Deregulation of renin-angiotensin system by SARS-CoV infection (Mus musculus)
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Description
The spike protein of SARS-CoV down regulates ACE2, leading to deregulation of the renin-angiotensin system. This deregulation can be the cause of lung injury that is linked to SARS-CoV infection. This work was done in a mouse model.
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Ontology Terms
Bibliography
- Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, Bao L, Zhang B, Liu G, Wang Z, Chappell M, Liu Y, Zheng D, Leibbrandt A, Wada T, Slutsky AS, Liu D, Qin C, Jiang C, Penninger JM; ''''; , PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
Ace2 | GeneProduct | ENSMUSG00000015405 (Ensembl) | |
Ace | GeneProduct | ENSMUSG00000020681 (Ensembl) | |
Agtr1a | GeneProduct | ENSMUSG00000049115 (Ensembl) | |
Agtr2 | GeneProduct | ENSMUSG00000068122 (Ensembl) | |
Angiotensin I | Metabolite | HMDB0061196 (HMDB) | |
Angiotensin II | Metabolite | HMDB0001035 (HMDB) | |
Angiotensin-(1-7) | Metabolite | CHEBI:55438 (ChEBI) | |
Angiotensin-(1-9) | Metabolite | CHEBI:80128 (ChEBI) | |
Angiotensinogen | Metabolite | CHEBI:2720 (ChEBI) | |
Lung injury | Pathway | WP5035 (WikiPathways) |
Annotated Interactions
No annotated interactions