DNA replication (Caenorhabditis elegans)

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1, 2p494. Switching of origins to post-replicative stateOrc complexUbiquitinCdt1Cdt1Orc3ADPATPOrc5RNA primer-DNA primerp180Pre-replicative complexDNA polymerase alpha: primase: origin complexdCTPOrc2dGTPOrc5Mcm6Mcm5Orc complexATPOrc Complex3. DNA replication initiationDNA polymerase alpha: primase: origin complexOrc4PrimaseMcm3RNA primer-DNA primer:origin duplex:PCNAOrc2Orc complexMcm3Orc1Degraded by proteasome in cytosolRFC37Mcm5Phosphorylation of Mcm 2-7 complexMcm6Cdc6RFC140UbiquitinDegraded by proteasome in cytosolRFC36dATPCdt1CTPOrc3Phosphorylated Orc1ATPOrc5Orc22. Activation of the pre-replicative complexRFC Heteropentamer:RNA primer-DNA primerRFC Heteropentamer:RNA primer-DNA primer:Orc3UTPADPMcm21. Assembly of the pre-replicative complexOrc2Cdc6Mcm7RFC38OriginMcm2Ubiquitinated Orc1ATPPhosphorylated Cdc65. Leading/lagging strand synthesisCdc6Ubiquitinated Cdc6GTPProcessive complexDNA PolymeraseCdt1Orc complexOrc4RFC40RNA PrimerMcm10p70GemininCdc6aCdt1Mcm 4,6,7 trimer forms and associates with the replication forkMcm4dUTPRNA primer-DNA primerp58Mcm4Mcm7Pre-replicative complexPCNA homotrimerOrc3mcm-2CDT1Y47D3A.29RPA4PCNAubq-1ORC5Lmcm-7F08B4.5GMNNORC3LF10C2.4RPA1mcm-4ORC6LRFC4CDC7POLD4RPA3div-1rfc-3ARPArfc-1POLD3mcm-3F33H2.5rfc-2pri-2orc-2ORC4Lcdc-6Y47D3A.28ASKY39A1A.12F34D10.2POLD2CDK2RPA2mcm-6CDC46pri-1ubq-2


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Ontology Terms

 

Bibliography

  1. Brauchle M, Baumer K, Gönczy P; ''Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos.''; Curr Biol, 2003 PubMed Europe PMC Scholia
  2. Rose A.; ''Replication and repair''; WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook, 2014 DOI Scholia

History

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CompareRevisionActionTimeUserComment
125278view16:10, 31 January 2023LarsgwAdd DOI to publication
118534view11:08, 28 May 2021DeSlAdded 2 lit. refs
118433view14:37, 27 May 2021UlasBabayigitConnected all lines to their nodes/labels
118149view10:40, 25 May 2021EweitzModified title
80063view08:51, 4 May 2015EgonwUbiquitin is a protein.
72573view12:17, 23 November 2013EgonwAdded a bunch of missing metabolite identifiers.
67161view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62522view12:40, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62521view12:36, 29 April 2013EgonwConverted a label into a Metabolite DataNode.
62518view11:57, 29 April 2013EgonwConnecting dots.
40644view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
35213view15:45, 11 February 2010ThomasModified description
35201view15:40, 11 February 2010ThomasModified description
21083view11:30, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:DNA replication Reactome]] moved to [[Pathway:WP192]]: Moved to stable identifier
8498view14:00, 7 January 2008MaintBotAdded to category $category
19414view14:00, 7 January 2008D.KorenUploaded new pathway
8496view14:00, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
ARPAGeneProduct176131 (Entrez Gene)
ASKGeneProduct
ATPMetaboliteCHEBI:15422 (ChEBI)
CDC46GeneProduct175552 (Entrez Gene)
CDC7GeneProduct
CDK2GeneProduct
CDT1GeneProduct
CTPMetaboliteCHEBI:17677 (ChEBI)
F08B4.5GeneProduct177673 (Entrez Gene)
F10C2.4GeneProduct179652 (Entrez Gene)
F33H2.5GeneProduct173368 (Entrez Gene)
F34D10.2GeneProduct175481 (Entrez Gene)
GMNNGeneProduct
GTPMetaboliteCHEBI:15996 (ChEBI)
ORC3LGeneProduct
ORC4LGeneProduct
ORC5LGeneProduct
ORC6LGeneProduct
PCNAGeneProduct
POLD2GeneProduct
POLD3GeneProduct
POLD4GeneProduct
RFC4GeneProduct
RPA1GeneProduct
RPA2GeneProduct
RPA3GeneProduct
RPA4GeneProduct
UTPMetaboliteCHEBI:15713 (ChEBI)
UbiquitinProtein
Y39A1A.12GeneProduct176486 (Entrez Gene)
Y47D3A.28GeneProduct176562 (Entrez Gene)
Y47D3A.29GeneProduct176544 (Entrez Gene)
cdc-6GeneProduct172029 (Entrez Gene)
dATPMetaboliteCHEBI:16284 (ChEBI)
dCTPMetaboliteCHEBI:16311 (ChEBI)
dGTPMetaboliteCHEBI:16497 (ChEBI)
dUTPMetaboliteCHEBI:17625 (ChEBI)
div-1GeneProduct176439 (Entrez Gene)
mcm-2GeneProduct174841 (Entrez Gene)
mcm-3GeneProduct180010 (Entrez Gene)
mcm-4GeneProduct171793 (Entrez Gene)
mcm-6GeneProduct176385 (Entrez Gene)
mcm-7GeneProduct178831 (Entrez Gene)
orc-2GeneProduct174676 (Entrez Gene)
pri-1GeneProduct176358 (Entrez Gene)
pri-2GeneProduct173122 (Entrez Gene)
rfc-1GeneProduct179967 (Entrez Gene)
rfc-2GeneProduct176946 (Entrez Gene)
rfc-3GeneProduct178259 (Entrez Gene)
ubq-1GeneProduct175840 (Entrez Gene)
ubq-2GeneProduct176718 (Entrez Gene)

Annotated Interactions

No annotated interactions
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