NO/cGMP/PKG mediated neuroprotection (Homo sapiens)

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NR1 SubunitNucleusMitochondrialPermeabilityTransitionPoresGCMicrogliaCalmodulinEndothelial CellSmall Solubles B SubunitsNR2 SubunitsMitochondrionNR1 Interacting ProteinsNeuronNMDA ReceptorNF-kBNMDAR: Ligand ComplexCNG Cation ChannelsCAMK IINatriuretric PeptidesA SubunitsCell DepolarizationCNGA4GRIN2DIL-1BCNGA2PKG2cAMPL-ArginineCAMK2ACNGB3Ca2+O2iNOSGUCY1A2PDE2NADPHCNGA1cGMPACTN2ApoptosisBCL2TBHNFKBIACytochrome CGTPDLG4NADPeNOSBNPCALM1LPSPDE3CREB1NFKB1GRIN2CCyclophilin DIFN-GammaGUCY1B2GUCY1A3NEFLAKAP9ANPTSPOXIAPCNGA3CAMK2GCAMK2BTNF-aGRIN2BNPR1CASP9Mg2+NOCAMK2DL-GlutamateCaspase CascadeNFKB3CNGB1AMPCa2+GRIN1nNOSL-CitrullineGRIN2ACa2+GUCY1B3K+O2L-ArginineNADPHTBHNADPL-CitrullineNOACTN2DLG4NR2 Interacting ProteinsCalmodulinCa2+CALM1O2L-ArginineNADPHTBHNADPL-CitrullineNONOSmall SolublesK+Ca2+BADSmall SolublesK+Ca2+Small SolublesK+Ca2+Mitochondrial DepolarizationCytochrome C


Description

NO/cGMP/PKG Neuroprotection. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
125786view10:03, 10 March 2023DeSlConverted PW node to current color scheme, added link for caspase cascade
123318view07:41, 16 July 2022EgonwTyped a datanode
117805view14:30, 22 May 2021EweitzModified title
110707view14:19, 28 May 2020LaurentAdded missing DataNode types - and one missing ID
107157view14:24, 17 September 2019MaintBotChEBI identifier normalization
106656view21:17, 12 September 2019KhanspersModified description
105657view05:15, 10 August 2019KhanspersModified description
96448view09:26, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96378view06:46, 11 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
92677view11:02, 28 June 2017SauerThorbenOntology Term : 'signaling pathway involving second messengers' added !
92676view11:01, 28 June 2017SauerThorbenOntology Term : 'signaling pathway' added !
92675view11:01, 28 June 2017SauerThorbenOntology Term : 'neuron' added !
92674view11:01, 28 June 2017SauerThorbenOntology Term : 'neural cell' added !
92673view11:01, 28 June 2017SauerThorbenOntology Term : 'dementia' added !
92672view09:59, 28 June 2017SauerThorbenModified title
92671view09:57, 28 June 2017SauerThorbenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTN2GeneProductENSG00000077522 (Ensembl)
AKAP9GeneProductENSG00000127914 (Ensembl)
AMPMetaboliteCHEBI:16027 (ChEBI)
ANPGeneProductENSG00000175206 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BNP GeneProductENSG00000120937 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
CAMK2AGeneProductENSG00000070808 (Ensembl)
CAMK2BGeneProductENSG00000058404 (Ensembl)
CAMK2DGeneProductENSG00000145349 (Ensembl)
CAMK2GGeneProductENSG00000148660 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CNGA1GeneProductENSG00000198515 (Ensembl)
CNGA2GeneProductENSG00000183862 (Ensembl)
CNGA3GeneProductENSG00000144191 (Ensembl)
CNGA4GeneProductENSG00000132259 (Ensembl)
CNGB1GeneProductENSG00000070729 (Ensembl)
CNGB3GeneProductENSG00000170289 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Caspase CascadePathwaySee https://www.abeomics.com/caspase-cascade as example for PW model
Cyclophilin DGeneProductENSG00000171497 (Ensembl)
Cytochrome CGeneProductENSG00000172115 (Ensembl)
DLG4GeneProductENSG00000132535 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductENSG00000161509 (Ensembl)
GRIN2D GeneProductENSG00000105464 (Ensembl)
GTPMetaboliteCHEBI:37565 (ChEBI)
GUCY1A2GeneProductENSG00000152402 (Ensembl)
GUCY1A3GeneProductENSG00000164116 (Ensembl)
GUCY1B2GeneProductENSG00000123201 (Ensembl)
GUCY1B3GeneProductENSG00000061918 (Ensembl)
IFN-GammaProteinENSG00000111537 (Ensembl)
IL-1BProteinENSG00000125538 (Ensembl)
K+MetaboliteCHEBI:29103 (ChEBI)
L-ArginineMetaboliteCHEBI:16467 (ChEBI)
L-CitrullineMetaboliteCHEBI:16349 (ChEBI)
L-GlutamateMetaboliteCHEBI:16015 (ChEBI)
LPSMetaboliteCHEBI:89981 (ChEBI)
Mg2+MetaboliteCHEBI:18420 (ChEBI)
NADP MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
NEFLGeneProductENSG00000277586 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB3GeneProductENSG00000173039 (Ensembl)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NOMetaboliteCHEBI:16480 (ChEBI)
NPR1GeneProductENSG00000169418 (Ensembl)
O2MetaboliteCHEBI:29372 (ChEBI)
PDE2GeneProductENSG00000186642 (Ensembl)
PDE3GeneProductENSG00000172572 (Ensembl)
PKG2GeneProductENSG00000138669 (Ensembl)
TBHMetaboliteCHEBI:64090 (ChEBI)
TNF-a ProteinENSG00000232810 (Ensembl)
TSPOGeneProductENSG00000100300 (Ensembl)
XIAPGeneProductENSG00000101966 (Ensembl)
cAMPMetaboliteCHEBI:17489 (ChEBI)
cGMPMetaboliteCHEBI:16356 (ChEBI)
eNOSGeneProductENSG00000164867 (Ensembl)
iNOSGeneProductENSG00000007171 (Ensembl)
nNOSGeneProductENSG00000089250 (Ensembl)

Annotated Interactions

No annotated interactions

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