AXL signaling (Homo sapiens)

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cell migration and invasionCollagenThrombosisBone morphogenicproteinsTranscription factorsRegulatory T cells(Tregs)NUCLEUSPLASMA MEMBRANEColorectal CancerProliferationOsteosarcoma EGFR nuclear translocation mediatorsImmune suppressionTumor progressionEMTLung adenocarcinomasCPTumor invasion/migrationLiver Inflammation, Steatohepatitis, and FibrosisChemokinesCellular senescenceTransmembrane proteinTranscriptional regulator Dormacy cell survivalMatrix metalloproteasesInflammationZEB1CCND1FN1NLRP3ATG5BECN1MYCANXA2LEF1MAP1LC3BTGFBR2AXIN2CASP11321MSNTGF4GLI2CALD1TGFB2TMEM132ASMOADAM11GLI3NRG1TGFB1I1SPARCBMP8BAKT3SNAI3MITFAHNAK2VAV14PBMP6EGFRY1173Y1101BMP726, 30CDK416SP1CAV225CDK616MYC CD274CXCL16TGFB1TMEFF1LINC00526CXCR6BMP8ALYNGLI1BCL2 RPS6KA1S36328T359BIRC5FOXP3TGFB2COL3A1CHEK128LIGHTTFTGFBR2TP53CCR2YESDKK3SERPINE1CCL2ADGRE1VIMAXL1, 36, 37Y860Y815Y779SOCS1ACOX1NFKBIA29MKI67CTLA4GSK3B S914, 17, 19, 31STAT1P36BCL2L1TGFB1MAPK8P6, 42, 43RPS68, 44S253S263S9MMP9CCND1CPT1AATF242PTNFANGPT2CASP340CTNNB1S552CD36CCNE1SOCS3MERTK53PCDKN2AVCAM-1PI3K18, 20, 47PMAP2K241, 51MAP2K151MAPK3Y204T2028, 34, 48MAPK1421PBcl-2MTORP32TWISTKDR52IRS-1VEGFA52SNAI1ACTA2CTNNB1JUNP42PDK1LTBCAV1TNS2Y48350CHUKP9, 15BIRC5MAPK9P6, 42TIMP1AKT1S47339, 46, 53T308SLUGPARP1MAPK1T185Y18724, 28, 45MET22ACTA1FOXO13PIL1BFOXO1RPS6KB1GAS633PTK2P12COL1A1PAK1P38SNAI2SCDELMO137NFKBIAP9CDKN1APTPN1152PSNAILMCP1COL1A1CYR61 KRASAutophagyPPARGAnti-apoptotic Signaling Cell migrationMMP2AngiogenesisCHEK128S280MDM416S314MDM2MDM4DAPKS3085CIP2A5ApoptosisCYTOPLASMCDH1Cell survivalRELA53RELA11, 40S529RAC35SRC2, 7, 23Y416SMAD36S213IL1BIL-18CTNNB110EGFRPRKACAFASFLT1COL3A1LEGENDLigandReceptorLeads to unknown mechanismPositive regulation of gene expressionNegative regulation of gene expressionTranslocationInhibitionPlasma membraneCytoplasmNucleusPMCPNUInduced CatalysisS100A10SOCS3SOCS1ProteinProtein-Protein InteractionProteinmRNAACTA2STAT327, 49CPNUNUPM


Description

Axl is a transmembrane protein comes under TAM (Tyro3,Axl and Mertk) family of receptor tyrosine kinase (RTK). It is first identified as transforming gene, isolated from primary human myeloid leukemia cells. Axl gene is located in chromosome 19, at 19q13.1 , which encodes 894 amino acids with molecular weight range between 100 and 140kDa. Axl receptor is having extracellular, transmembrane and an intracellular domain. Extra cellular domain contains two immunoglobulin like (IgL) and fibronectin type-III (FN III) like domain with a single pass transmembrane domain.

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Bibliography

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  18. Ruan GX, Kazlauskas A; ''Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis.''; J Biol Chem, 2013 PubMed Europe PMC Scholia
  19. Jin Y, Nie D, Li J, Du X, Lu Y, Li Y, Liu C, Zhou J, Pan J; ''Gas6/AXL Signaling Regulates Self-Renewal of Chronic Myelogenous Leukemia Stem Cells by Stabilizing -Catenin.''; Clin Cancer Res, 2017 PubMed Europe PMC Scholia
  20. Jin CW, Wang H, Chen YQ, Tang MX, Fan GQ, Wang ZH, Li L, Zhang Y, Zhang W, Zhong M; ''Gas6 delays senescence in vascular smooth muscle cells through the PI3K/ Akt/FoxO signaling pathway.''; Cell Physiol Biochem, 2015 PubMed Europe PMC Scholia
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  24. Tai KY, Shieh YS, Lee CS, Shiah SG, Wu CW; ''Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1.''; Oncogene, 2008 PubMed Europe PMC Scholia
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  49. Goudarzi S, Rivera A, Butt AM, Hafizi S; ''Gas6 Promotes Oligodendrogenesis and Myelination in the Adult Central Nervous System and After Lysolecithin-Induced Demyelination.''; ASN Neuro, 2016 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
129689view00:47, 22 May 2024EweitzModified title
129211view01:33, 16 March 2024EweitzOntology Term : 'colorectal cancer' added !
129210view01:33, 16 March 2024EweitzOntology Term : 'osteosarcoma' added !
129209view01:32, 16 March 2024EweitzOntology Term : 'regulatory T cell' added !
129208view01:30, 16 March 2024EweitzFix typo
126496view21:59, 9 May 2023AlexanderPicoremoved "Other" datanode xrefs
126493view19:56, 9 May 2023Khanspersmore datanode identifiers
126492view19:43, 9 May 2023Khanspersremoved labels as datanode identifier
126491view19:27, 9 May 2023KhanspersReverted to version '23:56, 2 May 2023' by Khanspers
126490view19:26, 9 May 2023Khanspersconnected interactions
126473view23:56, 2 May 2023Khanspersremoved "activation" from legend. This should be indicated with interactions and not as a node color. Or added as a structured comment for the phosphosite.
126472view23:53, 2 May 2023Khanspersremoved unnecessary comments
126471view23:52, 2 May 2023Khanspersadded xrefs
126470view23:45, 2 May 2023Khanspersremoved colors, changed labels to label type, connected interactions
123895view11:28, 25 August 2022Finterlyfixed special shape
115887view16:19, 19 March 2021Keshav
115876view06:03, 19 March 2021Keshav
115875view05:58, 19 March 2021KeshavPathway update
111812view18:27, 8 September 2020EgonwRemoved a space in a PubMed identifier.
111809view16:01, 8 September 2020EgonwRemoved semicolons from the PubMed identifiers
111785view14:01, 7 September 2020DeSlRemoved special characters in publication list.
111784view13:52, 7 September 2020DeSlUpdated PMID ID (removed semicolon).
111783view13:51, 7 September 2020DeSlUpdated SRC protein ID
111515view05:07, 24 August 2020Rex D A Bupdate
111146view06:44, 20 July 2020Rex D A Blegend updated
111142view03:27, 19 July 2020Rex D A B
111141view03:25, 19 July 2020Rex D A BConnections
111140view13:18, 18 July 2020KeshavModified description
111138view11:14, 17 July 2020Rex D A BConnections and protein name
109999view19:17, 11 April 2020KeshavOntology Term : 'Gas6 - Axl signaling axis' added !
109998view19:11, 11 April 2020Keshavinteractions
109917view16:59, 6 April 2020KhanspersOntology Term : 'signaling pathway' added !
109422view07:26, 17 March 2020KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
RPS6KA1ProteinNP_002944.2 (NCBI Protein)
ACOX1GeneProduct51 (Entrez Gene)
ACTA1GeneProduct58 (Entrez Gene)
ACTA2GeneProduct59 (Entrez Gene)
ADAM11GeneProduct4185 (Entrez Gene)
ADGRE1GeneProduct
AHNAK2GeneProduct113146 (Entrez Gene)
AKT1GeneProduct
AKT3GeneProduct10000 (Entrez Gene)
ANGPT2GeneProduct285 (Entrez Gene)
ANXA2GeneProduct
ATF2ProteinNP_001871.2 (NCBI Protein)
ATG5GeneProduct9474 (Entrez Gene)
AXIN2GeneProduct
AXLProteinNP_068713.2 (NCBI Protein)
AngiogenesisPathway
Anti-apoptotic Signaling Pathway
ApoptosisPathway
AutophagyPathway
BCL2GeneProduct596 (Entrez Gene)
BCL2L1GeneProduct596 (Entrez Gene)
BECN1GeneProduct8678 (Entrez Gene)
BIRC5GeneProduct332 (Entrez Gene)
BMP6GeneProduct654 (Entrez Gene)
BMP7GeneProduct655 (Entrez Gene)
BMP8AGeneProduct353500 (Entrez Gene)
BMP8BGeneProduct656 (Entrez Gene)
Bcl-2GeneProduct
CALD1GeneProduct800 (Entrez Gene)
CASP1GeneProduct
CASP3GeneProduct836 (Entrez Gene)
CAV1GeneProduct857 (Entrez Gene)
CAV2GeneProduct858 (Entrez Gene)
CCL2GeneProduct6347 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCR2GeneProduct729230 (Entrez Gene)
CD274GeneProduct29126 (Entrez Gene)
CD36GeneProduct948 (Entrez Gene)
CDH1GeneProduct999 (Entrez Gene)
CDK4GeneProduct1019 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN2AGeneProduct1029 (Entrez Gene)
CHEK1Protein1111 (Entrez Gene)
CHEK1ProteinCHEK1 (NCBI Protein)
CHUKProteinNP_001269.3 (NCBI Protein)
CIP2AGeneProduct57650 (Entrez Gene)
COL1A1GeneProduct1277 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
CPT1AGeneProduct1374 (Entrez Gene)
CTLA4GeneProduct12477 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
CXCL16GeneProduct58191 (Entrez Gene)
CXCR6GeneProduct10663 (Entrez Gene)
CYR61 GeneProduct3491 (Entrez Gene)
Cell migrationPathway
Cell survivalPathway
DAPKGeneProduct1612 (Entrez Gene)
DKK3GeneProduct27122 (Entrez Gene)
EGFRGeneProduct
ELMO1Protein9844 (Entrez Gene)
FASGeneProduct
FLT1GeneProduct2321 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
FOXO1GeneProduct2308 (Entrez Gene)
FOXO1ProteinNP_002006.2 (NCBI Protein)
FOXP3GeneProduct50943 (Entrez Gene)
GAS6GeneProduct2621 (Entrez Gene)
GLI1GeneProduct2735 (Entrez Gene)
GLI2GeneProduct2736 (Entrez Gene)
GLI3GeneProduct2737 (Entrez Gene)
GSK3B ProteinNP_002084.2 (NCBI Protein)
IL-18GeneProduct3606 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IRS-1GeneProduct3667 (Entrez Gene)
JUNProteinNP_002219.1 (NCBI Protein)
KDRProtein3791 (Entrez Gene)
KRASGeneProduct
LEF1GeneProduct51176 (Entrez Gene)
LIGHTGeneProduct8740 (Entrez Gene)
LINC00526GeneProduct147525 (Entrez Gene)
LTBGeneProduct4050 (Entrez Gene)
LYNGeneProduct
MAP1LC3BGeneProduct81631 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK14ProteinNP_001306.1 (NCBI Protein)
MAPK1ProteinNP_002736.3 (NCBI Protein)
MAPK3ProteinNP_002737.2 (NCBI Protein)
MAPK8ProteinNP_001310259.1 (NCBI Protein)
MAPK9ProteinNP_002743.3 (NCBI Protein)
MCP1GeneProduct
MDM2GeneProduct4193 (Entrez Gene)
MDM4GeneProduct4194 (Entrez Gene)
MDM4ProteinNP_002384.2 (NCBI Protein)
MERTKProtein10461 (Entrez Gene)
METGeneProduct4233 (Entrez Gene)
MITFGeneProduct4286 (Entrez Gene)
MKI67GeneProduct4288 (Entrez Gene)
MMP2GeneProduct4313 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
MSNGeneProduct4478 (Entrez Gene)
MTORProteinNP_004949.1 (NCBI Protein)
MYC GeneProduct4609 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
NFKBIAGeneProduct4790 (Entrez Gene)
NFKBIAProteinNP_065390.1 (NCBI Protein)
NLRP3GeneProduct114548 (Entrez Gene)
NRG1GeneProduct3084 (Entrez Gene)
PAK1ProteinNP_002567.3 (NCBI Protein)
PARP1GeneProduct142 (Entrez Gene)
PDK1GeneProduct5163 (Entrez Gene)
PI3KProteinNP_006209.2 (NCBI Protein)
PPARGGeneProduct5468 (Entrez Gene)
PRKACAGeneProduct5566 (Entrez Gene)
PTK2ProteinNP_001186578.1 (NCBI Protein)
PTPN11ProteinNP_002825.3 (NCBI Protein)
RACProteinNP_008839.2 (NCBI Protein)
RELAGeneProduct5970 (Entrez Gene)
RELAProteinNP_065390.1 (NCBI Protein)
RPS6KB1ProteinNP_003152.1 (NCBI Protein)
RPS6ProteinNP_001001.2 (NCBI Protein)
S100A10GeneProduct6281 (Entrez Gene)
SCDGeneProduct6319 (Entrez Gene)
SERPINE1GeneProduct5054 (Entrez Gene)
SLUGGeneProduct
SMAD3ProteinNP_005893.1 (NCBI Protein)
SMOGeneProduct6608 (Entrez Gene)
SNAI1GeneProduct6615 (Entrez Gene)
SNAI2GeneProduct6591 (Entrez Gene)
SNAI3GeneProduct333929 (Entrez Gene)
SNAILGeneProduct
SOCS1GeneProduct8651 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SP1GeneProduct28423548 (Entrez Gene)
SPARCGeneProduct6678 (Entrez Gene)
SRCProteinNP_005408.1 (NCBI Protein)
STAT1ProteinNP_009330.1 (NCBI Protein)
STAT3Protein6774 (Entrez Gene)
TFGeneProduct7018 (Entrez Gene)
TGF4GeneProduct6925 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFB1I1GeneProduct7041 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
TGFBR2GeneProduct7048 (Entrez Gene)
TIMP1GeneProduct7076 (Entrez Gene)
TMEFF1GeneProduct8577 (Entrez Gene)
TMEM132AGeneProduct54972 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TNS2ProteinNP_056134.2 (NCBI Protein)
TP53GeneProductTP53 (NCBI Protein)
TWISTGeneProduct7291 (Entrez Gene)
VAV1ProteinNP_005419.2 (NCBI Protein)
VCAM-1GeneProduct7412 (Entrez Gene)
VEGFAProtein7422 (Entrez Gene)
VIMGeneProduct7431 (Entrez Gene)
YESGeneProduct
ZEB1GeneProduct6935 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4847"
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