Sulindac metabolic pathway (Homo sapiens)
From WikiPathways
Description
Metabolism of sulindac sulfide is catalyzed by MsrA, MsrB2, and MsrB3.
Quality Tags
Ontology Terms
Bibliography
- Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H; ''Studies on the metabolism and biological activity of the epimers of sulindac.''; Drug Metab Dispos, 2011 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
CYP1A2 | GeneProduct | ENSG00000140505 (Ensembl) | |
CYP1B1 | GeneProduct | ENSG00000138061 (Ensembl) | |
FMO | GeneProduct | IPR000960 (InterPro) | |
MsrA | GeneProduct | ENSG00000175806 (Ensembl) | |
MsrB2 | GeneProduct | ENSG00000148450 (Ensembl) | |
MsrB3 | GeneProduct | ENSG00000174099 (Ensembl) | |
Sulfindac sulfide | Metabolite | 4509492 (Chemspider) | |
Sulindac sulfone | Metabolite | 4582441 (Chemspider) | The structure for the sulfone in the paper is inconsistent with the entries in ChemSpider and PubChem; I assume the paper made typographic errors. |
Sulindac-R | Metabolite | 16046677 (PubChem-compound) | |
Sulindac-S | Metabolite | 11245227 (PubChem-compound) |
Annotated Interactions
No annotated interactions