Methionine degradation (Saccharomyces cerevisiae)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none a demethylated methyl acceptorL-methioninehomocysteineadenosineSAH1phosphatediphosphateATPH2OSAM1SAM2S-adenosyl-L-methionineS-adenosyl-L-homocysteinea methylated methyl acceptorH+H2OName: Methionine degradationOrganism: Saccharomyces cerevisiae


Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. Description from [KEGG](https://www.kegg.jp/entry/map00270).

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Quality Tags

Image:NeedsRef.pngAdd references
Image:Curated.pngApproved version

Ontology Terms

Bibliography

  1. ''Cysteine and methionine metabolism''; KEGG,
  2. ''YeastPathways''; YeastPathways,

History

View all...
CompareRevisionActionTimeUserComment
138225
Approved
view19:51, 25 March 2025KhanspersModified description
138224view19:49, 25 March 2025Khanspersupdated reference
138223view19:47, 25 March 2025Khanspersupdated reference
138222view19:47, 25 March 2025KhanspersOntology Term : 'classic metabolic pathway' added !
138221view19:47, 25 March 2025Khanspersdecreased board height
138220view19:46, 25 March 2025Khanspersdecreased board size
138193view23:58, 21 March 2025Khanspersupdate based on KEGG, removed incomplete parts dowstream of homocysteine
117317view11:21, 20 May 2021EweitzModified title
92812view19:26, 8 July 2017AlexanderPicoReverted to version '11:31, 11 July 2013' by AlexanderPico
92794view15:28, 6 July 2017DeSlQuick edit to datanode annotation or property
69881view18:31, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69580view20:29, 8 July 2013MaintBotUpdated to 2013 gpml schema
67460view11:04, 26 June 2013DdiglesOntology Term : 'methionine degradation pathway' added !
53656view22:07, 10 November 2012EgonwConnecting dots...
41805view04:48, 2 March 2011MaintBotRemoved redundant pathway information and comments
20773view11:29, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Methionine Degradation]] moved to [[Pathway:WP46]]: Moved to stable identifier
12782view08:02, 17 May 2008MaintBotautomated metabolite conversion
8828view14:10, 7 January 2008MaintBotAdded to category $category
8826view14:10, 7 January 2008J.HeckmanUploaded new pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ATPMetabolite1927-31-7 (CAS)
H+Metabolite15378 (ChEBI)
H2OMetabolite15377 (ChEBI)
L-methionineMetabolite63-68-3 (CAS)
S-adenosyl-L-homocysteineMetabolite57856 (ChEBI)
S-adenosyl-L-methionineMetabolite59789 (ChEBI)
SAH1GeneProductS000000845 (SGD)
SAM1GeneProductS000004170 (SGD)
SAM2GeneProductS000002910 (SGD)
adenosineMetabolite58-61-7 (CAS)
diphosphateMetabolite2466-09-3 (CAS)
homocysteineMetabolite6027-13-0 (CAS)
phosphateMetabolite14265-44-2 (CAS)

Annotated Interactions

No annotated interactions

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