G alpha (s) signaling events (Homo sapiens)

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172, 16, 22, 2611131, 10, 272, 16, 22, 265, 12, 18, 21, 30...4, 14, 246-8, 25, 291920205, 12, 18, 21, 30...11172, 16, 22, 26153, 2811cytosolendoplasmic reticulum lumenOR2T29 OR52E4 INSL3(21-55) PTHLH TSHB OR2V2 RAMP3 CYSLTR2 MC4R OR3A4P OR14J1 OR6J1 OR2A1 OR51D1 OR5K4 OR5T3 OR10H5 OR2A25 OR2B2 OR1L3 GLP1R OR13C4 OR4E1 ADCYAP1R1 OR2K2 OR4F5 OR10S1 G alpha(s):GTP:p-Y416-SRCOR4K5 TAAR8 ADORA2A,B OR52K1 CALCA(83-119) OR8B4 GNB5 GRK6 TSHR PTH2(62-100) GRK6 OR6N1 OR10G3 OR13G1 OR1B1 ATP OR2AE1 OR10A6 GIP(52-93) OR6C68 OR5AP2 GLP2R OR51B5 OR4C6 NPSR1 OR4X1 OR5K2 NAd ATPOR56A1 OR52E4 OR6T1 PDE3B OR5A2 POMC(138-176) OR5M10 OR10D3 GPR39 OR5I1 CGA OR52J3 OR2B8P OR5K3 OR2B3 OR1L1 OR1E1 OR4D11 INSL3(106-131) PTGER4 TAAR2 OR2T4 OR2AT4 OR5AR1 OR1D5 OR5K4 OR56A3 OR4M1 OR9A1P OR8A1 OR52A1 OR1E2 ATP OR6B2 OR5B2 OR1J2 CALCR OR1S2 PDE3A,3BPGI2 OR7E24 ADCYAP1(132-158) ADCY3 OR4A5 OR6C74 TAAR3 OR6Q1 ADR CRHR2 OR52B2 OR2M2 OR9A2 OR51B6 GTP RAMP1 OR4C5 G-protein alpha(i):GTP:AdenylatecyclaseOR9A1P OR51B5 OR11H4 GNAI1 OR2Y1 ADM(95-146) GNB5 OR10V1 GNAI2 OR5M11 GNG5 OR13C3 ADCYAP1(82-129) OR5L2 OR1E1 PTH OR4K3 TAAR5 OR2AT4 OR2B11 ADORA2A CALCA(83-119) OR5AN1 OR1E3 CALCA(83-119) TAAR1 OR10J1 OR5B2 OR3A2 GNB1 INSL3(21-55) OR4C12 RAMP3 GNGT1 Ade-Rib OR52R1 OR5D18 CGA ADORA2B OR2T29 OR2T8 ADCY7 OR10AC1P OR2B3 OR10A5 OR3A4P MC3R(1-360) ADCY7 CRH GNAS1 ADCY9 POMC(138-176) FSHR OR4A8P CRHR2 OR7G3 RTPsOR2T7 OR5G3 OR56B2P OR2B2 CCA DCA OR4M2 OR8D1 PTH1R GDP OR8J3 pS-ADRB2 OR51G1 OR5H2 GNG7 GNGT1 OR4C16 OR52I1 OR1B1 Olfactory receptor:Gprotein trimerOR52L2P OR4C5 OR8U1 PTH OR4E2 OR2L5 OR10G6 OR5AS1 OR6C1 OR5G3 TSHR OR51M1 OR51I1 OR1Q1 OR6K6 OR5J2 Melanocortin receptors OR52K2 GDP OR51T1 GRK2, GRK3, GRK5,GRK6TAAR6 PTGER4 OR4D5 OR6F1 OR5H14 AVPR2 ADCY5 RTP4 GTP GPBAR1 GNB3 OR6C70 cAMPOR5AC1 OR4D11 OR51E1 RXFP2 HTR6 GLP2R OR8A1 OR7A17 OR51F1 OR52I2 OR10AD1 POMC(217-234) OR4D9 POMC(217-234) OR51Q1 TSHB OR51S1 GNAS1 Hist OR52Z1 OR10J4 OR9G9 ATP OR1L6 ADCY2 Mg2+ GHRH OR51L1 AVP(20-28) OR9G9 OR4E1 GHRH GNAT3 OR14I1 OR2B11 OR6C2 OR5H1 OR51G2 OR4E2 CCA OR5K1 RLN3(119-142) OR7G3 ADRB3 TAAR5 ADCY4 OR51B2 SRC OR2T5 OR2J1 OR10R2 FSHB ADRB1 OR2T6 RTP1 OR52N5 OR5B3 OR6V1 INSL3(106-131) OR56A4 OR2T10 OR2F1 CRH GNB2 OR52B6 Constitutively active orphan GPCRs GNG11 OR11L1 OR6X1 GNG12 GNG11 Hist GNAL OR2F2 GNGT2 Ligand:GPCRcomplexes thatactivate GsTAAR1 Ligands of GPCRsthat activate GsOR51D1 OR5J2 ADCYAP1R1 OR4C45 OR1J4 MC1R ADM(95-146) TSHR OR51Q1 Ade-Rib OR56B4 OR2A1 OR6P1 GNG2 GNAS2 OR2L8 PGD2 OR52D1 OR2F1 OR10H4 ATPOR8B3 OR8B12 VIPR1 OR10Q1 RTP2 AVP(20-28) OR5M1 OR7D2 OR8B2 OR13A1 ADRB2 OR1L8 OR4C3 INSL3(106-131) OR1N2 GNAI3 OR52K1 OR10G9 OR6C70 GNAL:GNB1:GNGT1OR2B6 OR10W1 OR1D2 OR8K1 OR5H1 OR52E5 GNG10 NAd OR2AG2 ADM(95-146) OR8I2 OR5M8 OR2T8 OR4C12 ADCY1 OR11H1 CGRP ligands OR2M4 GNG8 GRK5 ADR OR1J4 OR5AS1 OR4F17 TAAR9 OR5H6 ADCY8 OR13J1 PTGIR mature GLP-1 GNAS2 Trace amine-associated receptor OR10H3 OR2A4 OR13C2 HTR7 OR7C2 OR10H2 OR4F3 OR2T2 GCG(146-178) GNG10 PGI2 GNAS2 OR10K2 GRK2 GNG7 NAd OR4Q3 REEP4 OR52N5 OR7D2 REEP3 OR51J1 OR8B12 TSHB OR10G7 OR6K3 OR5H15 OR52A4 TAAR2 OR11G2 ADCY1 GIPR ADRB2 OR5K2 ATPGNGT2 OR51I2 DA OR2T33 HRH2 OR5M9 Constitutively active orphan GPCRs OR51A2 VIPR2 PGI2 OR11H1 ARRB2 OR2AG1 RXFP2 Olfactory receptorsOR8D1 OR52P1P PTGDR RLN3(26-52) PTGIR OR8J2 OR10A3 OR5H14 OR4C3 DRD1 OR14K1 ADR FSHR ADCY5 OR2D3 OR4Q2 P2RY11 OR4K15 OR5AK3P ARRB1 ADPMC4R Constitutively active orphan GPCRs OR2C3 OR8B4 OR4N4 OR2V2 GNG2 ARRB1 OR4X1 RXFP1 OR6C4 OR1A2 GNAL OR2W1 ADCY2 GNG13 OR9A4 GTP CALCA(83-119) OR5AU1 ADRB3 GNB3 Ade-Rib OR13J1 OR4A16 MC2R Hist PGD2 p-Y416-SRC OR10H1 OR6C3 PTGDR LHB OR4X2 SRCLCHA ADRB2 CALCA(83-119) OR2L3 OR2T3 GCG(53-81) ADR OR51I1 Phosphodiesterases, cyclic AMP-selective NPS OR5M8 OR10G7 OR2I1P CALCRL OR1J1 NAd OR13D1 OR10G2 OR14A16 OR13C5 OR1E2 OR5I1 OR52K2 GIP(52-93) SCTR OR2W3 IAPP(34-70) OR11H6 OR7A2P OR12D3 OR14A2 OR52E8 OR2W5 OR6C1 OR5AN1 OR2V1 MC1R OR4K17 TAAR3 OR8D4 MC2R OR4C11 CALCA(83-119) PDE3inhibitors:PDE3A,3BOR2D3 OR10H3 OR8K5 OR1S1 OR2C1 OR2G3 OR10G4 ADCY5 PGE2 VIP(125-152) OR1L1 OR8K5 PEA OR2A14 OR11H4 OR6Q1 OR7A10 OR52N4 OR5D14 CYSLTR2 OR56B1 Zn2+ GLP1R OR2I1P OR6C76 OR5B21 OR2G2 OR5D16 OR51M1 5HT ADORA2B OR2T34 OR2AG2 OR1G1 ADRB3 AVPR2 OR10K1 OR3A3 OR2H2 OR52E2 GNG4 OR10G3 OR10J5 OR4C16 GPHB5 OR10A4 OR1D4 ADCY1 OR5M3 NPS RTP5 OR6B3 PTGDR OR10J3 OR11L1 OR5F1 GLP1R OR1A1 FSHB OR2J3 OR52W1 DRD1,5 OR2AK2 LHCGR OR10W1 GNGT2 OR4F17 GNB4 POMC(217-234) OR1A1 OR4N5 OR2L5 OR10P1 OR4A8P SCTR LHB OR8I2 OR9G4 OR6P1 OR3A1 GNG4 OR1F12 PTGIR POMC(138-176) ADCYAP1(132-169) OR52N1 OR5K3 GNB1 GNB5 OR8J1 OR5AU1 GNB4 OR10S1 MC5R OR4N2 Adrenomedullin receptor RAMP1 GCG(146-178) OR52N2 OR2D2 OR5D14 GPBAR1 HTR7 GNG3 GNG13 OR4K13 OR2J3 OR2A12 G alpha(s):GTP:AdenylatecyclaseVIP(125-152) OR10H2 OR4K5 PTGER2,PTGER4 GNB2 OR4F21 OR2A2 LHCGR OR5L1 OR52P1P OR2W3 OR2S2 OR5B17 OR4C45 OR8H2 ADCY9 Ade-Rib GNGT1DRD1 cAMPphosphodiesterasesGNGT1 OR5C1 OR5B12 RAMP1 CALCR RLN2(25-53) ADCYAP1(132-158) RXFP1 IAPP(34-70) pS-ADRB2 REEP5 OR5M3 OR4A4P OR8H3 ADCY5 OR51A7 OR8H1 GNG10 OR2S2 OR4S1 GRK2 RLN3(26-52) OR5W2 OR5F1 OR6C65 OR2F2 Mg2+ OR51J1 POMC(138-150) LHB OR6A2 OR56B4 GNB1 OR3A2 OR51A4 OR11H7 OR4L1 OR8G2 OR2W1 ADPOR5V1 OR1N2 GPBAR1 GNG8 PTH2R OR13C9 OR10AG1 OR13C8 OR6Y1 TAAR2 OR10A5 RXFP1 pS-ADRB2:Catecholamine:ARRB1,ARRB2TAAR3 OR2Z1 AVP(20-28) HTR6 GNAS1 OR6B2 OR2T27 PTH1R OR2A12 ADCY8 GPCR:ligandcomplexes that actonGs:HeterotrimericG-protein Gs(active)OR9A4 OR1N1 NPSR1 OR2L3 OR52A4 GNB1 OR6C6 OR9I1 OR56A5 OR6S1 OR13C4 OR2T12 OR52R1 OR6T1 OR4M1 PTGER4 OR2H1 Mg2+ ADCY3 pS-ADRB2:Catecholamine:GRKOR7G2 OR4N4 GNAS1 OR2M7 ADRB2:ADR,NAdG alpha (s):GTP:SRCOR10C1 OR3A3 GRK5 OR4A15 FSHR OR5AK2 OR52H1 OR4K14 P2RY11 OR51F2 AMPOR4P4 OR8D4 HTR4 OR4L1 OR1P1 OR5M1 OR51V1 OR4A15 OR12D3 OR10A2 OR8U9 OR56B2P ADCY6 OR5T1 ADRB1 OR10A3 OR6M1 CALCA(83-119) ADCY4 OR6C3 GNGT1 GNG11 OR10G9 OR6Y1 OR8H2 GNG11 OR2AJ1 PGE2 OR10J4 OR6V1 OR2T33 OR2Z1 OR4D9 OR14K1 RLN2(25-53) OR52A1 HTR4 OR8B3 OR6B1 OR8U8 OR1C1 OR10D4P OR4D6 PTH1R OR4D1 OR5P3 ArgN-GCG(98-127) OR4F5 TAAR8 OR4C11 OR10G4 CDCA PDE3A GNAS1 GPHA2 PEA GTPOR9Q2 GLP-1 (7-37) DRD5 OR8K1 OR52L1 RXFP1 OR4F4 RTP3 OR2J1 ADRB2 REEP2 OR5M10 OR4D2 OR14C36 TAAR6 OR4C46 OR51E1 OR1L4 OR4F3 GNG2 OR13C8 OR4A4P CALCB(82-118) OR5D16 OR1P1 ADCY7 OR2AE1 OR5B3 OR2A5 OR8B8 OR5H15 SCT OR2T11 GNG12 GIPR ADCY8 OR4K2 OR9K2 GTP GNG13 GNAZ OR2T12 PTH1R,PTH2R Constitutively active orphan GPCRs OR13C5 CALCRL PGI2 OR8B2 OR7A10 GNB5 CCA p-Y416-SRCOR2J2 ADCY1 OR6K3 OR2A4 OR51V1 OR2A25 ADRB3 OR52E8 OR14C36 REEP6 OR5C1 pS-ADRB2 GCG(53-81) OR5A1 GNG3 OR1Q1 CRHR1 OR2M2 SCTR VIPR1,VIPR2 OR1D2 ADCYAP1(132-158) HTR4,6,7 TAAR9 HRH2 OR6C75 OR13C2 OR2T7 ADRB2 OR4B1 MC1R ADCY6 OR4F6 OR5D13 VIPR2 CALCRL Phosphodiesterases, dual (cAMP, cGMP) activity PGD2 IAPP(34-70) OR1J1 CALCR GNB2 OR9G1 OR1M1 OR9G4 GIPR OR5AC2 OR2V1 OR2T1 PPiOR8G1 HTR6 PTHLH OR1K1 OR52B6 OR8U1 GPHB5 ADRB2 OR2A14 CGA GPR39 OR5P2 CALCRL GNG5 H2OOR6C74 Zn2+ ADCYAP1(132-169) OR13C3 OR6A2 OR4C46 OR10Q1 OR8G1 OR56A4 OR4F15 PTGER2 POMC(77-87) ADCYAP1(82-129) OR4A16 OR4K14 ADCY9 Hist OR7E24 OR51H1P HeterotrimericG-protein Gs(inactive)OR2G2 OR10K2 GHRH GPHA2 RAMP3 VIPR1 OR5T1 OR2T4 OR5M11 OR4A47 OR7A17 HRH2 OR2L8 GNG8 OR5V1 GPCRs that activateGsGPR39 OR4K1 OR2B8P GNB4 GIP(52-93) OR7A2P OR10A6 OR51A2 GCG(53-81) OR2W6P ADR OR4C15 GNB4 OR7A5 OR52E6 OR52M1 SCT MC5R GNB3 OR4N5 ADCYAP1(132-169) ADCY3 OR5B21 OR6X1 GPBAR1 OR1S1 OR10G8 VIPR1 OR7C1 OR7C2 OR1C1 OR13G1 ADCYAP1 peptides OR9Q1 OR7C1 OR51A4 OR52E1 OR9G1 GNG7 ADORA2A OR4D2 OR2K2 TSHR OR2C3 ADCY8 AMY1-3 GNG4 REEP1 OR4Q2 GNAS2 OR10J1 ADR CYSLTR1,2 OR10Z1 POMC(138-150) OR8D2 DA RAMP2 ArgN-GCG(98-127) OR10J3 ADCY6 ADCY9 OR11H2 OR1L8 ADR OR14I1 GIP(52-93) OR8B8 MSH RLN2(162-185) OR52E5 OR1F2P OR52N4 OR5B17 OR10AC1P HRH2 OR6C65 RAMP1 GNGT2 GNB1 GNAS1 OR7D4 OR9K2 OR51B2 ADCY4 NAd OR8J1 OR8G5 ADORA2B DRD5 OR2AG1 MC3R(1-360) OR5AR1 GRK5 OR5AL1 GNG8 OR10Z1 AVPR2 GNG7 OR5AC2 ADM2(19-153) OR13A1 PTH2R GNG3 OR11A1 ADM2(19-153) OR6C2 NAd OR4K1 P2RY11 ADM2(19-153) OR2C1 OR4F21 OR2B6 OR2T5 OR4M2 NAd OR10J5 OR4K2 OR52L2P OR5L2 ADCYAP1(82-129) GTP OR10J6P PTGIR OR5AC1 RXFP2 ligands OR6M1 OR1N1 ADCY2 GIPR CGA TAAR1 GHRHR RLN2(162-185) RXFP2 OR2T11 TAAR9 OR51S1 GCG(146-178) POMC(77-87) PTGER2 OR6C76 SCTR OR6S1 OR9Q2 OR5T2 OR11G2 GNG10 OR7G2 OR2L13 OR4D5 LCHA PTGER2 GNGT1 OR10D4P OR52H1 PEA GRK2 OR8G5 CRH OR4F6 OR5H6 ADRB1 OR13H1 OR2T34 OR4N2 PTGDR GHRHR OR5P2 GNG13 OR10AG1 GDPGPHA2 OR8J3 IAPP(34-70) 5HT ADR OR6N2 RLN2(25-53) POMC(77-87) GNAS2 CRH OR4F4 OR8G2 OR10R2 DA LHCGR OR51L1 OR51F1 OR5AL1 OR4K17 OR1K1 CRHR2 OR4D10 AVP(20-28) ATP OR14A2 Mg2+ OR2L2 5HT OR4B1 OR14J1 MC2R OR8S1 ADCYAP1R1 OR5H2 OR5P3 GNG3 Relaxin-2, Relaxin-3 GNG5 ADRBK2 OR2G6 GNAS2 OR6C68 OR13C9 DCA OR6C4 OR2M4 GNG12 OR1F1 OR10T2 ADRB1 GCG(146-178) RLN3(119-142) OR2AP1 OR9Q1 OR11A1 OR10H5 pS-ADRB2:CatecholamineOR10P1 OR8S1 OR10D3 ADCY3 OR8H3 RXFP2 OR4S2 OR2H1 OR1S2 DRD1 PTH OR2M5 OR2T1 OR7A5 ADRBK2 OR4A5 ADCY6 NAd OR51H1P MC4R Bile acids OR8K3 OR51F2 OR2D2 OR51E2 OR52N1 OR1D4 OR10A4 OR8J2 CRHR1 OR2L2 OR10X1 OR14L1P OR4K3 OR4C13 TAAR6 GNAS2 OR13D1 OR6B1 OR1G1 OR5M9 OR10C1 OR51B4 OR52D1 OR2T35 OR2H2 ADCY2 GNALOR10G6 OR52I2 ADCY4 RLN3(26-52) DA PTH2R GPHB5 OR9A2 VIP(125-152) OR5AK3P OR56B1 OR5A1 OR52N2 OR4A47 OR7G1 GLP-1 (7-37) OR2T27 OR52E1 GNB1 OR5AK2 OR8D2 CALCB(82-118) PGE2 RAMP2 Ligand:GPCRcomplexes thatactivateGs:HeterotrimericG-protein Gs(inactive)OR51B4 ArgN-GCG(98-127) TAAR8 OR2G3 OR10A7 PTH1R,PTH2R ligands ADM,ADM2 OR3A1 OR5T2 Zn2+ GNG5 OR5A2 GNAS2 ARRBG-protein beta:gammasignallingOR5T3 OR52B2 OR2G6 OR2W6P OR1L3 OR52Z1 OR56A5 OR14L1P TSHB OR52W1 MC5R PTHLH REEPsOR10J6P TAAR5 OR51G2 VIP(125-152) OR4S1 GHRHR 5HT OR56A3 OR2M7 OR1F12 OR13F1 GNG4 OR52E2 CDCA OR2A7 OR4C13 OR52M1 MC2R OR1A2 OR6J1 GNAS1 OR5D13 CRHR1 PTH2(62-100) OR51A7 OR8U8 OR2Y1 LHCGR OR5B12 PEA OR10G2 OR2L13 GPHA2 OR1I1 OR1L6 GLP-1 (7-37) OR5W2 OR52E6 GPR39 GNAS1 OR5R1 OR12D2 ADRB2:Catecholamine:GRKAVPR2 GLP2R OR52L1 OR1I1 GNG2 ADCYAP1R1 OR10H1 CALCR OR6F1 OR2A5 ADRBK2 MC3R(1-360) OR51T1 OR2AJ1 OR4K13 OR12D2 G alpha (s):GDPPGD2 LCHA OR7D4 CYSLTR2 Adenylate cyclase(Mg2+ cofactor)OR4X2 OR4F15 OR52I1 OR2T35 NPS OR8H1 Zn2+ OR2M3 ADORA2A OR4C6 OR5L1 OR10A7 DCA OR6N1 RAMP2 OR51E2 OR1D5 OR14A16 OR2J2 PGE2 OR4D10 GNB2 OR10G8 GNB3 SCT NPSR1 OR4K15 OR6N2 CALCB(82-118) OR10AD1 OR2A7 OR1E3 GLP2R OR6K2 OR2AP1 OR2W5 OR52A5 OR6B3 OR7G1 OR6C6 G-protein beta-gammacomplexOR52J3 NPS GLP1R GRK6 OR11H2 PTH2(62-100) OR13F1 OR5K1 RLN2(162-185) OR6C75 ADR, NAd OR6K2 GPHB5 OR2AK2 OR4P4 FSHB VIPR2 OR5D18 RLN3(119-142) PiOR2T3 HTR7 OR4Q3 GHRH GNGT1 OR9I1 OR4D6 GHRHR OR10A2 GDP OR13H1 OR1L4 POMC(138-150) OR4D1 OR51I2 OR2M5 OR1J2 GCG(53-81) OR10T2 OR1F1 P2RY11 OR51B6 SCT OR6K6 OR2A2 OR10K1 INSL3(21-55) OR51G1 HTR4 OR2T10 OR1M1 NPSR1 OR5R1 GTP ADCY7 FSHR OR56A1 GNB1G-protein alpha(z):GTP:AdenylatecyclaseOR8U9 GNG12 GTP OR4C15 OR8K3 OR2M3 ARRB2 CRHR1, CRHR2 OR52A5 CDCA OR10X1 FSHB OR5AP2 OR2T2 OR2T6 DRD5 OR11H6 G alpha (s):GTPLHB OR4S2 OR10H4 POMC(138-176) OR1F2P OR11H7 OR10V1 923999


Description

The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase (Tesmer et al. 1997), which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. Another downstream effector of G alpha (s) is the protein tyrosine kinase c-Src (Ma et al. 2000). View original pathway at Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 418555
Reactome-version 
Reactome version: 74
Reactome Author 
Reactome Author: Jupe, Steve

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Bibliography

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History

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CompareRevisionActionTimeUserComment
116411view09:06, 7 May 2021EweitzModified title
113271view11:34, 2 November 2020ReactomeTeamReactome version 74
101710view14:50, 1 November 2018DeSlOntology Term : 'PW:0000230' removed !
101709view14:50, 1 November 2018DeSlOntology Term : 'G protein mediated signaling pathway via Galphas family' added !
101708view14:49, 1 November 2018DeSlOntology Term : 'G protein mediated signaling pathway via Galpha12/Galpha13 family' added !
101395view11:28, 1 November 2018ReactomeTeamreactome version 66
100933view21:04, 31 October 2018ReactomeTeamreactome version 65
100471view19:38, 31 October 2018ReactomeTeamreactome version 64
100276view16:57, 31 October 2018ReactomeTeamNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
5HT MetaboliteCHEBI:28790 (ChEBI)
ADCY1 ProteinQ08828 (Uniprot-TrEMBL)
ADCY2 ProteinQ08462 (Uniprot-TrEMBL)
ADCY3 ProteinO60266 (Uniprot-TrEMBL)
ADCY4 ProteinQ8NFM4 (Uniprot-TrEMBL)
ADCY5 ProteinO95622 (Uniprot-TrEMBL)
ADCY6 ProteinO43306 (Uniprot-TrEMBL)
ADCY7 ProteinP51828 (Uniprot-TrEMBL)
ADCY8 ProteinP40145 (Uniprot-TrEMBL)
ADCY9 ProteinO60503 (Uniprot-TrEMBL)
ADCYAP1 peptides R-HSA-420080 (Reactome)
ADCYAP1(132-158) ProteinP18509 (Uniprot-TrEMBL)
ADCYAP1(132-169) ProteinP18509 (Uniprot-TrEMBL)
ADCYAP1(82-129) ProteinP18509 (Uniprot-TrEMBL)
ADCYAP1R1 ProteinP41586 (Uniprot-TrEMBL)
ADM(95-146) ProteinP35318 (Uniprot-TrEMBL)
ADM,ADM2 R-HSA-420061 (Reactome)
ADM2(19-153) ProteinQ7Z4H4 (Uniprot-TrEMBL)
ADORA2A ProteinP29274 (Uniprot-TrEMBL)
ADORA2A,B R-HSA-418907 (Reactome)
ADORA2B ProteinP29275 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:456216 (ChEBI)
ADR MetaboliteCHEBI:28918 (ChEBI)
ADR, NAd R-ALL-390627 (Reactome)
ADRB1 ProteinP08588 (Uniprot-TrEMBL)
ADRB2 ProteinP07550 (Uniprot-TrEMBL)
ADRB2:ADR,NAdComplexR-HSA-8852028 (Reactome)
ADRB2:Catecholamine:GRKComplexR-HSA-8982633 (Reactome)
ADRB3 ProteinP13945 (Uniprot-TrEMBL)
ADRBK2 ProteinP35626 (Uniprot-TrEMBL)
AMPMetaboliteCHEBI:16027 (ChEBI)
AMY1-3 R-HSA-420237 (Reactome)
ARRB1 ProteinP49407 (Uniprot-TrEMBL)
ARRB2 ProteinP32121 (Uniprot-TrEMBL)
ARRBComplexR-HSA-1911410 (Reactome)
ATP MetaboliteCHEBI:30616 (ChEBI)
ATPMetaboliteCHEBI:30616 (ChEBI)
AVP(20-28) ProteinP01185 (Uniprot-TrEMBL)
AVPR2 ProteinP30518 (Uniprot-TrEMBL)
Ade-Rib MetaboliteCHEBI:16335 (ChEBI)
Adenylate cyclase (Mg2+ cofactor)ComplexR-HSA-170665 (Reactome)
Adrenomedullin receptor R-HSA-420118 (Reactome)
ArgN-GCG(98-127) ProteinP01275 (Uniprot-TrEMBL) The amide group at the C-terminus is not necessary for biological activity.
Bile acids R-ALL-444840 (Reactome)
CALCA(83-119) ProteinP01258 (Uniprot-TrEMBL)
CALCA(83-119) ProteinP06881 (Uniprot-TrEMBL)
CALCB(82-118) ProteinP10092 (Uniprot-TrEMBL)
CALCR ProteinP30988 (Uniprot-TrEMBL)
CALCRL ProteinQ16602 (Uniprot-TrEMBL)
CCA MetaboliteCHEBI:16359 (ChEBI)
CDCA MetaboliteCHEBI:16755 (ChEBI)
CGA ProteinP01215 (Uniprot-TrEMBL)
CGRP ligands R-HSA-419795 (Reactome)
CRH ProteinP06850 (Uniprot-TrEMBL)
CRHR1 ProteinP34998 (Uniprot-TrEMBL)
CRHR1, CRHR2 R-HSA-420140 (Reactome)
CRHR2 ProteinQ13324 (Uniprot-TrEMBL)
CYSLTR1,2 ProteinQ9NS75 (Uniprot-TrEMBL)
CYSLTR2 ProteinQ9NS75 (Uniprot-TrEMBL)
Constitutively active orphan GPCRs R-HSA-6805225 (Reactome)
DA MetaboliteCHEBI:18243 (ChEBI)
DCA MetaboliteCHEBI:28834 (ChEBI)
DRD1 ProteinP21728 (Uniprot-TrEMBL)
DRD1,5 R-HSA-390836 (Reactome)
DRD5 ProteinP21918 (Uniprot-TrEMBL)
FSHB ProteinP01225 (Uniprot-TrEMBL)
FSHR ProteinP23945 (Uniprot-TrEMBL)
G alpha

(s):GTP:Adenylate

cyclase
ComplexR-HSA-163622 (Reactome)
G alpha (s):GTP:p-Y416-SRCComplexR-HSA-8964279 (Reactome)
G alpha (s):GDPComplexR-HSA-164333 (Reactome)
G alpha (s):GTP:SRCComplexR-HSA-8964281 (Reactome)
G alpha (s):GTPComplexR-HSA-164358 (Reactome)
G-protein alpha

(i):GTP:Adenylate

cyclase
ComplexR-HSA-396910 (Reactome)
G-protein alpha

(z):GTP:Adenylate

cyclase
ComplexR-HSA-392049 (Reactome)
G-protein beta-gamma complexComplexR-HSA-167434 (Reactome)
G-protein beta:gamma signallingPathwayR-HSA-397795 (Reactome) The classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known that Gbeta/gamma subunits can directly modulate many effectors, including some also regulated by G alpha.
GCG(146-178) ProteinP01275 (Uniprot-TrEMBL)
GCG(53-81) ProteinP01275 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GHRH ProteinP01286 (Uniprot-TrEMBL)
GHRHR ProteinQ02643 (Uniprot-TrEMBL)
GIP(52-93) ProteinP09681 (Uniprot-TrEMBL)
GIPR ProteinP48546 (Uniprot-TrEMBL)
GLP-1 (7-37) ProteinP01275 (Uniprot-TrEMBL)
GLP1R ProteinP43220 (Uniprot-TrEMBL)
GLP2R ProteinO95838 (Uniprot-TrEMBL)
GNAI1 ProteinP63096 (Uniprot-TrEMBL)
GNAI2 ProteinP04899 (Uniprot-TrEMBL)
GNAI3 ProteinP08754 (Uniprot-TrEMBL)
GNAL ProteinP38405 (Uniprot-TrEMBL)
GNAL:GNB1:GNGT1ComplexR-HSA-380924 (Reactome) The heterotrimeric guanine nucleotide-binding proteins (G-proteins) function to transduce signals from this vast panoply of receptors to effector systems including ion channels and enzymes that alter the rate of production, release or degradation of intracellular second messengers. GPCRs activate the G-proteins, which consist of an alpha-subunit that binds and hydrolyses guanosine triphosphate (GTP), a beta and a gamma subunit.
GNALProteinP38405 (Uniprot-TrEMBL)
GNAS1 ProteinQ5JWF2 (Uniprot-TrEMBL)
GNAS2 ProteinP63092 (Uniprot-TrEMBL)
GNAT3 ProteinA8MTJ3 (Uniprot-TrEMBL)
GNAZ ProteinP19086 (Uniprot-TrEMBL)
GNB1 ProteinP62873 (Uniprot-TrEMBL)
GNB1ProteinP62873 (Uniprot-TrEMBL)
GNB2 ProteinP62879 (Uniprot-TrEMBL)
GNB3 ProteinP16520 (Uniprot-TrEMBL)
GNB4 ProteinQ9HAV0 (Uniprot-TrEMBL)
GNB5 ProteinO14775 (Uniprot-TrEMBL)
GNG10 ProteinP50151 (Uniprot-TrEMBL)
GNG11 ProteinP61952 (Uniprot-TrEMBL)
GNG12 ProteinQ9UBI6 (Uniprot-TrEMBL)
GNG13 ProteinQ9P2W3 (Uniprot-TrEMBL)
GNG2 ProteinP59768 (Uniprot-TrEMBL)
GNG3 ProteinP63215 (Uniprot-TrEMBL)
GNG4 ProteinP50150 (Uniprot-TrEMBL)
GNG5 ProteinP63218 (Uniprot-TrEMBL)
GNG7 ProteinO60262 (Uniprot-TrEMBL)
GNG8 ProteinQ9UK08 (Uniprot-TrEMBL)
GNGT1 ProteinP63211 (Uniprot-TrEMBL)
GNGT1ProteinP63211 (Uniprot-TrEMBL)
GNGT2 ProteinO14610 (Uniprot-TrEMBL)
GPBAR1 ProteinQ8TDU6 (Uniprot-TrEMBL)
GPCR:ligand

complexes that act on Gs:Heterotrimeric G-protein Gs

(active)
ComplexR-HSA-744890 (Reactome)
GPCRs that activate GsComplexR-HSA-790204 (Reactome)
GPHA2 ProteinQ96T91 (Uniprot-TrEMBL)
GPHB5 ProteinQ86YW7 (Uniprot-TrEMBL)
GPR39 ProteinO43194 (Uniprot-TrEMBL)
GRK2 ProteinP25098 (Uniprot-TrEMBL)
GRK2, GRK3, GRK5, GRK6ComplexR-HSA-8852026 (Reactome)
GRK5 ProteinP34947 (Uniprot-TrEMBL)
GRK6 ProteinP43250 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HRH2 ProteinP25021 (Uniprot-TrEMBL)
HTR4 ProteinQ13639 (Uniprot-TrEMBL)
HTR4,6,7 R-HSA-390942 (Reactome)
HTR6 ProteinP50406 (Uniprot-TrEMBL)
HTR7 ProteinP34969 (Uniprot-TrEMBL)
Heterotrimeric

G-protein Gs

(inactive)
ComplexR-HSA-391179 (Reactome)
Hist MetaboliteCHEBI:18295 (ChEBI)
IAPP(34-70) ProteinP10997 (Uniprot-TrEMBL)
INSL3(106-131) ProteinP51460 (Uniprot-TrEMBL)
INSL3(21-55) ProteinP51460 (Uniprot-TrEMBL)
LCHA MetaboliteCHEBI:16325 (ChEBI)
LHB ProteinP01229 (Uniprot-TrEMBL)
LHCGR ProteinP22888 (Uniprot-TrEMBL)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
ComplexR-HSA-744885 (Reactome)
Ligand:GPCR

complexes that

activate Gs
ComplexR-HSA-391181 (Reactome)
Ligands of GPCRs that activate GsComplexR-HSA-790205 (Reactome)
MC1R ProteinQ01726 (Uniprot-TrEMBL)
MC2R ProteinQ01718 (Uniprot-TrEMBL)
MC3R(1-360) ProteinP41968 (Uniprot-TrEMBL)
MC4R ProteinP32245 (Uniprot-TrEMBL)
MC5R ProteinP33032 (Uniprot-TrEMBL)
MSH R-HSA-388597 (Reactome)
Melanocortin receptors R-HSA-388601 (Reactome)
Mg2+ MetaboliteCHEBI:18420 (ChEBI)
NAd MetaboliteCHEBI:18357 (ChEBI)
NPS ProteinP0C0P6 (Uniprot-TrEMBL)
NPSR1 ProteinQ6W5P4 (Uniprot-TrEMBL)
OR10A2 ProteinQ9H208 (Uniprot-TrEMBL)
OR10A3 ProteinP58181 (Uniprot-TrEMBL)
OR10A4 ProteinQ9H209 (Uniprot-TrEMBL)
OR10A5 ProteinQ9H207 (Uniprot-TrEMBL)
OR10A6 ProteinQ8NH74 (Uniprot-TrEMBL)
OR10A7 ProteinQ8NGE5 (Uniprot-TrEMBL)
OR10AC1P ProteinQ8NH08 (Uniprot-TrEMBL)
OR10AD1 ProteinQ8NGE0 (Uniprot-TrEMBL)
OR10AG1 ProteinQ8NH19 (Uniprot-TrEMBL)
OR10C1 ProteinQ96KK4 (Uniprot-TrEMBL)
OR10D3 ProteinQ8NH80 (Uniprot-TrEMBL)
OR10D4P ProteinQ8NGN7 (Uniprot-TrEMBL)
OR10G2 ProteinQ8NGC3 (Uniprot-TrEMBL)
OR10G3 ProteinQ8NGC4 (Uniprot-TrEMBL)
OR10G4 ProteinQ8NGN3 (Uniprot-TrEMBL)
OR10G6 ProteinQ8NH81 (Uniprot-TrEMBL)
OR10G7 ProteinQ8NGN6 (Uniprot-TrEMBL)
OR10G8 ProteinQ8NGN5 (Uniprot-TrEMBL)
OR10G9 ProteinQ8NGN4 (Uniprot-TrEMBL)
OR10H1 ProteinQ9Y4A9 (Uniprot-TrEMBL)
OR10H2 ProteinO60403 (Uniprot-TrEMBL)
OR10H3 ProteinO60404 (Uniprot-TrEMBL)
OR10H4 ProteinQ8NGA5 (Uniprot-TrEMBL)
OR10H5 ProteinQ8NGA6 (Uniprot-TrEMBL)
OR10J1 ProteinP30954 (Uniprot-TrEMBL)
OR10J3 ProteinQ5JRS4 (Uniprot-TrEMBL)
OR10J4 ProteinP0C629 (Uniprot-TrEMBL)
OR10J5 ProteinQ8NHC4 (Uniprot-TrEMBL)
OR10J6P ProteinQ8NGY7 (Uniprot-TrEMBL)
OR10K1 ProteinQ8NGX5 (Uniprot-TrEMBL)
OR10K2 ProteinQ6IF99 (Uniprot-TrEMBL)
OR10P1 ProteinQ8NGE3 (Uniprot-TrEMBL)
OR10Q1 ProteinQ8NGQ4 (Uniprot-TrEMBL)
OR10R2 ProteinQ8NGX6 (Uniprot-TrEMBL)
OR10S1 ProteinQ8NGN2 (Uniprot-TrEMBL)
OR10T2 ProteinQ8NGX3 (Uniprot-TrEMBL)
OR10V1 ProteinQ8NGI7 (Uniprot-TrEMBL)
OR10W1 ProteinQ8NGF6 (Uniprot-TrEMBL)
OR10X1 ProteinQ8NGY0 (Uniprot-TrEMBL)
OR10Z1 ProteinQ8NGY1 (Uniprot-TrEMBL)
OR11A1 ProteinQ9GZK7 (Uniprot-TrEMBL)
OR11G2 ProteinQ8NGC1 (Uniprot-TrEMBL)
OR11H1 ProteinQ8NG94 (Uniprot-TrEMBL)
OR11H2 ProteinQ8NH07 (Uniprot-TrEMBL)
OR11H4 ProteinQ8NGC9 (Uniprot-TrEMBL)
OR11H6 ProteinQ8NGC7 (Uniprot-TrEMBL)
OR11H7 ProteinQ8NGC8 (Uniprot-TrEMBL)
OR11L1 ProteinQ8NGX0 (Uniprot-TrEMBL)
OR12D2 ProteinP58182 (Uniprot-TrEMBL)
OR12D3 ProteinQ9UGF7 (Uniprot-TrEMBL)
OR13A1 ProteinQ8NGR1 (Uniprot-TrEMBL)
OR13C2 ProteinQ8NGS9 (Uniprot-TrEMBL)
OR13C3 ProteinQ8NGS6 (Uniprot-TrEMBL)
OR13C4 ProteinQ8NGS5 (Uniprot-TrEMBL)
OR13C5 ProteinQ8NGS8 (Uniprot-TrEMBL)
OR13C8 ProteinQ8NGS7 (Uniprot-TrEMBL)
OR13C9 ProteinQ8NGT0 (Uniprot-TrEMBL)
OR13D1 ProteinQ8NGV5 (Uniprot-TrEMBL)
OR13F1 ProteinQ8NGS4 (Uniprot-TrEMBL)
OR13G1 ProteinQ8NGZ3 (Uniprot-TrEMBL)
OR13H1 ProteinQ8NG92 (Uniprot-TrEMBL)
OR13J1 ProteinQ8NGT2 (Uniprot-TrEMBL)
OR14A16 ProteinQ8NHC5 (Uniprot-TrEMBL)
OR14A2 ProteinQ96R54 (Uniprot-TrEMBL)
OR14C36 ProteinQ8NHC7 (Uniprot-TrEMBL)
OR14I1 ProteinA6ND48 (Uniprot-TrEMBL)
OR14J1 ProteinQ9UGF5 (Uniprot-TrEMBL)
OR14K1 ProteinQ8NGZ2 (Uniprot-TrEMBL)
OR14L1P ProteinQ8NHC6 (Uniprot-TrEMBL)
OR1A1 ProteinQ9P1Q5 (Uniprot-TrEMBL)
OR1A2 ProteinQ9Y585 (Uniprot-TrEMBL)
OR1B1 ProteinQ8NGR6 (Uniprot-TrEMBL)
OR1C1 ProteinQ15619 (Uniprot-TrEMBL)
OR1D2 ProteinP34982 (Uniprot-TrEMBL)
OR1D4 ProteinP47884 (Uniprot-TrEMBL)
OR1D5 ProteinP58170 (Uniprot-TrEMBL)
OR1E1 ProteinP30953 (Uniprot-TrEMBL)
OR1E2 ProteinP47887 (Uniprot-TrEMBL)
OR1E3 ProteinQ8WZA6 (Uniprot-TrEMBL)
OR1F1 ProteinO43749 (Uniprot-TrEMBL)
OR1F12 ProteinQ8NHA8 (Uniprot-TrEMBL)
OR1F2P ProteinQ96R84 (Uniprot-TrEMBL)
OR1G1 ProteinP47890 (Uniprot-TrEMBL)
OR1I1 ProteinO60431 (Uniprot-TrEMBL)
OR1J1 ProteinQ8NGS3 (Uniprot-TrEMBL)
OR1J2 ProteinQ8NGS2 (Uniprot-TrEMBL)
OR1J4 ProteinQ8NGS1 (Uniprot-TrEMBL)
OR1K1 ProteinQ8NGR3 (Uniprot-TrEMBL)
OR1L1 ProteinQ8NH94 (Uniprot-TrEMBL)
OR1L3 ProteinQ8NH93 (Uniprot-TrEMBL)
OR1L4 ProteinQ8NGR5 (Uniprot-TrEMBL)
OR1L6 ProteinQ8NGR2 (Uniprot-TrEMBL)
OR1L8 ProteinQ8NGR8 (Uniprot-TrEMBL)
OR1M1 ProteinQ8NGA1 (Uniprot-TrEMBL)
OR1N1 ProteinQ8NGS0 (Uniprot-TrEMBL)
OR1N2 ProteinQ8NGR9 (Uniprot-TrEMBL)
OR1P1 ProteinQ8NH06 (Uniprot-TrEMBL)
OR1Q1 ProteinQ15612 (Uniprot-TrEMBL)
OR1S1 ProteinQ8NH92 (Uniprot-TrEMBL)
OR1S2 ProteinQ8NGQ3 (Uniprot-TrEMBL)
OR2A1 ProteinQ8NGT9 (Uniprot-TrEMBL)
OR2A12 ProteinQ8NGT7 (Uniprot-TrEMBL)
OR2A14 ProteinQ96R47 (Uniprot-TrEMBL)
OR2A2 ProteinQ6IF42 (Uniprot-TrEMBL)
OR2A25 ProteinA4D2G3 (Uniprot-TrEMBL)
OR2A4 ProteinO95047 (Uniprot-TrEMBL)
OR2A5 ProteinQ96R48 (Uniprot-TrEMBL)
OR2A7 ProteinQ96R45 (Uniprot-TrEMBL)
OR2AE1 ProteinQ8NHA4 (Uniprot-TrEMBL)
OR2AG1 ProteinQ9H205 (Uniprot-TrEMBL)
OR2AG2 ProteinA6NM03 (Uniprot-TrEMBL)
OR2AJ1 ProteinQ8NGZ0 (Uniprot-TrEMBL)
OR2AK2 ProteinQ8NG84 (Uniprot-TrEMBL)
OR2AP1 ProteinQ8NGE2 (Uniprot-TrEMBL)
OR2AT4 ProteinA6NND4 (Uniprot-TrEMBL)
OR2B11 ProteinQ5JQS5 (Uniprot-TrEMBL)
OR2B2 ProteinQ9GZK3 (Uniprot-TrEMBL)
OR2B3 ProteinO76000 (Uniprot-TrEMBL)
OR2B6 ProteinP58173 (Uniprot-TrEMBL)
OR2B8P ProteinP59922 (Uniprot-TrEMBL)
OR2C1 ProteinO95371 (Uniprot-TrEMBL)
OR2C3 ProteinQ8N628 (Uniprot-TrEMBL)
OR2D2 ProteinQ9H210 (Uniprot-TrEMBL)
OR2D3 ProteinQ8NGH3 (Uniprot-TrEMBL)
OR2F1 ProteinQ13607 (Uniprot-TrEMBL)
OR2F2 ProteinO95006 (Uniprot-TrEMBL)
OR2G2 ProteinQ8NGZ5 (Uniprot-TrEMBL)
OR2G3 ProteinQ8NGZ4 (Uniprot-TrEMBL)
OR2G6 ProteinQ5TZ20 (Uniprot-TrEMBL)
OR2H1 ProteinQ9GZK4 (Uniprot-TrEMBL)
OR2H2 ProteinO95918 (Uniprot-TrEMBL)
OR2I1P ProteinQ8NGU4 (Uniprot-TrEMBL)
OR2J1 ProteinQ9GZK6 (Uniprot-TrEMBL)
OR2J2 ProteinO76002 (Uniprot-TrEMBL)
OR2J3 ProteinO76001 (Uniprot-TrEMBL)
OR2K2 ProteinQ8NGT1 (Uniprot-TrEMBL)
OR2L13 ProteinQ8N349 (Uniprot-TrEMBL)
OR2L2 ProteinQ8NH16 (Uniprot-TrEMBL)
OR2L3 ProteinQ8NG85 (Uniprot-TrEMBL)
OR2L5 ProteinQ8NG80 (Uniprot-TrEMBL)
OR2L8 ProteinQ8NGY9 (Uniprot-TrEMBL)
OR2M2 ProteinQ96R28 (Uniprot-TrEMBL)
OR2M3 ProteinQ8NG83 (Uniprot-TrEMBL)
OR2M4 ProteinQ96R27 (Uniprot-TrEMBL)
OR2M5 ProteinA3KFT3 (Uniprot-TrEMBL)
OR2M7 ProteinQ8NG81 (Uniprot-TrEMBL)
OR2S2 ProteinQ9NQN1 (Uniprot-TrEMBL)
OR2T1 ProteinO43869 (Uniprot-TrEMBL)
OR2T10 ProteinQ8NGZ9 (Uniprot-TrEMBL)
OR2T11 ProteinQ8NH01 (Uniprot-TrEMBL)
OR2T12 ProteinQ8NG77 (Uniprot-TrEMBL)
OR2T2 ProteinQ6IF00 (Uniprot-TrEMBL)
OR2T27 ProteinQ8NH04 (Uniprot-TrEMBL)
OR2T29 ProteinQ8NH02 (Uniprot-TrEMBL)
OR2T3 ProteinQ8NH03 (Uniprot-TrEMBL)
OR2T33 ProteinQ8NG76 (Uniprot-TrEMBL)
OR2T34 ProteinQ8NGX1 (Uniprot-TrEMBL)
OR2T35 ProteinQ8NGX2 (Uniprot-TrEMBL)
OR2T4 ProteinQ8NH00 (Uniprot-TrEMBL)
OR2T5 ProteinQ6IEZ7 (Uniprot-TrEMBL)
OR2T6 ProteinQ8NHC8 (Uniprot-TrEMBL)
OR2T7 ProteinP0C7T2 (Uniprot-TrEMBL)
OR2T8 ProteinA6NH00 (Uniprot-TrEMBL)
OR2V1 ProteinQ8NHB1 (Uniprot-TrEMBL)
OR2V2 ProteinQ96R30 (Uniprot-TrEMBL)
OR2W1 ProteinQ9Y3N9 (Uniprot-TrEMBL)
OR2W3 ProteinQ7Z3T1 (Uniprot-TrEMBL)
OR2W5 ProteinA6NFC9 (Uniprot-TrEMBL)
OR2W6P ProteinQ8NHA6 (Uniprot-TrEMBL)
OR2Y1 ProteinQ8NGV0 (Uniprot-TrEMBL)
OR2Z1 ProteinQ8NG97 (Uniprot-TrEMBL)
OR3A1 ProteinP47881 (Uniprot-TrEMBL)
OR3A2 ProteinP47893 (Uniprot-TrEMBL)
OR3A3 ProteinP47888 (Uniprot-TrEMBL)
OR3A4P ProteinP47883 (Uniprot-TrEMBL)
OR4A15 ProteinQ8NGL6 (Uniprot-TrEMBL)
OR4A16 ProteinQ8NH70 (Uniprot-TrEMBL)
OR4A47 ProteinQ6IF82 (Uniprot-TrEMBL)
OR4A4P ProteinQ8NGN8 (Uniprot-TrEMBL)
OR4A5 ProteinQ8NH83 (Uniprot-TrEMBL)
OR4A8P ProteinP0C604 (Uniprot-TrEMBL)
OR4B1 ProteinQ8NGF8 (Uniprot-TrEMBL)
OR4C11 ProteinQ6IEV9 (Uniprot-TrEMBL)
OR4C12 ProteinQ96R67 (Uniprot-TrEMBL)
OR4C13 ProteinQ8NGP0 (Uniprot-TrEMBL)
OR4C15 ProteinQ8NGM1 (Uniprot-TrEMBL)
OR4C16 ProteinQ8NGL9 (Uniprot-TrEMBL)
OR4C3 ProteinQ8NH37 (Uniprot-TrEMBL)
OR4C45 ProteinA6NMZ5 (Uniprot-TrEMBL)
OR4C46 ProteinA6NHA9 (Uniprot-TrEMBL)
OR4C5 ProteinQ8NGB2 (Uniprot-TrEMBL)
OR4C6 ProteinQ8NH72 (Uniprot-TrEMBL)
OR4D1 ProteinQ15615 (Uniprot-TrEMBL)
OR4D10 ProteinQ8NGI6 (Uniprot-TrEMBL)
OR4D11 ProteinQ8NGI4 (Uniprot-TrEMBL)
OR4D2 ProteinP58180 (Uniprot-TrEMBL)
OR4D5 ProteinQ8NGN0 (Uniprot-TrEMBL)
OR4D6 ProteinQ8NGJ1 (Uniprot-TrEMBL)
OR4D9 ProteinQ8NGE8 (Uniprot-TrEMBL)
OR4E1 ProteinP0C645 (Uniprot-TrEMBL)
OR4E2 ProteinQ8NGC2 (Uniprot-TrEMBL)
OR4F15 ProteinQ8NGB8 (Uniprot-TrEMBL)
OR4F17 ProteinQ8NGA8 (Uniprot-TrEMBL)
OR4F21 ProteinO95013 (Uniprot-TrEMBL)
OR4F3 ProteinQ6IEY1 (Uniprot-TrEMBL)
OR4F4 ProteinQ96R69 (Uniprot-TrEMBL)
OR4F5 ProteinQ8NH21 (Uniprot-TrEMBL)
OR4F6 ProteinQ8NGB9 (Uniprot-TrEMBL)
OR4K1 ProteinQ8NGD4 (Uniprot-TrEMBL)
OR4K13 ProteinQ8NH42 (Uniprot-TrEMBL)
OR4K14 ProteinQ8NGD5 (Uniprot-TrEMBL)
OR4K15 ProteinQ8NH41 (Uniprot-TrEMBL)
OR4K17 ProteinQ8NGC6 (Uniprot-TrEMBL)
OR4K2 ProteinQ8NGD2 (Uniprot-TrEMBL)
OR4K3 ProteinQ96R72 (Uniprot-TrEMBL)
OR4K5 ProteinQ8NGD3 (Uniprot-TrEMBL)
OR4L1 ProteinQ8NH43 (Uniprot-TrEMBL)
OR4M1 ProteinQ8NGD0 (Uniprot-TrEMBL)
OR4M2 ProteinQ8NGB6 (Uniprot-TrEMBL)
OR4N2 ProteinQ8NGD1 (Uniprot-TrEMBL)
OR4N4 ProteinQ8N0Y3 (Uniprot-TrEMBL)
OR4N5 ProteinQ8IXE1 (Uniprot-TrEMBL)
OR4P4 ProteinQ8NGL7 (Uniprot-TrEMBL)
OR4Q2 ProteinP0C623 (Uniprot-TrEMBL)
OR4Q3 ProteinQ8NH05 (Uniprot-TrEMBL)
OR4S1 ProteinQ8NGB4 (Uniprot-TrEMBL)
OR4S2 ProteinQ8NH73 (Uniprot-TrEMBL)
OR4X1 ProteinQ8NH49 (Uniprot-TrEMBL)
OR4X2 ProteinQ8NGF9 (Uniprot-TrEMBL)
OR51A2 ProteinQ8NGJ7 (Uniprot-TrEMBL)
OR51A4 ProteinQ8NGJ6 (Uniprot-TrEMBL)
OR51A7 ProteinQ8NH64 (Uniprot-TrEMBL)
OR51B2 ProteinQ9Y5P1 (Uniprot-TrEMBL)
OR51B4 ProteinQ9Y5P0 (Uniprot-TrEMBL)
OR51B5 ProteinQ9H339 (Uniprot-TrEMBL)
OR51B6 ProteinQ9H340 (Uniprot-TrEMBL)
OR51D1 ProteinQ8NGF3 (Uniprot-TrEMBL)
OR51E1 ProteinQ8TCB6 (Uniprot-TrEMBL)
OR51E2 ProteinQ9H255 (Uniprot-TrEMBL)
OR51F1 ProteinA6NGY5 (Uniprot-TrEMBL)
OR51F2 ProteinQ8NH61 (Uniprot-TrEMBL)
OR51G1 ProteinQ8NGK1 (Uniprot-TrEMBL)
OR51G2 ProteinQ8NGK0 (Uniprot-TrEMBL)
OR51H1P ProteinQ8NH63 (Uniprot-TrEMBL)
OR51I1 ProteinQ9H343 (Uniprot-TrEMBL)
OR51I2 ProteinQ9H344 (Uniprot-TrEMBL)
OR51J1 ProteinQ9H342 (Uniprot-TrEMBL)
OR51L1 ProteinQ8NGJ5 (Uniprot-TrEMBL)
OR51M1 ProteinQ9H341 (Uniprot-TrEMBL)
OR51Q1 ProteinQ8NH59 (Uniprot-TrEMBL)
OR51S1 ProteinQ8NGJ8 (Uniprot-TrEMBL)
OR51T1 ProteinQ8NGJ9 (Uniprot-TrEMBL)
OR51V1 ProteinQ9H2C8 (Uniprot-TrEMBL)
OR52A1 ProteinQ9UKL2 (Uniprot-TrEMBL)
OR52A4 ProteinA6NMU1 (Uniprot-TrEMBL)
OR52A5 ProteinQ9H2C5 (Uniprot-TrEMBL)
OR52B2 ProteinQ96RD2 (Uniprot-TrEMBL)
OR52B6 ProteinQ8NGF0 (Uniprot-TrEMBL)
OR52D1 ProteinQ9H346 (Uniprot-TrEMBL)
OR52E1 ProteinQ8NGJ3 (Uniprot-TrEMBL)
OR52E2 ProteinQ8NGJ4 (Uniprot-TrEMBL)
OR52E4 ProteinQ8NGH9 (Uniprot-TrEMBL)
OR52E5 ProteinQ8NH55 (Uniprot-TrEMBL)
OR52E6 ProteinQ96RD3 (Uniprot-TrEMBL)
OR52E8 ProteinQ6IFG1 (Uniprot-TrEMBL)
OR52H1 ProteinQ8NGJ2 (Uniprot-TrEMBL)
OR52I1 ProteinQ8NGK6 (Uniprot-TrEMBL)
OR52I2 ProteinQ8NH67 (Uniprot-TrEMBL)
OR52J3 ProteinQ8NH60 (Uniprot-TrEMBL)
OR52K1 ProteinQ8NGK4 (Uniprot-TrEMBL)
OR52K2 ProteinQ8NGK3 (Uniprot-TrEMBL)
OR52L1 ProteinQ8NGH7 (Uniprot-TrEMBL)
OR52L2P ProteinQ8NGH6 (Uniprot-TrEMBL)
OR52M1 ProteinQ8NGK5 (Uniprot-TrEMBL)
OR52N1 ProteinQ8NH53 (Uniprot-TrEMBL)
OR52N2 ProteinQ8NGI0 (Uniprot-TrEMBL)
OR52N4 ProteinQ8NGI2 (Uniprot-TrEMBL)
OR52N5 ProteinQ8NH56 (Uniprot-TrEMBL)
OR52P1P ProteinQ8NH57 (Uniprot-TrEMBL)
OR52R1 ProteinQ8NGF1 (Uniprot-TrEMBL)
OR52W1 ProteinQ6IF63 (Uniprot-TrEMBL)
OR52Z1 ProteinP0C646 (Uniprot-TrEMBL)
OR56A1 ProteinQ8NGH5 (Uniprot-TrEMBL)
OR56A3 ProteinQ8NH54 (Uniprot-TrEMBL)
OR56A4 ProteinQ8NGH8 (Uniprot-TrEMBL)
OR56A5 ProteinP0C7T3 (Uniprot-TrEMBL)
OR56B1 ProteinQ8NGI3 (Uniprot-TrEMBL)
OR56B2P ProteinQ8NGI1 (Uniprot-TrEMBL)
OR56B4 ProteinQ8NH76 (Uniprot-TrEMBL)
OR5A1 ProteinQ8NGJ0 (Uniprot-TrEMBL)
OR5A2 ProteinQ8NGI9 (Uniprot-TrEMBL)
OR5AC1 ProteinP0C628 (Uniprot-TrEMBL)
OR5AC2 ProteinQ9NZP5 (Uniprot-TrEMBL)
OR5AK2 ProteinQ8NH90 (Uniprot-TrEMBL)
OR5AK3P ProteinQ8NH89 (Uniprot-TrEMBL)
OR5AL1 ProteinP0C617 (Uniprot-TrEMBL)
OR5AN1 ProteinQ8NGI8 (Uniprot-TrEMBL)
OR5AP2 ProteinQ8NGF4 (Uniprot-TrEMBL)
OR5AR1 ProteinQ8NGP9 (Uniprot-TrEMBL)
OR5AS1 ProteinQ8N127 (Uniprot-TrEMBL)
OR5AU1 ProteinQ8NGC0 (Uniprot-TrEMBL)
OR5B12 ProteinQ96R08 (Uniprot-TrEMBL)
OR5B17 ProteinQ8NGF7 (Uniprot-TrEMBL)
OR5B2 ProteinQ96R09 (Uniprot-TrEMBL)
OR5B21 ProteinA6NL26 (Uniprot-TrEMBL)
OR5B3 ProteinQ8NH48 (Uniprot-TrEMBL)
OR5C1 ProteinQ8NGR4 (Uniprot-TrEMBL)
OR5D13 ProteinQ8NGL4 (Uniprot-TrEMBL)
OR5D14 ProteinQ8NGL3 (Uniprot-TrEMBL)
OR5D16 ProteinQ8NGK9 (Uniprot-TrEMBL)
OR5D18 ProteinQ8NGL1 (Uniprot-TrEMBL)
OR5F1 ProteinO95221 (Uniprot-TrEMBL)
OR5G3 ProteinP0C626 (Uniprot-TrEMBL)
OR5H1 ProteinA6NKK0 (Uniprot-TrEMBL)
OR5H14 ProteinA6NHG9 (Uniprot-TrEMBL)
OR5H15 ProteinA6NDH6 (Uniprot-TrEMBL)
OR5H2 ProteinQ8NGV7 (Uniprot-TrEMBL)
OR5H6 ProteinQ8NGV6 (Uniprot-TrEMBL)
OR5I1 ProteinQ13606 (Uniprot-TrEMBL)
OR5J2 ProteinQ8NH18 (Uniprot-TrEMBL)
OR5K1 ProteinQ8NHB7 (Uniprot-TrEMBL)
OR5K2 ProteinQ8NHB8 (Uniprot-TrEMBL)
OR5K3 ProteinA6NET4 (Uniprot-TrEMBL)
OR5K4 ProteinA6NMS3 (Uniprot-TrEMBL)
OR5L1 ProteinQ8NGL2 (Uniprot-TrEMBL)
OR5L2 ProteinQ8NGL0 (Uniprot-TrEMBL)
OR5M1 ProteinQ8NGP8 (Uniprot-TrEMBL)
OR5M10 ProteinQ6IEU7 (Uniprot-TrEMBL)
OR5M11 ProteinQ96RB7 (Uniprot-TrEMBL)
OR5M3 ProteinQ8NGP4 (Uniprot-TrEMBL)
OR5M8 ProteinQ8NGP6 (Uniprot-TrEMBL)
OR5M9 ProteinQ8NGP3 (Uniprot-TrEMBL)
OR5P2 ProteinQ8WZ92 (Uniprot-TrEMBL)
OR5P3 ProteinQ8WZ94 (Uniprot-TrEMBL)
OR5R1 ProteinQ8NH85 (Uniprot-TrEMBL)
OR5T1 ProteinQ8NG75 (Uniprot-TrEMBL)
OR5T2 ProteinQ8NGG2 (Uniprot-TrEMBL)
OR5T3 ProteinQ8NGG3 (Uniprot-TrEMBL)
OR5V1 ProteinQ9UGF6 (Uniprot-TrEMBL)
OR5W2 ProteinQ8NH69 (Uniprot-TrEMBL)
OR6A2 ProteinO95222 (Uniprot-TrEMBL)
OR6B1 ProteinO95007 (Uniprot-TrEMBL)
OR6B2 ProteinQ6IFH4 (Uniprot-TrEMBL)
OR6B3 ProteinQ8NGW1 (Uniprot-TrEMBL)
OR6C1 ProteinQ96RD1 (Uniprot-TrEMBL)
OR6C2 ProteinQ9NZP2 (Uniprot-TrEMBL)
OR6C3 ProteinQ9NZP0 (Uniprot-TrEMBL)
OR6C4 ProteinQ8NGE1 (Uniprot-TrEMBL)
OR6C6 ProteinA6NF89 (Uniprot-TrEMBL)
OR6C65 ProteinA6NJZ3 (Uniprot-TrEMBL)
OR6C68 ProteinA6NDL8 (Uniprot-TrEMBL)
OR6C70 ProteinA6NIJ9 (Uniprot-TrEMBL)
OR6C74 ProteinA6NCV1 (Uniprot-TrEMBL)
OR6C75 ProteinA6NL08 (Uniprot-TrEMBL)
OR6C76 ProteinA6NM76 (Uniprot-TrEMBL)
OR6F1 ProteinQ8NGZ6 (Uniprot-TrEMBL)
OR6J1 ProteinQ8NGC5 (Uniprot-TrEMBL)
OR6K2 ProteinQ8NGY2 (Uniprot-TrEMBL)
OR6K3 ProteinQ8NGY3 (Uniprot-TrEMBL)
OR6K6 ProteinQ8NGW6 (Uniprot-TrEMBL)
OR6M1 ProteinQ8NGM8 (Uniprot-TrEMBL)
OR6N1 ProteinQ8NGY5 (Uniprot-TrEMBL)
OR6N2 ProteinQ8NGY6 (Uniprot-TrEMBL)
OR6P1 ProteinQ8NGX9 (Uniprot-TrEMBL)
OR6Q1 ProteinQ8NGQ2 (Uniprot-TrEMBL)
OR6S1 ProteinQ8NH40 (Uniprot-TrEMBL)
OR6T1 ProteinQ8NGN1 (Uniprot-TrEMBL)
OR6V1 ProteinQ8N148 (Uniprot-TrEMBL)
OR6X1 ProteinQ8NH79 (Uniprot-TrEMBL)
OR6Y1 ProteinQ8NGX8 (Uniprot-TrEMBL)
OR7A10 ProteinO76100 (Uniprot-TrEMBL)
OR7A17 ProteinO14581 (Uniprot-TrEMBL)
OR7A2P ProteinQ8NGA2 (Uniprot-TrEMBL)
OR7A5 ProteinQ15622 (Uniprot-TrEMBL)
OR7C1 ProteinO76099 (Uniprot-TrEMBL)
OR7C2 ProteinO60412 (Uniprot-TrEMBL)
OR7D2 ProteinQ96RA2 (Uniprot-TrEMBL)
OR7D4 ProteinQ8NG98 (Uniprot-TrEMBL)
OR7E24 ProteinQ6IFN5 (Uniprot-TrEMBL)
OR7G1 ProteinQ8NGA0 (Uniprot-TrEMBL)
OR7G2 ProteinQ8NG99 (Uniprot-TrEMBL)
OR7G3 ProteinQ8NG95 (Uniprot-TrEMBL)
OR8A1 ProteinQ8NGG7 (Uniprot-TrEMBL)
OR8B12 ProteinQ8NGG6 (Uniprot-TrEMBL)
OR8B2 ProteinQ96RD0 (Uniprot-TrEMBL)
OR8B3 ProteinQ8NGG8 (Uniprot-TrEMBL)
OR8B4 ProteinQ96RC9 (Uniprot-TrEMBL)
OR8B8 ProteinQ15620 (Uniprot-TrEMBL)
OR8D1 ProteinQ8WZ84 (Uniprot-TrEMBL)
OR8D2 ProteinQ9GZM6 (Uniprot-TrEMBL)
OR8D4 ProteinQ8NGM9 (Uniprot-TrEMBL)
OR8G1 ProteinQ15617 (Uniprot-TrEMBL)
OR8G2 ProteinQ6IF36 (Uniprot-TrEMBL)
OR8G5 ProteinQ8NG78 (Uniprot-TrEMBL)
OR8H1 ProteinQ8NGG4 (Uniprot-TrEMBL)
OR8H2 ProteinQ8N162 (Uniprot-TrEMBL)
OR8H3 ProteinQ8N146 (Uniprot-TrEMBL)
OR8I2 ProteinQ8N0Y5 (Uniprot-TrEMBL)
OR8J1 ProteinQ8NGP2 (Uniprot-TrEMBL)
OR8J2 ProteinQ8NGG1 (Uniprot-TrEMBL)
OR8J3 ProteinQ8NGG0 (Uniprot-TrEMBL)
OR8K1 ProteinQ8NGG5 (Uniprot-TrEMBL)
OR8K3 ProteinQ8NH51 (Uniprot-TrEMBL)
OR8K5 ProteinQ8NH50 (Uniprot-TrEMBL)
OR8S1 ProteinQ8NH09 (Uniprot-TrEMBL)
OR8U1 ProteinQ8NH10 (Uniprot-TrEMBL)
OR8U8 ProteinP0C7N1 (Uniprot-TrEMBL)
OR8U9 ProteinP0C7N5 (Uniprot-TrEMBL)
OR9A1P ProteinQ8NGU1 (Uniprot-TrEMBL)
OR9A2 ProteinQ8NGT5 (Uniprot-TrEMBL)
OR9A4 ProteinQ8NGU2 (Uniprot-TrEMBL)
OR9G1 ProteinQ8NH87 (Uniprot-TrEMBL)
OR9G4 ProteinQ8NGQ1 (Uniprot-TrEMBL)
OR9G9 ProteinP0C7N8 (Uniprot-TrEMBL)
OR9I1 ProteinQ8NGQ6 (Uniprot-TrEMBL)
OR9K2 ProteinQ8NGE7 (Uniprot-TrEMBL)
OR9Q1 ProteinQ8NGQ5 (Uniprot-TrEMBL)
OR9Q2 ProteinQ8NGE9 (Uniprot-TrEMBL)
Olfactory receptor:G protein trimerComplexR-HSA-381747 (Reactome) Olfactory receptors (ORs) have diverse protein sequences but can be assigned to subfamilies on the basis of sequence relationships. Odorants and pheromones bind to these seven transmembrane domain G-protein-coupled receptors that permit signal transduction. These receptors are encoded by large multigene families that evolved in mammal species in function of specific olfactory needs. Members of the same subfamily have related sequences and are likely to recognize structurally related odorants.
Of the 960 human OR genes and pseudogenes, there is experimental evidence which indicates that at least 437 actually are expressed in human olfactory epithelium; this includes 357 OR genes, and 80 OR pseudogenes (Zhang, 2007). These 357 olfactory-expressed OR genes are therefore expected to be functional in the Olfactory Signaling Pathway, and to interact directly with human G alpha olf in human olfactory cells.

(Note: A subset of 200 of these 357 OR genes are shown as components of OR-G Protein reaction. The others will be added to Reactome later.)

Olfactory receptorsComplexR-HSA-381741 (Reactome)
P2RY11 ProteinQ96G91 (Uniprot-TrEMBL)
PDE3 inhibitors:PDE3A,3BComplexR-HSA-9629676 (Reactome)
PDE3A ProteinQ14432 (Uniprot-TrEMBL) Can hydrolyze both cAMP and cGMP
PDE3A,3BComplexR-HSA-9629669 (Reactome)
PDE3B ProteinQ13370 (Uniprot-TrEMBL) Can hydrolyze both cAMP and cGMP
PEA MetaboliteCHEBI:18397 (ChEBI)
PGD2 MetaboliteCHEBI:15555 (ChEBI)
PGE2 MetaboliteCHEBI:15551 (ChEBI)
PGI2 MetaboliteCHEBI:15552 (ChEBI)
POMC(138-150) ProteinP01189 (Uniprot-TrEMBL)
POMC(138-176) ProteinP01189 (Uniprot-TrEMBL)
POMC(217-234) ProteinP01189 (Uniprot-TrEMBL)
POMC(77-87) ProteinP01189 (Uniprot-TrEMBL)
PPiMetaboliteCHEBI:29888 (ChEBI)
PTGDR ProteinQ13258 (Uniprot-TrEMBL)
PTGER2 ProteinP43116 (Uniprot-TrEMBL)
PTGER2,PTGER4 R-HSA-391921 (Reactome)
PTGER4 ProteinP35408 (Uniprot-TrEMBL)
PTGIR ProteinP43119 (Uniprot-TrEMBL)
PTH ProteinP01270 (Uniprot-TrEMBL)
PTH1R ProteinQ03431 (Uniprot-TrEMBL)
PTH1R,PTH2R R-HSA-420554 (Reactome)
PTH1R,PTH2R ligands R-HSA-420569 (Reactome)
PTH2(62-100) ProteinQ96A98 (Uniprot-TrEMBL)
PTH2R ProteinP49190 (Uniprot-TrEMBL)
PTHLH ProteinP12272 (Uniprot-TrEMBL)
Phosphodiesterases, cyclic AMP-selective R-HSA-418543 (Reactome)
Phosphodiesterases, dual (cAMP, cGMP) activity R-HSA-418547 (Reactome)
PiMetaboliteCHEBI:43474 (ChEBI)
RAMP1 ProteinO60894 (Uniprot-TrEMBL)
RAMP2 ProteinO60895 (Uniprot-TrEMBL)
RAMP3 ProteinO60896 (Uniprot-TrEMBL)
REEP1 ProteinQ9H902 (Uniprot-TrEMBL)
REEP2 ProteinQ9BRK0 (Uniprot-TrEMBL)
REEP3 ProteinQ6NUK4 (Uniprot-TrEMBL)
REEP4 ProteinQ9H6H4 (Uniprot-TrEMBL)
REEP5 ProteinQ00765 (Uniprot-TrEMBL)
REEP6 ProteinQ96HR9 (Uniprot-TrEMBL)
REEPsComplexR-HSA-8939723 (Reactome)
RLN2(162-185) ProteinP04090 (Uniprot-TrEMBL)
RLN2(25-53) ProteinP04090 (Uniprot-TrEMBL)
RLN3(119-142) ProteinQ8WXF3 (Uniprot-TrEMBL)
RLN3(26-52) ProteinQ8WXF3 (Uniprot-TrEMBL)
RTP1 ProteinP59025 (Uniprot-TrEMBL)
RTP2 ProteinQ5QGT7 (Uniprot-TrEMBL)
RTP3 ProteinQ9BQQ7 (Uniprot-TrEMBL)
RTP4 ProteinQ96DX8 (Uniprot-TrEMBL)
RTP5 ProteinQ14D33 (Uniprot-TrEMBL)
RTPsComplexR-HSA-8939445 (Reactome)
RXFP1 ProteinQ9HBX9 (Uniprot-TrEMBL)
RXFP2 ProteinQ8WXD0 (Uniprot-TrEMBL)
RXFP2 ligands R-HSA-444902 (Reactome)
Relaxin-2, Relaxin-3 R-HSA-444858 (Reactome)
SCT ProteinP09683 (Uniprot-TrEMBL)
SCTR ProteinP47872 (Uniprot-TrEMBL)
SRC ProteinP12931 (Uniprot-TrEMBL)
SRCProteinP12931 (Uniprot-TrEMBL)
TAAR1 ProteinQ96RJ0 (Uniprot-TrEMBL)
TAAR2 ProteinQ9P1P5 (Uniprot-TrEMBL)
TAAR3 ProteinQ9P1P4 (Uniprot-TrEMBL)
TAAR5 ProteinO14804 (Uniprot-TrEMBL)
TAAR6 ProteinQ96RI8 (Uniprot-TrEMBL)
TAAR8 ProteinQ969N4 (Uniprot-TrEMBL)
TAAR9 ProteinQ96RI9 (Uniprot-TrEMBL)
TSHB ProteinP01222 (Uniprot-TrEMBL)
TSHR ProteinP16473 (Uniprot-TrEMBL)
Trace amine-associated receptor R-HSA-391201 (Reactome)
VIP(125-152) ProteinP01282 (Uniprot-TrEMBL)
VIPR1 ProteinP32241 (Uniprot-TrEMBL)
VIPR1,VIPR2 R-HSA-420267 (Reactome)
VIPR2 ProteinP41587 (Uniprot-TrEMBL)
Zn2+ MetaboliteCHEBI:29105 (ChEBI)
cAMP phosphodiesterasesComplexR-HSA-418562 (Reactome)
cAMPMetaboliteCHEBI:17489 (ChEBI)
enoximone
mature GLP-1 R-HSA-381662 (Reactome)
p-Y416-SRC ProteinP12931 (Uniprot-TrEMBL)
p-Y416-SRCProteinP12931 (Uniprot-TrEMBL)
pS-ADRB2 ProteinP07550 (Uniprot-TrEMBL)
pS-ADRB2:Catecholamine:ARRB1,ARRB2ComplexR-HSA-8852170 (Reactome)
pS-ADRB2:Catecholamine:GRKComplexR-HSA-8982648 (Reactome)
pS-ADRB2:CatecholamineComplexR-HSA-8852152 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ADPArrowR-HSA-8851797 (Reactome)
ADPArrowR-HSA-8964252 (Reactome)
ADRB2:ADR,NAdR-HSA-8982645 (Reactome)
ADRB2:Catecholamine:GRKArrowR-HSA-8982645 (Reactome)
ADRB2:Catecholamine:GRKR-HSA-8851797 (Reactome)
ADRB2:Catecholamine:GRKmim-catalysisR-HSA-8851797 (Reactome)
AMPArrowR-HSA-418553 (Reactome)
AMPArrowR-HSA-9629675 (Reactome)
ARRBR-HSA-8852167 (Reactome)
ATPR-HSA-392129 (Reactome)
ATPR-HSA-8851797 (Reactome)
ATPR-HSA-8964252 (Reactome)
Adenylate cyclase (Mg2+ cofactor)R-HSA-163617 (Reactome)
G alpha

(s):GTP:Adenylate

cyclase
ArrowR-HSA-163617 (Reactome)
G alpha

(s):GTP:Adenylate

cyclase
mim-catalysisR-HSA-392129 (Reactome)
G alpha (s):GTP:p-Y416-SRCArrowR-HSA-8964252 (Reactome)
G alpha (s):GTP:p-Y416-SRCR-HSA-8964287 (Reactome)
G alpha (s):GDPArrowR-HSA-164381 (Reactome)
G alpha (s):GDPR-HSA-751013 (Reactome)
G alpha (s):GTP:SRCArrowR-HSA-8964278 (Reactome)
G alpha (s):GTP:SRCR-HSA-8964252 (Reactome)
G alpha (s):GTP:SRCmim-catalysisR-HSA-8964252 (Reactome)
G alpha (s):GTPArrowR-HSA-744886 (Reactome)
G alpha (s):GTPArrowR-HSA-8964287 (Reactome)
G alpha (s):GTPR-HSA-163617 (Reactome)
G alpha (s):GTPR-HSA-164381 (Reactome)
G alpha (s):GTPR-HSA-8964278 (Reactome)
G alpha (s):GTPmim-catalysisR-HSA-164381 (Reactome)
G-protein alpha

(i):GTP:Adenylate

cyclase
TBarR-HSA-392129 (Reactome)
G-protein alpha

(z):GTP:Adenylate

cyclase
TBarR-HSA-392129 (Reactome)
G-protein beta-gamma complexArrowR-HSA-744886 (Reactome)
G-protein beta-gamma complexR-HSA-751013 (Reactome)
GDPArrowR-HSA-379044 (Reactome)
GNAL:GNB1:GNGT1ArrowR-HSA-381749 (Reactome)
GNAL:GNB1:GNGT1R-HSA-381750 (Reactome)
GNALR-HSA-381749 (Reactome)
GNB1R-HSA-381749 (Reactome)
GNGT1R-HSA-381749 (Reactome)
GPCR:ligand

complexes that act on Gs:Heterotrimeric G-protein Gs

(active)
ArrowR-HSA-379044 (Reactome)
GPCR:ligand

complexes that act on Gs:Heterotrimeric G-protein Gs

(active)
R-HSA-744886 (Reactome)
GPCRs that activate GsArrowR-HSA-744886 (Reactome)
GRK2, GRK3, GRK5, GRK6ArrowR-HSA-8982641 (Reactome)
GRK2, GRK3, GRK5, GRK6R-HSA-8982645 (Reactome)
GTPR-HSA-379044 (Reactome)
H2OR-HSA-418553 (Reactome)
H2OR-HSA-9629675 (Reactome)
Heterotrimeric

G-protein Gs

(inactive)
ArrowR-HSA-751013 (Reactome)
Heterotrimeric

G-protein Gs

(inactive)
R-HSA-744887 (Reactome)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
ArrowR-HSA-744887 (Reactome)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
R-HSA-379044 (Reactome)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
mim-catalysisR-HSA-379044 (Reactome)
Ligand:GPCR

complexes that

activate Gs
R-HSA-744887 (Reactome)
Ligands of GPCRs that activate GsArrowR-HSA-744886 (Reactome)
Olfactory receptor:G protein trimerArrowR-HSA-381750 (Reactome)
Olfactory receptorsR-HSA-381750 (Reactome)
PDE3 inhibitors:PDE3A,3BTBarR-HSA-9629675 (Reactome)
PDE3A,3Bmim-catalysisR-HSA-9629675 (Reactome)
PPiArrowR-HSA-392129 (Reactome)
PiArrowR-HSA-164381 (Reactome)
R-HSA-163617 (Reactome) G(s)-alpha:GTP binds to inactive adenylate cyclase, causing a conformational transition in adenylate cyclase exposing the catalytic site and activating it.
R-HSA-164381 (Reactome) When a ligand activates a G protein-coupled receptor, it induces a conformational change in the receptor (a change in shape) that allows the receptor to function as a guanine nucleotide exchange factor (GEF), stimulating the exchange of GDP for GTP on the G alpha subunit. In the traditional view of heterotrimeric protein activation, this exchange triggers the dissociation of the now active G alpha subunit from the beta:gamma dimer, initiating downstream signalling events. The G alpha subunit has intrinsic GTPase activity and will eventually hydrolyze the attached GTP to GDP, allowing reassociation with G beta:gamma. Additional GTPase-activating proteins (GAPs) stimulate the GTPase activity of G alpha, leading to more rapid termination of the transduced signal. In some cases the downstream effector may have GAP activity, helping to deactivate the pathway. This is the case for phospholipase C beta, which possesses GAP activity within its C-terminal region (Kleuss et al. 1994).
R-HSA-379044 (Reactome) The liganded receptor undergoes a conformational change, generating a signal that is propagated in a manner that is not completely understood to the the G-protein. This stimulates the exchange of GDP for GTP in the G-protein alpha subunit, activating the G-protein. This event is negatively regulated by some Activators of G protein signaling (AGS) proteins, a class of proteins identified in yeast functional screens for proteins able to activate G protein signaling in the absence of a G protein–coupled receptor (GPCR) (Cismowski et al. 1999, Takesono et al. 1999). AGS proteins contain G protein regulatory (GPR) motifs (also referred to as the GoLoco motif) that bind and stabilize the Galpha subunit in its GDP-bound conformation (Mochizuki et al. 1996, Peterson et al. 2000, Cao et al. 2004, Blumer & Lanier 2014). Some RGS proteins similarly bind to Galpha preventing the exchange of GDP for GTP (Soundararajan et al. 2008).
R-HSA-381749 (Reactome) The heterotrimeric guanine nucleotide-binding proteins (G-proteins) function to transduce signals from this vast panoply of receptors to effector systems including ion channels and enzymes that alter the rate of production, release or degradation of intracellular second messengers. GPCRs activate the G-proteins, which consist of an alpha-subunit that binds and hydrolyses guanosine triphosphate (GTP), a beta and a gamma subunit.
R-HSA-381750 (Reactome) Olfactory receptors (ORs) have diverse protein sequences but can be assigned to subfamilies on the basis of sequence relationships. Odorants and pheromones bind to these seven transmembrane domain G-protein-coupled receptors that permit signal transduction. These receptors are encoded by large multigene families that evolved in mammal species in function of specific olfactory needs. Members of the same subfamily have related sequences and are likely to recognize structurally related odorants.
Of the 960 human OR genes and pseudogenes, there is experimental evidence which indicates that at least 437 actually are expressed in human olfactory epithelium; this includes 357 OR genes, and 80 OR pseudogenes (Zhang, 2007). These 357 olfactory-expressed OR genes are therefore expected to be functional in the Olfactory Signaling Pathway, and to interact directly with human G alpha olf in human olfactory cells.

(Note: A subset of 200 of these 357 OR genes are shown as components of OR-G Protein reaction. The others will be added to Reactome later.)

R-HSA-392129 (Reactome) The activation of adenylyl (adenylate) cyclase (AC) results in the production of adenosine-3',5'-monophosphate i.e. cyclic AMP. Humans have 9 genes encoding membrane-associated AC and one encoding a soluble AC. Two of the classes of heterotrimeric G-proteins are named according to their effect on AC; G(s) stimulates all membrane-bound ACs (the s in G(s) denotes AC stimulatory); the G(i) class inhibits some AC isoforms, particularly 5 and 6. Beta-gamma subunits of heterotrimeric G-proteins can also regulate AC. Ca2+/Calmodulin activates some AC isoforms (1, 8 and 3) but is inhibitory to others (5 and 6).
R-HSA-418553 (Reactome) Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP. Some PDEs are cAMP selective (PDE4, 7 and 8), some cGMP selective (PDE5, 6 and 9) while others can hydrolyse cAMP and cGMP (PDE1, 2, 3, 10 and 11). PDEs are important as drug targets: Sildenafil (Viagra) is an inhibitor of PDE5; Cilostazol (Pletal) inhibits PDE3, increasing the flexibility of erythrocytes.
R-HSA-744886 (Reactome) The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
R-HSA-744887 (Reactome) The role of the guanine nucleotide-binding protein G alpha-s subunit (G alpha-s) (Kozasa T et al, 1988) is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn, activates cAMP-dependent protein kinase.
R-HSA-751013 (Reactome) The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active alpha subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (s):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates into the inactive heterotrimeric G-protein.
R-HSA-8851797 (Reactome) G protein-coupled receptor kinase 2 (ADRBK1, GRK2, beta-ARK), ADRBK2 (GRK3, beta-ARK2), GRK5 and GRK6 can phosphorylate activated beta-adrenergic receptors (Benovic et al. 1986a, Richardson et al. 1993, Menard et al. 1996, Violin et al. 2006). GRK2, GRK5 and GRK6 phosphorylate the beta-2 adrenergic receptor (ADRB2) in the carboxy-terminal tail region (Premont et al. 1994, 1995, Violin et al. 2006). GRK2 and GRK6 are thought to be the predominant GRKs that mediate ADRB2 desensitization (Violin et al. 2006), phosphorylating distinct serine residues (Nobles et al. 2011). GRK phosphorylation follwed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region. In GPCRs that require phosphorylation, the region most commonly involved in arrestin binding is the C-terminus, but many GPCRs have phosphorylation sites in the 3rd cytoplasmic loop, while in some cases phosphorylation sites are found in the first (i1) or second (i2) cytoplasmic loops (Gurevich & Gurevich 2006).
R-HSA-8852167 (Reactome) Two ubiquitously expressed forms of arrestin, arrestin-2 (ARRB1) and arrestin-3 (ARRB2), can bind and desensitize B2AR (Lohse et al. 1990, Attramadal et al. 1992, Sterne-Marr et al. 1993). Unlike visual arrestin, which has 10-fold greater affinity for phosphorylated rather than unphosphorylated rhodopsin, ARRB1 and ARRB2 show only a 2-fold difference in binding levels and are much less selective in their receptor preferences (Gurevich & Gurevich 2006). GRK-mediated receptor phosphorylation followed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs. included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region.
R-HSA-8964252 (Reactome) G-Protein Coupled Receptors sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the alpha subunit of the G protein (GNAS) can directly bind to SRC. In the presence of active GNAS, SRC can autophosphorylate the 416-tyrosine residue, which leads to the subsequent activation of SRC. Physiologically, the SRC family have implications in cell growth and cancer. GNAS increases SRC enzymatic activity by decreasing Km and not affecting Vm.
R-HSA-8964278 (Reactome) G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(s) subunit alpha (GNAS) can bind directly to proto-oncogene tyrosine-protein kinase Src (SRC) in vitro and in vivo. This binding results in autophosphorylation of SRC and subsequently its activation. Physiologically, the SRC family have implications in cell growth and cancer.
R-HSA-8964287 (Reactome) Upon autophosphorylation, SRC dissociates from GNAS and is subsequently activated. GNAS increases SRC enzymatic activity by decreasing Km and not affecting Vm. Physiologically, the SRC family have implications in cell growth and cancer.
R-HSA-8982641 (Reactome) G protein-coupled receptor kinase 2 (ADRBK1, GRK2, beta-ARK), ADRBK2 (GRK3, beta-ARK2), GRK5 and GRK6 can phosphorylate activated beta-adrenergic receptors (Benovic et al. 1986a, Richardson et al. 1993, Menard et al. 1996, Violin et al. 2006). GRK2, GRK5 and GRK6 can bind and phosphorylate the beta-2 adrenergic receptor (ADRB2) in the carboxy-terminal tail region (Premont et al. 1994, 1995, Violin et al. 2006). Following this, phosphorylated ADRB2 dissociates from the ADRB2:GRK complex. GRK2 and GRK6 are thought to be the predominant GRKs that mediate ADRB2 desensitization (Violin et al. 2006), phosphorylating distinct serine residues (Nobles et al. 2011).

GRK phosphorylation follwed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region. In GPCRs that require phosphorylation, the region most commonly involved in arrestin binding is the C-terminus, but many GPCRs have phosphorylation sites in the 3rd cytoplasmic loop, while in some cases phosphorylation sites are found in the first (i1) or second (i2) cytoplasmic loops (Gurevich & Gurevich 2006).
R-HSA-8982645 (Reactome) G protein-coupled receptor kinase 2 (ADRBK1, GRK2, beta-ARK), ADRBK2 (GRK3, beta-ARK2), GRK5 and GRK6 can phosphorylate activated beta-adrenergic receptors (Benovic et al. 1986a, Richardson et al. 1993, Menard et al. 1996, Violin et al. 2006). GRK2, GRK5 and GRK6 can bind to beta-2 adrenergic receptor (ADRB2) and subsequently phosphorylate them in the carboxy-terminal tail region (Premont et al. 1994, 1995, Violin et al. 2006). GRK2 and GRK6 are thought to be the predominant GRKs that mediate ADRB2 desensitization (Violin et al. 2006), phosphorylating distinct serine residues (Nobles et al. 2011).

GRK phosphorylation follwed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region. In GPCRs that require phosphorylation, the region most commonly involved in arrestin binding is the C-terminus, but many GPCRs have phosphorylation sites in the 3rd cytoplasmic loop, while in some cases phosphorylation sites are found in the first (i1) or second (i2) cytoplasmic loops (Gurevich & Gurevich 2006).
R-HSA-9629675 (Reactome) Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP (Maurice 2005). PDEs are important as drug targets:PDE3 inhibition promotes cardiac muscle contraction, a strategy used in heart failure.
REEPsArrowR-HSA-381750 (Reactome)
RTPsArrowR-HSA-381750 (Reactome)
SRCR-HSA-8964278 (Reactome)
cAMP phosphodiesterasesmim-catalysisR-HSA-418553 (Reactome)
cAMPArrowR-HSA-392129 (Reactome)
cAMPR-HSA-418553 (Reactome)
cAMPR-HSA-9629675 (Reactome)
p-Y416-SRCArrowR-HSA-8964287 (Reactome)
pS-ADRB2:Catecholamine:ARRB1,ARRB2ArrowR-HSA-8852167 (Reactome)
pS-ADRB2:Catecholamine:GRKArrowR-HSA-8851797 (Reactome)
pS-ADRB2:Catecholamine:GRKR-HSA-8982641 (Reactome)
pS-ADRB2:CatecholamineArrowR-HSA-8982641 (Reactome)
pS-ADRB2:CatecholamineR-HSA-8852167 (Reactome)
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