Eicosanoid metabolism via lipoxygenases (LOX) (Mus musculus)
From WikiPathways
Description
This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [1].
Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[2], lipooxygenases(LOX)[3], or cytochrome P450 monooxygenases (CYP)[4]. This pathway visualises the second route, via LOX.
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Ontology Terms
Saving...Bibliography
- Dennis EA, Norris PC; ''Eicosanoid storm in infection and inflammation.''; Nat Rev Immunol, 2015 PubMed Europe PMC Scholia
- Lee TH, Menica-Huerta JM, Shih C, Corey EJ, Lewis RA, Austen KF; ''Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product.''; J Biol Chem, 1984 PubMed Europe PMC Scholia
- Moreno JJ; ''New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
- Buczynski MW, Dumlao DS, Dennis EA; ''Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.''; J Lipid Res, 2009 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Annotated Interactions
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| Source | Target | Type | Database reference | Comment |
|---|---|---|---|---|
| 12S-HpETE | 12S-HETE | mim-conversion | 50709 (Rhea)  | EC:1.11.1.9 |
| 12S-HpETE | HXA3 | mim-conversion | 50217 (Rhea) | |
| 15-oxo-LXA4 | 13,14-dihydro- 15-oxo-LXA4 | mim-conversion | 41593 (Rhea) | |
| 15S-HETE | 15-oxoETE | mim-conversion | 23261 (Rhea) | EC:1.1.1.232 |
| 15S-HpETE | 15S-HETE | mim-conversion | 48857 (Rhea) | |
| 15S-HpETE | EXA4 | mim-conversion | 50141 (Rhea) | EC:1.13.11.33 |
| 20-hydroxy-LTB4 | 20-oxo-leukotriene B4 | mim-conversion | 48669 (Rhea) | |
| 20-oxo-leukotriene B4 | 20-carboxy-LTB4 | mim-conversion | 48673 (Rhea) | |
| 5S-HpETE | 5S-HETE | mim-conversion | 48621 (Rhea) | |
| 5S-HpETE | LTA4 | mim-conversion | 17962 (Rhea) | |
| Arachidonic acid | 12S-HpETE | mim-conversion | 10429 (Rhea) | |
| Arachidonic acid | 15S-HpETE | mim-conversion | 16870 (Rhea) | EC:1.13.11.33 |
| Arachidonic acid | 5S-HpETE | mim-conversion | 17486 (Rhea) | |
| Arachidonic acid | LTA4 | mim-conversion | 32308 (Rhea) | EC:1.13.11.34 |
| Arachidonic acid | mim-conversion | 38676 (Rhea) | ||
| HXA3 | Trioxilin A3 | mim-conversion | 50897 (Rhea) | |
| HXB3 | Trioxilin B3 | mim-conversion | 50901 (Rhea) | |
| LTA4 | LTC4 | mim-conversion | 17619 (Rhea) | |
| LTA4 | LXB4 | mim-catalysis | 22325 (Rhea) | EC:3.3.2.6 |
| LTA4 | mim-conversion | 22325 (Rhea) | EC:3.3.2.6 | |
| LTB4 | 12-oxo-LTB4 | mim-conversion | 50609 (Rhea) | EC:1.3.1.48 |
| LTB4 | 20-hydroxy-LTB4 | mim-conversion | 22177 (Rhea) | EC:1.14.14.94 |
| LTC4 | LTD4 | mim-conversion | 31564 (Rhea) | EC:3.4.19.14 |
| LTD4 | LTE4 | mim-conversion | 48617 (Rhea) | |
| LXA4 | 15-oxo-LXA4 | mim-conversion | 41573 (Rhea) |
