Common pathways underlying drug addiction (Homo sapiens)

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1NucleusPRKCACaMCAMK2AConnexin 32DRD4DRD1Ca++GnRH signalingMEK1ADCY1GlutamateDopamineGRIA1GRM1MEK2Inhibitor-1Regulation of actin cytoskeletonNeuroactive ligand-receptor interactionADCY1CAMK4DRD2MAPK signalingcAMP ACTBPRKACGGonadotropins geneexpression & secretionGsRegulation of gap junctionStrong depolarizationCREB1ERK1Long term potentiationGRIN1GiERK2ACTG1ACTG2ADCY8GRIA2GRIA3GRIA4GRIN2AGRM5CAMK2AGRIN1GRIN2APRKCBPRKCGPRKACAPRKACBPPP1CAPPP1CBPPP1CCPRKACGPRKACAPRKACBRAF1ARAFARAFRAP1BRAP1A


Description

The pathway was modeled after Figure 2 in Li, et al. 2008 and is based on the common pathways identified in their study as well as protein interaction data. Specifically, glutamate and dopamine neuroactive ligand-receptor interactions trigger long-term potentiation, MAPK and GnRH signaling and gap junction regulation (green outlined pathway nodes). Related functional modules such as depolarization, gene expression and cytoskeleton regulation are also indicated (non-outlined pathway nodes). Among the several positive feedback loops identified in this pathway, the authors highlighted fast and slow ones in red and blue, respectively. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Bibliography

  1. Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129835view00:39, 23 May 2024EweitzLink to WP pathway, refine clickability affordance, standardize case
116781view09:52, 14 May 2021EweitzModified title
106363view23:03, 22 August 2019KhanspersModified description
105556view06:15, 9 August 2019KhanspersModified description
95595view14:20, 5 January 2018DeSlFound incorrect identifier for glutamate (was the same as dopamine).
89423view22:39, 10 September 2016AlexanderPicoadded missing interactions and red/blue highlighted cycles
89422view22:36, 10 September 2016AlexanderPicoOntology Term : 'alcohol dependence' added !
89421view22:35, 10 September 2016AlexanderPicoOntology Term : 'nicotine addiction pathway' added !
89420view22:35, 10 September 2016AlexanderPicoOntology Term : 'morphine addiction pathway' added !
89419view22:33, 10 September 2016AlexanderPicoOntology Term : 'cocaine addiction pathway' added !
89418view22:33, 10 September 2016AlexanderPicoOntology Term : 'amphetamine addiction pathway' added !
89417view22:31, 10 September 2016AlexanderPicoModified description
89416view22:19, 10 September 2016AlexanderPicofinished adding xrefs and complexes
89415view22:07, 10 September 2016AlexanderPicoMore xrefs and complexes added
89414view21:37, 10 September 2016AlexanderPicoUpdated complexes and translation processes; additional layout changes
89413view21:12, 10 September 2016AlexanderPicoupdated layout and labels; added Actin
89374view06:24, 10 September 2016EgonwWidened label so that the full text is visible.
89373view06:23, 10 September 2016EgonwConnected lines.
87531view02:03, 25 July 2016AlexanderPicoOntology Term : 'drug pathway' added !
87530view02:02, 25 July 2016AlexanderPicoOntology Term : 'disease pathway' added !
87529view02:02, 25 July 2016AlexanderPicoModified title
84387view21:19, 18 February 2016KhanspersModified description
82194view09:47, 13 September 2015EgonwFixed the Ensembl data source ("Ensembl Human" -> "Ensembl")
73720view13:03, 19 February 2014Andraadded identifiers
73719view23:13, 18 February 2014AndraModified description
73718view23:08, 18 February 2014Andraadded identifiers
73717view22:50, 18 February 2014Andraadded connections
73716view22:48, 18 February 2014AndraNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTBGeneProductENSG00000075624 (Ensembl)
ACTG1GeneProductENSG00000184009 (Ensembl)
ACTG2GeneProductENSG00000163017 (Ensembl)
ADCY1GeneProductENSG00000164742 (Ensembl)
ADCY8GeneProductENSG00000155897 (Ensembl)
ARAFGeneProductENSG00000078061 (Ensembl)
CAMK2AGeneProductENSG00000070808 (Ensembl)
CAMK4GeneProductENSG00000152495 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
Ca++Metabolite266 (Chemspider)
CaMGeneProductENSG00000198668 (Ensembl)
Connexin 32GeneProductENSG00000169562 (Ensembl)
DRD1GeneProductENSG00000184845 (Ensembl)
DRD2GeneProductENSG00000149295 (Ensembl)
DRD4GeneProductENSG00000069696 (Ensembl)
DopamineMetabolite661 (Chemspider)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
GRIA1GeneProductENSG00000155511 (Ensembl)
GRIA2GeneProductENSG00000120251 (Ensembl)
GRIA3GeneProductENSG00000125675 (Ensembl)
GRIA4GeneProductENSG00000152578 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRM1GeneProductENSG00000152822 (Ensembl)
GRM5GeneProductENSG00000168959 (Ensembl)
GiGeneProductENSG00000127955 (Ensembl)
GlutamateMetaboliteQ181136 (Wikidata)
GnRH signalingPathwayhsa04912 (KEGG Pathway)
Gonadotropins gene expression & secretionPathway
GsGeneProductENSG00000087460 (Ensembl)
Inhibitor-1GeneProductENSG00000135447 (Ensembl)
Long term potentiationPathwayhsa04720 (KEGG Pathway)
MAPK signalingPathwayhsa04010 (KEGG Pathway)
MEK1GeneProductENSG00000169032 (Ensembl)
MEK2GeneProductENSG00000126934 (Ensembl)
Neuroactive ligand-receptor interactionPathway
PPP1CAGeneProductENSG00000172531 (Ensembl)
PPP1CBGeneProductENSG00000213639 (Ensembl)
PPP1CCGeneProductENSG00000186298 (Ensembl)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKCAGeneProductENSG00000154229 (Ensembl)
PRKCBGeneProductENSG00000166501 (Ensembl)
PRKCGGeneProductENSG00000126583 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RAP1AGeneProductENSG00000116473 (Ensembl)
RAP1BGeneProductENSG00000127314 (Ensembl)
Regulation of actin cytoskeletonPathwayWP51 (WikiPathways)
Regulation of gap junctionPathway
Strong depolarizationPathway
cAMP Metabolite5851 (Chemspider)

Annotated Interactions

No annotated interactions

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