Hepatocyte growth factor receptor signaling (Danio rerio)

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1TranscriptionAKT PathwayCDC42pathwayActinAP-1Transcriptionof Cox2RAC1pathwayCytoplasmChanges in Cytoskeletonand Cell mobilityAnoikisTrancriptionRHOpathwayExtracellulargab1srcLOC561737MAP4K1crklLOC570868ptk2.1mapk1pak1Metzgc:172209zgc:172250pxnrap1araf1srcptpn11LOC567895stat3fosptenbITGB1ptk2bbptk2bbptk2.1crkmap2k1hgfaHRASrasa1CH211-127H20.2mapk3junpxndock1grb2rap1bSOS1PPP


Description

Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP313(r21339) with a 86% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118749view10:59, 1 June 2021DeSlOntology Term : 'Rho/Rac/Cdc42 mediated signaling pathway' added !
118748view10:59, 1 June 2021DeSlOntology Term : 'hepatocyte' added !
118747view10:59, 1 June 2021DeSlRemoved textlabel
118746view10:58, 1 June 2021DeSlConverted "P" to states
118745view10:57, 1 June 2021DeSlConverted ReceptorSquare to MIM binding with lit. ref
118744view10:56, 1 June 2021DeSlAdded description from WP313
116905view11:35, 15 May 2021EweitzModified title
109424view07:59, 17 March 2020L DupuisChanged interactions to graphical lines representing the cell membrane
68677view05:35, 6 July 2013MaintBotUpdated to 2013 gpml schema
67646view11:44, 26 June 2013DdiglesOntology Term : 'scatter factor/hepatocyte growth factor signaling pathway' added !
40850view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
34232view21:38, 9 December 2009MaintBotAutomatic update of empty xrefs
32433view17:14, 15 August 2009MaintBotFixed text labels
32102view13:45, 14 August 2009MaintBotFixed group labels
31454view21:12, 13 August 2009MaintBotFixed text labels
31079view01:33, 30 July 2009MaintBotConverted from Homo sapiens
21614view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:Signaling of Hepatocyte Growth Factor Receptor Biocarta]] moved to [[Pathway:WP444]]: Moved to stable identifier
12024view08:44, 15 May 2008MaintBotAdded to category $category
12022view08:44, 15 May 2008MaintBotUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CH211-127H20.2GeneProduct558635 (Entrez Gene)
HRASGeneProduct550286 (Entrez Gene)
ITGB1GeneProduct
LOC561737GeneProduct561737 (Entrez Gene)
LOC567895GeneProduct567895 (Entrez Gene)
LOC570868GeneProduct570868 (Entrez Gene)
MAP4K1GeneProduct
MetGeneProduct0 (Entrez Gene)
SOS1GeneProductSon of sevenless homolog 1 (Drosophila) (predicted)
crkGeneProduct445234 (Entrez Gene)
crklGeneProduct556443 (Entrez Gene)
dock1GeneProduct572187 (Entrez Gene) Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
fosGeneProduct394198 (Entrez Gene)
gab1GeneProduct406666 (Entrez Gene)
grb2GeneProduct406308 (Entrez Gene)
hgfaGeneProduct493781 (Entrez Gene)
junGeneProduct335916 (Entrez Gene)
map2k1GeneProduct406728 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene)
mapk3GeneProduct399480 (Entrez Gene)
pak1GeneProduct373103 (Entrez Gene)
ptenbGeneProduct368415 (Entrez Gene)
ptk2.1GeneProduct142986 (Entrez Gene)
ptk2bbGeneProduct245950 (Entrez Gene)
ptpn11GeneProduct333979 (Entrez Gene)
pxnGeneProduct399546 (Entrez Gene)
raf1GeneProduct30716 (Entrez Gene)
rap1aGeneProduct415242 (Entrez Gene)
rap1bGeneProduct321107 (Entrez Gene)
rasa1GeneProduct100002155 (Entrez Gene)
srcGeneProduct325084 (Entrez Gene)
stat3GeneProduct30767 (Entrez Gene)
zgc:172209GeneProduct562720 (Entrez Gene)
zgc:172250GeneProduct100002225 (Entrez Gene)

Annotated Interactions

No annotated interactions
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