Diclofenac metabolic pathway (Homo sapiens)
From WikiPathways
Description
CYP metabolism of the diclofenac drug (a NSAID), commonly used to treat pain and inflammatory diseases.
Quality Tags
Ontology Terms
Bibliography
- Bort R, Macé K, Boobis A, Gómez-Lechón MJ, Pfeifer A, Castell J; ''Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways.''; Biochem Pharmacol, 1999 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
3'-Hydroxydiclofenac | Metabolite | 112230 (PubChem-compound) | |
4',5-Dihydroxydiclofenac | Metabolite | 3052567 (PubChem-compound) | |
4'-hydroxydiclofenac | Metabolite | 116545 (PubChem-compound) | |
5-hydroxydiclofenac | Metabolite | 3052566 (PubChem-compound) | |
CYP2B6 | Protein | P20813 (Uniprot-TrEMBL) | |
CYP2C18 | Protein | P33260 (Uniprot-TrEMBL) | |
CYP2C19 | Protein | P33261 (Uniprot-TrEMBL) | |
CYP2C8 | Protein | P10632 (Uniprot-TrEMBL) | |
CYP2C9 | Protein | Q6IRV8 (Uniprot-TrEMBL) | |
Metabolite | Metabolite | 10065052 (PubChem-compound) | |
diclofenac | Metabolite | 3033 (PubChem-compound) |
Annotated Interactions
No annotated interactions