Heroin metabolism (Homo sapiens)
From WikiPathways
Description
Pathway complementing the morphine metabolism pathway around heroin. The catalytic efficiency is substantially greater for CES2 (a.k.a. hCE-2) compared to other esterases.
Quality Tags
Ontology Terms
Bibliography
- Hatfield MJ, Tsurkan L, Hyatt JL, Yu X, Edwards CC, Hicks LD, Wadkins RM, Potter PM; ''Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin.''; Br J Pharmacol, 2010 PubMed Europe PMC Scholia
- Maurer HH, Sauer C, Theobald DS; ''Toxicokinetics of drugs of abuse: current knowledge of the isoenzymes involved in the human metabolism of tetrahydrocannabinol, cocaine, heroin, morphine, and codeine.''; Ther Drug Monit, 2006 PubMed Europe PMC Scholia
- Redinbo MR, Bencharit S, Potter PM; ''Human carboxylesterase 1: from drug metabolism to drug discovery.''; Biochem Soc Trans, 2003 PubMed Europe PMC Scholia
- Sawynok J; ''The therapeutic use of heroin: a review of the pharmacological literature.''; Can J Physiol Pharmacol, 1986 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
6-acetylmorphine | Metabolite | 5462507 (PubChem-compound) | 6-monoacetylmorphine |
CES1 | GeneProduct | ENSG00000198848 (Ensembl) | catalyzed in liver |
CES2 | GeneProduct | ENSG00000172831 (Ensembl) | catalyzed in liver; catalytic efficiency is substantially greater for hCE-2 compared to other esterases. |
Pseudo-ChE | Protein | ENSG00000114200 (Ensembl) | pseudocholinesterase |
heroin | Metabolite | CHEBI:27808 (ChEBI) | |
morphine metabolism | Pathway | WP1604 (WikiPathways) | |
morphine | Metabolite | CHEBI:17303 (ChEBI) |
Annotated Interactions
No annotated interactions