Thyroid stimulating hormone (TSH) signaling pathway (Homo sapiens)

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1, 2CCND3CCND3MAP2K1PMAPK3PPIK3R2PKAPIP2IP3cAMPPIP3DAGNUCYProteinTSH signal transduction pathwayLigandEnzyme ComplexReceptorCell proliferationmRNABRAFEGR1STAT1 PPAX8CGARAF1MYCSCRIBJUNHRASTTF2KCNIP3TTF1GNB1GNG2TSHBE2F1FOSTSHRSTAT3PPDPK1PIK3CAPPIK3R1CDK2PPSRCpMAP2K3PMAP2K6PAKT1PPRKCZRPS6KB1PMAPK1PRB1PCREB1PDE4DPPGNAI1GNA13GTPGTPGNAI2GTPGNA12GTPGNAO1GTPGNAQGTPGNAI3GTPMYL12BDePRALGDSGNASGTPJAK2PJAK1PRPS6MTORPADCY2ADCY3CDK2PCDK4PRPS6KA1PPLD1PLCB1RAP1BRAP1AGTPGTPRHOACCNE1MAPK14CDKN1BPCCND3CDK4RAP1GAPPPNUCYPKANUCYSmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMoleculeAPEX1APEX1NUCYProteinProtein


Description

Human thyroid-stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in the regulation of the hypothalamus-pituitary-thyroid axis by stimulating production and secretion of the thyroid hormone from the thyroid gland and – on a longer time scale – growth and differentiation of thyrocytes. TSH binds to TSH receptor which is a member of the G protein-coupled receptor superfamily of integral membrane proteins. TSH exerts its action through various signaling cascades such as cAMP cascade and the phospholipase C beta-mediated inositol phosphate generation. Further, it will give signaling to NF-kappa B, mitogen activated protein kinases, protein kinase C modules.


NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, please cite the NetPath website until the pathway is published.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

  1. Telikicherla D, Ambekar A, Palapetta SM, Dwivedi SB, Raju R, Sharma J, Prasad TsK, Ramachandra Y, Mohan SS, Maharudraiah J, Mukherjee S, Pandey A; ''A comprehensive curated resource for follicle stimulating hormone signaling.''; BMC Res Notes, 2011 PubMed Europe PMC Scholia
  2. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126346view09:28, 23 April 2023EgonwLicense is CCZero
122774view17:09, 12 May 2022JwdietrichModified description
122770view14:07, 12 May 2022JwdietrichModified description
122769view14:05, 12 May 2022JwdietrichModified title
120723view01:28, 24 December 2021EweitzStandardize font, weight, case
116395view23:15, 6 May 2021EweitzModified title
116394view23:15, 6 May 2021EweitzModified title
115927view08:04, 21 March 2021EgonwCopied the NetPath paper into the literature list
115925view07:59, 21 March 2021EgonwModified description
110976view14:24, 25 June 2020L DupuisConnected 2 unconnected lines
106594view19:34, 10 September 2019KhanspersModified description
105618view04:57, 10 August 2019KhanspersModified description
104862view15:14, 20 June 2019DeSlUpdated arrows to translocation
104861view15:10, 20 June 2019DeSlAdded lit. ref.
104859view15:04, 20 June 2019DeSlLauren has fixed legens (interactions to graphical line), connected lines in the figure, and updated interactions to MIM-types if available.
104856view14:56, 20 June 2019L DupuisConverted graphical representation of transcription and translation from lines to mim conversion type
104847view14:37, 20 June 2019L DupuisConverted interactions to graphical lines in legend. Connected unconnected lines
104844view14:35, 20 June 2019L DupuisConverted interactions to graphical lines in legend. Connected unconnected lines
104840view14:23, 20 June 2019L DupuisConverted interactions to graphical lines in legend. Connected unconnected lines
104838view14:18, 20 June 2019L DupuisConverted interactions to graphical lines in legend. Connected unconnected lines
89823view11:59, 6 October 2016MkutmonReverted to version '11:58, 6 October 2016' by Mkutmon
89822view11:58, 6 October 2016MkutmonModified description
89821view11:58, 6 October 2016MkutmonModified description
89820view11:58, 6 October 2016MkutmonModified description
86081view10:11, 29 June 2016MirellaKalafatiModified title
79960view13:13, 28 April 2015Zarichanged data node to label for protein box
78548view10:30, 7 January 2015MaintBotadded missing graphIds
75384view21:24, 21 May 2014KhanspersRemoved GenMAPP notes/comments
72116view23:06, 24 October 2013AlexanderPicoadded missing database to xref
71988view11:11, 24 October 2013MkutmonChanged Unknown -> GeneProduct for PIK3R2
71538view19:23, 17 October 2013MaintBotremoved data source from nodes without identifier
71336view17:23, 17 October 2013MaintBotRemoved empty labels with height = 0.0
70105view18:55, 12 July 2013MaintBotupdated to 2013 schema
67727view11:55, 26 June 2013DdiglesOntology Term : 'thyroid-stimulating hormone signaling pathway' added !
44635view18:24, 22 September 2011KhanspersModified categories
44634view18:23, 22 September 2011KhanspersModified description
44561view14:04, 20 September 2011DrrenugoelNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY2GeneProduct108 (Entrez Gene)
ADCY3GeneProduct109 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
APEX1GeneProduct328 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDK4GeneProduct1019 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CGAGeneProduct1081 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
E2F1Rna1869 (Entrez Gene)
EGR1Rna1958 (Entrez Gene)
FOSRna2353 (Entrez Gene)
GNA12GeneProduct2768 (Entrez Gene)
GNA13GeneProduct10672 (Entrez Gene)
GNAI1GeneProduct2770 (Entrez Gene)
GNAI2GeneProduct2771 (Entrez Gene)
GNAI3GeneProduct2773 (Entrez Gene)
GNAO1GeneProduct2775 (Entrez Gene)
GNAQGeneProduct2776 (Entrez Gene)
GNASGeneProduct2778 (Entrez Gene)
GNB1GeneProduct2782 (Entrez Gene)
GNG2GeneProduct54331 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JUNRna3725 (Entrez Gene)
KCNIP3GeneProduct30818 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MTORGeneProduct2475 (Entrez Gene)
MYCRna4609 (Entrez Gene)
MYL12BGeneProduct103910 (Entrez Gene)
PAX8Rna7849 (Entrez Gene)
PDE4DGeneProduct5144 (Entrez Gene)
PDPK1GeneProduct5170 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PLCB1GeneProduct23236 (Entrez Gene)
PLD1GeneProduct5337 (Entrez Gene)
PRKCZGeneProduct5934 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RALGDSGeneProduct5900 (Entrez Gene)
RAP1AGeneProduct5906 (Entrez Gene)
RAP1BGeneProduct5908 (Entrez Gene)
RAP1GAPGeneProduct5909 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RHOAGeneProduct3480 (Entrez Gene)
RPS6GeneProduct6194 (Entrez Gene)
RPS6KA1GeneProduct6195 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
SCRIBGeneProduct23513 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
STAT1 GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TSHBGeneProduct7252 (Entrez Gene)
TSHRGeneProduct7253 (Entrez Gene)
TTF1Rna7270 (Entrez Gene)
TTF2Rna8458 (Entrez Gene)

Annotated Interactions

No annotated interactions

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