Eicosanoid metabolism via cytochrome P450 monooxygenases (Mus musculus)
From WikiPathways
Description
This pathway is inspired by the LIPID MAPS>Eicosanoids Pathway expended pathway display [1] and extended with the bottom left side of Figure 1 from Dennis and Norris (2015 [2]).
Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[3], lipooxygenases(LOX)[4], or cytochrome P450 monooxygenases (CYP)[5]. This pathway visualises the third route, via CYP.
Orange boxes represent peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.Quality Tags
Ontology Terms
Bibliography
- Dennis EA, Norris PC; ''Eicosanoid storm in infection and inflammation.''; Nat Rev Immunol, 2015 PubMed Europe PMC Scholia
- Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
11,12-DiHETrE | Metabolite | LMFA03050008 (LIPID MAPS) | |
11,12-EpETrE | Metabolite | LMFA03090010 (LIPID MAPS) | |
14,15-DiHETrE | Metabolite | LMFA03050010 (LIPID MAPS) | |
14,15-EpETrE | Metabolite | LMFA03080005 (LIPID MAPS) | |
16-HETE | Metabolite | LMFA03090010 (LIPID MAPS) | |
17-HETE | Metabolite | LMFA03060091 (LIPID MAPS) | |
18-HETE | Metabolite | LMFA03060092 (LIPID MAPS) | |
19-HETE | Metabolite | LMFA03060106 (LIPID MAPS) | |
20-HETE | Metabolite | LMFA03060009 (LIPID MAPS) | |
5,6-DiHETrE | Metabolite | LMFA03050004 (LIPID MAPS) | |
5,6-EpETrE | Metabolite | LMFA03080002 (LIPID MAPS) | |
8,9-DiHETrE | Metabolite | LMFA03050006 (LIPID MAPS) | |
8,9-EpETrE | Metabolite | LMFA03080003 (LIPID MAPS) | |
Arachidonic acid | Metabolite | LMFA01030001 (LIPID MAPS) | |
Cyp2c29 | Protein | 13095 (Entrez Gene) | |
Cyp2c37 | Protein | 13096 (Entrez Gene) | |
Cyp2c38 | Protein | 13097 (Entrez Gene) | |
Cyp2c39 | Protein | 13098 (Entrez Gene) | |
Cyp2c40 | Protein | 13099 (Entrez Gene) | |
Cyp2c44 | Protein | 226143 (Entrez Gene) | |
Cyp2c54 | Protein | 404195 (Entrez Gene) | |
Cyp2c55 | Protein | 72082 (Entrez Gene) | |
Cyp2j5 | Protein | 13109 (Entrez Gene) | |
Cyp4a10 | GeneProduct | 13117 (Entrez Gene) | |
Cyp4a12a | GeneProduct | 277753 (Entrez Gene) | |
Cyp4a12b | GeneProduct | 13118 (Entrez Gene) | |
Cyp4f14 | GeneProduct | 64385 (Entrez Gene) | |
Cyp4f18 | GeneProduct | 72054 (Entrez Gene) | |
Ephx2 | GeneProduct | 13850 (Entrez Gene) | |
PPAR alpha | Protein | P23204 (Uniprot-TrEMBL) | AKA Peroxisome proliferator-activated receptor alpha |
PPAR gamma | Protein | P37238 (Uniprot-TrEMBL) | AKA Peroxisome proliferator-activated receptor gamma |
Annotated Interactions
No annotated interactions