Sphingolipid metabolism (integrated pathway) (Mus musculus)
From WikiPathways
Description
This pathway is inspired by the Lipidmaps>Sphingolipids pathway (all chain lengths) [1].
Sphingolipids are a class of lipids, which act as signal transduction and cell recognition molecules. This pathway shows all different tail lengths and their conversions into specific products. All products are annotated with lipid-specific identifiers (if available).
The general overview pathway can be found here.Quality Tags
Ontology Terms
Bibliography
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- Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
- Lahiri S, Futerman AH; ''LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
- Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, Futerman AH; ''Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.''; FEBS Lett, 2007 PubMed Europe PMC Scholia
- Mizutani Y, Kihara A, Igarashi Y; ''Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.''; Biochem J, 2005 PubMed Europe PMC Scholia
- Gosejacob D, Jäger PS, Vom Dorp K, Frejno M, Carstensen AC, Köhnke M, Degen J, Dörmann P, Hoch M; ''Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity.''; J Biol Chem, 2016 PubMed Europe PMC Scholia
- Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S; ''Characterization of murine sphingosine-1-phosphate phosphohydrolase.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
- Merrill AH Jr; ''De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
1-Hexadecenal | Metabolite | LMFA06000088 (LIPID MAPS) | |
3-keto-sphinganine | Metabolite | LMSP01020002 (LIPID MAPS) | |
ADP | Metabolite | CHEBI:456216 (ChEBI) | |
ATP | Metabolite | CHEBI:30616 (ChEBI) | |
Asah1 | Protein | Q9WV54 (Uniprot-TrEMBL) | |
C14DH-Ceramide | Metabolite | ||
C16 Cer | Metabolite | LMSP02010004 (LIPID MAPS) | |
C16 CerP | Metabolite | ||
C16 GalCer | Metabolite | ||
C16 GlcCer | Metabolite | LMSP0501AA03 (LIPID MAPS) | |
C16 SM | Metabolite | LMSP03010003 (LIPID MAPS) | SM = sphingomyelin |
C16DH CerP | Metabolite | ||
C16DH GalCer | Metabolite | ||
C16DH GlcCer | Metabolite | LMSP0501AA04 (LIPID MAPS) | |
C16DH SM | Metabolite | LMSP03010004 (LIPID MAPS) | SM = sphingomyelin |
C16DH-Cer | Metabolite | LMSP02020001 (LIPID MAPS) | |
C18 Cer | Metabolite | LMSP02010006 (LIPID MAPS) | |
C18 CerP | Metabolite | ||
C18 GalCer | Metabolite | ||
C18 GlcCer | Metabolite | LMSP0501AA05 (LIPID MAPS) | |
C18 SM | Metabolite | LMSP03010001 (LIPID MAPS) | SM = sphingomyelin |
C18DH CerP | Metabolite | ||
C18DH GalCer | Metabolite | ||
C18DH GlcCer | Metabolite | LMSP0501AA19 (LIPID MAPS) | |
C18DH SM | Metabolite | LMSP03010020 (LIPID MAPS) | SM = sphingomyelin |
C18DH-Cer | Metabolite | LMSP02020008 (LIPID MAPS) | |
C20 Cer | Metabolite | LMSP02010007 (LIPID MAPS) | |
C20 CerP | Metabolite | ||
C20 GalCer | Metabolite | ||
C20 GlcCer | Metabolite | LMSP0501AA06 (LIPID MAPS) | |
C20 SM | Metabolite | LMSP03010005 (LIPID MAPS) | SM = sphingomyelin |
C20DH CerP | Metabolite | ||
C20DH GalCer | Metabolite | ||
C20DH GlcCer | Metabolite | LMSP0501AA20 (LIPID MAPS) | |
C20DH SM | Metabolite | LMSP03010021 (LIPID MAPS) | SM = sphingomyelin |
C20DH-Cer | Metabolite | LMSP02020009 (LIPID MAPS) | |
C22 Cer | Metabolite | LMSP02010008 (LIPID MAPS) | |
C22 CerP | Metabolite | ||
C22 GalCer | Metabolite | ||
C22 GlcCer | Metabolite | LMSP0501AA07 (LIPID MAPS) | |
C22 SM | Metabolite | LMSP03010006 (LIPID MAPS) | SM = sphingomyelin |
C22DH CerP | Metabolite | ||
C22DH GalCer | Metabolite | ||
C22DH GlcCer | Metabolite | LMSP0501AA21 (LIPID MAPS) | |
C22DH SM | Metabolite | LMSP03010022 (LIPID MAPS) | SM = sphingomyelin |
C22DH-Cer | Metabolite | LMSP02020010 (LIPID MAPS) | |
C24 Cer | Metabolite | LMSP02010012 (LIPID MAPS) | |
C24 CerP | Metabolite | ||
C24 GalCer | Metabolite | ||
C24 GlcCer | Metabolite | LMSP0501AA09 (LIPID MAPS) | |
C24 SM | Metabolite | LMSP03010008 (LIPID MAPS) | SM = sphingomyelin |
C24:1 Cer | Metabolite | LMSP02010009 (LIPID MAPS) | |
C24:1 CerP | Metabolite | ||
C24:1 GalCer | Metabolite | ||
C24:1 GlcCer | Metabolite | LMSP0501AA08 (LIPID MAPS) | |
C24:1 SM | Metabolite | LMSP03010007 (LIPID MAPS) | SM = sphingomyelin |
C24:1DH CerP | Metabolite | ||
C24:1DH GalCer | Metabolite | ||
C24:1DH GlcCer | Metabolite | LMSP0501AA22 (LIPID MAPS) | |
C24:1DH SM | Metabolite | LMSP03010023 (LIPID MAPS) | SM = sphingomyelin |
C24:1DH-Cer | Metabolite | LMSP02020011 (LIPID MAPS) | |
C24DH CerP | Metabolite | ||
C24DH GalCer | Metabolite | ||
C24DH GlcCer | Metabolite | LMSP0501AA23 (LIPID MAPS) | |
C24DH SM | Metabolite | LMSP03010024 (LIPID MAPS) | SM = sphingomyelin |
C24DH-Cer | Metabolite | LMSP02020012 (LIPID MAPS) | |
C26 Cer | Metabolite | LMSP02010011 (LIPID MAPS) | |
C26 CerP | Metabolite | ||
C26 GalCer | Metabolite | ||
C26 GlcCer | Metabolite | LMSP0501AA11 (LIPID MAPS) | |
C26 SM | Metabolite | LMSP03010010 (LIPID MAPS) | SM = sphingomyelin |
C26:1 Cer | Metabolite | LMSP02010010 (LIPID MAPS) | |
C26:1 CerP | Metabolite | ||
C26:1 GalCer | Metabolite | ||
C26:1 GlcCer | Metabolite | LMSP0501AA10 (LIPID MAPS) | |
C26:1 SM | Metabolite | LMSP03010009 (LIPID MAPS) | SM = sphingomyelin |
C26:1DH CerP | Metabolite | ||
C26:1DH GalCer | Metabolite | ||
C26:1DH GlcCer | Metabolite | LMSP0501AA24 (LIPID MAPS) | |
C26:1DH SM | Metabolite | LMSP03010025 (LIPID MAPS) | SM = sphingomyelin |
C26:1DH-Cer | Metabolite | LMSP02020013 (LIPID MAPS) | |
C26DH CerP | Metabolite | ||
C26DH GalCer | Metabolite | ||
C26DH GlcCer | Metabolite | LMSP0501AA25 (LIPID MAPS) | |
C26DH SM | Metabolite | LMSP03010026 (LIPID MAPS) | SM = sphingomyelin |
C26DH-Cer | Metabolite | LMSP02020014 (LIPID MAPS) | |
CerS1 | Protein | P27545 (Uniprot-TrEMBL) | |
CerS4 | Protein | 67260 (Entrez Gene) | Protein found in literature (not in original LipidMapsPW) |
CerS5 | Protein | Q9D6K9 (Uniprot-TrEMBL) | AKA Lass5 |
CerS6 | Protein | Q8C172 (Uniprot-TrEMBL) | AKA Lass6 |
Cerk | Protein | 223753 (Entrez Gene) | |
Cers2 | Protein | 76893 (Entrez Gene) | |
Cers3 | Protein | Q1A3B0 (Uniprot-TrEMBL) | |
CoA(14:0) | Metabolite | ||
CoA(16:0) | Metabolite | LMFA07050360 (LIPID MAPS) | |
CoA(18:0) | Metabolite | LMFA07050369 (LIPID MAPS) | |
CoA(20:0) | Metabolite | LMFA07050329 (LIPID MAPS) | |
CoA(22:0) | Metabolite | LMFA07050289 (LIPID MAPS) | AKA "Coenzyme A, S-docosanoate" |
CoA(24:0) | Metabolite | LMFA07050372 (LIPID MAPS) | AKA "Coenzyme A, S-(tetracosanoate)" |
CoA(24:1) | Metabolite | LMFA07050098 (LIPID MAPS) | AKA "Coenzyme A, S-(15Z)-15-tetracosenoate" |
CoA(26:0) | Metabolite | LMFA07050327 (LIPID MAPS) | AKA "Coenzyme A, S-hexacosanoate" |
CoA(26:1) | Metabolite | LMFA07050099 (LIPID MAPS) | |
Degs1 | Protein | 13244 (Entrez Gene) | |
Degs2 | Protein | 70059 (Entrez Gene) | |
Ethanolamine-phosphate | Metabolite | 1015 (PubChem-compound) | |
H2O | Metabolite | CHEBI:15377 (ChEBI) | |
Hexadecanal | Metabolite | LMFA06000088 (LIPID MAPS) | |
Kdsr | Protein | Q6GV12 (Uniprot-TrEMBL) | AKA Fvt1 |
Palmitoyl-CoA | Metabolite | LMFA07050360 (LIPID MAPS) | aka CoA(16:0) |
Ppap2a | Protein | 19012 (Entrez Gene) | |
Ppap2b | Protein | 67916 (Entrez Gene) | |
Ppap2c | Protein | 50784 (NCBI Protein) | |
Serine | Metabolite | 5951 (PubChem-compound) | |
Sgms1 | Protein | 208449 (Entrez Gene) | |
Sgms2 | Protein | 74442 (Entrez Gene) | |
Sgpl1 | Protein | 20397 (Entrez Gene) | |
Sgpp1 | Protein | Q9JI99 (Uniprot-TrEMBL) | |
Sgpp2 | Protein | Q810K3 (Uniprot-TrEMBL) | |
Smpd1 | Protein | 20597 (Entrez Gene) | |
Sphinganine-1-phosphate | Metabolite | LMSP01050002 (LIPID MAPS) | |
Sphinganine | Metabolite | LMSP01020001 (LIPID MAPS) | |
Sphingosine-1-phosphate | Metabolite | LMSP01050001 (LIPID MAPS) | |
Sphingosine | Metabolite | LMSP01010001 (LIPID MAPS) | |
Sphk1 | Protein | Q8CI15 (Uniprot-TrEMBL) | |
Sphk2 | Protein | Q9JIA7 (Uniprot-TrEMBL) | |
Sptlc1 | Protein | 268656 (Entrez Gene) | |
Sptlc2 | Protein | P97363 (Uniprot-TrEMBL) | |
Ugcg | Protein | 22234 (Entrez Gene) | |
Ugt8a | Protein | 22239 (Entrez Gene) |
Annotated Interactions
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Source | Target | Type | Database reference | Comment |
---|---|---|---|---|
3-keto-sphinganine | Sphinganine | mim-conversion | 22642 (Rhea) | |
ADP | mim-conversion | 15466 (Rhea) | ||
ATP | mim-conversion | 15466 (Rhea) | ||
CoA(16:0) | mim-conversion | 36540 (Rhea) | ||
H2O | mim-conversion | 27515 (Rhea) | ||
Palmitoyl-CoA | 3-keto-sphinganine | mim-conversion | 14762 (Rhea) | |
Sphinganine-1-phosphate | Sphinganine | mim-conversion | 27515 (Rhea) | |
Sphinganine | Sphinganine-1-phosphate | mim-conversion | 15466 (Rhea) | |
Sphinganine | mim-conversion | 36540 (Rhea) | Kinetic info: [PMID:17977534] |