Serotonin transporter activity (Bos taurus)

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123INTB3IL1R1CitalopramSerotoninMAOANOS1TGFB1I1L-TryptophanIL1BSLC6A4STX1ASCAMP2TPH2PPP2CB


Description

Serotonin is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract (GI tract), blood platelets, and the central nervous system (CNS) of animals, including humans. It is popularly thought to be a contributor to feelings of well-being and happiness. This pathway summarizes the role of the antidepressant-sensitive serotonin (5-HT) transporter SERT (encoded by the SLC6A4 gene).

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1455(68965) with a 100.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Chanrion B, Mannoury la Cour C, Bertaso F, Lerner-Natoli M, Freissmuth M, Millan MJ, Bockaert J, Marin P; ''Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  2. Carneiro AM, Blakely RD; ''Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  3. Carneiro AM, Cook EH, Murphy DL, Blakely RD; ''Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.''; J Clin Invest, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125666view16:17, 6 March 2023DeSlConnected unconnected lines
125588view19:29, 2 March 2023AlexanderPicoModified description
117604view11:37, 21 May 2021EweitzModified title
105946view11:47, 16 August 2019MaintBotHMDB identifier normalization
101995view19:51, 22 November 2018EgonwRemoved whitespace in PubMed identifiers.
87660view08:55, 25 July 2016LindarieswijkOntology Term : 'serotonin signaling pathway' added !
80697view15:22, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CitalopramMetaboliteHMDB0005038 (HMDB)
IL1BGeneProductENSBTAG00000001321 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
IL1R1GeneProductENSBTAG00000005273 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3554
INTB3GeneProductENSBTAG00000009987 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690
L-TryptophanMetaboliteHMDB0000929 (HMDB)
MAOAGeneProductENSBTAG00000016206 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4128
NOS1GeneProductENSBTAG00000002023 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4842
PPP2CBGeneProductENSBTAG00000009245 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5516
SCAMP2GeneProductENSBTAG00000005844 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10066
SLC6A4GeneProductENSBTAG00000019349 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6532
STX1AGeneProductENSBTAG00000017075 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6804
SerotoninMetaboliteHMDB0000259 (HMDB)
TGFB1I1GeneProductENSBTAG00000002391 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7041
TPH2GeneProductENSBTAG00000020792 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:121278

Annotated Interactions

No annotated interactions
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