Folate metabolism (Homo sapiens)
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165, 204
40, 110, 156, 161, 231...
18, 59
165, 296
21, 40, 63, 172, 181
63
304
185, 242
3, 290
16
186
46, 86, 175
75
267, 308
131
Selenium status
Process or metabolism involved in Se Pathway
Selenoproteins
Reaction
Glycogenesis
Negative Effect
Cleavage
Protein tyrosine nitration
Binding
Prostaglandins metabolism
Lipoprotein melabolism
Inhibition
Overarching process
Protein*
Enzymes
Cofactor conversion
Catalysis
Cofactors
Stimulation
From intracellular part to the plasma
Metabolites
Transcription factor
Micronutrients
Biomarker for
Protein with polymorphism
is composed of
Other proteins
Conversion
LEGEND
Necessary stimulation
Lipid peroxidation
Intracellular
DNA oxidation
Methylation reactions
Apoptosis
Novo purine biosynthetic pathway
Plasma
FOLR2
Thromboxane B2
PGE2
PGF2a
NFKB2
PGE1
8-Isoprostaglandin F2a
F2-Isoprostane
FOLR4
PGE1
F2-Isoprostane
RELA
SLC46A1
FOLR3
NFKB1
PGE2
8-Isoprostaglandin F2a
p53
MCP1
Thromboxane A2
SLC19A1
MCP1
Thromboxane B2
FOLR1
PGF2a
24
34
43, 135
228
34
34
43, 135
100
128, 135, 240
73, 248
228
14, 135
24
14, 135
34
100
73
24
89, 131, 172, 175, 177...
128
128
24
MSR*
SHMT
MAT
MTHFD1*
DHFR
MTHFD2
AHCY
MTR*
271, 308
214, 238
47, 171, 178
139, 184, 214, 295
308
308, 325
131
237
CBS
184, 314
NADP+
NADP+
NADP+
NADP+
NADP+
NADP+
NADP+
Catalase
MPO
MPO
NOS
248
17, 21, 65, 211
17, 21, 65, 211
63, 193
Cysteine
Cysteine
tPA
Thrombin
Factor VII
PAI-1
PLG
Thrombin
PAI-1
Factor VII
PLG
tPA
190, 219
122
190, 219
122
190, 213
190, 213
122
122
122
122
GPX 4
H2O2
GAR
FGAR
(11R)-hydroxymethylene-THF
Dihydrofolate
10-Formyl-THF
5,10-Methenyl-THF
5,10-Methylene-THF
5-Formyl-THF
(11S)-hydroxymethylene-THF
267, 308
308
171
171, 308
308
267, 308
308
308
308
Folate
5-methyl-THF
5-methyl-THF
Folate
139, 171
24, 38, 86, 92, 100...
171
SOD3
SOD3
RFK
208
H2O
GPX 3
GPX 3
CTH
184
Heme
63, 193, 314
THF
171
NADPH
NADPH
NADPH
NADPH
NADPH
NADPH
NADPH
GPX 6
Manganese
Manganese
Folic acid
Folic acid
15, 171, 295
15, 171, 295
GPX 2
GPX 1
RNS
63, 304
SHMT
MTHFS
GART
MTHFR*
171, 295
267, 308
308
308
Homocysteine
Homocysteine
213
40, 46, 100, 110, 120...
SOD1
Pyridoxal 5'-phosphate
Pyridoxal 5'-phosphate
27, 294
27, 248, 294
L-Arginine
Glycine
Glycine
Serine
308, 325
92
308, 325
308, 325
LDL
HDL/APOA1
APOB
SAA1
Cholesterol
VLDL-TAG
VLDL
ACT
SRB1
oxLDL
SAA4
ACT
HDL
VLDL
SAA2
TAG
LDLR
VLDL/APOB
VLDL-TAG
APOA1-NO2Tyr
FMN
TAG
oxLDL
APOA1
ABCA1
Cholesterol
APOA1
APOB
HDL-C
HDL/SAA
HDL-C
HDL
LDL
SAA3
200
3, 120, 211, 212
81, 269
290
3, 120, 211, 212, 221
200
200
269
220, 290
200
220, 290
183, 200
127
200
290
3, 120, 211, 212
221, 290
290
290
127, 220, 290
220, 290
127, 290
183, 200
221, 290
200
290
164
200
250
290
81, 269
3, 120, 211, 212, 221
290
220, 290
O2
185
Cob(I)alamin
Cob(I)alamin
FAD
FAD
Cob(II)alamin
8-OHdG
8-OHdG
75
75
214, 238, 312
214
214, 238
214, 238, 312
164
ADP
ADP
Magnesium
Chlorine
Chlorine
Magnesium
Cystathionine
S-nitrosohomocysteine
279
SOD2
Serine
308, 325
ATP
Zinc
Zinc
HOCl
NO2
NO
O3
HNO2
NO
17, 65
17, 65, 175, 279
TNFa
HbA1c
CRP
HBA1
D-dimer
IL10
IL2
HbA1c
CSF1
sICAM-1
INSR
Fibrin
IFNg
TNFa
Fibrinogen
IL2
IL1B
IL6
HBB
CSF1
ALB
IFNg
IL4
Fibrin
ALB
IL10
IL4
Fibrinogen
IL1B
D-dimer
IL6
INS
INS
122, 219
183, 186, 318
177
326
177, 264
134
161
183, 186, 318
89, 243
122, 306
40, 231
122, 306
24
134
58, 110, 218
134
326
265, 318
38, 212, 218, 242, 248...
97
97
122, 219
156
177
24
231
40, 89, 204, 243
165, 204
40, 156, 218, 318
134
177, 264
161, 218
Riboflavin
198
O2
Methionine
S-Adenosylmethionine
S-Adenosylmethionine
Methionine
S-Adenosylhomocysteine
S-Adenosylhomocysteine
130, 171
131, 171, 188, 214
116
130, 171
171, 188, 214
116, 139, 171
ADP
Nitrotyrosine
Nitrotyrosine
ONOO/ONOOH
Tetrahydrobiopterin
92
304
304
ATP
ATP
Glucose
Fructosamine
Glucose
Fructosamine
134, 186
97
97
134, 186
Iron
Iron
61
61
FLAD1
52, 208
FGA
FGB
FGG