AXL signaling pathway (Homo sapiens)

From WikiPathways

Jump to: navigation, search
Transcription factorsLiver Inflammation, Steatohepatitis, and FibrosisDormacy cell survivalCellular senescenceTranscriptional regulator EMTColorectal CancerImmune suppressionPLASMA MEMBRANETumor invasion/migrationMatrix metalloproteasesCollagenTumor progressioncell migration and invasionEGFR nuclear translocation mediatorsInflammationLung adenocarcinomasChemokinesThrombosisRegulatory T cells(Tregs)CPBone morphogenicproteinsTransmembrane proteinOsteosarcoma NUCLEUSProliferationBECN1CASP1MAP1LC3BANXA2MYCTGFBR2AXIN2FN1NLRP3CCND1ATG5LEF1ZEB12113MSNTGF4GLI2CALD1TGFB2TMEM132ASMOADAM11GLI3NRG1TGFB1I1SPARCBMP8BAKT3SNAI3MITFAHNAK2VAV1P4BMP6EGFRY1173Y1101BMP726, 30CDK416CAV2SP125CDK616CD274MYC CXCL16TGFB1LINC00526TMEFF1BMP8ACXCR6GLI1LYNBCL2 RPS6KA128T359S363FOXP3BIRC5TGFB2COL3A1CHEK128LIGHTTFTGFBR2TP53CCR2YESDKK3SERPINE1CCL2ADGRE1VIMAXLY815Y7791, 36, 37Y860SOCS1ACOX1NFKBIA29MKI67CTLA4GSK3B S914, 17, 19, 31STAT1P36BCL2L1TGFB1MAPK86, 42, 43PRPS68, 44S9S253S263MMP9CCND1CPT1AATF2P42TNFANGPT2CASP340CTNNB1S552CD36CCNE1SOCS3MERTK53PCDKN2AVCAM-1PI3KP18, 20, 47MAP2K241, 51MAP2K151MAPK38, 34, 48Y204T202MAPK14P21Bcl-2MTORP32TWISTKDR52IRS-1VEGFA52SNAI1ACTA2CTNNB1JUNP42PDK1LTBCAV1TNS2Y48350CHUKP9, 15BIRC5MAPK9P6, 42TIMP1AKT1T308S47339, 46, 53SLUGPARP1MAPK124, 28, 45T185Y187MET22ACTA1FOXO1P3IL1BFOXO1RPS6KB1GAS633PTK2P12COL1A1PAK1P38SNAI2SCDELMO137NFKBIA9PCDKN1APTPN1152PSNAILMCP1COL1A1CYR61 KRASAutophagyPPARGAnti-apoptotic Signaling Cell migrationMMP2AngiogenesisCHEK128S280MDM4S31416MDM2MDM4DAPK5S308CIP2A5ApoptosisCYTOPLASMCDH1Cell survivalRELA53RELA11, 40S529RAC35SRC2, 7, 23Y416SMAD3S2136IL1BIL-18CTNNB110EGFRPRKACAFASFLT1COL3A1LEGENDLigandReceptorLeads to unknown mechanismPositive regulation of gene expressionNegative regulation of gene expressionTranslocationInhibitionPlasma membraneCytoplasmNucleusPMCPNUInduced CatalysisS100A10SOCS3SOCS1ProteinProtein-Protein InteractionProteinmRNAACTA2STAT327, 49CPNUNUPM


Description

Axl is a transmembrane protein comes under TAM (Tyro3,Axl and Mertk) family of receptor tyrosine kinase (RTK). It is first identified as transforming gene, isolated from primary human myeloid leukemia cells. Axl gene is located in chromosome 19, at 19q13.1 , which encodes 894 amino acids with molecular weight range between 100 and 140kDa. Axl receptor is having extracellular, transmembrane and an intracellular domain. Extra cellular domain contains two immunoglobulin like (IgL) and fibronectin type-III (FN III) like domain with a single pass transmembrane domain.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Peng CK, Wu CP, Lin JY, Peng SC, Lee CH, Huang KL, Shen CH; ''Gas6/Axl signaling attenuates alveolar inflammation in ischemia-reperfusion-induced acute lung injury by up-regulating SOCS3-mediated pathway.''; PLoS One, 2019 PubMed Europe PMC Scholia
  2. Baumann C, Ullrich A, Torka R; ''GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance.''; Mol Oncol, 2017 PubMed Europe PMC Scholia
  3. Bertin FR, Lemari CA, Robins RS, Blostein MD; ''Growth arrest-specific 6 regulates thrombin-induced expression of vascular cell adhesion molecule-1 through forkhead box O1 in endothelial cells.''; J Thromb Haemost, 2015 PubMed Europe PMC Scholia
  4. Grommes C, Lee CY, Wilkinson BL, Jiang Q, Koenigsknecht-Talboo JL, Varnum B, Landreth GE; ''Regulation of microglial phagocytosis and inflammatory gene expression by Gas6 acting on the Axl/Mer family of tyrosine kinases.''; J Neuroimmune Pharmacol, 2008 PubMed Europe PMC Scholia
  5. Chen YL, Tsai YT, Chao TT, Wu YN, Chen MC, Lin YH, Liao CH, Chou SP, Chiang HS; ''DAPK and CIP2A are involved in GAS6/AXL-mediated Schwann cell proliferation in a rat model of bilateral cavernous nerve injury.''; Oncotarget, 2018 PubMed Europe PMC Scholia
  6. Reichl P, Dengler M, van Zijl F, Huber H, Fhrlinger G, Reichel C, Sieghart W, Peck-Radosavljevic M, Grubinger M, Mikulits W; ''Axl activates autocrine transforming growth factor- signaling in hepatocellular carcinoma.''; Hepatology, 2015 PubMed Europe PMC Scholia
  7. Rankin EB, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep AN, LaGory EL, Kariolis MS, Chan A, Lindgren D, Axelson H, Miao YR, Krieg AJ, Giaccia AJ; ''Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.''; Proc Natl Acad Sci U S A, 2014 PubMed Europe PMC Scholia
  8. Martinelli E, Martini G, Cardone C, Troiani T, Liguori G, Vitagliano D, Napolitano S, Morgillo F, Rinaldi B, Melillo RM, Liotti F, Nappi A, Bianco R, Berrino L, Ciuffreda LP, Ciardiello D, Iaffaioli V, Botti G, Ferraiolo F, Ciardiello F; ''AXL is an oncotarget in human colorectal cancer.''; Oncotarget, 2015 PubMed Europe PMC Scholia
  9. Paccez JD, Vasques GJ, Correa RG, Vasconcellos JF, Duncan K, Gu X, Bhasin M, Libermann TA, Zerbini LF; ''The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target.''; Oncogene, 2013 PubMed Europe PMC Scholia
  10. Wang C, Jin H, Wang N, Fan S, Wang Y, Zhang Y, Wei L, Tao X, Gu D, Zhao F, Fang J, Yao M, Qin W; ''Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3-catenin Signaling.''; Theranostics, 2016 PubMed Europe PMC Scholia
  11. Collina F, La Sala L, Liotti F, Prevete N, La Mantia E, Chiofalo MG, Aquino G, Arenare L, Cantile M, Liguori G, Di Gennaro F, Pezzullo L, Losito NS, Vecchio G, Botti G, Melillo RM, Franco R; ''AXL Is a Novel Predictive Factor and Therapeutic Target for Radioactive Iodine Refractory Thyroid Cancer.''; Cancers (Basel), 2019 PubMed Europe PMC Scholia
  12. Ammoun S, Provenzano L, Zhou L, Barczyk M, Evans K, Hilton DA, Hafizi S, Hanemann CO; ''Axl/Gas6/NF-kappa-B signalling in schwannoma pathological proliferation, adhesion and survival.''; Oncogene, 2014 PubMed Europe PMC Scholia
  13. Yumoto K, Eber MR, Wang J, Cackowski FC, Decker AM, Lee E, Nobre AR, Aguirre-Ghiso JA, Jung Y, Taichman RS; ''Axl is required for TGF-2-induced dormancy of prostate cancer cells in the bone marrow.''; Sci Rep, 2016 PubMed Europe PMC Scholia
  14. Goruppi S, Chiaruttini C, Ruaro ME, Varnum B, Schneider C; ''Gas6 induces growth, beta-catenin stabilization, and T-cell factor transcriptional activation in contact-inhibited C57 mammary cells.''; Mol Cell Biol, 2001 PubMed Europe PMC Scholia
  15. Paccez JD, Duncan K, Vava A, Correa RG, Libermann TA, Parker MI, Zerbini LF; ''Inactivation of GSK3B pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma.''; Mol Biol Cell, 2015 PubMed Europe PMC Scholia
  16. de Polo A, Luo Z, Gerarduzzi C, Chen X, Little JB, Yuan ZM; ''AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex.''; J Mol Cell Biol, 2017 PubMed Europe PMC Scholia
  17. Wang C, Jin H, Wang N, Fan S, Wang Y, Zhang Y, Wei L, Tao X, Gu D, Zhao F, Fang J, Yao M, Qin W; ''Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3-catenin Signaling.''; Theranostics, 2016 PubMed Europe PMC Scholia
  18. Ruan GX, Kazlauskas A; ''Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis.''; J Biol Chem, 2013 PubMed Europe PMC Scholia
  19. Jin Y, Nie D, Li J, Du X, Lu Y, Li Y, Liu C, Zhou J, Pan J; ''Gas6/AXL Signaling Regulates Self-Renewal of Chronic Myelogenous Leukemia Stem Cells by Stabilizing -Catenin.''; Clin Cancer Res, 2017 PubMed Europe PMC Scholia
  20. Jin CW, Wang H, Chen YQ, Tang MX, Fan GQ, Wang ZH, Li L, Zhang Y, Zhang W, Zhong M; ''Gas6 delays senescence in vascular smooth muscle cells through the PI3K/ Akt/FoxO signaling pathway.''; Cell Physiol Biochem, 2015 PubMed Europe PMC Scholia
  21. Han J, Bae J, Choi CY, Choi SP, Kang HS, Jo EK, Park J, Lee YS, Moon HS, Park CG, Lee MS, Chun T; ''Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice.''; Autophagy, 2016 PubMed Europe PMC Scholia
  22. Antony J, Tan TZ, Kelly Z, Low J, Choolani M, Recchi C, Gabra H, Thiery JP, Huang RY; ''The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer.''; Sci Signal, 2016 PubMed Europe PMC Scholia
  23. Ammoun S, Provenzano L, Zhou L, Barczyk M, Evans K, Hilton DA, Hafizi S, Hanemann CO; ''Axl/Gas6/NFB signalling in schwannoma pathological proliferation, adhesion and survival.''; Oncogene, 2014 PubMed Europe PMC Scholia
  24. Tai KY, Shieh YS, Lee CS, Shiah SG, Wu CW; ''Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1.''; Oncogene, 2008 PubMed Europe PMC Scholia
  25. Lee EH, Kim EM, Ji KY, Park AR, Choi HR, Lee HY, Kim SM, Chung BY, Park CH, Choi HJ, Ko YH, Bai HW, Kang HS; ''Axl acts as a tumor suppressor by regulating LIGHT expression in T lymphoma.''; Oncotarget, 2017 PubMed Europe PMC Scholia
  26. Brand TM, Iida M, Corrigan KL, Braverman CM, Coan JP, Flanigan BG, Stein AP, Salgia R, Rolff J, Kimple RJ, Wheeler DL; ''The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor.''; Sci Signal, 2017 PubMed Europe PMC Scholia
  27. Gomes AM, Carron EC, Mills KL, Dow AM, Gray Z, Fecca CR, Lakey MA, Carmeliet P, Kittrell F, Medina D, Machado HL; ''Stromal Gas6 promotes the progression of premalignant mammary cells.''; Oncogene, 2019 PubMed Europe PMC Scholia
  28. Sen T, Tong P, Diao L, Li L, Fan Y, Hoff J, Heymach JV, Wang J, Byers LA; ''Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer.''; Clin Cancer Res, 2017 PubMed Europe PMC Scholia
  29. Tai KY, Shieh YS, Lee CS, Shiah SG, Wu CW; ''Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1.''; Oncogene, 2008 PubMed Europe PMC Scholia
  30. Elkabets M, Pazarentzos E, Juric D, Sheng Q, Pelossof RA, Brook S, Benzaken AO, Rodon J, Morse N, Yan JJ, Liu M, Das R, Chen Y, Tam A, Wang H, Liang J, Gurski JM, Kerr DA, Rosell R, Teixid C, Huang A, Ghossein RA, Rosen N, Bivona TG, Scaltriti M, Baselga J; ''AXL mediates resistance to PI3K inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas.''; Cancer Cell, 2015 PubMed Europe PMC Scholia
  31. Demarchi F, Verardo R, Varnum B, Brancolini C, Schneider C; ''Gas6 anti-apoptotic signaling requires NF-kappa B activation.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  32. Brown JE, Krodel M, Pazos M, Lai C, Prieto AL; ''Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.''; PLoS One, 2012 PubMed Europe PMC Scholia
  33. Yanagita M, Ishii K, Ozaki H, Arai H, Nakano T, Ohashi K, Mizuno K, Kita T, Doi T; ''Mechanism of inhibitory effect of warfarin on mesangial cell proliferation.''; J Am Soc Nephrol, 1999 PubMed Europe PMC Scholia
  34. Allen MP, Zeng C, Schneider K, Xiong X, Meintzer MK, Bellosta P, Basilico C, Varnum B, Heidenreich KA, Wierman ME; ''Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt.''; Mol Endocrinol, 1999 PubMed Europe PMC Scholia
  35. Abu-Thuraia A, Gauthier R, Chidiac R, Fukui Y, Screaton RA, Gratton JP, C JF; ''Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion.''; Mol Cell Biol, 2015 PubMed Europe PMC Scholia
  36. Wu G, McBride DW, Zhang JH; ''Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-B pathway after MCAO in rats.''; Neurobiol Dis, 2018 PubMed Europe PMC Scholia
  37. Li W, Xiong X, Abdalla A, Alejo S, Zhu L, Lu F, Sun H; ''HGF-induced formation of the MET-AXL-ELMO2-DOCK180 complex promotes RAC1 activation, receptor clustering, and cancer cell migration and invasion.''; J Biol Chem, 2018 PubMed Europe PMC Scholia
  38. Li Y, Jia L, Liu C, Gong Y, Ren D, Wang N, Zhang X, Zhao Y; ''Axl as a downstream effector of TGF-1 via PI3K/Akt-PAK1 signaling pathway promotes tumor invasion and chemoresistance in breast carcinoma.''; Tumour Biol, 2015 PubMed Europe PMC Scholia
  39. Leconet W, Larbouret C, Chard T, Thomas G, Neiveyans M, Busson M, Jarlier M, Radosevic-Robin N, Pugnire M, Bernex F, Penault-Llorca F, Pasquet JM, Plegrin A, Robert B; ''Preclinical validation of AXL receptor as a target for antibody-based pancreatic cancer immunotherapy.''; Oncogene, 2014 PubMed Europe PMC Scholia
  40. Hasanbasic I, Cuerquis J, Varnum B, Blostein MD; ''Intracellular signaling pathways involved in Gas6-Axl-mediated survival of endothelial cells.''; Am J Physiol Heart Circ Physiol, 2004 PubMed Europe PMC Scholia
  41. Allen MP, Xu M, Linseman DA, Pawlowski JE, Bokoch GM, Heidenreich KA, Wierman ME; ''Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathway.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  42. Lee Y, Lee M, Kim S; ''Gas6 induces cancer cell migration and epithelial-mesenchymal transition through upregulation of MAPK and Slug.''; Biochem Biophys Res Commun, 2013 PubMed Europe PMC Scholia
  43. ''''; , PubMed Europe PMC Scholia
  44. Yu H, Liu R, Ma B, Li X, Yen HY, Zhou Y, Krasnoperov V, Xia Z, Zhang X, Bove AM, Buscarini M, Parekh D, Gill IS, Liao Q, Tretiakova M, Quinn D, Zhao J, Gill PS; ''Axl receptor tyrosine kinase is a potential therapeutic target in renal cell carcinoma.''; Br J Cancer, 2015 PubMed Europe PMC Scholia
  45. Sainaghi PP, Castello L, Bergamasco L, Galletti M, Bellosta P, Avanzi GC; ''Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor.''; J Cell Physiol, 2005 PubMed Europe PMC Scholia
  46. Song X, Wang H, Logsdon CD, Rashid A, Fleming JB, Abbruzzese JL, Gomez HF, Evans DB; ''Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma.''; Cancer, 2011 PubMed Europe PMC Scholia
  47. Shankar SL, O'Guin K, Kim M, Varnum B, Lemke G, Brosnan CF, Shafit-Zagardo B; ''Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis.''; J Neurosci, 2006 PubMed Europe PMC Scholia
  48. Ben-Batalla I, Schultze A, Wroblewski M, Erdmann R, Heuser M, Waizenegger JS, Riecken K, Binder M, Schewe D, Sawall S, Witzke V, Cubas-Cordova M, Janning M, Wellbrock J, Fehse B, Hagel C, Krauter J, Ganser A, Lorens JB, Fiedler W, Carmeliet P, Pantel K, Bokemeyer C, Loges S; ''Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma.''; Blood, 2013 PubMed Europe PMC Scholia
  49. Goudarzi S, Rivera A, Butt AM, Hafizi S; ''Gas6 Promotes Oligodendrogenesis and Myelination in the Adult Central Nervous System and After Lysolecithin-Induced Demyelination.''; ASN Neuro, 2016 PubMed Europe PMC Scholia
  50. Cheng LC, Chen YL, Cheng AN, Lee AY, Cho CY, Huang JS, Chuang SE; ''AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells.''; J Biomed Sci, 2018 PubMed Europe PMC Scholia
  51. Heidemann D; ''[The speedomatic amalgam condensation instrument set. Clinical experiences].''; Quintessenz, 1983 PubMed Europe PMC Scholia
  52. Gallicchio M, Mitola S, Valdembri D, Fantozzi R, Varnum B, Avanzi GC, Bussolino F; ''Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor.''; Blood, 2005 PubMed Europe PMC Scholia
  53. Brcena C, Stefanovic M, Tutusaus A, Joannas L, Menndez A, Garca-Ruiz C, Sancho-Bru P, Mar­ M, Caballeria J, Rothlin CV, Fernndez-Checa JC, de Frutos PG, Morales A; ''Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation.''; J Hepatol, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129211view01:33, 16 March 2024EweitzOntology Term : 'colorectal cancer' added !
129210view01:33, 16 March 2024EweitzOntology Term : 'osteosarcoma' added !
129209view01:32, 16 March 2024EweitzOntology Term : 'regulatory T cell' added !
129208view01:30, 16 March 2024EweitzFix typo
126496view21:59, 9 May 2023AlexanderPicoremoved "Other" datanode xrefs
126493view19:56, 9 May 2023Khanspersmore datanode identifiers
126492view19:43, 9 May 2023Khanspersremoved labels as datanode identifier
126491view19:27, 9 May 2023KhanspersReverted to version '23:56, 2 May 2023' by Khanspers
126490view19:26, 9 May 2023Khanspersconnected interactions
126473view23:56, 2 May 2023Khanspersremoved "activation" from legend. This should be indicated with interactions and not as a node color. Or added as a structured comment for the phosphosite.
126472view23:53, 2 May 2023Khanspersremoved unnecessary comments
126471view23:52, 2 May 2023Khanspersadded xrefs
126470view23:45, 2 May 2023Khanspersremoved colors, changed labels to label type, connected interactions
123895view11:28, 25 August 2022Finterlyfixed special shape
115887view16:19, 19 March 2021Keshav
115876view06:03, 19 March 2021Keshav
115875view05:58, 19 March 2021KeshavPathway update
111812view18:27, 8 September 2020EgonwRemoved a space in a PubMed identifier.
111809view16:01, 8 September 2020EgonwRemoved semicolons from the PubMed identifiers
111785view14:01, 7 September 2020DeSlRemoved special characters in publication list.
111784view13:52, 7 September 2020DeSlUpdated PMID ID (removed semicolon).
111783view13:51, 7 September 2020DeSlUpdated SRC protein ID
111515view05:07, 24 August 2020Rex D A Bupdate
111146view06:44, 20 July 2020Rex D A Blegend updated
111142view03:27, 19 July 2020Rex D A B
111141view03:25, 19 July 2020Rex D A BConnections
111140view13:18, 18 July 2020KeshavModified description
111138view11:14, 17 July 2020Rex D A BConnections and protein name
109999view19:17, 11 April 2020KeshavOntology Term : 'Gas6 - Axl signaling axis' added !
109998view19:11, 11 April 2020Keshavinteractions
109917view16:59, 6 April 2020KhanspersOntology Term : 'signaling pathway' added !
109422view07:26, 17 March 2020KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
RPS6KA1ProteinNP_002944.2 (NCBI Protein)
ACOX1GeneProduct51 (Entrez Gene)
ACTA1GeneProduct58 (Entrez Gene)
ACTA2GeneProduct59 (Entrez Gene)
ADAM11GeneProduct4185 (Entrez Gene)
ADGRE1GeneProduct
AHNAK2GeneProduct113146 (Entrez Gene)
AKT1GeneProduct
AKT3GeneProduct10000 (Entrez Gene)
ANGPT2GeneProduct285 (Entrez Gene)
ANXA2GeneProduct
ATF2ProteinNP_001871.2 (NCBI Protein)
ATG5GeneProduct9474 (Entrez Gene)
AXIN2GeneProduct
AXLProteinNP_068713.2 (NCBI Protein)
AngiogenesisPathway
Anti-apoptotic Signaling Pathway
ApoptosisPathway
AutophagyPathway
BCL2GeneProduct596 (Entrez Gene)
BCL2L1GeneProduct596 (Entrez Gene)
BECN1GeneProduct8678 (Entrez Gene)
BIRC5GeneProduct332 (Entrez Gene)
BMP6GeneProduct654 (Entrez Gene)
BMP7GeneProduct655 (Entrez Gene)
BMP8AGeneProduct353500 (Entrez Gene)
BMP8BGeneProduct656 (Entrez Gene)
Bcl-2GeneProduct
CALD1GeneProduct800 (Entrez Gene)
CASP1GeneProduct
CASP3GeneProduct836 (Entrez Gene)
CAV1GeneProduct857 (Entrez Gene)
CAV2GeneProduct858 (Entrez Gene)
CCL2GeneProduct6347 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCR2GeneProduct729230 (Entrez Gene)
CD274GeneProduct29126 (Entrez Gene)
CD36GeneProduct948 (Entrez Gene)
CDH1GeneProduct999 (Entrez Gene)
CDK4GeneProduct1019 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN2AGeneProduct1029 (Entrez Gene)
CHEK1Protein1111 (Entrez Gene)
CHEK1ProteinCHEK1 (NCBI Protein)
CHUKProteinNP_001269.3 (NCBI Protein)
CIP2AGeneProduct57650 (Entrez Gene)
COL1A1GeneProduct1277 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
CPT1AGeneProduct1374 (Entrez Gene)
CTLA4GeneProduct12477 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
CXCL16GeneProduct58191 (Entrez Gene)
CXCR6GeneProduct10663 (Entrez Gene)
CYR61 GeneProduct3491 (Entrez Gene)
Cell migrationPathway
Cell survivalPathway
DAPKGeneProduct1612 (Entrez Gene)
DKK3GeneProduct27122 (Entrez Gene)
EGFRGeneProduct
ELMO1Protein9844 (Entrez Gene)
FASGeneProduct
FLT1GeneProduct2321 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
FOXO1GeneProduct2308 (Entrez Gene)
FOXO1ProteinNP_002006.2 (NCBI Protein)
FOXP3GeneProduct50943 (Entrez Gene)
GAS6GeneProduct2621 (Entrez Gene)
GLI1GeneProduct2735 (Entrez Gene)
GLI2GeneProduct2736 (Entrez Gene)
GLI3GeneProduct2737 (Entrez Gene)
GSK3B ProteinNP_002084.2 (NCBI Protein)
IL-18GeneProduct3606 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IRS-1GeneProduct3667 (Entrez Gene)
JUNProteinNP_002219.1 (NCBI Protein)
KDRProtein3791 (Entrez Gene)
KRASGeneProduct
LEF1GeneProduct51176 (Entrez Gene)
LIGHTGeneProduct8740 (Entrez Gene)
LINC00526GeneProduct147525 (Entrez Gene)
LTBGeneProduct4050 (Entrez Gene)
LYNGeneProduct
MAP1LC3BGeneProduct81631 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK14ProteinNP_001306.1 (NCBI Protein)
MAPK1ProteinNP_002736.3 (NCBI Protein)
MAPK3ProteinNP_002737.2 (NCBI Protein)
MAPK8ProteinNP_001310259.1 (NCBI Protein)
MAPK9ProteinNP_002743.3 (NCBI Protein)
MCP1GeneProduct
MDM2GeneProduct4193 (Entrez Gene)
MDM4GeneProduct4194 (Entrez Gene)
MDM4ProteinNP_002384.2 (NCBI Protein)
MERTKProtein10461 (Entrez Gene)
METGeneProduct4233 (Entrez Gene)
MITFGeneProduct4286 (Entrez Gene)
MKI67GeneProduct4288 (Entrez Gene)
MMP2GeneProduct4313 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
MSNGeneProduct4478 (Entrez Gene)
MTORProteinNP_004949.1 (NCBI Protein)
MYC GeneProduct4609 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
NFKBIAGeneProduct4790 (Entrez Gene)
NFKBIAProteinNP_065390.1 (NCBI Protein)
NLRP3GeneProduct114548 (Entrez Gene)
NRG1GeneProduct3084 (Entrez Gene)
PAK1ProteinNP_002567.3 (NCBI Protein)
PARP1GeneProduct142 (Entrez Gene)
PDK1GeneProduct5163 (Entrez Gene)
PI3KProteinNP_006209.2 (NCBI Protein)
PPARGGeneProduct5468 (Entrez Gene)
PRKACAGeneProduct5566 (Entrez Gene)
PTK2ProteinNP_001186578.1 (NCBI Protein)
PTPN11ProteinNP_002825.3 (NCBI Protein)
RACProteinNP_008839.2 (NCBI Protein)
RELAGeneProduct5970 (Entrez Gene)
RELAProteinNP_065390.1 (NCBI Protein)
RPS6KB1ProteinNP_003152.1 (NCBI Protein)
RPS6ProteinNP_001001.2 (NCBI Protein)
S100A10GeneProduct6281 (Entrez Gene)
SCDGeneProduct6319 (Entrez Gene)
SERPINE1GeneProduct5054 (Entrez Gene)
SLUGGeneProduct
SMAD3ProteinNP_005893.1 (NCBI Protein)
SMOGeneProduct6608 (Entrez Gene)
SNAI1GeneProduct6615 (Entrez Gene)
SNAI2GeneProduct6591 (Entrez Gene)
SNAI3GeneProduct333929 (Entrez Gene)
SNAILGeneProduct
SOCS1GeneProduct8651 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SP1GeneProduct28423548 (Entrez Gene)
SPARCGeneProduct6678 (Entrez Gene)
SRCProteinNP_005408.1 (NCBI Protein)
STAT1ProteinNP_009330.1 (NCBI Protein)
STAT3Protein6774 (Entrez Gene)
TFGeneProduct7018 (Entrez Gene)
TGF4GeneProduct6925 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFB1I1GeneProduct7041 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
TGFBR2GeneProduct7048 (Entrez Gene)
TIMP1GeneProduct7076 (Entrez Gene)
TMEFF1GeneProduct8577 (Entrez Gene)
TMEM132AGeneProduct54972 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TNS2ProteinNP_056134.2 (NCBI Protein)
TP53GeneProductTP53 (NCBI Protein)
TWISTGeneProduct7291 (Entrez Gene)
VAV1ProteinNP_005419.2 (NCBI Protein)
VCAM-1GeneProduct7412 (Entrez Gene)
VEGFAProtein7422 (Entrez Gene)
VIMGeneProduct7431 (Entrez Gene)
YESGeneProduct
ZEB1GeneProduct6935 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4847"
Personal tools