CAMKK2 pathway (Homo sapiens)

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Laminar shear stressWithdrawal of essential amino acids.Pulsed electric field13143CAMKK2 pathwayLabelIFI44LNFATC2MAP1LC3ACa2+HMOX1STIM1CALM1DRP1MAFVCAM1FIS110322710, 16GATMASNSKLF1GALNT9FASNPFKFB2Theasinensins8ERMAPRPTOR39NEDD4LCaulerpin22ABCA1HK2MTORS244817CYB5R3CAMK134S100A8ACACAS7923HK2ARHGEF7S516 35EPORFOXO3AS321S31811CCNE1PFKFB2TMEM176BIsorhamnetin5Adropin36CCL5Hydrogen sulphide42TRPV4EP3003S1834 KDRSFI1WDR35Ramipril38SMC123NRF2MAP1LC3BCCND1NOS3 S117728SLCO3A1MAPK14 Y12241TSPAN33NLRP1WFS119MAP1LC3AMAPK118MX2Homocysteine sulfinic acid41C1QTNF12CD28KEAP1MID1Apigenin1IL15RPS6KB1HMBSEstrogen29CD28CAMK4P25RELA9VCAM1OASLCTSEMetabolitesSPINT1NOS144SREBF1CDH1GIT135SQSTM121MAP1LC3BRASGRP1PPAP2AEugenol4IRGCGlyceollin30RPS6PAK1 7CREB13HFEQuercetin24WFS1PCK2Hypoxia43CDC25AOxytocin15SELLTSPAN8CHRM316TREM3EIF4EBP1T37S656T46SLC2A4ATP1B2PLAC8ICAM133GATMGDH1 37Poly unsaturated fatty acids40TNFCAMKK28, 12TBXTAQP1ACACARAC17IRS-111, 30S639S636CXCL11GCKSPIRE1PARP1CCR9HDCA425EPORBupivacaine9FAM20CHMOX1Betulinic acid28INN27CCND2HK1SLC2A1CAR1SLC25A21RHDMAMDC2MT1TBC1D4 26T642 ATP10DCRTC2MS4A3PFKFB3SLC38A5AHSPCPOXRHAGFatty acid biosysthesisTranslocationPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionInduced catalysisLEGENDProteinNucleusCytoplasmCYNUProtein-protein dissociationInhibitionSmall moleculePlasma membranePMNucleusSmall moleculeCREB1TSC16SIRT1 31AKTS473T3082RPS6KB1T389AutophagyAnoikisAnaerobic metabolismCytokineCellcycleHypoxiaCalcium channel transporterApoptosisGlyconeogensis Signal transductionTransportHeme biosynthesisHIF1AMembraneChemokineHK1Erythrocyte developmentPRKAA28T172ULK1S757317S555 ApoptosisCell proliferation and migrationUbiquitinationDissociationMAPK318TSC2T1462 6PRKCAT639 20NRF2NUCYNUCYCytoplasmMetabolitesActivationmRNA


Description

CaMKK2 is a 66–68-kDa serine kinase, consists of unique N- and C-terminal domains and a central Ser/Thr-directed kinase domain that is followed by a regulatory domain composed of overlapping autoinhibitory and CaM-binding regions (PMID:9335539). CAMKK2 is activated once calmodulin (CALM1) binds with CAAMKK2. The most well-characterized substrates of CaMKK2 are CaMKI, CaMKIV and AMPKα. CaMKK2 phosphorylates CaMKIV, CaMKI and AMPKα on activation loop Thr residues (Thr-200, Thr-177 and Thr-172, respectively), which increases their kinase activities (PMID:9822657). CaMKK2 is present in many areas of the brain, including the olfactory bulb, hippocampus, dentate gyrus, amygdala, hypothalamus, and cerebellum (PMID:9822657, 12654522). The creation of this pathway is described in Najar et al.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
134958view09:42, 30 July 2024EgonwAdded datanode types based on the xref datasource
134666view14:27, 25 July 2024Ash iyerupdate metabolites annotation and added grahical elements.
134665view14:11, 25 July 2024Ash iyerchanging datanodes to graphical elements.
134664view14:06, 25 July 2024Ash iyeradded missing annotation on datanodes.
134659view10:40, 25 July 2024Ash iyeradd missing annotation for datanodes
134658view10:20, 25 July 2024Ash iyerModified description
134646view08:55, 24 July 2024EgonwRemoved labels that were listed as identifier without datasource
126535view09:44, 29 May 2023EgonwTyped datanodes
124683view07:26, 24 November 2022Rex D A B
121708view04:43, 26 February 2022EweitzUse gene symbol
117669view11:58, 22 May 2021EweitzModified title
113833view08:50, 30 November 2020Fehrhartconnected some of the unconnected lines
113771view18:21, 19 November 2020KhanspersModified description
112884view18:20, 14 October 2020EgonwReplaced gene symbols by Entrez Gene identifiers
112274view00:43, 9 October 2020Rex D A Bconnections and gene name
112262view12:10, 8 October 2020KeshavModified description
111803view15:17, 7 September 2020DeSlRemoved special characters for TNF- node (assuming this is TNF-alpha).
111802view15:15, 7 September 2020DeSladded ID for Adropin (changed from Metabolite to Protein, since it's a peptide hormone).
111801view15:11, 7 September 2020DeSladded ID for Apigenin
111800view15:10, 7 September 2020DeSladded ID for Betulinic acid
111799view15:09, 7 September 2020DeSladded ID for bupivacine (assumed this should be bupivacaine, as wikipedia suggests)
111798view15:07, 7 September 2020DeSladded ID for cauleprin (assumed this should be caulerpin, as reference suggests)
111796view14:48, 7 September 2020DeSladded ID for eugenol
111795view14:44, 7 September 2020DeSladded ID for Glyceollin
111794view14:43, 7 September 2020DeSladded ID for Homocysteine sulfinic acid
111793view14:38, 7 September 2020DeSladded ID for Isorhamnetin
111792view14:36, 7 September 2020DeSladded ID for oxytocin
111791view14:28, 7 September 2020DeSladded ID for quericin (assumed this should be quercetin, as reference suggests)
111790view14:26, 7 September 2020DeSladded ID for ramipril
111789view14:24, 7 September 2020DeSlremoved name as ID for Theasinensins
110018view19:19, 12 April 2020Keshavconnections
110016view19:13, 12 April 2020KeshavInteractions
109756view18:30, 30 March 2020KeshavOntology Term : 'cancer' added !
109755view18:29, 30 March 2020KeshavOntology Term : 'calcium/calcium-mediated signaling pathway' added !
109750view17:53, 30 March 2020KeshavTitle
109749view17:49, 30 March 2020KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCA1GeneProductABCA1 (HGNC)
ACACAGeneProductACACA (HGNC)
ACACAProteinNP_942131.1 (NCBI Protein)
AHSPGeneProductAHSP (HGNC)
AKTProteinNP_001014431.1 (NCBI Protein)
AQP1GeneProductAQP1 (HGNC)
ARHGEF7GeneProduct8874 (Entrez Gene)
ASNSGeneProductASNS (HGNC)
ATP10DGeneProductATP10D (HGNC)
ATP1B2GeneProductATP1B2 (HGNC)
AdropinProtein375704 (Entrez Gene)
ApigeninMetaboliteCHEBI:18388 (ChEBI)
Betulinic acidMetaboliteCHEBI:3087 (ChEBI)
BupivacaineMetaboliteCHEBI:31322 (ChEBI)
C1QTNF12GeneProduct388581 (Entrez Gene)
CALM1GeneProduct801 (Entrez Gene)
CAMK1GeneProduct8536 (Entrez Gene)
CAMK4GeneProduct814 (Entrez Gene)
CAMKK2GeneProduct10645 (Entrez Gene)
CAR1GeneProductCAR1 (HGNC)
CCL5GeneProduct6352 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct595 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCR9GeneProductCCR9 (HGNC)
CD28GeneProduct940 (Entrez Gene)
CD28GeneProductCD28 (HGNC)
CDC25AGeneProductCDC25A (HGNC)
CDH1GeneProductCDH1 (HGNC)
CHRM3GeneProduct1131 (Entrez Gene)
CPOXGeneProductCPOX (HGNC)
CREB1GeneProduct1385 (Entrez Gene)
CRTC2GeneProductCRTC2 (HGNC)
CTSEGeneProduct1510 (Entrez Gene)
CXCL11GeneProductCXCL11 (HGNC)
CYB5R3GeneProductCYB5R3 (HGNC)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CaulerpinMetaboliteCHEBI:80923 (ChEBI)
DRP1GeneProduct10059 (Entrez Gene)
EIF4EBP1ProteinNP_004086.1 (NCBI Protein)
EP300GeneProduct2033 (Entrez Gene)
EPORGeneProduct2057 (Entrez Gene)
ERMAPGeneProductERMAP (HGNC)
EstrogenMetaboliteCHEBI:50114 (ChEBI)
EugenolMetaboliteCHEBI:4917 (ChEBI)
FAM20CGeneProduct56975 (Entrez Gene)
FASNGeneProductFASN (HGNC)
FIS1GeneProduct51024 (Entrez Gene)
FOXO3AProteinNP_001446.1 (NCBI Protein)
GALNT9GeneProductGALNT9 (HGNC)
GATMGeneProductGATM (HGNC)
GCKGeneProductGCK (HGNC)
GDH1 GeneProduct854557 (Entrez Gene)
GIT1GeneProduct28964 (Entrez Gene)
GlyceollinMetaboliteCHEBI:16470 (ChEBI)
HDCA4GeneProduct9759 (Entrez Gene)
HFEGeneProductHFE (HGNC)
HIF1AGeneProductHIF1A (HGNC)
HK1GeneProductHK1 (HGNC)
HK2GeneProductHK2 (HGNC)
HMBSGeneProductHMBS (HGNC)
HMOX1GeneProduct3162 (Entrez Gene)
Homocysteine sulfinic acidMetaboliteCHEBI:137439 (ChEBI)
Hydrogen sulphideMetaboliteCHEBI:16136 (ChEBI)
HypoxiaPathway
ICAM1GeneProduct3383 (Entrez Gene)
IFI44LGeneProductIFI44L (HGNC)
IL15GeneProduct3600 (Entrez Gene)
INNGeneProductINN (HGNC)
IRGCGeneProduct56269 (Entrez Gene)
IRS-1ProteinNP_005535.1 (NCBI Protein)
IsorhamnetinMetaboliteCHEBI:6052 (ChEBI)
KDRGeneProductKDR (HGNC)
KEAP1GeneProductKEAP1 (HGNC)
KLF1GeneProductKLF1 (HGNC)
MAFGeneProduct4094 (Entrez Gene)
MAMDC2GeneProductMAMDC2 (HGNC)
MAP1LC3AGeneProduct84557 (Entrez Gene)
MAP1LC3AGeneProductMAP1LC3A (HGNC)
MAP1LC3BGeneProductMAP1LC3B (HGNC)
MAPK14 ProteinNP_001306.1 (NCBI Protein)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3 GeneProduct5595 (Entrez Gene)
MID1GeneProduct4281 (Entrez Gene)
MS4A3GeneProductMS4A3 (HGNC)
MT1GeneProduct17748 (Entrez Gene)
MTORGeneProduct2475 (Entrez Gene)
MX2GeneProduct4600 (Entrez Gene)
MetabolitesGeneProduct
NEDD4LGeneProductNEDD4L (HGNC)
NFATC2GeneProduct4773 (Entrez Gene)
NLRP1GeneProductNLRP1 (HGNC)
NOS1GeneProduct4842 (Entrez Gene)
NOS3 ProteinNP_000594.2 (NCBI Protein)
NRF2GeneProduct4780 (Entrez Gene)
NRF2GeneProductNRF2 (HGNC)
OASLGeneProduct8638 (Entrez Gene)
OxytocinMetaboliteCHEBI:7872 (ChEBI)
PAK1 GeneProduct5058 (Entrez Gene)
PARP1GeneProduct142 (Entrez Gene)
PCK2GeneProductPCK2 (HGNC)
PFKFB2GeneProductPFKFB2 (HGNC)
PFKFB3GeneProductPFKFB3 (HGNC)
PLAC8GeneProduct51316 (Entrez Gene)
PPAP2AGeneProductPPAP2A (HGNC)
PRKAA2GeneProductNP_006243.2 (NCBI Protein)
PRKCAProteinNP_002728.1 (NCBI Protein)
Poly unsaturated fatty acidsGeneProduct
ProteinProtein5894 (Entrez Gene)
QuercetinMetaboliteCHEBI:16243 (ChEBI)
RAC1GeneProduct5879 (Entrez Gene)
RASGRP1GeneProduct10125 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RHAGGeneProductRHAG (HGNC)
RHDGeneProductRHD (HGNC)
RPS6KB1GeneProductRPS6KB1 (HGNC)
RPS6GeneProductRPS6 (HGNC)
RPTORGeneProduct57521 (Entrez Gene)
RamiprilMetaboliteCHEBI:8774 (ChEBI)
S100A8GeneProduct6279 (Entrez Gene)
SELLGeneProduct6402 (Entrez Gene)
SFI1GeneProduct9814 (Entrez Gene)
SIRT1 GeneProduct23411 (Entrez Gene)
SLC25A21GeneProduct89874 (Entrez Gene)
SLC2A1GeneProduct6513 (Entrez Gene)
SLC2A4GeneProductSLC2A4 (HGNC)
SLC38A5GeneProduct92745 (Entrez Gene)
SLCO3A1GeneProductSLCO3A1 (HGNC)
SMC1GeneProduct8243 (Entrez Gene)
SPINT1GeneProductSPINT1 (HGNC)
SPIRE1GeneProduct56907 (Entrez Gene)
SQSTM1GeneProduct8878 (Entrez Gene)
SREBF1GeneProductSREBF1 (HGNC)
STIM1GeneProduct6786 (Entrez Gene)
TBC1D4 ProteinNP_001273587.1 (NCBI Protein)
TBXTGeneProduct6862 (Entrez Gene)
TMEM176BGeneProductTMEM176B (HGNC)
TNFGeneProduct7124 (Entrez Gene)
TREM3GeneProductTREM3 (HGNC)
TRPV4GeneProduct59341 (Entrez Gene)
TSC1GeneProduct7248 (Entrez Gene)
TSC2ProteinNP_000539.2 (NCBI Protein)
TSPAN33GeneProductTSPAN33 (HGNC)
TSPAN8GeneProductTSPAN8 (HGNC)
TheasinensinsMetabolite390965 (Chemspider)
ULK1GeneProductULK1 (HGNC)
VCAM1GeneProduct7412 (Entrez Gene)
WDR35GeneProduct57539 (Entrez Gene)
WFS1GeneProduct7466 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4874"
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