Kennedy pathway from sphingolipids (Homo sapiens)

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1, 2CholineATPPCYT2ADPL-SerineSAHEthanolamineCHPT1CMPCholinePhosphocholinePhosphatidylcholinesO-PhosphoethanolamineCDP-cholineCEPT1ETNK2L-SerinePTDSS2PhosphatidylethanolamineCHKAPCYT1APEMTCDP-EthanolamineCTPPisdSGPL1PCYT1BPhosphatidylserineDAGCHKBAAGPTDSS1SphingolipidPPiSAMEthanolamineETNK1


Description

The CDP-choline pathway, first identified by Eugene Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules. The CDP-choline pathway on the left-hand side represents one half of what is known as the Kennedy pathway. The other half on the right-hand side is the CDP-ethanolamine pathway which is responsible for the biosynthesis of the phospholipid product phosphatidylethanolamine (PE). Source: Wikipedia

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "Kennedy pathway", WP1771 revision 79806, with a 92.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Gibellini F, Smith TK; ''The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine.''; IUBMB Life, 2010 PubMed Europe PMC Scholia
  2. Tavasoli M, Lahire S, Reid T, Brodovsky M, McMaster CR; ''Genetic Diseases of the Kennedy Pathway for Phospholipid Synthesis.''; J Biol Chem, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127616view20:08, 8 November 2023LarsgwFix PMID in reference
116372view12:48, 4 May 2021EweitzModified title
114252view06:19, 1 January 2021EgonwAdded another reference
107150view14:23, 17 September 2019MaintBotChEBI identifier normalization
105104view12:52, 8 July 2019DeSlChanged ID for Pisd from wikidata to ensembl.
95585view13:23, 3 January 2018DeSlModified description
95584view13:11, 3 January 2018DeSlAdded correct ID for phosphatidylcholine
95583view12:52, 3 January 2018DeSlAdded wikidata as database source where applicable; removed licence number
95582view12:50, 3 January 2018DeSlAdded last missing identifiers
95581view12:31, 3 January 2018DeSlOntology Term : 'lipid metabolic pathway' added !
94533view13:36, 19 September 2017DeSl
94532view13:35, 19 September 2017DeSlModified title
94213view21:41, 25 August 2017DeSlSplit up datanodes for AAG/DAG. Added ID for AAG
91098view01:15, 4 January 2017Khanspersadded lit ref
91097view01:15, 4 January 2017KhanspersModified description
90945view03:56, 19 December 2016KhanspersModified description
90763view01:14, 14 December 2016Khanspersupdated source pathway information
90762view01:13, 14 December 2016KhanspersOntology Term : 'CDP-choline pathway of phosphatidylcholine biosynthesis' added !
90761view01:12, 14 December 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AAGMetaboliteCHEBI:73341 (ChEBI)
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
CDP-EthanolamineMetaboliteC00570 (KEGG Compound)
CDP-cholineMetaboliteC00307 (KEGG Compound)
CEPT1GeneProductENSG00000134255 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:99712
CHKAGeneProductENSG00000110721 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12660
CHKBGeneProductENSG00000100288 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12651
CHPT1GeneProductENSG00000111666 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:212862
CMPMetaboliteCHEBI:17361 (ChEBI)
CTPMetabolite2056-98-6 (CAS)
CholineMetaboliteC00114 (KEGG Compound)
DAGMetaboliteCHEBI:18035 (ChEBI) DAG = diacylglycerol
ETNK1GeneProductENSG00000139163 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75320
ETNK2GeneProductENSG00000143845 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:214253
EthanolamineMetaboliteC00189 (KEGG Compound)
L-SerineMetaboliteC00065 (KEGG Compound)
O-PhosphoethanolamineMetaboliteC00346 (KEGG Compound)
PCYT1AGeneProductENSG00000161217 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13026
PCYT1BGeneProductENSG00000102230 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:236899
PCYT2GeneProductENSG00000185813 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68671
PEMTGeneProductENSG00000133027 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18618
PPiMetaboliteQ290828 (Wikidata) PPi=pyrophosphate
PTDSS1GeneProductENSG00000156471 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19210
PTDSS2GeneProductENSG00000174915 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:27388
PhosphatidylcholinesMetaboliteQ650187 (Wikidata)
PhosphatidylethanolamineMetaboliteC00350 (KEGG Compound)
PhosphatidylserineMetaboliteC02737 (KEGG Compound)
PhosphocholineMetaboliteCHEBI:18132 (ChEBI)
PisdGeneProductENSG00000241878 (Ensembl) phosphatidylserine decarboxylase
SAHMetaboliteC00021 (KEGG Compound)
SAMMetaboliteC00019 (KEGG Compound)
SGPL1GeneProductENSG00000166224 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20397
SphingolipidMetaboliteCHEBI:26739 (ChEBI)

Annotated Interactions

No annotated interactions
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