Microglia pathogen phagocytosis pathway (Mus musculus)

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1VesicleMicrogliaPathogenPik3Actin reorganizationOxidative burstSigleceSykPik3r1OxygenItgamTyrobpFcer1gIgGTrem1Fcgr1C1qaHckPIP2Pik3PPPPPPTrem2Trem3Itgb2LynPtpn6Plcg2LatPRac1Rac2Rac3Vav1Vav2Vav3Nckap1lArpc1bNcf4Ncf2Ncf1CybbCybaNcf1Ncf4PPPNcf2Rac1Rac2Rac3CybbCybaPhagocytosismigrationC1qbC1qcPIP3Pik3cgPik3caPik3cdPik3cbPik3r2Pik3c3Pik3c2aPik3r6Pik3r3


Description

Pathogens are recognized by complement C1q or immunoglobulin (IgG) that bind to microglia complement receptors (e.g., ITGAM/ITGB2) or Fc-receptors (e.g., FCGR1) that signal via the immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor molecules TYROBP or FCER1G, respectively. Alternatively, pathogens are directly recognized by classical innate immune receptors (e.g., TREM2) that require the interaction with TYROBP for further signaling. This pathway was converted from the original human pathway to mouse.

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Ontology Terms

 

Bibliography

  1. Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T, Tran L, Dobrin R, Fluder E, Clurman B, Melquist S, Narayanan M, Suver C, Shah H, Mahajan M, Gillis T, Mysore J, MacDonald ME, Lamb JR, Bennett DA, Molony C, Stone DJ, Gudnason V, Myers AJ, Schadt EE, Neumann H, Zhu J, Emilsson V; ''Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.''; Cell, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116838view10:31, 14 May 2021EweitzModified title
106884view13:36, 17 September 2019MaintBotHMDB identifier normalization
102043view18:46, 26 November 2018Khanspersfixed labels
101910view17:05, 16 November 2018EgonwRemoved "undefined" as data source.
94209view21:20, 25 August 2017DeSlAdded ID for PIP2
87399view11:05, 22 July 2016MaintBotadded missing graphids
85691view17:52, 5 June 2016AlexanderPicoOntology Term : 'innate immune response pathway' added !
85690view17:52, 5 June 2016AlexanderPicoOntology Term : 'Alzheimer disease pathway' added !
85689view17:50, 5 June 2016AlexanderPicoOntology Term : 'microglial cell' added !
85684view02:58, 5 June 2016KhanspersModified description
85103view00:40, 14 April 2016AlexanderPicoModified description
84871view00:20, 29 March 2016KhanspersQuick edit to datanode annotation or property
84870view00:17, 29 March 2016AlexanderPicoQuick edit to datanode annotation or property
84869view00:00, 29 March 2016Khanspersadded lit ref
84868view23:59, 28 March 2016KhanspersModified description
84867view23:55, 28 March 2016Khanspersfinal
84866view23:53, 28 March 2016KhanspersPeriodical save, work in progress
84865view23:51, 28 March 2016Khanspersfinal
84864view23:43, 28 March 2016KhanspersPeriodical save, work in progress
84863view23:33, 28 March 2016KhanspersPeriodical save, work in progress
84862view23:23, 28 March 2016KhanspersPeriodical save, work in progress
84861view23:16, 28 March 2016Khanspersfirst draft
84860view23:13, 28 March 2016KhanspersPeriodical save, work in progress
84859view23:03, 28 March 2016KhanspersPeriodical save, work in progress
84858view22:53, 28 March 2016KhanspersPeriodical save, work in progress
84857view22:43, 28 March 2016KhanspersPeriodical save, work in progress
84856view22:33, 28 March 2016KhanspersPeriodical save, work in progress
84806view23:16, 22 March 2016Khanspersfirst draft
84805view23:14, 22 March 2016KhanspersPeriodical save, work in progress
84804view23:04, 22 March 2016KhanspersPeriodical save, work in progress
84803view22:54, 22 March 2016KhanspersPeriodical save, work in progress
84802view22:44, 22 March 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Arpc1bGeneProductENSMUSG00000029622 (Ensembl)
C1qaGeneProductENSMUSG00000036887 (Ensembl)
C1qbGeneProductENSMUSG00000036905 (Ensembl)
C1qcGeneProductENSMUSG00000036896 (Ensembl)
CybaGeneProductENSMUSG00000006519 (Ensembl)
CybbGeneProductENSMUSG00000015340 (Ensembl)
Fcer1gGeneProductENSMUSG00000058715 (Ensembl)
Fcgr1GeneProductENSMUSG00000015947 (Ensembl)
HckGeneProductENSMUSG00000003283 (Ensembl)
IgGGeneProduct
ItgamGeneProductENSMUSG00000030786 (Ensembl)
Itgb2GeneProductENSMUSG00000000290 (Ensembl)
LatGeneProductENSMUSG00000030742 (Ensembl)
LynGeneProductENSMUSG00000042228 (Ensembl)
Ncf1GeneProductENSMUSG00000015950 (Ensembl)
Ncf2GeneProductENSMUSG00000026480 (Ensembl)
Ncf4GeneProductENSMUSG00000071715 (Ensembl)
Nckap1lGeneProductENSMUSG00000022488 (Ensembl)
OxygenMetaboliteHMDB0001377 (HMDB)
PIP2MetaboliteQ27088398 (Wikidata)
PIP3MetaboliteHMDB0004249 (HMDB)
Pik3GeneProduct
Pik3c2aGeneProductENSMUSG00000030660 (Ensembl)
Pik3c3GeneProductENSMUSG00000033628 (Ensembl)
Pik3caGeneProductENSMUSG00000027665 (Ensembl)
Pik3cbGeneProductENSMUSG00000032462 (Ensembl)
Pik3cdGeneProductENSMUSG00000039936 (Ensembl)
Pik3cgGeneProductENSMUSG00000020573 (Ensembl)
Pik3r1GeneProductENSMUSG00000041417 (Ensembl)
Pik3r2GeneProductENSMUSG00000031834 (Ensembl)
Pik3r3GeneProductENSMUSG00000028698 (Ensembl)
Pik3r6GeneProductENSMUSG00000046207 (Ensembl)
Plcg2GeneProductENSMUSG00000034330 (Ensembl)
Ptpn6GeneProductENSMUSG00000004266 (Ensembl)
Rac1GeneProductENSMUSG00000001847 (Ensembl)
Rac2GeneProductENSMUSG00000033220 (Ensembl)
Rac3GeneProductENSMUSG00000018012 (Ensembl)
SigleceGeneProductENSMUSG00000030474 (Ensembl) Siglece interacts with Ptpn6 according to BioGRID
SykGeneProductENSMUSG00000021457 (Ensembl)
Trem1GeneProductENSMUSG00000042265 (Ensembl)
Trem2GeneProductENSMUSG00000023992 (Ensembl)
Trem3GeneProductENSMUSG00000041754 (Ensembl)
TyrobpGeneProductENSMUSG00000030579 (Ensembl)
Vav1GeneProductENSMUSG00000034116 (Ensembl)
Vav2GeneProductENSMUSG00000009621 (Ensembl)
Vav3GeneProductENSMUSG00000033721 (Ensembl)

Annotated Interactions

No annotated interactions

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