Pluripotent stem cell differentiation pathway (Homo sapiens)

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1Definitive endodermFP6SortSerumEndodermal3D matrigel cultureAnterior endodermDAPTTGFB1SB431542FGF2NOGBMP4BMP4NiacinamideAscorbic acidRACXCR1SHHSeleniumA-83-01NT5ECyclopamineES/IPS cellsKITEGFVEGFAFGF4IGF1HGFNOTCH1EGFBMP4NOGWNT3AMultipotent LungProgenitorsHindgut endodermMultipotent endodermalprogenitor cellsHGFFGF4EGFNODALFGF10RAFGF10Intestinal Tissueخ² cellsPancreatic progenitorsHepatocytesHepaticprogenitorsBMP4VEGFASCFTPOFLT3LGSCFCSF1IL6IL3VEGFABMP4SCFTPOIL3EPOINHBAFGF2BMP4FLT3LGTPOFGF2VEGFAFGF2SB431542TGFB1PDGFBIL3IL6VEGFASCFIL11DKK1VEGFAWNT1DKK1WNT1VEGFATGFB3NTF4FGF2BMP4FSTNTF4BMP4FGF2GDF5HemangioblastErythropoietic cellsLymphoid progenitorsOsteoclastsEndothelial cellsCardiomyocytesSmooth muscle cellsSkeletal myoblastsOsteogenic cellsMesenchymal stem/precursor cellsAscorbic acidBeta-Glycerophosphoric acidDexamethasoneDexamethasoneINSINSTFOP-9cocultureOP-9 coculture Semisolid cultureOP-9 orMS-5cocultureSortSemisolid cultureMesenchymo-angioblastAdipogenicCellHematopoieticprogenitorsMonocyte/macrophageprogenitorChondrogeniccellsCardiovascular colonyforming cellsVEGFATPOEPOIL6IL3IL11CSF1RTNFSF11Primitive streakMesodermBMP4WNT2B47WNT5AWNT7BWNT2FGF2IL6IL6RBMP4OP-9 coculture MesodermalGABA neuronsEpidermisPA6/MS-5cocultureCortical layersOptic cupNeural progenitorsDA neuronsSort P75+, HNK1Cortical neuronsKeratinocytesAdherent cultureOligodendrocytesNueral retina(NR)Retinal Pigment epithelium (RPE)Neural crest stem cellsSpinal motor neuronsPhotoreceptorsculture on artificialmatrixUtriclestromacultureKSR or adherantcultureRetinal pigment epitheliumOctic hair cells3D matrigel cultureNeuroectodermAstrocytesSFEBq cultureEctodermFGF2INHBASHHNiacinamideTaurineIGF1FGF8WNT1ALKVitamin ALEFTY1SHHBMP4CNTFNaltrexoneFGF2NODALDKK1PDGFARetinoic acidEGFFGF1FGF2NOGVitamin ASHHSHHINHBAINHBABMP4EctodermalIGF143TPOEPOFLT3LGFGF2


Description

This pathway provides an overview of the directed differentiation molecules used to induce early and derivative cell lineages from human pluripotent stem cells. This overview differentiates between the three primary germ cell layers (ectoderm-outer layer, endoderm-inner layer, mesoderm-middle layer), which are formed in the earliest state of embryonic development and give rise to different tissue types. The initial version of this pathway is a direct adaptation of the SnapShot "Directed Differentiation of Pluripotent Stem Cells" pathway authored by Luis A. Williams, Brandi N. Davis-Dusenbery, and Kevin C. Eggan, HHMI, Harvard University, Cell 149, May 25, 2012 Elsevier Inc. DOI 10.1016/j.cell.2012.05.015. http://download.cell.com/pdf/PIIS0092867412005946.pdf. This adaptation was generated by Meenakshi Venkatasubramanian and Krithika Ramasamy Subramanian at Cincinnati Children's Hospital in the laboratory of Nathan Salomonis. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
134324view12:02, 20 July 2024EweitzOntology Term : 'myoblast' added !
134323view11:57, 20 July 2024EweitzOntology Term : 'neural stem cell' added !
134322view11:57, 20 July 2024EweitzOntology Term : 'oligodendrocyte' added !
134321view11:29, 20 July 2024EweitzOntology Term : 'spinal cord motor neuron' added !
134320view11:28, 20 July 2024EweitzOntology Term : 'keratinocyte' added !
134258view05:01, 18 July 2024EgonwRemoved template comments
120814view15:12, 11 January 2022SusanOntology Term : 'growth factor signaling pathway' added !
117095view11:29, 17 May 2021EweitzModified title
107975view13:41, 18 November 2019Fehrhartconnecting unconnected interactions
107905view22:12, 9 November 2019DdiglesModified description
107833view16:29, 6 November 2019DeSlModified description
107832view16:25, 6 November 2019DeSlModified description
107829view11:16, 6 November 2019DeSlChnaged 13-cis-retinol (Vit A) to all-trans-retinol (Vit. A) for linkouts.
107828view11:11, 6 November 2019DeSlUpdated Vit. A ID again
107827view10:42, 6 November 2019DeSlUpdated Vitamin A ID
106388view21:25, 28 August 2019KhanspersModified description
106210view12:10, 16 August 2019MaintBotHMDB identifier normalization
105570view06:26, 9 August 2019KhanspersModified description
102217view20:41, 11 December 2018Khanspersfixed interactions, adjusted layout and node sizing, grouped objects, added interactions and anchors
102214view00:31, 11 December 2018Khansperscreating groups and connecting interactions
89940view13:53, 6 October 2016EgonwModified description
87893view12:50, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
80009view13:05, 30 April 2015Zaricorrected Ensembl Id for NTF4
78558view10:31, 7 January 2015MaintBotadded missing graphIds
77643view13:55, 1 October 2014EgonwFixed three PubChem CIDs which incorrectly included the "CID" string.
77642view13:53, 1 October 2014EgonwReplace the CAS numbers (we don't generally have mappings) with the PubChem CIDs provided in the comment.
77579view21:46, 29 September 2014AlexanderPicoFixed "Ensembl Human" to "Ensembl"
77578view21:41, 29 September 2014AlexanderPicoAdded Hematopoietic factors from Chou (2012) PNAS
77570view18:21, 28 September 2014AlexanderPicoFixed SCFD1 to KITLG (SCF)
77488view17:30, 16 September 2014KhanspersOntology Term : 'stem cell' added !
77473view00:32, 14 September 2014NsalomonisModified description
77472view00:22, 14 September 2014NsalomonisNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A-83-01Metabolite16218924 (PubChem-compound)
ALKGeneProductENSG00000171094 (Ensembl)
Ascorbic acidMetaboliteHMDB0000044 (HMDB)
BMP4GeneProduct652 (Entrez Gene)
BMP4GeneProductENSG00000125378 (Ensembl)
Beta-Glycerophosphoric acidMetaboliteHMDB0002520 (HMDB)
CNTFGeneProductENSG00000242689 (Ensembl)
CSF1GeneProductENSG00000184371 (Ensembl)
CSF1RGeneProductENSG00000182578 (Ensembl)
CXCR1GeneProductENSG00000163464 (Ensembl)
CyclopamineMetabolite442972 (PubChem-compound)
DAPTMetabolite5311272 (PubChem-compound) http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5311272&loc=ec_rcs
DKK1GeneProductENSG00000107984 (Ensembl)
DexamethasoneMetaboliteHMDB0015364 (HMDB)
EGFGeneProductENSG00000138798 (Ensembl)
EPOGeneProductENSG00000130427 (Ensembl)
FGF10GeneProductENSG00000070193 (Ensembl)
FGF1GeneProductENSG00000113578 (Ensembl)
FGF2GeneProductENSG00000138685 (Ensembl)
FGF4GeneProductENSG00000075388 (Ensembl)
FGF8GeneProductENSG00000107831 (Ensembl)
FLT3LGGeneProductENSG00000090554 (Ensembl)
FSTGeneProductENSG00000134363 (Ensembl)
GDF5GeneProductENSG00000125965 (Ensembl)
HGFGeneProductENSG00000019991 (Ensembl)
IGF1GeneProductENSG00000017427 (Ensembl)
IL11GeneProductENSG00000095752 (Ensembl)
IL3GeneProductENSG00000164399 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL6RGeneProductENSG00000160712 (Ensembl)
INHBAGeneProduct3624 (Entrez Gene)
INHBAGeneProductENSG00000122641 (Ensembl)
INSGeneProductENSG00000254647 (Ensembl)
KITGeneProductENSG00000157404 (Ensembl)
LEFTY1GeneProductENSG00000243709 (Ensembl)
NODALGeneProductENSG00000156574 (Ensembl)
NOGGeneProductENSG00000183691 (Ensembl)
NOTCH1GeneProduct4851 (Entrez Gene)
NT5EGeneProductENSG00000135318 (Ensembl)
NTF4GeneProductENSG00000225950 (Ensembl)
NaltrexoneMetaboliteHMDB0014842 (HMDB)
NiacinamideMetaboliteHMDB0001406 (HMDB)
PDGFAGeneProductENSG00000197461 (Ensembl)
PDGFBGeneProductENSG00000100311 (Ensembl)
RAMetaboliteHMDB0001852 (HMDB)
Retinoic acidMetaboliteHMDB0001852 (HMDB)
SB431542Metabolite4521392 (PubChem-compound) http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4521392
SCFGeneProductENSG00000049130 (Ensembl)
SHHGeneProductENSG00000164690 (Ensembl)
SeleniumMetaboliteHMDB0001349 (HMDB)
TFGeneProductENSG00000091513 (Ensembl)
TGFB1GeneProduct7040 (Entrez Gene)
TGFB3GeneProductENSG00000119699 (Ensembl)
TNFSF11GeneProductENSG00000120659 (Ensembl)
TPOGeneProductENSG00000115705 (Ensembl)
TaurineMetaboliteHMDB0000251 (HMDB)
VEGFAGeneProductENSG00000112715 (Ensembl)
Vitamin AMetaboliteQ424976 (Wikidata)
WNT1GeneProductENSG00000125084 (Ensembl)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3AGeneProductENSG00000154342 (Ensembl)
WNT5AGeneProduct7474 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)

Annotated Interactions

No annotated interactions

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