Mammary gland development: involution - stage 4 of 4 (Homo sapiens)
From WikiPathways
Description
After pregnancy and lactation, the mammary gland undergoes a tissue remodeling process, known as involution. This process is characterized by the alveoli degeneration through apoptosis.
CHI3L1 inhibits mammary epithelial cell differentiation and polarization in the presence of lactogenic hormones, such as prolactin, hydrocortisone and insulin. CHI3L1 suppress CDH1 and increases MMP9 and this is an important process for involution 1.
In the SOCS3-STAT3 signaling pathway, STAT5 induces SOCS3, which binds to its receptor, IL6ST. Then, IL6ST activates STAT3 2. SOCS3/STAT3 signaling pathway is associated with MYC and, thereafter, with MYC target genes such as TP53, BAX and E2F1. Changes in the SOCS3/STAT3 signaling pathway affect MYC. As SOCS3 has an anti-apoptotic function and MYC an apoptotic function, SOCS3 is considered an important regulator of involution 3.Quality Tags
Ontology Terms
Saving...Bibliography
- Hennighausen L, Robinson GW; ''Information networks in the mammary gland.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC Scholia
- Scully S, Yan W, Bentley B, Cao QJ, Shao R; ''Inhibitory activity of YKL-40 in mammary epithelial cell differentiation and polarization induced by lactogenic hormones: a role in mammary tissue involution.''; PLoS One, 2011 PubMed Europe PMC Scholia
- Sutherland KD, Lindeman GJ, Visvader JE; ''Knocking off SOCS genes in the mammary gland.''; Cell Cycle, 2007 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| BAX | GeneProduct | 581 (Entrez Gene)  | |
| CDH1 | GeneProduct | 999 (Entrez Gene) | |
| CHI3L1 | GeneProduct | 1116 (Entrez Gene) | |
| DNA | Metabolite | CHEBI:16991 (ChEBI) | |
| E2F1 | GeneProduct | 1869 (Entrez Gene) | |
| Embryonic development | Pathway | WP2813 (WikiPathways) | |
| IL6ST | GeneProduct | 3572 (Entrez Gene) | |
| Involution | Pathway | WP2815 (WikiPathways) | |
| MMP9 | GeneProduct | 4318 (Entrez Gene) | |
| MYC | GeneProduct | 4609 (Entrez Gene) | |
| Pregnancy and lactation | Pathway | WP2817 (WikiPathways) | |
| Puberty | Pathway | WP2814 (WikiPathways) | |
| SOCS3 | GeneProduct | 9021 (Entrez Gene) | |
| STAT3 | GeneProduct | 6774 (Entrez Gene) | |
| STAT5 | GeneProduct | IPR035858 (InterPro) | |
| TP53 | GeneProduct | 7157 (Entrez Gene) |
Annotated Interactions
No annotated interactions
