Toll-like receptor signaling related to MyD88 (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none MYD88 dependentMYD88 independentTICAM2TLR4MYD88TLR4TLR9TLR5IRF3TICAM1TRAF3MAPK1TLR3IRF7TRAF6IRAK4IRAK1TIRAPMYD88TOLLIPTIRAPMYD88TLR8TLR7IKBKBCHUKIKBKGTLR2TLR6TLR2TLR1TBK1IKBKERELANFKB2RELBc-RELNFKB1Name: Toll-like receptor signaling related to MyD88Organism: Homo sapiens


Description

TLR and NFkB are important in inflammation in the body and in the cancerous cells. TLR signaling pathways are usually connected with MyD88 dependent pathways and MyD88 independent pathways. TLR pathways that involve MyD88 dependent pathways such as this one involve IRAK complexes. The finding of TLR or NFkB genes within the body usually correlates with breast cancer within the person.

This pathway is based on the figure 1 of "Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study" (see bibliography).

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3858).

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Ontology Terms

 

Bibliography

  1. Resler AJ, Malone KE, Johnson LG, Malkki M, Petersdorf EW, McKnight B, Madeleine MM; ''Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study.''; BMC Cancer, 2013 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
137308view15:57, 1 March 2025EweitzModified description
137307view15:56, 1 March 2025EweitzRefine node arrangement
137306view15:55, 1 March 2025EweitzAlign nodes
137305view15:53, 1 March 2025EweitzEconomize layout
137304view15:52, 1 March 2025EweitzStandardize case
137303view15:51, 1 March 2025EweitzEconomize layout
137302view15:49, 1 March 2025EweitzEconomize layout
137301view15:48, 1 March 2025EweitzEconomize layout
137297view15:41, 1 March 2025EweitzTailor node width
137296view15:37, 1 March 2025EweitzIncrease font size
137220view09:00, 1 March 2025EgonwModified description
117850view15:18, 22 May 2021EweitzModified title
107438view06:58, 8 October 2019DeSlOntology Term : 'cancer' added !
107437view06:57, 8 October 2019DeSlOntology Term : 'cancer pathway' added !
107436view06:57, 8 October 2019DeSlOntology Term : 'immune response pathway' added !
107435view06:54, 8 October 2019DeSlModified title
105843view23:12, 15 August 2019KhanspersModified description
89945view14:11, 6 October 2016EgonwModified description
89752view00:05, 30 September 2016KhanspersModified title
89634view23:28, 21 September 2016Khansperschanged to humna based on lit ref
89633view23:22, 21 September 2016Khansperswork in progress
88838view15:19, 15 August 2016AAR&CoAdded Labels and groups
88455view17:17, 8 August 2016AAR&CoFix excess space
88219view00:46, 1 August 2016AAR&CoAdded Identifier
88218view00:44, 1 August 2016AAR&CoIdentifier Modified
87419view11:32, 22 July 2016MkutmonOntology Term : 'breast cancer pathway' added !
87418view11:31, 22 July 2016MkutmonOntology Term : 'disease pathway' added !
87417view11:31, 22 July 2016MkutmonOntology Term : 'Toll-like receptor signaling pathway' added !
87304view20:47, 20 July 2016EgonwMouse pathway? It's all mouse genes.
87288view18:46, 20 July 2016AAR&CoModified description
87287view18:27, 20 July 2016AAR&CoAdded Literature Reference
87286view17:42, 20 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
CHUKGeneProductENSG00000213341 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKEGeneProductENSG00000263528 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
IRAK1GeneProductENSG00000184216 (Ensembl)
IRAK4GeneProductENSG00000198001 (Ensembl)
IRF3GeneProductENSG00000126456 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MYD88GeneProductENSG00000172936 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
RELAGeneProduct5970 (Entrez Gene)
RELBGeneProduct5971 (Entrez Gene)
TBK1GeneProductENSG00000183735 (Ensembl)
TICAM1GeneProductENSG00000127666 (Ensembl)
TICAM2GeneProductENSG00000243414 (Ensembl)
TIRAPGeneProductENSG00000150455 (Ensembl)
TLR1GeneProductENSG00000174125 (Ensembl)
TLR2GeneProductENSG00000137462 (Ensembl)
TLR3GeneProductENSG00000164342 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TLR5GeneProductENSG00000187554 (Ensembl)
TLR6GeneProductENSG00000174130 (Ensembl)
TLR7GeneProductENSG00000196664 (Ensembl)
TLR8GeneProductENSG00000101916 (Ensembl)
TLR9GeneProductENSG00000239732 (Ensembl)
TOLLIPGeneProductENSG00000078902 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
c-RELGeneProduct5966 (Entrez Gene)

Annotated Interactions

No annotated interactions

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