Nanomaterial induced apoptosis (Homo sapiens)

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Apotosis caused by nanomaterials, such as single-walled carbon nanohorns, titanium oxide, and polystyrene nanoparticles, may be induced through lysosomal impairment. For example, PAMAMs have been found to cause mitochondrial membrane destabilization, and silver and gold nanoparticles are reported to induce ER stress, which may lead to cytochrome c release from mitochondria.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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  1. Tahara Y, Nakamura M, Yang M, Zhang M, Iijima S, Yudasaka M; ''Lysosomal membrane destabilization induced by high accumulation of single-walled carbon nanohorns in murine macrophage RAW 264.7.''; Biomaterials, 2012 PubMed Europe PMC Scholia
  2. Lee JH, Cha KE, Kim MS, Hong HW, Chung DJ, Ryu G, Myung H; ''Nanosized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction.''; Toxicol Lett, 2009 PubMed Europe PMC Scholia
  3. Xia T, Kovochich M, Liong M, Zink JI, Nel AE; ''Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways.''; ACS Nano, 2008 PubMed Europe PMC Scholia
  4. Zhang R, Piao MJ, Kim KC, Kim AD, Choi JY, Choi J, Hyun JW; ''Endoplasmic reticulum stress signaling is involved in silver nanoparticles-induced apoptosis.''; Int J Biochem Cell Biol, 2012 PubMed Europe PMC Scholia
  5. Tsai YY, Huang YH, Chao YL, Hu KY, Chin LT, Chou SH, Hour AL, Yao YD, Tu CS, Liang YJ, Tsai CY, Wu HY, Tan SW, Chen HM; ''Identification of the nanogold particle-induced endoplasmic reticulum stress by omic techniques and systems biology analysis.''; ACS Nano, 2011 PubMed Europe PMC Scholia
  6. Hussain S, Thomassen LC, Ferecatu I, Borot MC, Andreau K, Martens JA, Fleury J, Baeza-Squiban A, Marano F, Boland S; ''Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells.''; Part Fibre Toxicol, 2010 PubMed Europe PMC Scholia
  7. Andón FT, Fadeel B; ''Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials.''; Acc Chem Res, 2012 PubMed Europe PMC Scholia


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123897view11:31, 25 August 2022Finterlyfixed special shape
123310view07:02, 15 July 2022EgonwBetter type as molecule, to allow links out
123104view14:46, 3 July 2022EgonwMade a pathway clickable
110715view15:44, 28 May 2020Marvin M2changed unknown datanodes to metabolites and labels
107131view14:21, 17 September 2019MaintBotChEBI identifier normalization
106659view21:19, 12 September 2019KhanspersModified description
105660view05:16, 10 August 2019KhanspersModified description
105112view13:33, 8 July 2019DeSlConverted UPR to Pathway node, and added WP1939 as ID.
102133view09:18, 2 December 2018EgonwReplaced Wikipedia with Wikidata identifiers.
98247view09:06, 15 August 2018Mkutmonchanged GO identifier for gene to Ensembl identifier
97098view05:35, 28 April 2018EgonwUndo revision 97097 by [[Special:Contributions/Mechebek|Mechebek]] ([[User talk:Mechebek|Talk]])
97097view20:19, 27 April 2018WpblockedModified title
92314view08:49, 20 May 2017EgonwOntology Term : 'nanomaterial response pathway' added !
89231view11:41, 24 August 2016Torresandonfix author name
88584view19:24, 11 August 2016Mkutmonfix unconnected lines
86008view08:38, 24 June 2016FehrhartAdded some missing annotatins
85993view09:45, 23 June 2016FehrhartConnected lines
78557view10:31, 7 January 2015MaintBotadded missing graphIds
74150view11:38, 1 April 2014Bart SmeetsFixed some names
74141view10:01, 1 April 2014Bart SmeetsExpanded description for nanomaterials, added some literature references
74140view09:57, 1 April 2014Bart Smeets
74139view09:07, 1 April 2014Bart SmeetsSpecify description
73824view14:59, 25 February 2014Bart Smeetsfixed some gene names to original name
73822view14:45, 25 February 2014Bart Smeetsremoved underscores UPR
73821view14:44, 25 February 2014Bart SmeetsAdded wikipedia database for UPR
73820view14:40, 25 February 2014Bart SmeetsFew GeneIDs were added
70982view20:29, 19 September 2013EgonwFound another gene ID.
70981view20:18, 19 September 2013EgonwOne more gene identifier.
70980view20:11, 19 September 2013EgonwModified description
70978view19:58, 19 September 2013EgonwAdded a number of gene identifiers.
70960view14:11, 18 September 2013Egonw
70486view11:56, 7 August 2013EgonwAdded Wikpedia's DNA entry as identifier for "DNA".
65707view12:30, 11 June 2013EgonwAdded a few caspase identifiers.
65021view20:58, 4 June 2013MaintBotModified categories
64719view08:36, 2 June 2013EgonwOntology Term : 'apoptotic cell death pathway' added !
64641view09:35, 31 May 2013AnweshaChanged the node for apoptosis (made it a pathway node)
64613view19:03, 30 May 2013EgonwAdding the last corner.
64576view05:45, 30 May 2013EgonwAdded a bit I missed yesterday.
64575view05:44, 30 May 2013EgonwAdded another section of the full pathway.
64545view16:16, 29 May 2013EgonwFixed the data source. Should be PubChem-compound.
64544view15:55, 29 May 2013EgonwAdded the ChEBI ID for the fullerenes.
64537view12:39, 29 May 2013EgonwAdded the paper from which this is a figure.
64536view12:36, 29 May 2013EgonwNew pathway

External references


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NameTypeDatabase referenceComment
AIFGeneProductENSG00000156709 (Ensembl)
APAF-1GeneProductENSG00000120868 (Ensembl)
APOPTOSISPathwayWP254 (WikiPathways)
Ag NPMetaboliteNPO_1892 (NanoParticle Ontology)
Au NPMetaboliteNPO_401 (NanoParticle Ontology)
BAKGeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP6GeneProductENSG00000138794 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
Ca2+Metabolite271 (PubChem-compound)
Cyt CGeneProductENSG00000172115 (Ensembl)
DNAMetaboliteCHEBI:16991 (ChEBI)
EndoGGeneProductENSG00000167136 (Ensembl)
FADDGeneProductENSG00000168040 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FLIPGeneProductENSG00000003402 (Ensembl)
HTRA2/OMIGeneProductENSG00000115317 (Ensembl)
NanohornMetaboliteNPO_457 (NanoParticle Ontology)
PAMAMMetaboliteNPO_965 (NanoParticle Ontology)
PerforinGeneProductENSG00000180644 (Ensembl)
Polystyrene NPMetaboliteCHEBI:134403 (ChEBI)
SMAC/DIABLOGeneProductENSG00000184047 (Ensembl)
TiO2 NPMetaboliteNPO_1485 (NanoParticle Ontology)
UPRPathwayWP1939 (WikiPathways)
tBIDGeneProductENSG00000015475 (Ensembl)

Annotated Interactions

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