Fatty acid biosynthesis (Homo sapiens)
From WikiPathways
Description
The production of fatty acids from acetyl-CoA and NADPH through the use of enzymes known as fatty acid synthases is referred to as fatty acid synthesis. This biological process occurs within the cytoplasm of cells. The majority of acetyl-CoA that is transformed into fatty acids originates from carbohydrates through the glycolytic pathway.
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
Quality Tags
Ontology Terms
Bibliography
- Weiss L, Hoffmann GE, Schreiber R, Andres H, Fuchs E, Körber E, Kolb HJ; ''Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase.''; Biol Chem Hoppe Seyler, 1986 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
View all... |
Name | Type | Database reference | Comment |
---|---|---|---|
3-L-Hydroxyacyl-CoA | Metabolite | CHEBI:57318 (ChEBI) | |
3-ketoacyl-CoA | Metabolite | CHEBI:57347 (ChEBI) | aka 3-oxo-fatty acyl-CoA(4−) |
ACAA2 | GeneProduct | 10449 (Entrez Gene) | |
ACACA | GeneProduct | 31 (Entrez Gene) | |
ACACB | GeneProduct | 32 (Entrez Gene) | |
ACAS2 | GeneProduct | 55902 (Entrez Gene) | |
ACLY | GeneProduct | 47 (Entrez Gene) | |
ACSL1 | GeneProduct | 2180 (Entrez Gene) | |
ACSL3 | GeneProduct | 2181 (Entrez Gene) | |
ACSL4 | GeneProduct | 2182 (Entrez Gene) | |
ACSL5 | GeneProduct | 51703 (Entrez Gene) | |
ACSL6 | GeneProduct | 23305 (Entrez Gene) | |
Acetoacetyl-ACP | Metabolite | CHEBI:2393 (ChEBI) | |
Acetyl-ACP | Metabolite | Q59811305 (Wikidata) | |
Acetyl-CoA | Metabolite | CHEBI:15351 (ChEBI) | |
Acetyl-synthase | Protein | ENSG00000131069 (Ensembl) | |
Acyl-CoA (n+2) | Metabolite | CHEBI:17984 (ChEBI) | |
Butyryl-ACP | Metabolite | CHEBI:3247 (ChEBI) | |
Citrate | Metabolite | 29081 (Chemspider) | |
Crotonoyl-ACP | Metabolite | C04618 (KEGG Compound) | aka (3R)-3-Hydroxybutanoyl-[acyl-carrier protein] |
DECR1 | GeneProduct | 1666 (Entrez Gene) | |
ECH1 | GeneProduct | 1891 (Entrez Gene) | |
ECHDC1 | GeneProduct | 55862 (Entrez Gene) | |
ECHDC2 | GeneProduct | 55268 (Entrez Gene) | |
ECHDC3 | GeneProduct | 79746 (Entrez Gene) | |
ECHS1 | GeneProduct | 1892 (Entrez Gene) | |
FASN | GeneProduct | 2194 (Entrez Gene) | |
Fatty acyl CoA | Metabolite | CHEBI:37554 (ChEBI) | |
HADHSC | GeneProduct | 3033 (Entrez Gene) | |
Long-Chain fatty acid | Metabolite | CHEBI:15904 (ChEBI) | |
MECR | GeneProduct | 51102 (Entrez Gene) | |
Malonyl-ACP | Metabolite | C01209 (KEGG Compound) | |
Malonyl-CoA | Metabolite | 524-14-1 (CAS) | Used in small tissue samples as [14C] isotope tracer to improve sensiticity of FASN activity. [https://doi.org/10.1515/bchm3.1986.367.2.905] |
Oxaloacetate | Metabolite | CHEBI:30744 (ChEBI) | |
PC | GeneProduct | 5091 (Entrez Gene) | |
PECR | GeneProduct | 55825 (Entrez Gene) | |
Palmitate | Metabolite | 440215 (Chemspider) | |
Palmitoyl-ACP | Metabolite | C16520 (KEGG Compound) | |
SCD | GeneProduct | 6319 (Entrez Gene) | |
TCA Cycle | Pathway | WP78 (WikiPathways) | |
Triacylglyceride Synthesis pathway | Pathway | WP325 (WikiPathways) | |
beta-hydroxybutyryl | Metabolite | ||
pyruvate | Metabolite | CHEBI:15361 (ChEBI) | |
trans-delta2-enoyl-CoA | Metabolite |
Annotated Interactions
Source | Target | Type | Database reference | Comment |
---|---|---|---|---|
3-ketoacyl-CoA | 3-L-Hydroxyacyl-CoA | mim-conversion | 22434 (Rhea) |