Kennedy pathway (Mus musculus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none EthanolamineSAMPisdPPiCept1PhosphocholineSphingolipidsPemtPhosphatidylserinePhosphatidylethanolamineSAHDAGCMPATPSgpl1Ptdss1PhosphatidylcholinesEthanolamineL-SerineADPCDP-cholineL-SerinePcyt2CholineCholineChpt1Ptdss2O-PhosphoethanolamineAAGCDP-EthanolamineCTPEtnk1Etnk2Pcyt1bPcyt1aChkbChkaName: Kennedy pathwayLast Modified: 10/17/2013Organism: Mus musculus


Description

The CDP-choline pathway, first identified by Eugene Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules. The CDP-choline pathway represents one half of what is known as the Kennedy pathway. The other half is the CDP-ethanolamine pathway which is responsible for the biosynthesis of the phospholipid product phosphatidylethanolamine (PE). Source: [Wikipedia](https://en.wikipedia.org/wiki/CDP-choline_pathway)

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Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes

Ontology Terms

 

Bibliography

  1. Gibellini F, Smith TK; ''The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine.''; IUBMB Life, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137455
Approved
view13:20, 2 March 2025EgonwModified description
126406view19:41, 26 April 2023EgonwLicense is CCZero
107199view14:28, 17 September 2019MaintBotChEBI identifier normalization
94212view21:38, 25 August 2017DeSlSPlit up metabolite node for DAG/AAG. Added ID for AAG.
91100view01:17, 4 January 2017Khanspersadded lit ref
91099view01:16, 4 January 2017KhanspersModified description
90946view03:57, 19 December 2016KhanspersModified description
79806view16:32, 16 April 2015Mkutmonfixed unconnected line
77259view00:54, 9 August 2014MaintBotremoved bothersome newline characters
77241view08:00, 8 August 2014Mkutmonconnected interactions
71328view17:18, 17 October 2013MaintBotAutomated update of data sources
70994view12:09, 22 September 2013EgonwAdded three identfiers.
69155view18:18, 8 July 2013MaintBotUpdated to 2013 gpml schema
67422view10:59, 26 June 2013DdiglesOntology Term : 'CDP-choline pathway of phosphatidylcholine biosynthesis' added !
45176view08:54, 7 October 2011ThomasOntology Term : 'phospholipid metabolic pathway' added !
42210view21:26, 7 March 2011KhanspersModified categories
41343view00:26, 2 March 2011MaintBotRemoved redundant pathway information and comments
39588view08:22, 28 December 2010MaintBotNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AAGMetaboliteCHEBI:73318 (ChEBI)
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
CDP-EthanolamineMetaboliteC00570 (KEGG Compound)
CDP-cholineMetaboliteC00307 (KEGG Compound)
CMPMetaboliteCHEBI:17361 (ChEBI)
CTPMetabolite2056-98-6 (CAS)
Cept1GeneProduct99712 (Entrez Gene)
ChkaGeneProduct12660 (Entrez Gene)
ChkbGeneProduct12651 (Entrez Gene)
CholineMetaboliteC00114 (KEGG Compound)
Chpt1GeneProduct212862 (Entrez Gene)
DAGMetaboliteDAG = aspartate-alanine-glycine
EthanolamineMetaboliteC00189 (KEGG Compound)
Etnk1GeneProduct75320 (Entrez Gene)
Etnk2GeneProduct214253 (Entrez Gene)
L-SerineMetaboliteC00065 (KEGG Compound)
O-PhosphoethanolamineMetaboliteC00346 (KEGG Compound)
PPiMetaboliteCHEBI:18361 (ChEBI)
Pcyt1aGeneProduct13026 (Entrez Gene)
Pcyt1bGeneProduct236899 (Entrez Gene)
Pcyt2GeneProduct68671 (Entrez Gene)
PemtGeneProduct18618 (Entrez Gene)
PhosphatidylcholinesMetabolite8002-43-5 (CAS)
PhosphatidylethanolamineMetaboliteC00350 (KEGG Compound)
PhosphatidylserineMetaboliteC02737 (KEGG Compound)
PhosphocholineMetaboliteCHEBI:18132 (ChEBI)
PisdGeneProduct320951 (Entrez Gene)
Ptdss1GeneProduct19210 (Entrez Gene)
Ptdss2GeneProduct27388 (Entrez Gene)
SAHMetaboliteC00021 (KEGG Compound)
SAMMetaboliteC00019 (KEGG Compound)
Sgpl1GeneProduct20397 (Entrez Gene)
SphingolipidsMetaboliteCHEBI:26739 (ChEBI)

Annotated Interactions

No annotated interactions

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