Selenium micronutrient network (Homo sapiens)
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156
105, 239
5, 19, 40, 55, 73...
202
109
6, 134, 147, 202
263
51
156
10, 89, 156, 184
182
149
146, 179
90
63, 228
140, 150, 260
5, 54
44, 48, 82, 184
108
179
93
Lipoprotein melabolism
Necessary stimulation
Conversion
Selenoproteins
is composed of
Negative Effect
LEGEND
Metabolic stress
Binding
Cleavage
Status
Micronutrients
Overarching process
Leukotriene metabolism
Stimulation
Inflammation and
immune response
Transcription factor
Protein tyrosine nitration
Prostaglandins metabolism
Glycogenesis
Biomarker for
Cofactors
Selenium status
Other proteins
Ca++ metabolism
Inhibition
Enzymes
Process or metabolism involved in Se Pathway
Catalysis
Cofactor conversion
Tryptophan metabolism
Metabolites
Reaction
Lipid peroxidation
From intracellular part to the plasma
Oxidative stress
Intracellular
Glutathione metabolism
NAD+ metabolism
ER protein folding
DNA oxidation
Folate metabolism
Plasma
EPA
Lipoxin B4
NFKB2
Arachidonic acid
DPA
PGE2
Lipoxin A4
COX1
PGD2
8-Isoprostaglandin F2a
PGF2a
Thromboxane A2
PGI2
DHA
COX2
DPA
PGG2
F2-Isoprostane
Lipoxin B4
PGH2
PGH3
a-Tocopherol
F2-Isoprostane
FGA
PGE1
MDA
8-Isoprostaglandin F2a
Linoleic acid
DGLA
Lipoxin A4
a-Tocopherol
PGI2
PGE3
ALA
PGD2
PGE1
PGF2a
Thromboxane B2
PGE2
Arachidonic acid
Linoleic acid
RELA
Thromboxane B2
DHA
NFKB1
MDA
ALA
EPA
21, 158
219
113
19, 47, 92, 113, 158...
7, 96, 112, 213, 221...
47, 215, 220, 231
172, 253
7, 112, 213, 221, 248
215
81, 172
54
172
220
172
47
54
172
266
47
172
219
159
47
29, 42, 113, 167, 215
159, 172, 225
29, 42
240
47, 264
14, 172
219, 240
167
172
159
21, 158
219, 240
113
266
113
113
21, 158
240
29, 42
266
266
Kynurenine
146
MTR
79, 109
TRXR1
CBS
79, 237
Iodine
Iodine
259
259
KMO
146
15-HETE
Triiodothyronine (T3)
5,6-Epoxytetraene
R-Triiodothyronine (rT3)
5-HETE
5-HETE
Thyroxine (T4)
5-HPETE
Triiodothyronine (T3)
Thyroxine (T4)
15-HETE
R-Triiodothyronine (rT3)
80, 238
167
80, 238
55, 131, 167
55, 131, 167
80, 259
80, 238
167, 266
55, 131, 167
266
80, 259
80, 259
NADP+
MPO
Catalase
MPO
72, 89, 143, 163
156, 235
89
Uric acid
41, 239
Cysteine
Factor VII
Thrombin
GGT1
PAI-1
PLG
PAI-1
tPA
Factor VII
tPA
Thrombin
PLG
129
74, 97
74, 187
74, 97
129
200
74, 187
129
129
129
129
GPX 4
TRXR2
Xantine oxidase
41, 166
PRDX5
H2O2
ALOX5
ALOX15B
11, 84, 92, 213, 266
76, 167
Copper
Uric acid
41, 239
Vitamin B12
17, 38
5,10-Methylene-THF
SelR
10, 254
Tryptophan
146, 179
5-methyl-THF
SOD3
PRDX1
RFK
174
H2O
GPX 3
Niacinamide
CTH
79
PNPO
227
Heme
149, 156, 225, 235, 237
NADPH
Lipoic acid
147
Manganese
FAD
261
Methionine sulfoxide
10
Dehydroascorbic acid
106, 134
Leukotriene A4
68, 133
NADPH
FAD
261
THF
Hydroxykynurenine
146
Folic acid
109
NADP+
NADPH
Selenium
Selenium
137
137
SelK
Sep15
208
82, 184, 196
GPX 6
GSH
189
Nicotinamidase
179
Calcium
68
Methionine
10
Manganese
NADPH
Folic acid
109
FMN
261
Selenophosphate
Selenide
Selenocysteine
6, 80
6, 80
6, 80
Cysteine
Leukotriene C4
Leukotriene C4
68, 200
GPX 3
73
Dehydroascorbic acid
134
GPX 2
SelP
102
Trx-S2
134, 147, 202
Ascorbic acid
106
Lipoic acid
147
PRDX4
GPX 1
NADP+
Homocysteine
ROS
RNS
7, 10, 12, 41, 44...
156, 182
NADPH
Vitamin B12
17, 38
MTHFR
109
Homocysteine
97
SelV
DIO2
SelP
SPS2
SelH
SelT
SelN
SelO
DIO3
DIO1
SelI
SelS
SelM
190
44, 103, 148
190
140, 150, 190
190
108, 217
23, 48, 171
80, 176
190, 260
80, 104, 259
80, 259
12, 25, 78, 102
80, 259
SOD1
Pyridoxal 5'-phosphate
146
Serine
Iron
68
Hypoxanthine
PRDX3
GSR
132
LDL
HDL-C
SAA4
APOB
SAA3
LDL
APOB
ACT
SAA1
APOA1-NO2Tyr
ABCA1
HDL/SAA
VLDL
SAA2
FMN
TAG
oxLDL
TAG
ACT
Cholesterol
SRB1
HDL
Cholesterol
HDL
VLDL-TAG
oxLDL
VLDL-TAG
HDL-C
LDLR
VLDL/APOB
APOA1
APOA1
HDL/APOA1
VLDL
224, 228
228
194
5, 40, 63, 143
261
160, 185, 230
117, 194
111, 228
228
160, 185, 230
228
5, 40, 63, 143
224
5, 40, 63, 96, 143
111, 228
5, 40, 63, 96, 143
46
228
194
185
194
228
228
111, 228
194
111, 224, 228
111, 228
228
228
194
117, 194
228
194
194
O2
54
Pyridoxal 5'-phosphate
146
8-OHdG
8-OHdG
FAD
93
93
261
PRDX2
ADP
Leukotriene D4
Leukotriene D4
200
Copper
Chlorine
Chlorine
Cystathionine
FAD
261
SOD2
Dihydrolipoate
147, 181
Serine
NADP+
ATP
Zinc
NADP+
GSSG
NADPH
Zinc
Niacin
Leukotriene B4
Leukotriene B4
68, 133
133
Quinolinic Acid
146, 179
PMP
O3
HNO2
NO2
NO
HOCl
NO
72, 163
72, 163
NADP+
GSH
108, 133, 189
FLAP
INS
HBB
CCL2
INSR
Fibrin
IL10
IL6
D-dimer
IL1B
CRP
Fibrin
IFNg
IFNg
D-dimer
sICAM-1
Fibrinogen
TNFa
sICAM-1
CCL2
IL6
INS
HbA1c
Fibrinogen
ALB
IL1B
TNFa
HbA1c
IL10
ALB
HBA1
25, 222
25
25, 222
51
2, 71, 90, 255
25
5, 27, 56, 96
18, 27, 242
23
104
51, 56, 104
9
9
23
11
18, 27, 242
9
2, 71, 90, 117, 255
116, 129
66
9
2, 71
129, 187
116, 129
23, 78, 170
18, 78, 104
66
129, 187
18, 23, 170, 222
104
SelW
61, 75, 189
Riboflavin
26
SOD3
105
TRXR1
202
Ascorbate
106, 134
O2-radical (aka Hyperoxid or superoxide)
Xanthine
Calcium
68
Kynureninase
146
Methionine
10
ADP
Trx-(SH)2
147, 202
ONOO-/ONOOH
Nitrotyrosine
Nitrotyrosine
182
182
ATP
Leukotriene E4
Leukotriene E4
200
Glucose
Fructosamine
Fructosamine
Leukotriene F4
9, 90
66
66
8, 200
Iron
68
Hypoxanthine
TRXR3
FLAD1
100, 174
Ascorbic acid
7, 106, 112
FGB
FGG