Serotonin receptor 4/6/7 and NR3C signaling (Bos taurus)

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145, 1553, 71, 76, 100823, 28, 31, 33, 42...44, 457, 13, 24, 35, 55...89, 948, 10, 12, 29, 43...17, 39, 48, 51, 58...664, 9122, 408311, 25, 32, 37, 47...16, 9, 16, 19, 23...38, 9636, 8730, 60, 65, 70, 9750, 7879, 989277, 10188, 934472, 8056, 10520, 5485264, 81, 8667, 7418, 21, 59, 62, 732746, 5214, 41, 49, 75, 90...2Cyclic AMPELK4ADCYHTR7HTR6SRFGR-AMAP2K2BRAFMAPK3HTR4serotoninMAP2K1GNASMAPK1RAP1ACREB1MAPKAPK2ELK1RPS6KRPS6KA5ATF1PKAEGR1


Description

This pathway depicts the downstream signaling of serotonin via receptors 4, 6, and 7, resulting in the activation of EGR1 and NR3C1.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP734(74438) with a 86.0% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
125632view01:59, 6 March 2023AlexanderPicoModified description
117603view11:37, 21 May 2021EweitzModified title
101988view06:34, 22 November 2018EgonwRemoved whitespace in PubMed identifiers.
101982view20:36, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
80922view15:31, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADCYGeneProductAdenylate cyclase
ATF1GeneProductENSBTAG00000018131 (Ensembl)
  • activating transcription factor 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:466
BRAFGeneProductENSBTAG00000021761 (Ensembl)
  • v-raf murine sarcoma viral oncogene homolog B1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
CREB1GeneProductENSBTAG00000005474 (Ensembl)
  • cAMP response element-binding protein 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
Cyclic AMPMetabolite60-92-4 (CAS)
EGR1GeneProductENSBTAG00000010069 (Ensembl)
  • early growth response protein
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1958
ELK1GeneProductENSBTAG00000015817 (Ensembl)
  • ELK1, member of ETS oncogene family
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
ELK4GeneProductENSBTAG00000004953 (Ensembl)
  • ETS domain-containing protein Elk-4 (SRF accessory protein 1)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2005
GNASGeneProductENSBTAG00000017475 (Ensembl)
  • GNAS (guanine nucleotide binding protein, alpha stimulating)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2778
GR-AGeneProductENSBTAG00000019472 (Ensembl)
  • nuclear receptor, subfamily 3, group C, member 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2908
HTR4GeneProductENSBTAG00000010837 (Ensembl)
  • 5 hydroxytryptamine (serotonin) receptor 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3360
HTR6GeneProductENSBTAG00000007996 (Ensembl)
  • 5-hydroxytryptamine (serotonin) receptor 6
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3362
HTR7GeneProductENSBTAG00000008783 (Ensembl)
  • 5-hydroxytryptamine (serotonin) receptor 7
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3363
MAP2K1GeneProductENSBTAG00000033983 (Ensembl)
  • mitogen activated protein kinase kinase 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl)
  • mitogen activated protein kinase kinase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAPK1GeneProductENSBTAG00000010312 (Ensembl)
  • mitogen activated protein kinase 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAPK1
MAPK3GeneProductENSBTAG00000016156 (Ensembl)
  • mitogen activated protein kinase 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPKAPK2GeneProductENSBTAG00000038107 (Ensembl)
  • MAP kinase-activated protein kinase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9261
PKAGeneProductcAMP-dependent protein kinase, protein kinase A
RAP1AGeneProductENSBTAG00000014710 (Ensembl)
  • RAS-related protein-1a
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
RPS6KGeneProductribosomal protein S6 kinase
RPS6KA5GeneProductENSBTAG00000010906 (Ensembl)
  • ribosomal protein S6 kinase, polypeptide 5
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9252
SRFGeneProductENSBTAG00000012777 (Ensembl)
  • serum response factor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6722
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions
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