PPAR signaling pathway (Homo sapiens)

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1KetogenesisACSL3PLTPCYP4A11ANGPTL4LPLSLC27A4EHHADHACSBG1CYP7A1RXRACD36CD36PPARGSORBS1ACOX2FABP4RXRACYP4A11Primary bile acid biosynthesisSLC27A2RXRGFABP3PPARAAdipocytokine signaling pathwayGlycerophospholipid metabolismSCDSynthesis and degradation of ketone bodiesAPOA2RXRBCPT2ADIPOQFABP1FABP6RXRBAPOA5GK3PFABP5CYP4A11FABP7ACAA1SLC27A6ACADMACSBG2FABP2SCP2CYP4A11NR1H3DBIFADS2ACAA1CYP4A11ACSL6CPT1AFABP1SLC27A4RXRGCPT1BGK2PDPK1MMP1ACADLACOX1UbcSCDOLR1ACSL1APOC3unsaturated fatty acidsCYP4A11RXRGSCDFABP4APOA1AQP7RXRBPCK2Fatty acid metabolismPLIN1SLC27A5FABP3cytochrome P450 4A14-likeHMGCS2MMP1ACOX3CYP4A11CYP4A11SLC27A1CYP8B1ME1RXRACPT1CCYP27A1UCP1ACSL5ILKPPARDSCDPCK1ACSL4SLC27A1saturated fatty acidseicosanoidciprofibrateNSAIDs9-cis-Retinoic acidLipid transportLipogenesisCholesterol metabolismFatty acid transportFatty acid oxidationLipid metabolismAdipocyte differentiationAdaptive thermogenesisCell survivalGluconeogenesisUbiquitinationunsaturated fatty acids9-cis-Retinoic acidunsaturated fatty acidseicosanoidNSAIDsThiazolidine derivative9-cis-Retinoic acidLiverSkeletal muscleSkeletal muscleAdipocyteAdipocyte


Description

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP2316 revision 69143, with a 92.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Fujii H; ''[PPARs-mediated intracellular signal transduction].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106517view23:28, 5 September 2019KhanspersModified description
106205view12:10, 16 August 2019MaintBotHMDB identifier normalization
105777view19:42, 15 August 2019KhanspersModified description
104982view19:15, 27 June 2019KhanspersModified description
94205view21:11, 25 August 2017DeSlAdded ID for thiazolidine compound class from ChEBI.
91095view01:11, 4 January 2017Khanspersfixed unconnected interactions, updated missing xrefs, added lit ref
90815view18:40, 14 December 2016KhanspersOntology Term : 'cell of skeletal muscle' added !
90814view18:39, 14 December 2016KhanspersOntology Term : 'white fat cell' added !
90813view18:37, 14 December 2016KhanspersOntology Term : 'signaling pathway' added !
90812view18:36, 14 December 2016KhanspersOntology Term : 'peroxisome proliferator-activated receptor signaling pathway' added !
90811view18:36, 14 December 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
9-cis-Retinoic acidMetaboliteHMDB0002369 (HMDB)
ACAA1GeneProductENSG00000060971 (Ensembl)
  • Original kegg element: gene;21;mmu:113868 mmu:235674
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868
ACADLGeneProductENSG00000115361 (Ensembl)
  • Original kegg element: gene;23;mmu:11363
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11363
ACADMGeneProductENSG00000117054 (Ensembl)
  • Original kegg element: gene;22;mmu:11364
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11364
ACOX1GeneProductENSG00000161533 (Ensembl)
  • Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430
ACOX2GeneProductENSG00000168306 (Ensembl)
  • Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732
ACOX3GeneProductENSG00000087008 (Ensembl)
  • Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911
ACSBG1GeneProductENSG00000103740 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94180
ACSBG2GeneProductENSG00000130377 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:328845
ACSL1GeneProductENSG00000151726 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081
ACSL3GeneProductENSG00000123983 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205
ACSL4GeneProductENSG00000068366 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790
ACSL5GeneProductENSG00000197142 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:433256
ACSL6GeneProductENSG00000164398 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:216739
ADIPOQGeneProductENSG00000181092 (Ensembl)
  • Original kegg element: gene;53;mmu:11450
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11450
ANGPTL4GeneProductENSG00000167772 (Ensembl)
  • Original kegg element: gene;41;mmu:57875
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57875
APOA1GeneProductENSG00000118137 (Ensembl)
  • Original kegg element: gene;61;mmu:11806
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11806
APOA2GeneProductENSG00000158874 (Ensembl)
  • Original kegg element: gene;46;mmu:11807
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11807
APOA5GeneProductENSG00000110243 (Ensembl)
  • Original kegg element: gene;64;mmu:66113
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66113
APOC3GeneProductENSG00000110245 (Ensembl)
  • Original kegg element: gene;57;mmu:11814
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11814
AQP7GeneProductENSG00000165269 (Ensembl)
  • Original kegg element: gene;7;mmu:11832
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11832
Adipocytokine signaling pathwayGeneProductOriginal kegg element: map;34;path:mmu04920
CD36GeneProductENSG00000135218 (Ensembl)
  • Original kegg element: gene;11;mmu:12491
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491
CPT1AGeneProductENSG00000110090 (Ensembl)
  • Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12894
CPT1BGeneProductENSG00000205560 (Ensembl)
  • Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12895
CPT1CGeneProductENSG00000169169 (Ensembl)
  • Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78070
CPT2GeneProductENSG00000157184 (Ensembl)
  • Original kegg element: gene;26;mmu:12896
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12896
CYP27A1GeneProductENSG00000135929 (Ensembl)
  • Original kegg element: gene;60;mmu:104086
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086
CYP4A11GeneProductENSG00000187048 (Ensembl)
  • Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:435802
CYP7A1GeneProductENSG00000167910 (Ensembl)
  • Original kegg element: gene;33;mmu:13122
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13122
CYP8B1GeneProductENSG00000180432 (Ensembl)
  • Original kegg element: gene;58;mmu:13124
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13124
DBIGeneProductENSG00000155368 (Ensembl)
  • Original kegg element: gene;63;mmu:13167
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13167
EHHADHGeneProductENSG00000113790 (Ensembl)
  • Original kegg element: gene;25;mmu:74147
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147
FABP1GeneProductENSG00000163586 (Ensembl)
  • Original kegg element: gene;44;mmu:14080
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080
FABP2GeneProductENSG00000145384 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14079
FABP3GeneProductENSG00000121769 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14077
FABP4GeneProductENSG00000170323 (Ensembl)
  • Original kegg element: gene;40;mmu:11770
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11770
FABP5GeneProductENSG00000164687 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16592
FABP6GeneProductENSG00000170231 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16204
FABP7GeneProductENSG00000164434 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12140
FADS2GeneProductENSG00000134824 (Ensembl)
  • Original kegg element: gene;56;mmu:56473
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473
Fatty acid metabolismGeneProductOriginal kegg element: map;35;path:mmu00071
GK2GeneProductENSG00000196475 (Ensembl)
  • Original kegg element: gene;8;mmu:14626 mmu:14933
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14626
GK3PGeneProductENSG00000229894 (Ensembl)
  • Original kegg element: gene;8;mmu:14626 mmu:14933
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14933
Glycerophospholipid metabolismGeneProductOriginal kegg element: map;52;path:mmu00564
HMGCS2GeneProductENSG00000134240 (Ensembl)
  • Original kegg element: gene;37;mmu:15360
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360
ILKGeneProductENSG00000166333 (Ensembl)
  • Original kegg element: gene;43;mmu:16202
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16202
LPLGeneProductENSG00000175445 (Ensembl)
  • Original kegg element: gene;30;mmu:16956
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16956
ME1GeneProductENSG00000065833 (Ensembl)
  • Original kegg element: gene;65;mmu:17436
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17436
MMP1GeneProductENSG00000196611 (Ensembl)
  • Original kegg element: gene;39;mmu:83995 mmu:83996
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83995
NR1H3GeneProductENSG00000025434 (Ensembl)
  • Original kegg element: gene;59;mmu:22259
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22259
NSAIDsMetaboliteCHEBI:35475 (ChEBI)
OLR1GeneProductENSG00000173391 (Ensembl)
  • Original kegg element: gene;29;mmu:108078
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108078
PCK1GeneProductENSG00000124253 (Ensembl)
  • Original kegg element: gene;9;mmu:18534 mmu:74551
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18534
PCK2GeneProductENSG00000100889 (Ensembl)
  • Original kegg element: gene;9;mmu:18534 mmu:74551
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74551
PDPK1GeneProductENSG00000140992 (Ensembl)
  • Original kegg element: gene;45;mmu:18607
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607
PLIN1GeneProductENSG00000166819 (Ensembl)
  • Original kegg element: gene;10;mmu:103968
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:103968
PLTPGeneProductENSG00000100979 (Ensembl)
  • Original kegg element: gene;47;mmu:18830
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18830
PPARAGeneProductENSG00000186951 (Ensembl)
  • Original kegg element: gene;14;mmu:19013
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19013
PPARDGeneProductENSG00000112033 (Ensembl)
  • Original kegg element: gene;16;mmu:19015
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19015
PPARGGeneProductENSG00000132170 (Ensembl)
  • Original kegg element: gene;18;mmu:19016
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19016
Primary bile acid biosynthesisGeneProductOriginal kegg element: map;51;path:mmu00120
RXRAGeneProductENSG00000186350 (Ensembl)
  • Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181
RXRBGeneProductENSG00000204231 (Ensembl)
  • Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182
RXRGGeneProductENSG00000143171 (Ensembl)
  • Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183
SCDGeneProductENSG00000099194 (Ensembl)
  • Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20249
SCP2GeneProductENSG00000116171 (Ensembl)
  • Original kegg element: gene;20;mmu:20280
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20280
SLC27A1GeneProductENSG00000130304 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457
SLC27A2GeneProductENSG00000140284 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26458
SLC27A4GeneProductENSG00000167114 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569
SLC27A5GeneProductENSG00000083807 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26459
SLC27A6GeneProductENSG00000113396 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:225579
SORBS1GeneProductENSG00000095637 (Ensembl)
  • Original kegg element: gene;38;mmu:20411
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20411
Synthesis and degradation of ketone bodiesGeneProductOriginal kegg element: map;50;path:mmu00072
Thiazolidine derivativeMetaboliteCHEBI:35622 (ChEBI)
UCP1GeneProductENSG00000109424 (Ensembl)
  • Original kegg element: gene;66;mmu:22227
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22227
UbcGeneProduct
  • Original kegg element: gene;62;mmu:22190
  • No homologues found for original id L:22190
ciprofibrateMetaboliteCHEBI:50867 (ChEBI)
cytochrome P450 4A14-likeGeneProductOriginal kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
eicosanoidMetaboliteCHEBI:23899 (ChEBI)
saturated fatty acidsMetaboliteCHEBI:26607 (ChEBI)
unsaturated fatty acidsMetaboliteCHEBI:27208 (ChEBI)

Annotated Interactions

No annotated interactions
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