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Neuromedin U Neuropeptide Y / peptide YY Hormone protein Follicle stimulating hormone C-X-C Chemokine Class A Orphans Chemokine receptor-like Somatostatin Amine Acetylcholine (muscarinic) Olfactory Olfactory Other Mas proto-oncogene Vasopressin-like (Rhod)opsin Rhodopsin Vertebrate Purinoceptor type Y Rhodopsin Other Endothelin Thyrotropin-releasing hormone and Secretagogue ORPH LGR like (hormone receptors) Class A Orphan/other Platelet ADP & KI01 receptors Adrenoceptors Alpha Adrenoceptors Platelet activating factor Other Chemokine Receptors Adrenomedullin (G10D) Cannabis C5a anaphylatoxin GP40 like Beta Adrenoceptors Orexin & neuropeptide FF Chemokine C-C Chemokine Fmet-leu-phe Bombesin Melanocortin Lutropin-choriogonadotropic hormone Nucleotide-like Adenosine Purinoceptors Interleukin-8 Opioid SREB GPR45 like Neuropeptide Y APJ like BONZO receptors (CXC6R) Melatonin CCK Thrombin Ccr9 Cnr1 Olr1750 GPR77 Olr217 Ptgir Drd5 Adra2b Ltb4r Gpr22 Gpcr12 Sstr4 Ccr8 Npbwr1 Adrb1 Npy5r Gpr52 Opn1mw OR10H1 Olr836 OR1C1 GPR39 MAS1L Q9UDD9 Bdkrb1 Avpr1a OR2A4 Olr1743 Agtr1a P2ry10 OR1F1 Gper GPR6 Mc5r Adra1b Gpr1 NPY1R Ptger4 GPR8 Prostaglandin Ppyr1 Bradykinin Chrm3 Adora1 Avpr2 Olr808 Gpr63 Gpr35 Gpr50 Hcrtr2 Rgr Ptger1 Htr7 Htr1d Lhcgr Cxcr5 HTR1E Fpr3 Drd3 Drd2 Npffr1 Oprk1 Ccr3 Drd1a Olr464 Ednra OPN1MW Bdkrb2 Olr227 Nmur1 Gpr171 Gpr174 NPY6R GPR109B Chrm2 Adora2b Aplnr Tbxa2r OR2J1 Cxcr3 MC1R Ccr6 Adora3 Cx3cr1 Htr6 Adrb2 Sstr5 Angiotensin II Htr2b Gpr81 NTSR2 Olr806 Mc4r Ntsr1 Olr226 OR2B3 OR1G1 P2ry6 Gpr85 Npy2r Olr1662 Olr1654 Ptgfr Prlhr Gpr3 ADRA2A MLNR P2ry2 Ptger3 Gpr18 Olr1329 Cxcr7 Mc2r P2ry1 Adra1a OR3A3 P2ry14 Drd4 OR3A4 Gpr31 Xcr1 Ffar2 Adra2c GPR32 Olr1517 Il8rb OR10H3 OR7C1 Olr1467 Gpr68 Adrb3 Olr588 Hrh2 OR1A1 Sstr3 P2ry5 F2RL3 OR1D2 F2rl1 Gpr75 Gpr25 F2r OR12D3 OR1A2 Olr811 Gpr37 Olr1606 Agtr2 CCR2 Gpr83 Mc3r Mtnr1a P2ry13 OR2J2 Ccrl2 Gpr65 Gpr15 Ptger2 P2ry12 Olr1466 Cnr2 Adra1d Gpr34 Htr1b Gpr37l1 Chrm1 Olr1749 Gpr87 Olr1086 Ptafr Cysltr2 Sstr2 Olr1077 Olr1356 Fpr2 Chrm5 Il8ra Ccr5 Gpr27 Olr1087 Gpr173 Ednrb Fshr Cmklr1 Galr3 Rho P2RY11 Cysltr1 Lpar5 Olr1730 Nmur2 Olr1075 Htr1f Oprl1 Htr2a Gpr19 Olr1073 Hrh1 OR2N1P Gpr45 Htr1a OR1D4 PTGDR Cckbr Ccr10 Sucnr1 Serotonin Olr1579 OR2B6 RGD1563245 Adora2a Fpr1 LOC685243 Mchr1 GPR17 OR10H2 Ccbp2 Oxtr Hrh3 Olr420 Lpar4 Rrh Dopamine GALR1 Htr2c Olr1693 Avpr1b Olr1201 Olr231 Ffar3 Olr1671 GPR42 Trhr F2rl2 Opn4 Chrm4 Oprm1 Olr1512 Ffar1 Npffr2 C3ar1 P2ry4 Cxcr4 Oprd1 Ccr1 OR1D5 Htr4 Histamine Gpr21 Mtnr1b Gpr44 OR2D2 Gpr4 Cckar Hcrtr1 Brs3 Ccr7 Mas1 Grpr Opn3 Galr2 Htr5a Ccr4 Gpr20 Nmbr Sstr1 Ghsr Opn1sw
Description
This pathway was created using the GPCRDB (Horn et al., 1998),
http://www.gpcr.org/7tm/ (originally at
http://www.cmbi.kun.nl/7tm/ ). The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references.
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