CAMKK2 pathway (Homo sapiens)

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LabelCAMKK2 pathwayVCAM1MAP1LC3ACALM1DRP1MAFCa2+STIM1NFATC2HMOX1FIS1IFI44L44434120, 44GATMASNSKLF1GALNT9FASNPFKFB2Theasinensins15ERMAPRPTOR3NEDD4LCaulerpin36ABCA1HK2MTORS244829CYB5R3CAMK118S100A8ACACAS7939HK2ARHGEF738S516 EPORFOXO3AS321S31840CCNE1PFKFB2TMEM176BIsorhamnetin31Adropin17CCL5Hydrogen sulphide19TRPV4EP300S1834 30KDRSFI1WDR35Ramipril14SMC139NRF2MAP1LC3BCCND1NOS3 S11778SLCO3A1MAPK14 Y12216TSPAN33NLRP1WFS110MAP1LC3AMAPK132MX2Homocysteine sulfinic acid16FAM132aCD28KEAP1MID1Apigenin5IL15RPS6KB1HMBSEstrogen9CD28CAMK425PRELA33VCAM1OASLCTSEMetabolitesSPINT1NOS142SREBF1CDH1GIT138SQSTM135MAP1LC3BRASGRP1Withdrawal of essential amino acids13PPAP2AEugenol12IRGCGlyceollin7RPS6PAK1 24CREB130HFEQuercetin1WFS1PCK2Hypoxia28CDC25AOxytocin23SELLTSPAN8CHRM320TREM3EIF4EBP16S65T37T46SLC2A4ATP1B2PLAC8ICAM122GATMGDH1 26Poly unsaturated fatty acids21TNFCAMKK215, 34TBXTLaminar shear stress30AQP1ACACARAC124IRS-1S639S6367, 40CXCL11GCKSPIRE1PARP1Pulsed electric field2CCR9HDCA425EPORBupivacaine33FAM20CHMOX1Betulinic acid8INN41CCND2HK1SLC2A1CAR1SLC25A21RHDMAMDC2MT1TBC1D4 37T642 ATP10DCRTC2MS4A3PFKFB3SLC38A5AHSPCPOXRHAGFatty acid biosysthesisTranslocationPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionInduced catalysisLEGENDProteinNucleusCytoplasmCYNUProtein-protein dissociationInhibitionSmall moleculePlasma membranePMNucleusSmall moleculeCREB1TSC16SIRT1 27AKTT308S47311RPS6KB1T389AutophagyAnoikisAnaerobic metabolismCytokineCellcycleHypoxiaCalcium channel transporterApoptosisGlyconeogensis Signal transductionTransportHeme biosynthesisHIF1AMembraneChemokineHK1Erythrocyte developmentPRKAA2T17215ULK1317S757S555 ApoptosisCell proliferation and migrationUbiquitinationDissociationMAPK3TSC232T1462 6PRKCAT639 4NRF2NUCYNUCYCytoplasmMetabolitesActivationmRNA


Description

CaMKK2 is a 66–68-kDa serine kinase, consists of unique N- and C-terminal domains and a central Ser/Thr-directed kinase domain that is followed by a regulatory domain composed of overlapping autoinhibitory and CaM-binding regions (PMID:9335539). CAMKK2 is activated once calmodulin (CALM1) binds with CAAMKK2. The most well-characterized substrates of CaMKK2 are CaMKI, CaMKIV and AMPKα. CaMKK2 phosphorylates CaMKIV, CaMKI and AMPKα on activation loop Thr residues (Thr-200, Thr-177 and Thr-172, respectively), which increases their kinase activities (PMID:9822657). CaMKK2 is present in many areas of the brain, including the olfactory bulb, hippocampus, dentate gyrus, amygdala, hypothalamus, and cerebellum (PMID:9822657, 12654522). The creation of this pathway is described in Najar et al.

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Bibliography

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  1. Dhanya R, Arya AD, Nisha P, Jayamurthy P; ''Quercetin, a Lead Compound against Type 2 Diabetes Ameliorates Glucose Uptake via AMPK Pathway in Skeletal Muscle Cell Line.''; Front Pharmacol, 2017 PubMed Europe PMC Scholia
  2. Morotomi-Yano K, Akiyama H, Yano K; ''Nanosecond pulsed electric fields activate AMP-activated protein kinase: implications for calcium-mediated activation of cellular signaling.''; Biochem Biophys Res Commun, 2012 PubMed Europe PMC Scholia
  3. Sinha RA, Singh BK, Zhou J, Wu Y, Farah BL, Ohba K, Lesmana R, Gooding J, Bay BH, Yen PM; ''Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling.''; Autophagy, 2015 PubMed Europe PMC Scholia
  4. Kim N, Lee JO, Lee HJ, Lee YW, Kim HI, Kim SJ, Park SH, Lee CS, Ryoo SW, Hwang GS, Kim HS; ''AMPK, a metabolic sensor, is involved in isoeugenol-induced glucose uptake in muscle cells.''; J Endocrinol, 2016 PubMed Europe PMC Scholia
  5. Tong X, Smith KA, Pelling JC; ''Apigenin, a chemopreventive bioflavonoid, induces AMP-activated protein kinase activation in human keratinocytes.''; Mol Carcinog, 2012 PubMed Europe PMC Scholia
  6. Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L, Warren A, Scott H, Madhu B, Sharma N, Bon H, Zecchini V, Smith DM, Denicola GM, Mathews N, Osborne M, Hadfield J, Macarthur S, Adryan B, Lyons SK, Brindle KM, Griffiths J, Gleave ME, Rennie PS, Neal DE, Mills IG; ''The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.''; EMBO J, 2011 PubMed Europe PMC Scholia
  7. Yoon EK, Jeong YT, Li X, Song-Cui, Park DC, Kim YH, Kim YD, Chang HW, Lee SH, Hwang SL; ''Glyceollin improves endoplasmic reticulum stress-induced insulin resistance through CaMKK-AMPK pathway in L6 myotubes.''; J Nutr Biochem, 2013 PubMed Europe PMC Scholia
  8. Jin SW, Choi CY, Hwang YP, Kim HG, Kim SJ, Chung YC, Lee KJ, Jeong TC, Jeong HG; ''Betulinic Acid Increases eNOS Phosphorylation and NO Synthesis via the Calcium-Signaling Pathway.''; J Agric Food Chem, 2016 PubMed Europe PMC Scholia
  9. Yang S, Wang J; ''Estrogen Activates AMP-Activated Protein Kinase in Human Endothelial Cells via ERβ/Ca(2+)/Calmodulin-Dependent Protein Kinase Kinase β Pathway.''; Cell Biochem Biophys, 2015 PubMed Europe PMC Scholia
  10. Wang Y, Zhang Y, Peng H, Rui J, Zhang Z, Wang S, Li Z; ''WSF-P-1, a novel AMPK activator, promotes adiponectin multimerization in 3T3-L1 adipocytes.''; Biosci Biotechnol Biochem, 2017 PubMed Europe PMC Scholia
  11. Cheng PY, Lee YM, Law KK, Lin CW, Yen MH; ''The involvement of AMP-activated protein kinases in the anti-inflammatory effect of nicotine in vivo and in vitro.''; Biochem Pharmacol, 2007 PubMed Europe PMC Scholia
  12. Jo HK, Kim GW, Jeong KJ, Kim DY, Chung SH; ''Eugenol ameliorates hepatic steatosis and fibrosis by down-regulating SREBP1 gene expression via AMPK-mTOR-p70S6K signaling pathway.''; Biol Pharm Bull, 2014 PubMed Europe PMC Scholia
  13. Ghislat G, Patron M, Rizzuto R, Knecht E; ''Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β).''; J Biol Chem, 2012 PubMed Europe PMC Scholia
  14. Tian S, Ge X, Wu K, Yang H, Liu Y; ''Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKKβ/AMPK and heme oxygenase-1 activation.''; J Pharmacol Exp Ther, 2014 PubMed Europe PMC Scholia
  15. Qiu J, Maekawa K, Kitamura Y, Miyata Y, Tanaka K, Tanaka T, Soga M, Tsuda T, Matsui T; ''Stimulation of glucose uptake by theasinensins through the AMP-activatedprotein kinase pathway in rat skeletal muscle cells.''; Biochem Pharmacol, 2014 PubMed Europe PMC Scholia
  16. Kim JH, Lee JO, Lee SK, Moon JW, You GY, Kim SJ, Park SH, Park JM, Lim SY, Suh PG, Uhm KO, Song MS, Kim HS; ''The glutamate agonist homocysteine sulfinic acid stimulates glucose uptake through the calcium-dependent AMPK-p38 MAPK-protein kinase C zeta pathway in skeletal muscle cells.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  17. Yang F, Zhou L, Qian X, Wang D, He WJ, Tang ZW, Yin J, Huang QY; ''Adropin Is a Key Mediator of Hypoxia Induced Anti-Dipsogenic Effects via TRPV4-CamKK-AMPK Signaling in the Circumventricular Organs of Rats.''; Front Mol Neurosci, 2017 PubMed Europe PMC Scholia
  18. Anderson KA, Means RL, Huang QH, Kemp BE, Goldstein EG, Selbert MA, Edelman AM, Fremeau RT, Means AR; ''Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  19. Chen X, Zhao X, Lan F, Zhou T, Cai H, Sun H, Kong W; ''Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells.''; Sci Rep, 2017 PubMed Europe PMC Scholia
  20. Wang N, Yao M, Xu J, Quan Y, Zhang K, Yang R, Gao WQ; ''Autocrine Activation of CHRM3 Promotes Prostate Cancer Growth and Castration Resistance via CaM/CaMKK-Mediated Phosphorylation of Akt.''; Clin Cancer Res, 2015 PubMed Europe PMC Scholia
  21. Kang S, Huang J, Lee BK, Jung YS, Im E, Koh JM, Im DS; ''Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120).''; Biochim Biophys Acta Mol Cell Biol Lipids, 2018 PubMed Europe PMC Scholia
  22. Martinelli R, Gegg M, Longbottom R, Adamson P, Turowski P, Greenwood J; ''ICAM-1-mediated endothelial nitric oxide synthase activation via calcium and AMP-activated protein kinase is required for transendothelial lymphocyte migration.''; Mol Biol Cell, 2009 PubMed Europe PMC Scholia
  23. Lee ES, Uhm KO, Lee YM, Kwon J, Park SH, Soo KH; ''Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway.''; Regul Pept, 2008 PubMed Europe PMC Scholia
  24. Kwon HB, Castillo PE; ''Long-term potentiation selectively expressed by NMDA receptors at hippocampal mossy fiber synapses.''; Neuron, 2008 PubMed Europe PMC Scholia
  25. Hirata M, Endo K, Katsumata K, Ichikawa F, Kubodera N, Fukagawa M; ''A comparison between 1,25-dihydroxy-22-oxavitamin D(3) and 1,25-dihydroxyvitamin D(3) regarding suppression of parathyroid hormone secretion and calcaemic action.''; Nephrol Dial Transplant, 2002 PubMed Europe PMC Scholia
  26. Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi GN, Kang Y, Zhou L, Yu WM, Magliocca KR, Khuri FR, Qu CK, Metallo C, Owonikoko TK, Kang S; ''The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer.''; Mol Cell, 2018 PubMed Europe PMC Scholia
  27. Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T; ''Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.''; Nature, 2010 PubMed Europe PMC Scholia
  28. Sallé-Lefort S, Miard S, Nolin MA, Boivin L, Paré MÈ, Debigaré R, Picard F; ''Hypoxia upregulates Malat1 expression through a CaMKK/AMPK/HIF-1α axis.''; Int J Oncol, 2016 PubMed Europe PMC Scholia
  29. Lv C, Wu C, Zhou YH, Shao Y, Wang G, Wang QY; ''Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway.''; Int J Endocrinol, 2014 PubMed Europe PMC Scholia
  30. Takai J, Santu A, Zheng H, Koh SD, Ohta M, Filimban LM, Lemaître V, Teraoka R, Jo H, Miura H; ''Laminar shear stress upregulates endothelial Ca²�-activated K� channels KCa2.3 and KCa3.1 via a Ca²�/calmodulin-dependent protein kinase kinase/Akt/p300 cascade.''; Am J Physiol Heart Circ Physiol, 2013 PubMed Europe PMC Scholia
  31. Dong GZ, Lee JH, Ki SH, Yang JH, Cho IJ, Kang SH, Zhao RJ, Kim SC, Kim YW; ''AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction.''; Eur J Pharmacol, 2014 PubMed Europe PMC Scholia
  32. Schmitt JM, Guire ES, Saneyoshi T, Soderling TR; ''Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation.''; J Neurosci, 2005 PubMed Europe PMC Scholia
  33. Huang L, Kondo F, Gosho M, Feng GG, Harato M, Xia ZY, Ishikawa N, Fujiwara Y, Okada S; ''Enhanced expression of WD repeat-containing protein 35 via CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells.''; PLoS One, 2014 PubMed Europe PMC Scholia
  34. Abbott MJ, Edelman AM, Turcotte LP; ''CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle.''; Am J Physiol Regul Integr Comp Physiol, 2009 PubMed Europe PMC Scholia
  35. Takasawa K, Takasawa A, Osanai M, Aoyama T, Ono Y, Kono T, Hirohashi Y, Murata M, Sawada N; ''Claudin-18 coupled with EGFR/ERK signaling contributes to the malignant potentials of bile duct cancer.''; Cancer Lett, 2017 PubMed Europe PMC Scholia
  36. Yu H, Zhang H, Dong M, Wu Z, Shen Z, Xie Y, Kong Z, Dai X, Xu B; ''Metabolic reprogramming and AMPKα1 pathway activation by caulerpin in colorectal cancer cells.''; Int J Oncol, 2017 PubMed Europe PMC Scholia
  37. White MA, Tsouko E, Lin C, Rajapakshe K, Spencer JM, Wilkenfeld SR, Vakili SS, Pulliam TL, Awad D, Nikolos F, Katreddy RR, Kaipparettu BA, Sreekumar A, Zhang X, Cheung E, Coarfa C, Frigo DE; ''GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling.''; Endocr Relat Cancer, 2018 PubMed Europe PMC Scholia
  38. Saneyoshi T, Wayman G, Fortin D, Davare M, Hoshi N, Nozaki N, Natsume T, Soderling TR; ''Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex.''; Neuron, 2008 PubMed Europe PMC Scholia
  39. Vara-Ciruelos D, Dandapani M, Gray A, Egbani EO, Evans AM, Hardie DG; ''Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival.''; Mol Cancer Res, 2018 PubMed Europe PMC Scholia
  40. Gocher AM, Azabdaftari G, Euscher LM, Dai S, Karacosta LG, Franke TF, Edelman AM; ''Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells.''; J Biol Chem, 2017 PubMed Europe PMC Scholia
  41. Yang H, Zhao P, Tian S; ''Clopidogrel Protects Endothelium by Hindering TNFα-Induced VCAM-1 Expression through CaMKKβ/AMPK/Nrf2 Pathway.''; J Diabetes Res, 2016 PubMed Europe PMC Scholia
  42. Harten SK, Shukla D, Barod R, Hergovich A, Balda MS, Matter K, Esteban MA, Maxwell PH; ''Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin.''; Mol Biol Cell, 2009 PubMed Europe PMC Scholia
  43. Huang Q, Cao H, Zhan L, Sun X, Wang G, Li J, Guo X, Ren T, Wang Z, Lyu Y, Liu B, An J, Xing J; ''Mitochondrial fission forms a positive feedback loop with cytosolic calcium signaling pathway to promote autophagy in hepatocellular carcinoma cells.''; Cancer Lett, 2017 PubMed Europe PMC Scholia
  44. Marcelo KL, Means AR, York B; ''The Ca(2+)/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft.''; Trends Endocrinol Metab, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126535view09:44, 29 May 2023EgonwTyped datanodes
124683view07:26, 24 November 2022Rex D A B
121708view04:43, 26 February 2022EweitzUse gene symbol
117669view11:58, 22 May 2021EweitzModified title
113833view08:50, 30 November 2020Fehrhartconnected some of the unconnected lines
113771view18:21, 19 November 2020KhanspersModified description
112884view18:20, 14 October 2020EgonwReplaced gene symbols by Entrez Gene identifiers
112274view00:43, 9 October 2020Rex D A Bconnections and gene name
112262view12:10, 8 October 2020KeshavModified description
111803view15:17, 7 September 2020DeSlRemoved special characters for TNF- node (assuming this is TNF-alpha).
111802view15:15, 7 September 2020DeSladded ID for Adropin (changed from Metabolite to Protein, since it's a peptide hormone).
111801view15:11, 7 September 2020DeSladded ID for Apigenin
111800view15:10, 7 September 2020DeSladded ID for Betulinic acid
111799view15:09, 7 September 2020DeSladded ID for bupivacine (assumed this should be bupivacaine, as wikipedia suggests)
111798view15:07, 7 September 2020DeSladded ID for cauleprin (assumed this should be caulerpin, as reference suggests)
111796view14:48, 7 September 2020DeSladded ID for eugenol
111795view14:44, 7 September 2020DeSladded ID for Glyceollin
111794view14:43, 7 September 2020DeSladded ID for Homocysteine sulfinic acid
111793view14:38, 7 September 2020DeSladded ID for Isorhamnetin
111792view14:36, 7 September 2020DeSladded ID for oxytocin
111791view14:28, 7 September 2020DeSladded ID for quericin (assumed this should be quercetin, as reference suggests)
111790view14:26, 7 September 2020DeSladded ID for ramipril
111789view14:24, 7 September 2020DeSlremoved name as ID for Theasinensins
110018view19:19, 12 April 2020Keshavconnections
110016view19:13, 12 April 2020KeshavInteractions
109756view18:30, 30 March 2020KeshavOntology Term : 'cancer' added !
109755view18:29, 30 March 2020KeshavOntology Term : 'calcium/calcium-mediated signaling pathway' added !
109750view17:53, 30 March 2020KeshavTitle
109749view17:49, 30 March 2020KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCA1GeneProductABCA1
ACACAGeneProductACACA
ACACAProteinNP_942131.1 (NCBI Protein)
AHSPGeneProductAHSP
AKTProteinNP_001014431.1 (NCBI Protein)
AQP1GeneProduct
ARHGEF7GeneProduct8874 (Entrez Gene)
ASNSGeneProductASNS
ATP10DGeneProductATP10D
ATP1B2GeneProductATP1B2
AdropinProteinIPR034461 (InterPro)
ApigeninMetaboliteCHEBI:18388 (ChEBI)
Betulinic acidMetaboliteCHEBI:3087 (ChEBI)
BupivacaineMetaboliteCHEBI:31322 (ChEBI)
CALM1GeneProduct801 (Entrez Gene)
CAMK1GeneProduct8536 (Entrez Gene)
CAMK4GeneProduct814 (Entrez Gene)
CAMKK2GeneProduct10645 (Entrez Gene)
CAR1GeneProductCAR1
CCL5GeneProductCCL5
CCND1GeneProductCCND1
CCND2GeneProductCCND2
CCNE1GeneProductCCNE1
CCR9GeneProductCCR9
CD28GeneProductCD28
CDC25AGeneProductCDC25A
CDH1GeneProductCDH1
CHRM3GeneProduct1131 (Entrez Gene)
CPOXGeneProductCPOX
CREB1GeneProduct1385 (Entrez Gene)
CRTC2GeneProductCRTC2
CTSEGeneProductCTSE
CXCL11GeneProductCXCL11
CYB5R3GeneProductCYB5R3
Ca2+Metabolite
CaulerpinMetaboliteCHEBI:80923 (ChEBI)
DRP1GeneProduct10059 (Entrez Gene)
EIF4EBP1ProteinNP_004086.1 (NCBI Protein)
EP300GeneProduct2033 (Entrez Gene)
EPORGeneProductEPOR
ERMAPGeneProductERMAP
EstrogenGeneProduct
EugenolMetaboliteCHEBI:4917 (ChEBI)
FAM132aGeneProductFAM132a
FAM20CGeneProductFAM20C
FASNGeneProductFASN
FIS1GeneProduct51024 (Entrez Gene)
FOXO3AProteinNP_001446.1 (NCBI Protein)
GALNT9GeneProductGALNT9
GATMGeneProductGATM
GCKGeneProductGCK
GDH1 GeneProduct854557 (Entrez Gene)
GIT1GeneProduct28964 (Entrez Gene)
GlyceollinMetaboliteCHEBI:16470 (ChEBI)
HDCA4GeneProduct9759 (Entrez Gene)
HFEGeneProductHFE
HIF1AGeneProductHIF1A
HK1GeneProduct
HK1GeneProductHK1
HK2GeneProduct
HK2GeneProductHK2
HMBSGeneProductHMBS
HMOX1GeneProduct3162 (Entrez Gene)
Homocysteine sulfinic acidMetaboliteCHEBI:137439 (ChEBI)
Hydrogen sulphideGeneProduct
HypoxiaPathwayHypoxia
ICAM1GeneProduct3383 (Entrez Gene)
IFI44LGeneProductIFI44L
IL15GeneProductIL15
INNGeneProduct
IRGCGeneProductIRGC
IRS-1ProteinNP_005535.1 (NCBI Protein)
IsorhamnetinMetaboliteCHEBI:6052 (ChEBI)
KDRGeneProductKDR
KEAP1GeneProductKEAP1
KLF1GeneProductKLF1
Laminar shear stressPathwayLaminar shear stress (Other)
MAFGeneProduct4094 (Entrez Gene)
MAMDC2GeneProductMAMDC2
MAP1LC3AGeneProduct84557 (Entrez Gene)
MAP1LC3AGeneProductMAP1LC3A
MAP1LC3BGeneProductMAP1LC3B
MAPK14 ProteinNP_001306.1 (NCBI Protein)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3 GeneProduct5595 (Entrez Gene)
MID1GeneProductMID1
MS4A3GeneProductMS4A3
MT1GeneProductMT1
MTORGeneProduct2475 (Entrez Gene)
MX2GeneProductMX2
MetabolitesGeneProductMetabolites
NEDD4LGeneProductNEDD4L
NFATC2GeneProduct4773 (Entrez Gene)
NLRP1GeneProductNLRP1
NOS1GeneProduct4842 (Entrez Gene)
NOS3 ProteinNP_000594.2 (NCBI Protein)
NRF2GeneProduct4780 (Entrez Gene)
NRF2GeneProductNRF2
OASLGeneProductOASL
OxytocinMetaboliteCHEBI:7872 (ChEBI)
PAK1 GeneProduct5058 (NCBI Protein)
PARP1GeneProductPARP1
PCK2GeneProductPCK2
PFKFB2GeneProductPFKFB2
PFKFB3GeneProductPFKFB3
PLAC8GeneProductPLAC8
PPAP2AGeneProductPPAP2A
PRKAA2GeneProductNP_006243.2 (NCBI Protein)
PRKCAProteinNP_002728.1 (NCBI Protein)
Poly unsaturated fatty acidsGeneProduct
ProteinProtein5894 (Entrez Gene)
Pulsed electric fieldGeneProduct
QuercetinMetaboliteCHEBI:16243 (ChEBI)
RAC1GeneProduct5879 (Entrez Gene)
RASGRP1GeneProductRASGRP1
RELAGeneProduct5970 (Entrez Gene)
RHAGGeneProductRHAG
RHDGeneProductRHD
RPS6KB1GeneProductRPS6KB1
RPS6GeneProductRPS6
RPTORGeneProduct57521 (Entrez Gene)
RamiprilMetaboliteCHEBI:8774 (ChEBI)
S100A8GeneProductS100A8
SELLGeneProductSELL
SFI1GeneProductSFI1
SIRT1 GeneProduct23411 (Entrez Gene)
SLC25A21GeneProductSLC25A21
SLC2A1GeneProductSLC2A1
SLC2A4GeneProductSLC2A4
SLC38A5GeneProductSLC38A5
SLCO3A1GeneProductSLCO3A1
SMC1GeneProduct8243 (Entrez Gene)
SPINT1GeneProductSPINT1
SPIRE1GeneProductSPIRE1
SQSTM1GeneProduct8878 (Entrez Gene)
SREBF1GeneProductSREBF1
STIM1GeneProduct6786 (Entrez Gene)
TBC1D4 ProteinNP_001273587.1 (NCBI Protein)
TBXTGeneProductTBXT
TMEM176BGeneProductTMEM176B
TNFGeneProduct
TREM3GeneProductTREM3
TRPV4GeneProductTRPV4
TSC1GeneProduct7248 (Entrez Gene)
TSC2ProteinNP_000539.2 (NCBI Protein)
TSPAN33GeneProductTSPAN33
TSPAN8GeneProductTSPAN8
TheasinensinsMetabolite
ULK1GeneProductULK1
VCAM1GeneProduct7412 (Entrez Gene)
WDR35GeneProductWDR35
WFS1GeneProduct7466 (Entrez Gene)
WFS1GeneProductWFS1
Withdrawal of essential amino acidsGeneProduct

Annotated Interactions

No annotated interactions

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