Lidocaine metabolism (Bos taurus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none 2,6-xylidine3-hydroxymonoethylglycinexylidideglycinexylidideLidocaine2-amino-3-methylbenzoatemonoethylglycinexylidideCYP3A4CYP1A23-hydroxylidocaine4-hydroxy-2,6-dimethylanilineCYP1A2CYP3A4Name: Lidocaine metabolismOrganism: Bos taurus


Description

Lidocaine is primarily metabolized by CYP1A2 but minor involvement of CYP3A4 is observed too. Lidocaine, also known as xylocaine and lignocaine is a medication used to numb tissue in a specific area.

Comments

 
Based on KEGG pathway http://www.genome.jp/kegg-bin/show_pathway?hsa00982.
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2646(74430) with a 100.0% conversion rate.

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Quality Tags

Image:Curated.pngApproved version
Homology Converted

Ontology Terms

Pathway Ontology : regulatory pathway
 

Bibliography

  1. Orlando R, Piccoli P, De Martin S, Padrini R, Floreani M, Palatini P; ''Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function.''; Clin Pharmacol Ther, 2004 PubMed Europe PMC Scholia
  2. Isohanni MH, Neuvonen PJ, Olkkola KT; ''Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine.''; Basic Clin Pharmacol Toxicol, 2006 PubMed Europe PMC Scholia
  3. Wang JS, Backman JT, Wen X, Taavitsainen P, Neuvonen PJ, Kivistö KT; ''Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro.''; Pharmacol Toxicol, 1999 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106002
Approved
view11:52, 16 August 2019MaintBotHMDB identifier normalization
92725view11:41, 30 June 2017DeSlOntology Term : 'xenobiotic metabolic pathway' added !
92724view11:40, 30 June 2017DeSlOntology Term : 'drug pathway' added !
92722view11:24, 30 June 2017DeSlOntology Term : 'lidocaine drug pathway' added !
92721view11:22, 30 June 2017DeSlModified description
80892view15:30, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
2,6-xylidineMetaboliteCHEBI:28738 (ChEBI)
2-amino-3-methylbenzoateMetabolite4161142 (PubChem-compound)
3-hydroxylidocaineMetabolite161824 (PubChem-compound)
3-hydroxymonoethyl glycinexylidideMetaboliteC16572 (KEGG Compound)
4-hydroxy- 2,6-dimethylanilineMetaboliteCHEBI:55545 (ChEBI)
CYP1A2GeneProductENSBTAG00000000085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505
CYP3A4GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868
LidocaineMetaboliteHMDB0014426 (HMDB)
glycinexylidideMetaboliteCHEBI:357241 (ChEBI)
monoethyl glycinexylidideMetabolite24415 (PubChem-compound)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3254"
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