Pathogenic Escherichia coli infection (Homo sapiens)

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1ToxinsARPC1AARHGEF2ARPC1BPhosphatidylethanolamineTUBB3EspFUARPC2CDC42ApoptosisWASTUBBStxBTUBA3ETirTUBB2BToll-like receptor signaling pathwayTUBB2AEspG2LY96CTTNCD14TUBA4ANCK2HCLS1ARPC5PRKCAMapTight junctionARPC4Regulation of actin cytoskeletonTUBB6TUBA3DFYNTUBB4QRegulation of actin cytoskeletonTUBB2CROCK2NCLEspG2TUBB1EspHEZRTUBAL3TUBA3CMapTirBfpCTNNB1OCLNEaeACTBTUBB4YWHAZEspGKRT18EspFTUBA8ABL1TLR4EspGWASLFlagellar assemblyTUBA1AEspFUITGB1StxATUBA1CARPC5LTLR5ROCK1CLDN1CDH1EspFUNCK1RHOATUBB8ARPC3TUBA1BEspHYWHAQEspFactin-related protein 2/3 complex subunit 1B-likeoccludin-likeACTG1Adherens junctionPathogen: Enteropathogenic escherichia coli (EPEC)Enterohermorrhagic escherichia coli (EHEC)PilusLEE-encoded effectorsnon-LEE-encoded effectorsProphage-carried effectorsType III proteinsecretion systemFlagellinLPSHost: Small intestinal epithelial cell (EPEC)Large intestinal epithelial cell (EHEC)NleHNleAInflammationStress fiber formationPedestal formationCytoskeletonrearrangementDisruption ofmicrotuble networkRetraction of filopodiumFilipodium formationAlterations in theIF network architectureDisruption of tight junctionsDisruption of adherens junctionsDisruption of barrierfunction and increase inmonolayer permeabilityRedistributionMitochondrial dysfunctionouter membrane proteinp+p+TranslocationIntestinal tractKidney .......Inhibition of protein synthesisTUBB6TUBB1TUBB4QTUBB8TUBB2BTUBB4TUBB2CTUBBTUBB2ATUBB3


Description

Sources: KEGG

Escherichia coli (commonly abbreviated E. coli) is a gram-negative, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms (endotherms). Most E. coli strains are harmless, but some serotypes are pathogenic and can cause serious food poisoning in humans, and are occasionally responsible for product recalls. E. coli are also responsible for a majority of cases of urinary tract infections. The harmless strains are part of the normal flora of the gut, and can benefit their hosts by producing vitamin K2, and by preventing the establishment of pathogenic bacteria within the intestine.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kaper, James B., James P. Nataro, Harry LT Mobley.; ''Pathogenic escherichia coli.''; Nature Reviews Microbiology, 2004 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118427view14:25, 27 May 2021Marvin M2added pubmed id
106514view21:01, 5 September 2019KhanspersModified description
105780view19:43, 15 August 2019KhanspersModified description
97629view10:42, 31 May 2018AMTanOntology Term : 'epithelial cell of large intestine' added !
97628view10:42, 31 May 2018AMTanOntology Term : 'epithelial cell of small intestine' added !
97525view14:11, 24 May 2018AMTanSee below
97523view14:02, 24 May 2018AMTanConverted some nodes to pathway nodes, updated them with our own pathways rather than KEGG genes pathways
95730view21:06, 18 January 2018AlexanderPicoreplaced all kegg ortholog links with uniprot links for ecoli proteins
95729view20:50, 18 January 2018AlexanderPicotesting uniprot for Ecoli
95728view20:49, 18 January 2018AlexanderPicotesting uniprot for Ecoli
95727view20:47, 18 January 2018AlexanderPicotesting uniprot for Ecoli
95377view08:08, 11 December 2017DeSlRemoved last modified part
95376view08:07, 11 December 2017DeSlAdded literature reference
95375view08:03, 11 December 2017DeSlConnected unconnected line.
95374view08:00, 11 December 2017DeSlModified description
95136view02:26, 17 November 2017AlexanderPicoconnected interactions
78594view14:51, 7 January 2015MaintBotadded missing graphIds
71367view18:37, 17 October 2013MaintBotAutomated update of data sources
71225view20:23, 15 October 2013MaintBotUpdated KEGG xrefs
71224view20:20, 15 October 2013MaintBotUpdated KEGG Compound xrefs
68925view17:33, 8 July 2013MaintBotUpdated to 2013 gpml schema
53131view01:51, 30 October 2012AlexanderPicoModified description
53130view01:50, 30 October 2012AlexanderPicoModified categories
53129view01:50, 30 October 2012AlexanderPicoModified categories
50535view03:03, 17 August 2012NsalomonisPeriodical save, work in progress
50465view05:25, 16 August 2012NsalomonisModified description
50464view05:25, 16 August 2012NsalomonisOntology Term : 'pathogenic Escherichia coli infection pathway' added !
50463view05:21, 16 August 2012NsalomonisSpecify description
50462view05:20, 16 August 2012NsalomonisSpecify description
50461view05:16, 16 August 2012NsalomonisSpecify description
50460view05:12, 16 August 2012NsalomonisPeriodical save, work in progress
50459view05:10, 16 August 2012NsalomonisSpecify description
50458view05:02, 16 August 2012NsalomonisPeriodical save, work in progress
50457view04:52, 16 August 2012NsalomonisPeriodical save, work in progress
50454view04:42, 16 August 2012NsalomonisPeriodical save, work in progress
50453view04:31, 16 August 2012NsalomonisPeriodical save, work in progress
50452view04:21, 16 August 2012NsalomonisPeriodical save, work in progress
50445view23:25, 15 August 2012NsalomonisSpecify description
50444view23:23, 15 August 2012NsalomonisSpecify description
50441view23:21, 15 August 2012NsalomonisPeriodical save, work in progress
50436view23:09, 15 August 2012NsalomonisSpecify description
50435view23:06, 15 August 2012NsalomonisSpecify description
50434view22:59, 15 August 2012NsalomonisPeriodical save, work in progress
50433view22:34, 15 August 2012NsalomonisNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene) Original kegg element: gene;35;hsa:25 hsa:2534
ACTBGeneProduct60 (Entrez Gene) Original kegg element: gene;55;hsa:60 hsa:71
ACTG1GeneProduct71 (Entrez Gene) Original kegg element: gene;55;hsa:60 hsa:71
ARHGEF2GeneProduct9181 (Entrez Gene) Original kegg element: gene;42;hsa:9181
ARPC1AGeneProduct10552 (Entrez Gene) Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
ARPC1BGeneProduct10095 (Entrez Gene) Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
ARPC2GeneProduct10109 (Entrez Gene) Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
ARPC3GeneProduct10094 (Entrez Gene) Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
ARPC4GeneProduct10093 (Entrez Gene) Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
ARPC5GeneProduct10092 (Entrez Gene) Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
ARPC5LGeneProduct81873 (Entrez Gene) Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
Adherens junctionPathwaypath:hsa04520 (KEGG Genes) Original kegg element: map;5;path:hsa04520
ApoptosisPathwayWP254 (WikiPathways)
  • Original kegg element: map;19;path:hsa04210
  • WP254
BfpGeneProductQ0H044 (Uniprot-TrEMBL)
CD14GeneProduct929 (Entrez Gene) Original kegg element: gene;2;hsa:929
CDC42GeneProduct998 (Entrez Gene) Original kegg element: gene;32;hsa:998
CDH1GeneProduct999 (Entrez Gene) Original kegg element: gene;17;hsa:999
CLDN1GeneProduct9076 (Entrez Gene) Original kegg element: gene;39;hsa:9076
CTNNB1GeneProduct1499 (Entrez Gene) Original kegg element: gene;26;hsa:1499
CTTNGeneProduct2017 (Entrez Gene) Original kegg element: gene;27;hsa:2017 hsa:3059
EZRGeneProduct7430 (Entrez Gene) Original kegg element: gene;31;hsa:7430
EaeGeneProductP43261 (Uniprot-TrEMBL)
EspFGeneProductO85622 (Uniprot-TrEMBL)
EspFUGeneProductP0DJ88 (Uniprot-TrEMBL)
EspG2GeneProductQ9EZE8 (Uniprot-TrEMBL)
EspGGeneProductO85646 (Uniprot-TrEMBL)
EspHGeneProductO85629 (Uniprot-TrEMBL)
FYNGeneProduct2534 (Entrez Gene) Original kegg element: gene;35;hsa:25 hsa:2534
Flagellar assemblyPathwaypath:map02040 (KEGG Genes) Original kegg element: map;4;path:map02040
HCLS1GeneProduct3059 (Entrez Gene) Original kegg element: gene;27;hsa:2017 hsa:3059
ITGB1GeneProduct3688 (Entrez Gene) Original kegg element: gene;40;hsa:3688
KRT18GeneProduct3875 (Entrez Gene) Original kegg element: gene;25;hsa:3875
LY96GeneProduct23643 (Entrez Gene) Original kegg element: gene;3;hsa:23643
MapGeneProductQ9R8E4 (Uniprot-TrEMBL)
NCK1GeneProduct4690 (Entrez Gene) Original kegg element: gene;41;hsa:4690 hsa:8440
NCK2GeneProduct8440 (Entrez Gene) Original kegg element: gene;41;hsa:4690 hsa:8440
NCLGeneProduct4691 (Entrez Gene) Original kegg element: gene;45;hsa:4691
NleAGeneProductQ71HP5 (Uniprot-TrEMBL)
NleHGeneProductD3QNI6 (Uniprot-TrEMBL)
OCLNGeneProduct4950 (Entrez Gene) Original kegg element: gene;30;hsa:100506658 hsa:4950
PRKCAGeneProduct5578 (Entrez Gene) Original kegg element: gene;36;hsa:5578
PhosphatidylethanolamineMetaboliteC00350 (KEGG Compound)
RHOAGeneProduct387 (Entrez Gene) Original kegg element: gene;44;hsa:387
ROCK1GeneProduct6093 (Entrez Gene) Original kegg element: gene;28;hsa:6093 hsa:9475
ROCK2GeneProduct9475 (Entrez Gene) Original kegg element: gene;28;hsa:6093 hsa:9475
Regulation of actin cytoskeletonPathwayWP51 (WikiPathways)
  • Original kegg element: map;1;path:hsa04810
  • WP51
StxAGeneProductA8B1H9 (Uniprot-TrEMBL)
StxBGeneProductA7UQX3 (Uniprot-TrEMBL)
TLR4GeneProduct7099 (Entrez Gene) Original kegg element: gene;9;hsa:7099
TLR5GeneProduct7100 (Entrez Gene) Original kegg element: gene;10;hsa:7100
TUBA1AGeneProduct7846 (Entrez Gene) Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBA1BGeneProduct10376 (Entrez Gene) Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBA1CGeneProduct84790 (Entrez Gene) Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBA3CGeneProduct7278 (Entrez Gene) Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBA3DGeneProduct113457 (Entrez Gene) Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBA3EGeneProduct112714 (Entrez Gene) Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBA4AGeneProduct7277 (Entrez Gene) Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBA8GeneProduct51807 (Entrez Gene) Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBAL3GeneProduct79861 (Entrez Gene) Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBB1GeneProduct81027 (Entrez Gene) Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBBGeneProduct203068 (Entrez Gene) Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB2AGeneProduct7280 (Entrez Gene) Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB2BGeneProduct347733 (Entrez Gene) Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB2CGeneProduct10383 (Entrez Gene) Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB3GeneProduct10381 (Entrez Gene) Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB4GeneProduct10382 (Entrez Gene) Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB4QGeneProduct56604 (Entrez Gene) Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB6GeneProduct84617 (Entrez Gene) Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB8GeneProduct347688 (Entrez Gene) Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
Tight junctionPathwaypath:hsa04530 (KEGG Genes) Original kegg element: map;6;path:hsa04530
TirGeneProductP0DJ92 (Uniprot-TrEMBL)
Toll-like receptor signaling pathwayPathwayWP75 (WikiPathways)
  • Original kegg element: map;7;path:hsa04620
  • WP75
Type III protein secretion systemGeneProductOriginal kegg element: map;4;path:map02040
WASGeneProduct7454 (Entrez Gene) Original kegg element: gene;37;hsa:7454 hsa:8976
WASLGeneProduct8976 (Entrez Gene) Original kegg element: gene;37;hsa:7454 hsa:8976
YWHAQGeneProduct10971 (Entrez Gene) Original kegg element: gene;18;hsa:10971
YWHAZGeneProduct7534 (Entrez Gene) Original kegg element: gene;23;hsa:7534
actin-related protein 2/3 complex subunit 1B-likeGeneProduct653888 (Entrez Gene) Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
occludin-likeGeneProduct100506658 (Entrez Gene) Original kegg element: gene;30;hsa:100506658 hsa:4950

Annotated Interactions

No annotated interactions

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