Mammary gland development: puberty - stage 2 of 4 (Homo sapiens)
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Description
The primary mammary gland persists until puberty, when it grows and becomes branched. This results in the formation of secondary mammary gland.
ESR1 and NRIP1 co-regulates PGR, STAT5A and AREG, which control proliferation and differentiation during mammary gland development. NRIP1 is also required for ductal elongation, in both epithelial and in stromal compartments 1. Estrogen may also execute its growth effect through EGF. Especially, ERBB2, an EGF receptor, may activate or inhibit the growth according to the stage of development. In puberty, ERBB2 impairs the mammary epithelial cell proliferation 2.
AP1 regulates postnatal mammary gland development, mainly in puberty. Some AP1-dependent genes are shown in the figure 3. FOSL1 is a FOS family member. FOS family members dimerize with JUN family members to form AP1 complex. MYC and CCND1 are associated with cell proliferation. VIM is a component of intermediate filaments and FN1 are related to cell adhesion and migration. TIMP1 is a protease inhibitor.Quality Tags
Ontology Terms
Saving...Bibliography
- Mukherjee S, Louie SG, Campbell M, Esserman L, Shyamala G; ''Ductal growth is impeded in mammary glands of C-neu transgenic mice.''; Oncogene, 2000 PubMed Europe PMC Scholia
- Nautiyal J, Steel JH, Mane MR, Oduwole O, Poliandri A, Alexi X, Wood N, Poutanen M, Zwart W, Stingl J, Parker MG; ''The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals.''; Development, 2013 PubMed Europe PMC Scholia
- Shen Q, Zhang Y, Uray IP, Hill JL, Kim HT, Lu C, Young MR, Gunther EJ, Hilsenbeck SG, Chodosh LA, Colburn NH, Brown PH; ''The AP-1 transcription factor regulates postnatal mammary gland development.''; Dev Biol, 2006 PubMed Europe PMC Scholia
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| AP1 | GeneProduct | ||
| AREG | GeneProduct | ENSG00000109321 (Ensembl)  | |
| CCND1 | GeneProduct | ENSG00000110092 (Ensembl) | |
| EGF | GeneProduct | ENSG00000138798 (Ensembl) | |
| ERBB2 | GeneProduct | ENSG00000141736 (Ensembl) | |
| ESR1 | GeneProduct | ENSG00000091831 (Ensembl) | |
| Embryonic development | Pathway | WP2813 (WikiPathways) | |
| Estrogen signaling pathway | Pathway | WP712 (WikiPathways) | |
| FN1 | GeneProduct | ENSG00000115414 (Ensembl) | |
| FOSL1 | GeneProduct | ENSG00000175592 (Ensembl) | |
| Involution | Pathway | WP2815 (WikiPathways) | |
| MYC | GeneProduct | 4609 (Entrez Gene) | |
| NRIP1 | GeneProduct | ENSG00000180530 (Ensembl) | |
| PGR | GeneProduct | ENSG00000082175 (Ensembl) | |
| Pregnancy and lactation | Pathway | WP2817 (WikiPathways) | |
| Puberty | Pathway | WP2814 (WikiPathways) | |
| STAT5A | GeneProduct | ENSG00000126561 (Ensembl) | |
| TIMP1 | GeneProduct | ENSG00000102265 (Ensembl) | |
| VIM | GeneProduct | ENSG00000026025 (Ensembl) |
Annotated Interactions
No annotated interactions
