlexanderPicoreplacing legend datanodes with shapes
78775view23:15, 26 January 2015AlexanderPicoreplacing legend datanode with shape
73505view23:16, 29 January 2014KhanspersModified title
73504view23:14, 29 January 2014KhanspersModified title
73357view04:57, 23 January 2014MaintBotfixed character representation of hyphen in gpml
72365view09:35, 13 November 2013EgonwFixed the type of two proteins.
71706view19:58, 17 October 2013MaintBotUpdated data sources
70119view19:19, 12 July 2013MaintBotupdated to 2013 schema
68043view11:14, 29 June 2013EgonwAdded two missing metabolite identifiers.
68041view11:08, 29 June 2013EgonwUndo revision 68036 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
68040view11:07, 29 June 2013EgonwUndo revision 68037 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
68039view11:06, 29 June 2013EgonwUndo revision 68038 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
68038view11:02, 29 June 2013EgonwRemoved a few empty, unlinked gene product data nodes.
68037view10:58, 29 June 2013EgonwRemoved an empty unlinked 'protein'.
68036view10:57, 29 June 2013EgonwRemoved an empty unlinked 'metabolite'.
68035view10:49, 29 June 2013EgonwFixed EC number data source.
61689view22:06, 16 April 2013MaintBotremoved data source without identifer
56489view09:45, 8 January 2013EgonwFixed DataNode @Type from Metabolite to Protein for those with an Entrez Gene identifier.
54708view14:04, 7 December 2012AndraRDF Tidy
48242view06:08, 17 May 2012MaintBotUpdating PubChem xrefs
48216view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45021view18:39, 6 October 2011ThomasOntology Term : 'selenoamino acid metabolic pathway' added !

External references

DataNodes

View all...
NameTypeDatabase referenceComment
15-HETEMetaboliteHMDB0003876 (HMDB) 15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
5,10-Methylene-THFMetaboliteHMDB0001533 (HMDB) 5,10-Methylenetetrahydrofolate
5,6-EpoxytetraeneMetaboliteC14815 (KEGG Compound)
5-HETEMetaboliteHMDB0011134 (HMDB) 5-hydroxyeicosatetraenoic acid
5-HPETEMetaboliteHMDB0001193 (HMDB) 5(S)-Hydroperoxyeicosatetraenoic acid
5-methyl-THFMetaboliteHMDB0001396 (HMDB) 5-methyltetrahydrofolate
8-Isoprostaglandin F2aMetaboliteHMDB0005083 (HMDB)
8-OHdGMetaboliteHMDB0003333 (HMDB) 8-Hydroxy-deoxyguanosine
ABCA1Protein19 (Entrez Gene) ATP-binding cassette, sub-family A (ABC1), member 1
ACTProtein12 (Entrez Gene)
  • alpha-1-antichymotrypsin
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
ADPMetaboliteHMDB0001341 (HMDB) Adenosine diphosphate
ALAMetaboliteHMDB0001388 (HMDB) Alpha-Linolenic acid
ALBProtein213 (Entrez Gene) albumin
ALOX15BProtein247 (Entrez Gene)
  • EC 1.13.11.33
  • arachidonate 15-lipoxygenase, type B
ALOX5Protein240 (Entrez Gene)
  • EC 1.13.11.34
  • arachidonate 5-lipoxygenase
APOA1-NO2TyrProtein335 (Entrez Gene) Nitrotyrosinated apolipoprotein A-I
APOA1Protein335 (Entrez Gene) apolipoprotein A-I
APOBProtein338 (Entrez Gene) apolipoprotein B
ATPMetaboliteHMDB0000538 (HMDB) Adenosine triphosphate
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
AscorbateMetaboliteCHEBI:38290 (ChEBI)
Ascorbic acidMetaboliteCHEBI:29073 (ChEBI)
CBSProtein875 (Entrez Gene)
  • EC 4.2.1.22
  • cystathionine-beta-synthase
CCL2Protein6347 (Entrez Gene) chemokine (C-C motif) ligand 2
COX1Protein5742 (Entrez Gene)
  • EC 1.14.99.1
  • Cyclooxygenase 1
  • COX-1 constitutive
COX2Protein5743 (Entrez Gene)
  • EC 1.14.99.1
  • Cyclooxygenase 2
  • COX-2 inducible
CRPProtein1401 (Entrez Gene) C-reactive protein, pentraxin-related
CTHProtein1491 (Entrez Gene)
  • EC 4.4.1.1
  • cystathionase
CalciumMetaboliteHMDB0000464 (HMDB)
CatalaseProtein847 (Entrez Gene) EC 1.11.1.6
ChlorineMetaboliteHMDB0000492 (HMDB)
CholesterolMetaboliteHMDB0000067 (HMDB)
CopperMetaboliteHMDB0000657 (HMDB)
CystathionineMetaboliteHMDB0000099 (HMDB)
CysteineMetaboliteHMDB0000574 (HMDB)
D-dimerProteinhttp://en.wikipedia.org/wiki/Fibrin_degradation_product
DGLAMetaboliteHMDB0002925 (HMDB)
  • Dihomo-gamma-linolenic acid
  • 8,11,14-Eicosatrienoic acid
DHAMetaboliteHMDB0002183 (HMDB) Docosahexaenoic acid
DIO1Protein1733 (Entrez Gene)
  • EC 1.97.1.10
  • Selenoprotein-deiodinase, iodothyronine, type I
DIO2Protein1734 (Entrez Gene)
  • EC 1.97.1.10
  • Selenoprotein-deiodinase, iodothyronine, type II
DIO3Protein1735 (Entrez Gene)
  • EC 1.97.1.11
  • Selenoprotein-deiodinase, iodothyronine type III
DPAMetaboliteHMDB0001976 (HMDB) Docosapentaenoic acid
Dehydroascorbic acidMetaboliteCHEBI:17242 (ChEBI)
DihydrolipoateMetaboliteHMDB0012210 (HMDB)
EPAMetaboliteHMDB0001999 (HMDB) Eicosapentaenoic acid
F2-IsoprostaneMetaboliteQ33659470 (Wikidata)
FADMetaboliteHMDB0001248 (HMDB) Flavin adenine dinucleotide
FGAProteinENSG00000171560 (Ensembl)
FGBProteinENSG00000171564 (Ensembl)
FGGProteinENSG00000171557 (Ensembl)
FLAD1Protein80308 (Entrez Gene)
  • EC 2.7.7.2
  • FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
FLAPProtein241 (Entrez Gene) arachidonate 5-lipoxygenase-activating protein
FMNMetaboliteHMDB0001520 (HMDB) Flavin Mononucleotide
Factor VIIProtein2155 (Entrez Gene)
  • EC 3.4.21.21
  • coagulation factor VII (serum prothrombin conversion accelerator)
FibrinProteinQ27205 (Wikidata)
FibrinogenProtein
Folic acidMetaboliteHMDB0000121 (HMDB)
FructosamineMetaboliteHMDB0002030 (HMDB)
GGT1Protein2678 (Entrez Gene)
  • EC 2.3.2.2
  • gamma-glutamyltransferase 1
GPX 1Protein2876 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 1
GPX 2Protein2877 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 2
GPX 3Protein2878 (Entrez Gene) Selenoprotein-glutathione peroxidase 3
GPX 4Protein2879 (Entrez Gene)
  • EC 1.11.1.12
  • Selenoprotein-glutathione peroxidase 4
GPX 6Protein257202 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 6
GSHMetaboliteHMDB0000125 (HMDB) Glutathione
GSRProtein2936 (Entrez Gene)
  • EC 1.8.1.7
  • glutathione reductase
GSSGMetaboliteHMDB0000656 (HMDB) Glutathione disulfide
GlucoseMetaboliteHMDB0000122 (HMDB)
H2O2MetaboliteHMDB0003125 (HMDB) Hydrogen peroxide
H2OMetaboliteHMDB0002111 (HMDB) Glutathione disulfide
HBA1Protein3039 (Entrez Gene) hemoglobin, alpha 1
HBBProtein3043 (Entrez Gene) hemoglobin, beta
HDL-CMetaboliteCHEBI:47775 (ChEBI) high-density lipoprotein cholesterol
HDL/APOA1MetaboliteCHEBI:39025 (ChEBI)
  • high-density lipoprotein
  • ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles
HDL/SAAMetaboliteCHEBI:39025 (ChEBI)
  • high-density lipoprotein
  • SAA circulates in plasma as a constituent of high density lipoproteins (HDL).
HDLMetaboliteCHEBI:39025 (ChEBI) high-density lipoprotein
HNO2MetaboliteCHEBI:25567 (ChEBI) Nitrous acid
HOClMetaboliteHMDB0001050 (HMDB) Hypochlorite
HbA1cProtein
  • Glycated hemoglobin
  • http://en.wikipedia.org/wiki/Glycated_hemoglobin
HemeMetaboliteHMDB0003178 (HMDB)
HomocysteineMetaboliteHMDB0000742 (HMDB)
HydroxykynurenineMetaboliteHMDB0000732 (HMDB)
HypoxanthineMetaboliteHMDB0000157 (HMDB)
IFNgProtein3458 (Entrez Gene) interferon, gamma
IL10Protein3458 (Entrez Gene) interferon, gamma
IL1BProtein3553 (Entrez Gene) interleukin 1, beta
IL6Protein3569 (Entrez Gene) interleukin 6 (interferon, beta 2)
INSProtein3630 (Entrez Gene) Insulin
INSRProtein3643 (Entrez Gene) Insulin receptor
IodineMetaboliteQ1103 (Wikidata)
IronMetaboliteQ26840996 (Wikidata)
KMOProtein8564 (Entrez Gene)
  • EC 1.14.13.9
  • kynurenine 3-hydroxylase
KynureninaseProtein8942 (Entrez Gene) EC 3.7.1.3
KynurenineMetaboliteHMDB0000684 (HMDB)
LDLMetaboliteCHEBI:39026 (ChEBI) low-density lipoprotein
LDLRProtein3949 (Entrez Gene) low density lipoprotein receptor
Leukotriene A4MetaboliteHMDB0001337 (HMDB)
Leukotriene B4MetaboliteHMDB0001085 (HMDB)
Leukotriene C4MetaboliteHMDB0001198 (HMDB)
Leukotriene D4MetaboliteHMDB0003080 (HMDB)
Leukotriene E4MetaboliteHMDB0002200 (HMDB)
Leukotriene F4MetaboliteHMDB0006465 (HMDB)
Linoleic acidMetaboliteHMDB0000673 (HMDB)
Lipoic acidMetaboliteHMDB0001451 (HMDB)
Lipoxin A4MetaboliteHMDB0004385 (HMDB)
Lipoxin B4MetaboliteHMDB0005082 (HMDB)
MDAMetaboliteHMDB0006112 (HMDB) Malondialdehyde
MPOProtein4353 (Entrez Gene)
  • EC 1.11.1.7
  • Myeloperoxidase
MTHFRProtein4524 (Entrez Gene)
  • EC 1.5.1.20
  • 5,10-methylenetetrahydrofolate reductase
MTRProtein4548 (Entrez Gene)
  • EC 2.1.1.13
  • 5-methyltetrahydrofolate-homocysteine methyltransferase
ManganeseMetaboliteHMDB0001333 (HMDB)
Methionine sulfoxideMetaboliteHMDB0002005 (HMDB)
MethionineMetaboliteHMDB0000696 (HMDB)
NADP+MetaboliteHMDB0000217 (HMDB) Nicotinamide adenine dinucleotide phosphate-Oxidized
NADPHMetaboliteHMDB0000221 (HMDB) Nicotinamide adenine dinucleotide phosphate-Reduced
NFKB1GeneProduct4790 (Entrez Gene) nuclear factor NF-kappa-B p50 subunit
NFKB2GeneProduct4791 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
NO2MetaboliteCHEBI:33101 (ChEBI) Nitrogen dioxide
NOMetaboliteHMDB0003378 (HMDB) Nitric oxide
NiacinMetaboliteHMDB0001488 (HMDB)
NiacinamideMetaboliteHMDB0001406 (HMDB)
NicotinamidaseProtein3.5.1.19 (Enzyme Nomenclature) Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3 GO:0008936
NitrotyrosineMetaboliteHMDB0001904 (HMDB)
O2-radical (aka Hyperoxid or superoxide)MetaboliteHMDB0002168 (HMDB) Superoxide
O2MetaboliteHMDB0001377 (HMDB)
O3MetaboliteCHEBI:25812 (ChEBI) ozone
ONOO-/ONOOHMetaboliteHMDB0002179 (HMDB) Peroxynitrite
PAI-1Protein5054 (Entrez Gene) Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
PGD2MetaboliteHMDB0001403 (HMDB) Prostaglandin D2
PGE1MetaboliteHMDB0001442 (HMDB) Prostaglandin E1
PGE2MetaboliteHMDB0001220 (HMDB) Prostaglandin E2
PGE3MetaboliteHMDB0002664 (HMDB) Prostaglandin E3
PGF2aMetaboliteHMDB0001139 (HMDB) Prostaglandin F2a
PGG2MetaboliteHMDB0003235 (HMDB) Prostaglandin G2
PGH2MetaboliteHMDB0001381 (HMDB) Prostaglandin H2
PGH3MetaboliteHMDB0013040 (HMDB) Prostaglandin H3
PGI2MetaboliteHMDB0001335 (HMDB) Prostaglandin I2
PLGProtein5340 (Entrez Gene)
  • EC 3.4.21.7
  • Plasminogen
PMPMetaboliteHMDB0001555 (HMDB) Pyridoxamine 5'-phosphate
PNPOProtein55163 (Entrez Gene)
  • EC 1.4.3.5
  • pyridoxamine 5'-phosphate oxidase
PRDX1Protein5052 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 1
PRDX2Protein7001 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 2
PRDX3Protein10935 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 3
PRDX4Protein10549 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 4
PRDX5Protein25824 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 5
Pyridoxal 5'-phosphateMetaboliteHMDB0001491 (HMDB)
Quinolinic AcidMetaboliteHMDB0000232 (HMDB)
R-Triiodothyronine (rT3)MetaboliteCHEBI:28774 (ChEBI) Reverse triiodothyronine
RELAGeneProduct5970 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
RFKProtein55312 (Entrez Gene)
  • EC 2.7.1.26
  • riboflavin kinase
RNSMetaboliteCHEBI:62764 (ChEBI)
  • reactive nitrogen species
  • http://en.wikipedia.org/wiki/Reactive_nitrogen_species
ROSMetaboliteCHEBI:26523 (ChEBI)
  • reactive oxygen species
  • http://en.wikipedia.org/wiki/Reactive_Oxygen_Species
RiboflavinMetaboliteHMDB0000244 (HMDB)
SAA1Protein6288 (Entrez Gene) serum amyloid A1
SAA2Protein6289 (Entrez Gene) serum amyloid A2
SAA3Protein6290 (Entrez Gene) serum amyloid A3 pseudogene
SAA4Protein6291 (Entrez Gene) serum amyloid A4, constitutive
SOD1Protein6647 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 1, soluble
SOD2Protein6648 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 2, mitochondrial
SOD3Protein6649 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 3, extracellular
SPS2Protein22928 (Entrez Gene)
  • EC2.7.9.3
  • Selenoprotein-selenophosphate synthetase 2
SRB1Protein949 (Entrez Gene) scavenger receptor class B, member 1
SelHProtein280636 (Entrez Gene) Selenoprotein-selenoprotein H-chromosome 11 open reading frame 31
SelIProtein85465 (Entrez Gene)
  • Selenoprotein-selenoprotein I
  • Unknown function
SelKProtein58515 (Entrez Gene) Selenoprotein-selenoprotein K
SelMProtein140606 (Entrez Gene) Selenoprotein-selenoprotein M
SelNProtein57190 (Entrez Gene) Selenoprotein-selenoprotein N, 1
SelOProtein83642 (Entrez Gene)
  • Selenoprotein-selenoprotein O
  • Unknown function
SelPProtein6414 (Entrez Gene) Selenoprotein-selenoprotein P
SelRProtein51734 (Entrez Gene)
  • EC 1.8.4.-
  • Selenoprotein-selenoprotein X
SelSProtein55829 (Entrez Gene) Selenoprotein-selenoprotein S
SelTProtein51714 (Entrez Gene) Selenoprotein-selenoprotein T
SelVProtein348303 (Entrez Gene)
  • Selenoprotein-selenoprotein V
  • Unknown function
SelWProtein6415 (Entrez Gene) Selenoprotein-selenoprotein W
SelenideMetaboliteCHEBI:15076 (ChEBI)
SeleniumMetaboliteHMDB0001349 (HMDB)
SelenocysteineMetaboliteHMDB0003288 (HMDB)
SelenophosphateMetaboliteCHEBI:16144 (ChEBI)
Sep15Protein9403 (Entrez Gene) Selenoprotein-15 kDa selenoprotein
SerineMetaboliteHMDB0000187 (HMDB)
TAGMetaboliteCHEBI:17855 (ChEBI)
  • Triglyceride
  • Triacylglycerol
THFMetaboliteHMDB0001846 (HMDB) Tetrahydrofolic acid
TNFaProtein7124 (Entrez Gene) tumor necrosis factor (TNF superfamily, member 2)
TRXR1Protein7296 (Entrez Gene) Selenoprotein-thioredoxin reductase 1
TRXR2Protein10587 (Entrez Gene)
  • EC 1.8.1.9
  • Selenoprotein-thioredoxin reductase 2
TRXR3Protein114112 (Entrez Gene)
  • EC 1.8.1.9
  • Selenoprotein-thioredoxin reductase 3
ThrombinProtein2147 (Entrez Gene)
  • EC 3.4.21.5
  • coagulation factor II (thrombin)
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
Thromboxane B2MetaboliteHMDB0003252 (HMDB)
Thyroxine (T4)MetaboliteCHEBI:30660 (ChEBI)
Triiodothyronine (T3)MetaboliteCHEBI:18258 (ChEBI)
Trx-(SH)2Protein7295 (Entrez Gene) reduced thioredoxin
Trx-S2Protein7295 (Entrez Gene) oxidized thioredoxin
TryptophanMetaboliteHMDB0000929 (HMDB)
Uric acidMetaboliteHMDB0000289 (HMDB)
VLDL-TAGMetaboliteCHEBI:47776 (ChEBI)
  • very-low-density lipoprotein-triglyceride
  • Triglyceride transport
VLDL/APOBMetaboliteCHEBI:39027 (ChEBI)
  • very-low-density lipoprotein
  • The VLDL is produced in the liver, contains one molecule of apoB100
VLDLMetaboliteCHEBI:39027 (ChEBI) very-low-density lipoprotein
Vitamin B12MetaboliteHMDB0002174 (HMDB)
XanthineMetaboliteHMDB0000292 (HMDB)
Xantine oxidaseProtein7498 (Entrez Gene)
  • EC 1.17.3.2
  • http://en.wikipedia.org/wiki/Xanthine_oxidase
ZincMetaboliteHMDB0015532 (HMDB)
a-TocopherolMetaboliteHMDB0001893 (HMDB)
oxLDLMetaboliteCHEBI:60151 (ChEBI) oxidized low-density lipoprotein
sICAM-1Protein3383 (Entrez Gene) soluble intercellular adhesion molecule 1
tPAProtein5327 (Entrez Gene)
  • EC 3.4.21.68
  • plasminogen activator, tissue

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP15"
Personal tools