Pilocytic astrocytoma (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Cytoplasmic targetsCell growthSurvivalMotilityTranscription factorsSRGAP3:RAF1fusion proteinKIAA1549:BRAFfusion proteinNucleusRAS in "on" stateMAPK cascadeERKMEKNF1RTKSOS1GRB2PTPN11RAF1BRAFRAS in "off" stateHRASKRASNRASGDPHRASKRASNRASGTPName: Pilocytic astrocytomaOrganism: Homo sapiens


Description

This pathway shows the relationship between BRAF signaling and the development and behavior of pilocytic astrocytoma (PA), normally induced by MAPK pathway activation.

BRAF is related in two alternative mechanisms in MAPK activation. The first is oncogenic fusion between SRGAP3 and RAF1, highlighted in yellow. The second is a 3 basepair insertion in BRAF (KIAA1549), also highlighted in yellow.

This pathway is based on Figure 3 "An overview of MAPK pathway alterations in PAs" from [Jones et al](https://doi.org/10.1038/onc.2009.73).

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Quality Tags

Ontology Terms

 

Bibliography

  1. McKay MM, Morrison DK; ''Integrating signals from RTKs to ERK/MAPK.''; Oncogene, 2007 PubMed Europe PMC Scholia
  2. Jones DT, Kocialkowski S, Liu L, Pearson DM, Ichimura K, Collins VP; ''Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma.''; Oncogene, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137724view12:05, 7 March 2025EweitzModified description
137723view12:02, 7 March 2025EweitzRefine padding, membrane position
137722view12:02, 7 March 2025EweitzRefine interaction type
137721view12:00, 7 March 2025EweitzRefine complexes
137711view11:43, 7 March 2025EweitzRefine connections
137710view11:41, 7 March 2025EweitzConnect pathway
137709view11:37, 7 March 2025EweitzAdd vertical padding
137708view11:37, 7 March 2025EweitzRefine labels
137707view11:35, 7 March 2025EweitzRefine complex, per source
137706view11:32, 7 March 2025EweitzShow RTK as membrane protein
137705view11:30, 7 March 2025EweitzIncrease font size
137698view05:40, 7 March 2025EgonwModified description
129826view23:09, 22 May 2024EweitzPoint RTK to gene family
128531view15:25, 11 February 2024EweitzOntology Term : 'cancer' added !
128530view15:23, 11 February 2024EweitzEconomize layout, fix typos, increase font size for readability
112071view10:16, 18 September 2020DeSlConnected last unconnected interaction.
111811view17:25, 8 September 2020EgonwFixed another identifier.
111810view17:24, 8 September 2020EgonwFixed an Ensembl identifier
111781view13:27, 7 September 2020DeSlModified description
111780view13:26, 7 September 2020DeSlUpdated interations, added IDs for ERK and MEK, added mutation info from paper
111779view13:15, 7 September 2020DeSlAdded IDs for BRAF and RAF1
111778view13:06, 7 September 2020DeSlStarted updating interaction types + IDs RAS
111777view12:44, 7 September 2020DeSlRemoved last modified item.
111776view12:43, 7 September 2020DeSlUpdate RTK EC number (without space)
111775view12:42, 7 September 2020DeSlOntology Term : 'mitogen activated protein kinase signaling pathway' added !
111774view12:42, 7 September 2020DeSlOntology Term : 'pilocytic astrocytoma' added !
111773view12:41, 7 September 2020DeSlOntology Term : 'astrocytoma' added !
111772view12:41, 7 September 2020DeSlAdded ref for PW, updated description.
109364view14:09, 16 March 2020L DupuisConnected line
106707view13:13, 17 September 2019MaintBotHMDB identifier normalization
102358view19:49, 20 December 2018Fehrhartfixed some graphical issues
94224view22:42, 25 August 2017DeSlChanged RTK metabolite node to protein node, added ID for this node.
74520view21:34, 28 April 2014KhanspersModified title
69013view17:47, 8 July 2013MaintBotUpdated to 2013 gpml schema
67597view11:31, 26 June 2013DdiglesOntology Term : 'glioma pathway' added !
59199view19:14, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
54370view15:01, 28 November 2012MaintBotremoved mim-gap end type
53138view02:00, 30 October 2012MaintBotModified categories
49791view10:47, 26 July 2012DeviModified description
49790view06:50, 26 July 2012DeviPilocytic astrocytoma
49771view19:24, 25 July 2012MaintBotconnected nodes to database object
49739view10:32, 25 July 2012DeviNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
BRAFGeneProductENSG00000157764 (Ensembl)
ERKGeneProductIPR008350 (InterPro)
GDPMetaboliteHMDB0000960 (HMDB)
GRB2GeneProductENSG00000177885 (Ensembl)
GTPMetaboliteCHEBI:15996 (ChEBI)
HRASGeneProductENSG00000174775 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAPK cascadePathwayWP422 (WikiPathways)
MEKGeneProduct2.7.12.2 (Enzyme Nomenclature)
NF1GeneProductENSG00000196712 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
PTPN11GeneProductENSG00000179295 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RTKGeneProductWP5471 (WikiPathways) RTKs have to be activated first
SOS1GeneProductENSG00000115904 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2253"
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