Thiamine metabolic pathways (Homo sapiens)

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2Plasma MembranePentose phosphate pathwayTHTR1 deficiencyCytoplasmCitric acid cycleMitochondrionThiamine pyrophosphate(TPP)TPK1OGDHBCKDKpyruvateD-Glyceraldehyde 3-phosphateGlycerol 3-phosphateAcetyl-CoAalpha-ketoglutarateBranched chain amino acidsD-Ribose 5-phosphatePhospholipidpathwaySpingolipids pathwayBranched chain acylCoAsBranched chain keto acid dehydrogenase E1THTR1(SLC19A2)serineGlucose 1-phosphateSLC25A19citrateOxaloacetateDNATHTR2(SLC19A3)TKTisocitrateDHAPsuccinatePyruvate dehydrogenase E1Glucose 6-phosphatePPTPPTPPTPPTPPTPPsphingolipidsplasmalogensphospholipidsWernicke's-like encephalopathyand BRBGBilateral stiatalnecrosisThiamine monophosphate (TMP)1Pthiamine


Description

Thiamine is absorbed in the form of thiamine or thiamine monophosphate and transported through the plasma membrane by thiamine transporter 1 (THTR1) and thiamine transporter 2 (THTR2), which are encoded for by the genes SLC19A2 and SLC19A3, respectively. Upon cell entrance, thiamine undergoes pyrophosphorylation by thiamine pyrophosphokinase (TPK) to thiamine pyrophosphate (TPP). TPP is the active form of thiamine and serves as a cofactor of transketolase in the pentose phosphate pathway in the cytosol. TPP also functions as a cofactor for pyruvate, ketoglutarate and branched chain alpha-keto acid dehydrogenases in the mitochondrion after entrance via TPP transporter encoded by SLC25A19. This pathway was inspired by Chapter 15 (Thiamine Disorders) of the book of Blau (ISBN 3642403360 (978-3642403361)).

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Ontology Terms

 

Bibliography

  1. Rindi G, Laforenza U; ''Thiamine intestinal transport and related issues: recent aspects.''; Proc Soc Exp Biol Med, 2000 PubMed Europe PMC Scholia
  2. Blau, Nenad, Duran, Marinus, Gibson, K. Michael, Dionisi-Vici, Carlo; ''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''''; ISBN 978-3-642-40337-8 , Chapter 15, 2014

History

View all...
CompareRevisionActionTimeUserComment
129257view11:17, 16 March 2024EgonwNot a mim-conversion
124272view12:41, 6 October 2022DeSlFixed interaction to label as Graphical Lines
124271view12:40, 6 October 2022DeSlAdded missing IDs
120409view09:26, 30 November 2021Fehrhartboxed pathway nodes
119258view19:46, 22 June 2021Finterlyfixed ISBN from ebook to hardcover
119253view19:37, 22 June 2021FinterlyAdded ISBN for book citation
110714view14:56, 28 May 2020Fehrhartadded type for plasmalogens (no ID available yet)
106795view13:27, 17 September 2019MaintBotHMDB identifier normalization
104026view17:40, 25 April 2019IreneHemelModified description
98951view12:24, 17 October 2018DeSlModified description
98309view11:43, 20 August 2018DeSlModified description
98308view11:41, 20 August 2018DeSlChanged layout of disease nodes.
97959view14:04, 26 June 2018Youssefwalidadded lit ref for thiamine absorption
97958view13:18, 26 June 2018DeSlModified description
97957view13:13, 26 June 2018DeSlAdded phosphorylation states
97930view09:50, 25 June 2018Youssefwalidmade red lines thicker and corrected thiamine absorption nodes
97903view12:19, 22 June 2018YoussefwalidConnected lines
97846view08:28, 11 June 2018YoussefwalidModified description
97796view15:12, 8 June 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
97795view13:33, 8 June 2018DeSlOntology Term : 'energy metabolic pathway' added !
97794view13:29, 8 June 2018DeSlMinor layout changes
97793view13:19, 8 June 2018DeSlAdded PW nodes+links, disease nodes+ URLs to OMIM
97792view13:04, 8 June 2018DeSlOntology Term : 'thiamine metabolic pathway' added !
97791view12:47, 8 June 2018DeSlAdded lit. ref.
97755view13:18, 7 June 2018YoussefwalidAdded node annotations
97609view08:40, 30 May 2018Youssefwalid
97585view06:36, 27 May 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
97496view14:08, 23 May 2018Youssefwalid
97495view14:02, 23 May 2018YoussefwalidModified description
97493view14:00, 23 May 2018YoussefwalidNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
BCKDKGeneProductENSG00000103507 (Ensembl)
Branched chain

keto acid

dehydrogenase E1		ProteinA0A024R0K3 (Uniprot-TrEMBL)
Branched chain acylCoAsMetaboliteCHEBI:61912 (ChEBI)
Branched chain amino acidsMetaboliteCHEBI:22918 (ChEBI)
Citric acid cyclePathwayWP78 (WikiPathways)
D-Glyceraldehyde 3-phosphateMetaboliteHMDB0001112 (HMDB)
D-Ribose 5-phosphateMetaboliteHMDB0001548 (HMDB)
DHAPMetaboliteCHEBI:16108 (ChEBI)
DNAMetaboliteCHEBI:16991 (ChEBI)
Glucose 1-phosphateMetaboliteHMDB0001586 (HMDB)
Glucose 6-phosphateMetaboliteHMDB0001401 (HMDB)
Glycerol 3-phosphateMetaboliteHMDB0000126 (HMDB)
OGDHGeneProductENSG00000105953 (Ensembl)
OxaloacetateMetaboliteCHEBI:30744 (ChEBI)
Pentose

phosphate

pathway		PathwayWP134 (WikiPathways)
Phospholipid pathwayPathwayWP3933 (WikiPathways)
Pyruvate

dehydrogenase

E1		GeneProductENSG00000131828 (Ensembl)
SLC25A19GeneProductENSG00000125454 (Ensembl)
Spingolipids pathwayPathwayWP4142 (WikiPathways)
THTR1 (SLC19A2)GeneProductENSG00000117479 (Ensembl)
THTR2 (SLC19A3)GeneProductENSG00000135917 (Ensembl)
TKTGeneProductENSG00000163931 (Ensembl)
TPK1GeneProductENSG00000196511 (Ensembl)
TPPMetaboliteCHEBI:45931 (ChEBI)
Thiamine monophosphate (TMP)MetaboliteCHEBI:9533 (ChEBI) Thiamine enters the cell via diffusion or transphosphorylation to thiamine monophosphate (TMP).
Thiamine pyrophosphate (TPP)MetaboliteCHEBI:45931 (ChEBI)
alpha-ketoglutarateMetaboliteCHEBI:16810 (ChEBI)
citrateMetaboliteCHEBI:133748 (ChEBI)
isocitrateMetaboliteCHEBI:16087 (ChEBI)
phospholipidsMetaboliteCHEBI:16247 (ChEBI)
plasmalogensPathwayWP3790 (WikiPathways) Class of phospholipids
pyruvateMetaboliteCHEBI:15361 (ChEBI)
serineMetaboliteCHEBI:17822 (ChEBI)
sphingolipidsMetaboliteCHEBI:26739 (ChEBI)
succinateMetaboliteCHEBI:30031 (ChEBI)
thiamineMetaboliteCHEBI:33283 (ChEBI)

Annotated Interactions

No annotated interactions

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